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In Vivo Suppression of Bisphenol A on Estradiol 2- and 4-Hydroxylase Activities in Hepatic Microsomal Fractions of Male and Female Sprague-Dawley Rats
Nugraha. Boya, Yoon. Ae-Rin, Kandagaddala. Lakshmi Devi, Cho. Hyo-Joo, Chung. Bong-Chul, Kwon. Oh-Seung 한국응용약물학회 Biomolecules & therapeutics 11 Pages
한국응용약물학회 Biomolecules & therapeutics 2009, Vol.17 No.2 188-198 (11 pages)
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Inhibition of Hypoxia-induced Apoptosis in PC12 Cells by Estradiol
JiYeonJung, KwangHoonRoh, YeonJinJeong, SunHunKim, EunJuLee, MinSeokKim, WonMannOh, HeeKyunOh, WonJaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.4 7 231-238 (8 pages)
H2O2 and heme-containing O2 sensors in hypoxic regulation of tyrosine hydroxylase gene expression. Am J Physiol 274: 167－174, 1998 Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell RA. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384: 368 －372, 1996 Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Al- nemri ES, Wand X.... a female sex hormone with steroid structure known to provide neuroprotection through multiple mechanisms in the central nervous system. This study was aimed to investigate the signal transduction pathway of CoCl2-induced neuronal cell death and the inhibitory effects of estradiol. Administration of CoCl2 decreased cell viability in both a dose- and time-dependent manner in PC12 cells. CoCl2-induced cell death produced genomic DNA fragmentation and morphologic changes such as cell shrinkage and... -
Rifampicin Inhibits the LPS-induced Expression of Toll-like Receptor 2 via the Suppression of NF-κB DNA-binding Activity in RAW 264.7 Cells
SeongKeunKim, YoungMiKim, ChungEunYeum, Song-HyoJin, GueTaeChae, Seong-BeomLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 11 475-482 (8 pages)
27-hydroxylase (Li et al., 2007), as compared to non-treated control cells (Fig. 4C). We then assessed whether rifampicin is able to increase the physical association between PXR and NF- κB subunits. As shown in Fig. 5, rifampicin increased the degree of phys- ical association between PXR and NF- κB p65, as compared to the values for the LPS treatment only. These results sug- gest that the... effects of rifampicin. Therefore, we hypothesized that rifampicin may influence the TLR2 expression in LPS-activated RAW 264.7 cells. In this study, we determined that rifampicin suppresses LPS-induced TLR2 mRNA expression. The down-regulation of TLR2 expression coincided with decreased production of TNF-Ձ. Since NF-ՊB is a major transcription factor that regulates genes for TLR2 and TNF-Ձ, we examined the effect of rifampicin on the LPS-induced NF-ՊB activation. Rifampic... -
Catecholamines 에 관(關)하여 -제일편(第一編) Catecholamines의 생성(生成), 저장(貯藏), 유리(遊離) 및 대사(代謝)-
이자주(Lee, W.C.), 대한약리학회 대한약리학잡지 20 Pages
대한약리학회 대한약리학잡지 1971, 제 7권 제 1호 1 1-20 (20 pages)
nine¾ ~4joJ] $Jt,j-%}.31. illU'!lioJ]h] :/iZM~tt epinephrine ¾ ~l±\%}E....s!...#J Blaschko sJ :ttlllrn .iE1l!.11: Al~ 4. ::L~ °'1 "1 *½.2.J litf5!;..s!..--2.J 7-} f)!:lli\i'oJl mffijij,;s;J i::-M*7} mftmfl~J!;s;J o-J 1964 : tyrosine hydroxylase s] moo¾ :/llt~..s!.. 0 };\J ill ca- techolamine ~bx; ~f,'fs] ~IDi!7} ~~ -x{.31. ::L ~f,'foJ] iffiji'J,;s;J i=" .51.. ~... -
精神分裂病에서의 血小板 Monoamine Oxidase 活性度와 血發 Estradiol, Progesterone 및 Testosterone의 相關關係에 關한 硏究
金鍾億, 李定均, 禹鍾仁, 朴賛, 雄 대한신경정신의학회 신경정신의학 15 Pages
대한신경정신의학회 신경정신의학 1984, 제 23권 제 1호 3 22-36 (15 pages)
on plasma and platelet monoamine oxidase (MAO) and plasma dopamine beta-hydroxylase (DBH) activities in the rhesus monkey. Psychosomatic Med. 37 : 417-428 Redmond, D.E., Baulu, J., Murphy, D.L., Loriaux, D.L., Zeigler, M.G., and Lake, C.R. (1976) The effects o f testosterone on plasma and platelet monoamine oxidase (MAO) and plasma dopami ne beta-hydroxylase (DBH) activities in the male... -
