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Effect of Stimulus Waveform of Biphasic Current Pulse on Retinal Ganglion Cell Responses in Retinal Degeneration (rd1) mice
KunNoAhn, JeongYeolAhn, Jae-hyungKim, KyoungrokCho, Kyo-inKoo, SolomonS.Senok, YongSookGoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 12 167-175 (9 pages)
viable retinal prosthesis. Here, we investigated the effects of different charge-balanced biphasic pulses with regard to their effectiveness in evoking retinal ganglion cell (RGC) responses. Retinal degeneration ( rd1 ) mice were used (n=17). From the ex-vivo retinal preparation, retinal patches were placed ganglion cell layer down onto an 8×8 multielectrode array (MEA) and RGC responses were... evoking retinal ganglion cell (RGC) responses. Retinal degeneration (rd1) mice were used (n=17). From the ex-vivo retinal preparation, retinal patches were placed ganglion cell layer down onto an 8×8 multielectrode array (MEA) and RGC responses were recorded while applying electrical stimuli. For asymmetric pulses, 1st phase of the pulse is the same with symmetric pulse but the amplitude of 2nd phase of the pulse is less than 10 μA and charge balanced condition is satisfied by lengthening the... -
Fine Structure of Diapause Regulator Cell in the Suboesophageal Ganglion in the Silkworm, Bombyx Mori
Park. Kwang E. 한국잠사학회 韓國蠶絲學會誌 9 Pages
한국잠사학회 韓國蠶絲學會誌 1971, Vol.13 No.2 99-107 (9 pages)
전자현미경관찰에 의하여 가잠의 식도하신경구에서 휴면요인세포(diapause factor cell)에 어떤 정보를 주는 것으로 생각되는 휴면조절세포(diapause regulator producing cell)를 발견하였다. 휴면조절세포의 과립은 이 세포가 부분적으로 둘러싸고 있는 휴면요인세포의 과립의 직경보다 크며(직경 .2,000∼5,000A), 휴면란을 산란하는 개체의 휴면조절세포에서는 전자밀도가 높은 리소좀이 관찰되었으나, 비휴면란을 산란하는 개체에서는 이것이 관찰되지 않았다. 다수의 세포질과립이 리소좀과 결합되었다가 소형의 과립으로 되어... -
Pineal Photoreceptor and Ganglion Cells in River Lamprey, Lampetra japonica -Two Types of Pineal Ganglion Cell-
Tamotsu. Satoshi, Kinugawa. Yoshimi, Kawano. Emi, Watanabe. Mai, Samejima. Michikazu, Oishi. Tadashi 한국광과학회 Journal of photoscience: an international journal officail organ of the Korean Society of Photoscien 4 Pages
한국광과학회 Journal of photoscience: an international journal officail organ of the Korean Society of Photoscien 2002, Vol.9 No.2 21-24 (4 pages)
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PR-domain containing protein 12 (Prdm12) is a downstream target of transcription factor Zic1 during brain cell differentiation
Byung Yong Park, Mahfujur Rahman, In shik Kim, Dong choon Ahn, Rashedunnabi Akanda 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 308 502-503 (2 pages)
and in the neuro-ectoderm. prdm12 specifically expressed in the pre-placodal ectoderm, trigeminal ganglion, along with the dorsal spinal cord. prdm12 expression was more prominent in the midbrain, ventral part of the forebrain and hind brain domain, neural crest, trigeminal ganglion. In the posterior region, the prdm12 expression was restricted to the motor neuron of the spinal cord. In a... -
Effect of EDCs on calcium channels in cardiomyocytes derived from mES cell
Jae Hwan Lee, Jin Yong An, Eui Bae Jeung 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 197 317-318 (2 pages)
in the spinal trigeminal ganglion. Like the expression of calbindin-D 9k, mRNA levels of TRPV1 and NCX1 only increased in response to Dex treatment. Conclusions: These results are correlated with calbindin-D 9k, TRPV1 and NCX1 expressions were regulated by glucocorticoids in brainstem. Especially, the localization and regulation of calbindin-D 9k in trigeminal ganglion could indicate that... -
The advantage of topographic prominence-adopted filter for the detection of short-latency spikes of retinal ganglion cells
JungryulAhn, Myoung-HwanChoi, KwangsooKim, SolomonS.Senok, Dong-ilDanCho, Kyo-inKoo, YongsookGoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 10 555-563 (9 pages)
Kyo-in Koo E-mail: kikoo@ulsan.ac.kr Key Words Electrical stimulus artifact Long-latency spike Retinal ganglion cell Retinal prosthesis Short-latency spike #These authors contributed equally to this work. ABStrAct Electrical stimulation through retinal prosthesis elicits both short and long-latency retinal ganglion cell (RGC) spikes. Because the short-latency RGC spike is usually obscured by... Electrical stimulation through retinal prosthesis elicits both short and long-latency retinal ganglion cell (RGC) spikes. Because the short-latency RGC spike is usually obscured by electrical stimulus artifact, it is very important to isolate spike from stimulus artifact. Previously, we showed that topographic prominence (TP) discriminator based algorithm is valid and useful for artifact subtraction. In this study, we compared the performance of forward backward (FB) filter only vs. TP-adopted... -
