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Effects of Extracellular Signaling on the Endogenous Expression of Self-Renewal-Stimulating Factor Genes in Mouse Embryonic Stem Cells
Gong. Seung-Pyo, Lee. Seung-Tae 한국동물번식학회 Reproductive & developmental biology 7 Pages
한국동물번식학회 Reproductive & developmental biology 2012, Vol.36 No.1 13-19 (7 pages)
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Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Activates Pro-Survival Signaling Pathways, Nuclear Factor-${kappa}B$ and Extracellular Signal-Regulated Kinase 1/2 in Trophoblast Cell Line, JEG-3
Ka. Hakhyun 한국동물번식학회 Reproductive & developmental biology 8 Pages
한국동물번식학회 Reproductive & developmental biology 2005, Vol.29 No.2 101-108 (8 pages)
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Effect of low intensity pulsed ultrasound in activating the mitogen-activated protein kinase signaling pathway and inhibition inflammation cytokine synthesis in chondrocytes
Eun-Jung Kim, Gye-Yeop Kim 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2014, 제 3권 제 1호 6 33-37 (5 pages)
to synthesize the surrounding extracellular matrix. Accordingly, the ability to maintain cartilage homeostasis is decreased in aged chondrocytes, and matrix proteins are smaller and more irregular [21]. The pathological mecha- nism of OA is closely associated with excessive mechanical and oxidative stress, but its underlying mechanisms have not been fully clarified. The present study... -
Role of c-di-GMP signaling for the pathophysiology of enteropathogenic Escherichia coli
Dalmuri Han, Hyung Tae Lee, June Bong Lee, Jang Won Yoon 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 84 229-230 (2 pages)
the cardiac magnesium homeostasis. Materials and Methods: When changing the extracellular pH o or [pH]i, [Mg 2+ ]i and intracellular Na + concentration ([Na + ]i) and total Mg efflux([Mg] e) were measured in perfused heart, isolated papillary muscle and cardiac cell by ion-selective microelectrode technique, fluorescence microscopy and atomic absorbance spectrophotometry. Results: In both... -
Hinokitiol inhibits adipocyte differentiation via AMPK signaling in mesenchymal stem cells
Ju Hee Lee, Ji Hong Moon, Uddin Nazim, Rasheduzzaman Mohammad, You Jin Lee, Jae Won Seol, Sang Youel Park 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 79 126-127 (2 pages)
complex, has been classified into γ, δ, ε, and ζ chains. The CD3γ, CD3δ, and CD3 ε chains are highly related to cell surface proteins of theimmunoglobulin superf amily containing a single extracellular immunoglobulindo main. In mammals, T cells were characterized by detecting one of the CD3molecules through the use of specific antibody for CD3ε. This suggests that CD3molecules can b... -
Sciatic nerve leachate of cattle causes neuronal differentiation of PC12 cells via ERK1/2 signaling pathway
Ziqiang Zhang, Yumei Liu, Xuemin Zhu, Lan Wei, Jiamin Zhu, Ke Shi, Guotao Wang, Li Pan 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 4호 6 512-518 (7 pages)
(a useful cell model for studying neuronal differentiation). The mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 (MEK/ERK1/2) signaling pathway is often linked with cells survival, proliferation, and differentiation. Previous studies have shown a mechanistic role for MEK/ERK1/2 in the regulation of neurite elongation: the duration of ERK activation determines the... cells treated with the cattle sciatic nerve leachate for 3, 6, and 9 days was significantly improved, and the expressions of β3-tubulin and microtubule-associated protein 2 (two neuron-specific proteins) were increased. Moreover, the ERK1/2 signaling pathway was activated after PC12 cells were incubated with cattle sciatic nerve leachate for 9 days. Thus, a sciatic nerve leachate obtained from cattle can effectively induce neuronal differentiation of rat PC12 cells via ERK1/2 signaling pathway. -
Involvement of the Ca signaling pathway in osteoprotegerin inhibition of osteoclast differentiation and maturation