Microglial involvement in the development of olfactory dysfunction
Yoojin Seo, Hyung-Sik Kim, Kyung-Sun Kang 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 1 319-330 (12 pages)
in a decline in OB size due to massive loss of tyrosine hydroxylase-positive dopaminergic interneurons in the OB [50]. Notably, progressive microgliosis within the OB was also observed with the morphological transformation from resting state into the amoeboid state, indicating increased phagocytic activity. As a result, most adult-born OB neurons are engulfed by microglia in the occluded OB,... Olfactory impairment is the most common clinical manifestation among the elderly, and its prevalence increases sharply with age. Notably, growing evidence has shown that olfactory dysfunction is the first sign of neurodegeneration, indicating the importance of olfactory assessment an early marker in the diagnosis of neurological disorders. In this review, we describe the nature of olfactory dysfunction and the advantage of using animal models in olfaction study, and we include a brief... -
Development of in vitro produced porcine embryos according to serum types as macromolecule
Jungmin Son, Don Buddika Oshadi Malaweera, Eunsong Lee, Sangtae Shin, Jongki Cho 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 3호 11 315-321 (7 pages)
2, 359-370. 5. C o n l e y A J , B i r d I M . The role of cytochrome P450 17 α-hydroxylase and 3β-hydroxysteroid dehydrogenase in the integration of gonadal and adrenal steroidogenesis via the Δ5 and Δ4 pathways of steroidogenesis in mammals. Biol Reprod 1997, 56, 789-799. 6. Coy P, Romar R. In vitro production of pig embryos: a point of view. Reprod Fertil Dev 2002, 14, 275-286. 7. Daen... This study was conducted to establish an in vitro maturation (IVM) system by selection of efficient porcine serum during porcine in vitro production. To investigate the efficient porcine serum (PS), different types of PS [newborn pig serum, prepubertal gilt serum (PGS), estrus sow serum, and pregnancy sow serum] were used to supplement IVM media with or without gonadotrophin (GTH) and development rates of parthenogenetic activation (PA) and in vitro fertilization (IVF) embryos were then... -
알코올 의존 환자에서의 혈청 성호르몬, 성선자극호르몬, 코티졸 및 프로락틴
서동수, 박두병, 이길홍 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 1998, 제 37권 제 3호 12 527-536 (10 pages)
중요한 간효소인 estr ogen-2-hydroxylase의 뚜 렷한 감소를 야기한다고 보고하였다. 이러한 에스트로젠의 증가는 신경화학적으로 뇌에 영향을 미칠수 있는데 경련에 대한 역치를 낮출 수 있 으며 35) 알코올 의존의 병태 생리와 병인론에 관계될 수 있는 주요한 신경전달물질 체계에 영향을 미칠수 있다. 즉 에스트로젠은 도파민 대사를 증가시킬 수 있고 36) 도 파민 수용체 농도와 도파민 수용체로부터 유도된 ad- enylate... 방 법： 알코올 의존을 가진 15명의 환자군에서 금단중과 금주후 21일후에 시상하부-뇌하수체-성선축 호르몬 (테스토스테론, 에스트라디올, 황체화 호르몬, 난포자극 호르몬)을 검사하였으며 이축에 영향을 미칠 수 있는 코티졸과 프로락틴도 포함시켰다. 그리고 12명의 건강 대조군에서 동일한 검사를 시행하여 그 결과를 환자 군과 비교하였다. 결 과： 금단중에 황체화 호르몬, 에스트라디올, 코티졸, 프로락틴은 의미있게 상승되었고 이들 호르몬 중 황체화 호르몬과 프로락틴은 금주후 3주뒤에도 여전히 상승되어있었다. 결 론： 본... -
생식정신의학：폐경주변기 및 폐경기
대한신경정신의학회 신경정신의학 2003, 제 42권 제 1호 5 46-53 (8 pages)
25)와 같이 생식선 스테로 이드의 형성과정을 살펴보면, 콜레스테롤에서 테스토스 테론, 테스토스테론에서 estradiol이 형성되어 여성호르 몬과 남성호르몬 사이에 밀접한 관계가 있음을 알 수 있 Fig. 4. Synthetic pathways fo r steroid hormones. 25) Circled nu- mbers identify synthetic enzy- mes ： 1： cytochrome P450 (CYP) 11A (cholesterol desmo- lase), 2：3β-hydroxysteroid de- hydrogenase, 3 ：CYP21 (21-... -
정신분열병의 사회인구학적 요인 및 임상양상의 성별차이
이은정, 우행원 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 1996, 제 35권 제 4호 3 753-762 (10 pages)
효소인 tyrosine hydroxylase 의 유전자 전시를 감소 시킴(Blum등 1987) 으로 정신증에 대항하는 보호작용 을 갖는다(Seeman과 Lang 1990) 고 알려 져 있다. 또한 여성은 남성보다 뇌혈류량이 15% 더 많으므로(Gur등 1982) 뇌에서 항정신병약물이 보다 효과적인 분포를 이 루고, 체지방이 남성보다 2배이므로(Frisch 1988) 지방 친화성이 강한 항정신병 약물이 오랜 시간 저장될 수 있 다. 또한 이러한 증진된 약물반응성으로...