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Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway
Sijun Deng, Hui Yuan, Jine Yi, Yin Lu, Qiang Wei, Chengzhi Guo, Jing Wu, Liyun Yuan, Zuping He 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 3호 7 281-289 (9 pages)
μmol/L) [34]. Therefore, the results of the present study indicate a relatively high sensitivity of mouse macrophages to GA. Apoptosis is the process of programmed cell death that may occur in multicellular organisms [14], which is a normal physiological mechanism of maintaining body steady-state. Apoptosis is characterized by a series of morphological changes including cytosol shrinkage,... for GA-induced cell apoptosis, RAW264.7 cells were treated with GA (25∼35 μmol/L) for 24 h and the cytotoxicity was determined by MTT assay, while apoptotic cells were identified by TUNEL assay, acridine orange/ethidium bromide staining and flow cytometry. Moreover, mitochondrial membrane potential (ΔΨm) with Rhodamine 123 and reactive oxygen species (ROS) with DCFH-DA were analyzed by fluorescence spectrofluorometry. In addition, the expression of caspase-3 and caspase-9 was assessed by... -
Comparative analysis of heart functions in micropigs and conventional pigs using echocardiography and radiography
Min Young Lee, Sang Hun Lee, Seung Gon Lee, Soo Hyun Park, Chai Yong Lee, Kye Hun Kim, Sun Ho Hwang, Sang Yub Lim, Young Keun Ah 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 1호 2 7-14 (8 pages)
great significance, but multicellular organisms also require cells to be able to communicate with each other through hormones and other molecules. Moreover, little is known about these more complex cross-species compatibilities. The question as to whether the pig heart is functionally and anatomically similar to its human counterpart was investigated [4]. In this study, we could observe that there... The production of miniature animals has been suggested for use in organ transplantation. At present, many of the studies about application of animal organs to human have been focused on pigs because of the number of advantages involved and due to their similarities with human. However, a physiological analysis of the organs to be transplanted has not yet been carried out. Therefore, this study analyzed whether or not there were physiological and morphological differences in the hearts of... -
산삼 배양액을 급여한 육계에서 근육의 프로테옴 분석
설재원, 황인호, 채준석, 강형섭 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2005, 제 45권 제 2호 3 155-161 (7 pages)
the multicellular aggregate (slug). Electrophoresis 1997, 18, 491-497. 20. Yan JX, Harry RA, Wait R, Welson SY, Emery PW, Preedy VR, Dunn MJ. Separation and identification of rat skeletal muscle proteins using two-dimensional gel electrophoresis and mass spectrometry. Proteomics 2001, 1, 424-434. 21. Yun TK. Experimental and epidemiological evidence on non-organ specific cancer preventive effect... -
Bis is Induced by Oxidative Stress via Activation of HSF1
HyungJaeYoo, Chang-NimIm, Dong-YeYoun, HyeHyeonYun, Jeong-HwaLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.5 8 403-409 (7 pages)
the heat stress response: implications in aging and disease. Annu Rev Biochem. 2011;80:1089-1115. 34. Gidalevitz T, Prahlad V, Morimoto RI. The stress of protein misfolding: from single cells to multicellular organisms. Cold Spring Harb Perspect Biol. 2011;3. pii: a009704. 35. Liao Q, Ozawa F, Friess H, Zimmermann A, Takayama S, Reed JC, Kleeff J, Buchler MW. The anti-apoptotic protein BAG-3... The Bis protein is known to be involved in a variety of cellular processes including apoptosis, migration, autophagy as well as protein quality control. Bis expression is induced in response to a number of types of stress, such as heat shock or a proteasome inhibitor via the activation of heat shock factor (HSF)1. We report herein that Bis expression is increased at the transcriptional level in HK-2 kidney tubular cells and A172 glioma cells by exposure to oxidative stress such as H2O2 treatment... -
Mechanisms of Selective Antimicrobial Activity of Gaegurin 4
HeejeongKim, ByeongJaeLee, MunHanLee, SeongGeunHong, PanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.1 7 39-48 (10 pages)
Simmaco M, Mignogna G, Barra D, Bossa F. Novel antimicrobial peptides from skin secretion of the European frog, Rana esculenta. FEBA Lett 324: 159 161, 1993 Won HS, Kang SJ, Lee BJ. Action mechanism and structural requirements of the antimicrobial peptides, gaegurins. Biochim Biophys Acta 2009 (In press). Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 415: 389 395, 2002 Gaegurin 4 (GGN4), an antimicrobial peptide isolated from a Korean frog, is five times more potent against Gram-positive than Gram-negative bacteria, but has little hemolytic activity. To understand the mechanism of such cell selectivity, we examined GGN4-induced K＋ efflux from target cells, and membrane conductances in planar lipid bilayers. The K＋ efflux from Gram-positive M. luteus (2.5</SUP>Ռg/ml) was faster and larger than that from Gram-negative E. coli (75Ռg/ml), while... -