Yingxiao Fu, Jianhong Gu, Yi Wang, Yan Yuan, Xuezhong Liu, Jianchun Bian, Zong-Ping Liu 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 2호 3 151-156 (6 pages)
signaling pathway promotes OPG inhibition of osteoclast differentiation and activation. Ca 2+ enters the cytoplasm from the extracellular environment and intracellular calcium stores following activation of the Ca 2+ signaling pathway [26]. [Ca 2+]i has been shown to be increased in many types of cells during apoptosis, particularly during the early phase [16,11]. [Ca 2+]i is one of the key... significantly increased [Ca]i and CaMKII phosphorylation in osteoclasts (p ＜ 0.01), and that these effects were subsequently decreased by OPG treatment. Exposure to specific inhibitors of the Ca signaling pathway revealed that these changes varied between the different OPG treatment groups. Findings from the present study indicated that the Ca signaling pathway is involved in both the regulation of osteoclastogenesis as well as inhibition of osteoclast differentiation and activation by OPG. -
Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway
Sijun Deng, Hui Yuan, Jine Yi, Yin Lu, Qiang Wei, Chengzhi Guo, Jing Wu, Liyun Yuan, Zuping He 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 3호 7 281-289 (9 pages)
remove the extracellular DCFH-DA. The fluorescence was then determined at 488 nm excitation and 525 nm emission using a spectrofluorometer. Western blot analysis To determine changes in caspase-3 and caspase-9 expression in GA-treated RAW264.7 cells, Western blot analysis was performed as previously described [30]. Briefly, the RAW264.7 cells exposed to GA were washed with PBS and lysed... proliferation of RAW264.7 cells in a dose-dependent manner, and caused obvious cell apoptosis and a loss of ΔΨm in RAW264.7 cells. Moreover, the ROS production in cells was elevated, and the levels of activated caspase-3 and caspase-9 were up-regulated in a dose-dependent manner. Notably, GA-induced cell apoptosis was markedly inhibited by caspase inhibitors. These results suggest that GA-induced RAW264.7 cell apoptosis may be mediated via a caspase-dependent mitochondrial signaling pathway. -
Extracellular acidity enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis via DR5 in gastric cancer cells
Ran Hong, Song Iy Han 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 5 513-523 (11 pages)
Tumor tissues are often exposed to acidic extracellular pH since tumors produce high levels of lactic acid and H + by using the anaerobic glycolytic pathway for energy production [1]. Such extracellular acidification constitutes a stress to cells, and certain mechanisms by which tumor cells adapt to this stressful environ- ment may enhance their malignant characteristics. Accumulat- ing... extracellular acidity and attempted to identify a means of enhancing treatment efficacy. Acidic conditions caused several changes in GC cells adversely affecting chemotherapeutic treatment. Extracellular acidity did inhibit GC cell growth by inducing cell cycle arrest, but did not induce cell death at pH values down to 6.2, which was consistent with downregulated cyclin D1 and up-regulated p21 mRNA expression. Additionally, an acidic environment altered the expression of atg5, HSPA1B, collagen... -
Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model
HwayoungLee, JiyunIm, HansolWon, WooyoungNam, YoungOckKim, SangWonLee, SanghyunLee, Ik-HyunCho, Hyung-KiKim, Jun-TackKwon, Hak-JaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 1 361-370 (10 pages)
in the lumbar spinal dorsal horn [22]. BDNF function is also strongly associated with the transmission of nociceptive information related to BDNF receptor tropomyosin receptor kinase (TrkB), extracellular signal regulated kinase (ERK), and CREB of ERK downstream target [23]. CREB is a transcription factor that plays a key role in adaptive neuronal responses. It also has complex functions in... Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepressants, tianeptine has been reported to be able to prevent neurodegeneration due to chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM...