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Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau
Song-InKim, Won-KiLee, Sang-SooKang, Sue-YoungLee, Myeong-JaJeong, HeeJaeLee, Sung-SooKim, GallV.W.Johnson, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 6 107-114 (8 pages)
..PAGE:1 107 Korean J Physiol Pharmacol Vol 15: 107 －114, April, 2011 DOI: 10.4196/kjpp.2011.15.2.107 ABBREVIATIONS: AD, Alzheimer's disease; NFT, neurofibrillary tangle; FTDP-17, parkinsonism linked to chromosome 17; PHFs, paired helical filaments; GSK3 β, glycogen synthase kinase 3 β. Received March 25, 2011, Revised April 17, 2011, Accepted April 20, 2011 Corresponding to: Wanjoo Chun,... of GSK3Ղ-mediated phosphorylation of tau species on their autophagic degradation. We transfected wild type tau (T4), caspase-3-cleaved tau at Asp421 (T4C3), or pseudophosphorylated tau at Ser396/Ser404 (T4-2EC) in the presence of active or enzyme-inactive GSK3Ղ. Trehalose and 3-methyladenine (3-MA) were used to enhance or inhibit autophagic activity, respectively. All tau species showed increased accumulation with 3-MA treatment whereas reduced with trehalose, indicating that tau...