Effects of High Glucose on Na,K-ATPase and Na/glucose Cotransporter Activity in Primary Rabbit Kidney Proximal Tubule Cells
Han, Ho-Jae 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 1호 7 69-80 (12 pages)
culture cells The morphology of the cultures are shown in Fig. 2. After IO days the monolayers demonstrated multicellular dome formation, indicative of vector- ial sodium and water transport, with as many as three to four domes visible at low ( X 40) mag- nification (Fig. 2A). Dome formation was not observed in isolated cell colonies. Analysis by electron microscopy of several fields showed... Renal proximal tubular hypertrophy and hyperfunction are known to be early manifestations of experimental and human diabetes. As the hypertrophy and hyperfunction have been suggested to be central components in the progression to renal failure, an understanding of their underlying causes is potentially important for the development of therapy. A primary rabbit kidney proximal tubule cell culture system was utilized to evaluate the possibility that the renal proximal tubular hypertrophy and... -
Calcium Balance in the Heart -Annual Review Lecture, October 13, 1990-
Noble, Denis 대한생리학회 대한생리학회지 16 Pages
대한생리학회 대한생리학회지 1991, 제 25권 제 1호 1 1-16 (16 pages)
the external calcium transient. The preparation here is a multicellular one, so there are narrow in- tercelluar spaces in which calcium accumula- tion and depletion can occur. The result is ex- actly as predicted: calcium depletion ( corre- sponding to net calcium entry into the cells) occurs almost immediately after the action po- tential upskroke, and continues for about 30 > 8... -
Open Access : Altered Gene Expression and Intracellular Changes of the Viable But Nonculturable State in Ralstonia solanacearum by Copper Treatment
한국식물병리학회 The Plant Pathology Journal 12 Pages
한국식물병리학회 The Plant Pathology Journal 2013, 29권 4호 3 374-385 (12 pages)
pathogenic bacteria, 3rd ed., APS press, St. Paul, MN. Shapiro, J. A. 1988. Bacteria as multicellular organisms. Sci. Am. 258:62 Tobiason, D. M. and Seifert, H. S. 2010. Genomic content of Neisseria species. J. Bacteriol. 192:2160 van Elsas, J. D., Kastelein, P., de Vries, P. M. and van Overbeek, L. S. 2001. Effects of ecological factors on the survival and physiology of Ralstonia solanacearum bv.... Environmental stresses induce several plant pathogenic bacteria into a viable but nonculturable (VBNC) state, but the basis for VBNC is largely uncharacterized. We investigated the physiology and morphology of the copperinduced VBNC state in the plant pathogen Ralstonia solanacearum in liquid microcosm. Supplementation of 200 μM copper sulfate to the liquid microcosm completely suppressed bacterial colony formation on culture media; however, LIVE/DEAD BacLight bacterial viability staining... -
Research Articles : Purification and Structural Analysis of Surfactin Produced by Endophytic Bacillus subtilis EBS05 and its Antagonistic Activity Against Rhizoctonia cerealis
한국식물병리학회 The Plant Pathology Journal 7 Pages
한국식물병리학회 The Plant Pathology Journal 2011, 27권 4호 6 342-348 (7 pages)
by Bacillus polyfer- menticus KJS-2. Arch. Pharm. Res. 32:711715. Krzysztofa Nagorska, Mariusz Bikwoski and Michal Obu- chowski. 2007. Multicellular behaviour and production of a wide variety of toxic substances support usage of Bacillus sub- tilis as a powerful biocontrol agent. Acta Biochim. Pol. 54:495508. Lee, S. C., Kim, S. H., Park, I. H., Chung, S. Y. and Choi, Y. L. 2007. Isolation and... th of strain EBS05 can more effectively control WSED than can fludioxonil. The fermentation broth and bacteria-free filter ability to suppress WSED was not significantly different, suggesting that an active secreted substance played a major role in controlling WSED. Separation and purification of the active compounds was carried out by serial processes, including hydrochloric acid (pH 2.0) treatment, methanol extraction and Sephadex LH-20 column chromatography, silica gel column chromatography... -
The History of the Korean Science Curriculum and the Introduction of the Present 2015 Science Curriculum
Ha Minsu 이화여자대학교 교과교육연구소 교과교육학연구 14 Pages
이화여자대학교 교과교육연구소 교과교육학연구 2017, 제 21권 3호 1 171-184 (14 pages)
action of the endocrine system and nervous system is to maintain homeostasis. Continuity of life Reproduction The organism is maintained through sexual reproduction or asexual reproduction. Multicellular organisms produce gametes and make individuals through fertiliza- tion and development. Heredity The traits of living things are transmitted to their offspring by genetic principles. The trait of... The purpose of this study is to identify the history of the science curriculum in Korea and to review the science curriculum launched in 2015. Science has become an independent subject from the secondary curriculum for the purposes of developing Korean industry. The third curriculum was published by revising the second curriculum and adding an academic focus. The third curriculum was revised to create the fourth curriculum by introducing the notion of a human-centered curriculum, which is mainly...