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Biphasic augmentation of alpha-adrenergic contraction by plumbagin in rat systemic arteries
HaeJinKim, HaeYoungYoo, YinHuaZhang, WooKyungKim, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 14 687-694 (8 pages)
neither mimicked nor inhibited ΔT Plum in DFA. Also, pretreat- ment with tiron or catalase did not affect ΔTPlum of DFA. Under the inhibition of PhE- contraction with L-type Ca 2+ channel blocker (nifedipine, 1 M), plumbagin still in- duced tonic contraction, suggesting Ca 2+-sensitization mechanism of smooth muscle. Although ΔTPlum was consistently observed under pretreatment with Rho... of PhE-contraction with L-type Ca2+ channel blocker (nifedipine, 1 μM), plumbagin still induced tonic contraction, suggesting Ca2+-sensitization mechanism of smooth muscle. Although ΔTPlum was consistently observed under pretreatment with Rho A-kinase inhibitor (Y27632, 1 μM), a PKC inhibitor (GF 109203X, 10 μM) largely suppressed ΔTPlum. Taken together, it is suggested that plumbagin facilitates the PKC activation in the presence of vasoactive agonists in skeletal arteries. The biphasic... -
Activation of transient receptor potential vanilloid 3 by the methanolic extract of Schisandra chinensis fruit and its chemical constituent γ-schisandrin
YuranNam, HyunJongKim, Young-MiKim, Young-WonChin, YungKyuKim, HyoSangBae, JooHyunNam, WooKyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.3 5 309-316 (8 pages)
SC fruits (SCEtOH), and SC seed oil (SCseed oil). In the case of SCMeOH, we treated the cells with 2-aminoethyl diphenyl borate (2-APB) to activate ITRPV3. We then treated the cells with the TRPV3 blocker ruthenium red (R.R) to inhibit TRPV3. It was observed that no current was generated from the SC extract or 2-APB treatment in the mock-transfected HEK293T cells. Fig. 3. Structures of the four... Transient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel with modest permeability to calcium ions. It is involved in intracellular calcium signaling and is therefore important in processes such as thermal sensation, skin barrier formation, and wound healing. TRPV3 was initially proposed as a warm temperature sensor. It is activated by synthetic small-molecule chemicals and plantderived natural compounds such as camphor and eugenol. Schisandra chinensis (Turcz.) Baill... -
선택적 COX-2 억제제 NS 398과 EGF 수용체 차단제 AG 1478의 복합투여가 HeLa 세포주의 방사선 감수성에 미치는 영향
윤선민, 오영기, 김주헌, 박미자, 성인옥, 강기문, 채규영, Youn. Seon Min, Oh. Young Kee, Kim. Joo Heon, Park. Mi Ja, Seong. In Ock, Kang. Kimun, Chai. Gyuyong 대한방사선종양학회 대한방사선종양학회지 10 Pages
대한방사선종양학회 대한방사선종양학회지 2005, Vol.23 No.1 51-60 (10 pages)
목적 : 분자 표적의 선택적 억제가 방사선 세포 살상 효과를 증진시키는 것으로 알려져 있으므로 선택적 COX-2 억제제와 EGF 수용체 차단제를 HeLa 세포주에 처리한 후 방사선 효과의 상승작용을 알아보고자 하였다. 대상 및 방법 : 자궁경부암 세포주인 HeLa세포에서 EGF 수용체 차단제 AG 1478, 선택적 COX-2 억제제 NS 398과 방사선을 복합 투여하여 세포성장 억제 분석(cell graph inhibition assay)과 세포사멸 분석(apoptosis assay)을 시행하였고, 방사선 감수성 변화를 살펴보기 위해 세포생존 분석(clonogenic survival assay)을... -
The Critical Roles of Zinc: Beyond Impact on Myocardial Signaling
SungRyulLee, SuJinNoh, JuliusRyanPronto, YuJeongJeong, HyoungKyuKim, InSungSong, ZhelongXu, HyogYoungKwon, SeChanKang, Eun-HwaSohn, KyungS 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 1 389-400 (12 pages)
B. B-blocker timolol prevents arrhythmogenic Ca 2+ release and normalizes Ca 2+ and Zn 2+ dyshomeostasis in hyperglycemic rat heart. PLoS One. 2013;8:e71014. 58. Korichneva I, Hoyos B, Chua R, Levi E, Hammerling U. Zinc release from protein kinase C as the common event during activation by lipid second messenger or reactive oxygen. J Biol Chem. 2002;277:44327-44331. 59. Wang G, Strang C,... Zinc has been considered as a vital constituent of proteins, including enzymes. Mobile reactive zinc (Zn2+) is the key form of zinc involved in signal transductions, which are mainly driven by its binding to proteins or the release of zinc from proteins, possibly via a redox switch. There has been growing evidence of zinc’s critical role in cell signaling, due to its flexible coordination geometry and rapid shifts in protein conformation to perform biological reactions. The importance and...