Dust particles-induced intracellular Ca2+ signaling and reactive oxygen species in lung fibroblast cell line MRC5
DongUnLee, MinJeongJi, JungYunKang, SunYoungKyung, JeongHeeHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.3 7 327-334 (8 pages)
N, Kiyonaka S. Receptor signaling integration by TRP channelsomes. Adv Exp Med Biol. 2011;704:373-389. 34. Takahashi N, Kozai D, Kobayashi R, Ebert M, Mori Y. Roles of TRPM2 in oxidative stress. Cell Calcium. 2011;50:279-287. 35. Nazırolu M, Ozgul C, Celik O, Ci B, Sozbir E. Aminoethoxy- diphenyl borate and flufenamic acid inhibit Ca 2+ influx through TRPM2 channels in rat dorsal root gangli... Epidemiologic interest in particulate matter (PM) is growing particularly because of its impact of respiratory health. It has been elucidated that PM evoked inflammatory signal in pulmonary epithelia. However, it has not been established Ca2+ signaling mechanisms involved in acute PM-derived signaling in pulmonary fibroblasts. In the present study, we explored dust particles PM modulated intracellular Ca2+ signaling and sought to provide a therapeutic strategy by antagonizing PM-induced... -
The TREK2 Channel Is Involved in the Proliferation of 253J Cell, a Human Bladder Carcinoma Cell
Kyung-SunPark, MinHoHan, HeeKyungJang, Kyung-AKim, Eun-JongCha, Wun-JaeKim, YungHyunChoi, YangmiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.6 6 511-516 (6 pages)
a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif. 2003;36:131-149. 27. Park KS, Kim Y. Functional expression of mechanosensitive two-pore domain potassium channel in human bladder carci- noma cells. J Biomed Res. 2013;14:71-76. 28. Kang D, Kim D. TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K ＋ channels in dorsal root ganglion neurons. Am J... TREK2, in the human bladder cancer cell line, 253J. We confirmed that TREK2 was expressed in bladder cancer cell lines by Western blot and quantitative real-time PCR. Using the patch-clamp technique, the mechanosensitive TREK2 channel was recorded in the presence of symmetrical 150 mM KCl solutions. In 253J cells, the TREK2 channel was activated by polyunsaturated fatty acids, intracellular acidosis at －60 mV and mechanical stretch at −40 mV or 40 mV. Furthermore, small interfering RNA... -
Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons
YunjuJin, JunKim, JiyeonKwak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 10 211-217 (7 pages)
Korean J Physiol Pharmacol Vol 16: 211 －217, June, 2012 http://dx.doi.org/10.4196/kjpp.2012.16.3.211 ABBREVIATIONS: DRG, dorsal root ganglion (DRG); IC50, concen- tration causing 50% of maximal inhibition; NO, nitric oxide; TRPV1, transient receptor potential vanilloid subtype 1. Received April 10, 2012, Revised June 11, 2012, Accepted June 12, 2012 Corresponding to: Jiyeon Kwak, Department of... cultured rat dorsal root ganglion (DRG) neurons. NO donors, sodium nitroprusside (SNP) and S-nitro-N-acetylpenicillamine (SNAP), decreased capsaicin-evoked currents (Icap). NO scavengers, hemoglobin and 2-(4-carboxyphenyl)- 4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (CPTIO), prevented the inhibitory effect of SNP on Icap. Membrane-permeable cGMP analogs, 8-bromoguanosine 3', 5'-cyclic monophosphate (8bromo-cGMP) and 8-(4chlorophenylthio)-guanosine 3',5'-cyclic monophosphate (8-pCPT-cGMP), and... -
Bile Acid Inhibition of N-type Calcium Channel Currents from Sympathetic Ganglion Neurons
HyeKyungLee, KyoungHwaLee, Eui-SicCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.1 4 25-30 (6 pages)
selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture. Proc Natl Acad Sci USA. 1987;84:5469-5473. 43. Scroggs RS, Fox AP. Multiple Ca 2＋ currents elicited by action potential waveforms in acutely isolated adult rat dorsal root ganglion neurons. J Neurosci. 1992;12:1789-1801. 44. Bowersox SS, Gadbois T, Singh T, Pettus M, Wang YX,... bile acids on gating of neuronal (N)-type Ca2＋ channel that is essential for neurotransmitter release at synapses of the peripheral and central nervous system. N-type Ca2＋ channel currents were recorded from bullfrog sympathetic neuron under a cell-attached mode using 100 mM Ba2＋ as a charge carrier. Cholic acid (CA, 10－6 M) that is relatively hydrophilic thus less cytotoxic was included in the pipette solution. CA suppressed the open probability of N-type Ca2＋ channel, which appeared to be...