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  • 알츠하이머병 환자에서 해마 위축과 정신병적 증상
  • Hippocampal Atrophy and Psychotic Symptoms in Patients with Alzheimer’s Disease
저자명
정희정(Hee Jeong Jeong)이영민(Young Min Lee),박제민(Je Min Park),이병대(Byung Dae Lee),문은수(Eun Soo Moon),김수연(Soo Yeon Kim),이강윤(Kang Yoon Lee
간행물명
신경정신의학KCI
권/호정보
2018년|57권 3호|pp.261-265 (5 pages)
발행정보
대한신경정신의학회|한국
파일정보
정기간행물|KOR|
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영문초록

Objectives This study examined the difference in the volume or thickness of the medial temporal lobe between Alzheimer’s disease patients with psychosis (AD+P) and those without psychosis (AD-P). Methods Overall, 31 AD+P patients and 29 AD-P patients were included from the Memory impairment clinics of Pusan National University Hospital in Korea. AD+P was diagnosed according to Jeste and Finkel’s proposed diagnostic criteria for psychosis of Alzheimer’s disease. AD-P included AD patients with no psychotic symptoms during a 5-year follow-up period. Medial temporal volume or thickness was measured by 3-tesla MRI and freesufer analysis. Analysis of variance was used to examine the difference in the volume or thickness of medial temporal lobe between AP+P and AD-P after controlling for age, gender, education years, Clinical Dementia Rating scale-Sum of Box, and total intracranial volume. Results The hippocampal volume in AD+P was smaller than that in AD-P. Conclusion These findings suggest that AD+P is associated with a reduced hippocampal volume.

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