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Inhibitory Effects of Nampungchal Sorghum Ethanol Extract on Proliferation in PC-3 cells via apoptosis and cell cycle arrest
Jae Myun Ryu, Gwi Yeong Jang, Heon Sang Jeong, Dae Joong Kim 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 101 139-140 (2 pages)
of dietary phytochemicals against cancer invasion and metastasis: phenolic acids, monophenol, polyphenol, and their derivatives. Cancer Treat Rev. 2012, 38(1): 76-87. [3] Sheth S, Jajoo S, Kaur T, Mukherjea D, Sheehan K, Rybak LP, Ramkumar V. Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/ MicroRNA-21 pathway. PLoS One. 2012, 7(12): e51655. 임 상 P-90 Canine... -
Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes
Young Chul Kim, So Young Choi, Eun Ye Park 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 2호 1 135-143 (9 pages)
a higher concentration (50 g/mL) reduced melan-A cell viability to 62% and 76% relative to the untreated control, respectively. EGCG was found to have the greatest cytotoxicity among the tested compounds. At 25 and 50 g/mL, this reagent decreased cell viability to 38% and 6% relative to the control group, respectively. Thus, BT, KA, and AT had the weakest cytotoxicity (≤ 50 g/mL), followed... Tea contains polyphenols and is one of the most popular beverages consumed worldwide. Because most tyrosinase inhibitors that regulate melanogenesis are phenol/catechol derivatives, this study investigated the inhibitory effects of Camellia sinensis water extracts (CSWEs), including black tea, green tea, and white tea extracts, on melanogenesis using immortalized melanocytes. CSWEs inhibited melanin accumulation and melanin synthesis along with tyrosinase activity in a concentration-dependent... -
생리,약리,화학 : 비만 유도 흰쥐에 대한 양파의 항비만 효과
강원영, 김문용, 진주연, 양희경, 홍현주, 김동건, 한창훈, 이영재 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 10 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2010, 제 50권 제 1호 1 1-10 (10 pages)
fl avonoids는 polyphenol compounds로 음식으로 사용하는 식물과 과일에 풍부하 ..PAGE:8 8 강원영·김문용·진주연·양희경·홍현주·김동건·한창훈·이영재 게 포함되어 있는 물질이고, 대표적인 flavonoid인 quercetin은 양파에 다량 포함되어 있다. Quercetin은 혈 관이완 효과와 항혈전 효과가 있는 것으로 보고되었고 [17, 22], in vivo [16, 19]와 in vitro [30, 31]에서 강한 항 산화 효과를 가지는 것으로 보고되었다.... -
천문동 뿌리의 자연발효에 관여하는 미생물 및 발효 후 효능 변화
김민지, 신나래, 이명종, 김호준 한방비만학회 대한한방비만학회지 10 Pages
한방비만학회 대한한방비만학회지 2018, 제 18권 제 2호 5 96-105 (10 pages)
(2-NBDG) uptake in C2C12 skeletal muscle cell. Results: Both pH and total sugar of fAC were decreased significantly compared to un- fermented AC. And the abundance of total bacteria and lactic acid bacteria increased dur- ing fermentation, especially Lactobacillus plantarum. Also fermentation of AC increased the content of total polyphenol. On the metabolic aspects, we found that AC and fAC sup-... -
백출, 어성초, 금은화, 황금, 황련과 Metformin의 병용 투여 시 항산화 효과 및 전지방세포 분화 억제 효과
장세주(Se ju Chang), 한경선(Kyung sun Han), 왕경화(Jing Hua Wang), 채희성(Hee Sung Chae), 최영희(Yong Hee Choi), 진영원(Young Won Chin), 최한석(Han Seok Ch 한방비만학회 대한한방비만학회지 9 Pages
한방비만학회 대한한방비만학회지 2015, 제 15권 제 1호 3 24-32 (9 pages)
and 3T3-L1 cell lines. Methods: Three different types of herb extracts (A. Rhizoma Alba, H. Herba, L. Flos, S. Radix, and C. Rhizoma; water 100%, ethanol 30%, ethanol 100%) were used in this study. Total polyphenol compound, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, reactive oxygen species (ROS) activity, NO production and cell proliferation were measured. Results: Total polyphenol... -
천연발효 경과에 따른 삼정환의 미생물 변화 및 발효특성
신나래(Na Rae Shin), 왕경화(Jing Hua Wang), 임동우(Dong woo Lim), 이명종(Myeong Jong Lee), 김호준(Ho jun Kim) 한방비만학회 대한한방비만학회지 8 Pages
한방비만학회 대한한방비만학회지 2015, 제 15권 제 2호 7 123-130 (8 pages)
measured total polyphenol and total flavonoid contents and 1,1-Diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity. In order to select starter candidate, several lactic acid bacteria were isolated from fermented SJH. Results: pH of fermented SJH was decreased from 4.7 to 3.0 and acidity was increased from 0.45% to 1.72%. Also, fermented SJH increased antioxidant indicator such as... -
Antioxidant Effects of Pyrogallol in Neural Cells and Mice Brain
Jisub Moon, Heesun Gwak, Tae-Hee Lee, Eun Suk An, Yun-Bae Kim, Dongsun Park 한국교원대학교 뇌기반교육연구소 Brain, Digital, & Learning 12 Pages
한국교원대학교 뇌기반교육연구소 Brain, Digital, & Learning 2019, 제 9권 제 3호 2 113-124 (12 pages)
a polyphenol, up-regulated antioxidant activity in neuroblastoma and human neural stem cells in vitro, and mouse brain tissue in vivo. The antioxidant activity of phenolic compounds results mainly from their redox properties,which permit them to act as reducing agents, singlet oxygen quenchers, or hydrogen donors. Although pyrogallol is used as a superoxide generator for the SOD activity assay,... polyphenol found in a variety of fruits and vegetables. Therefore, plants containing pyrogallol can be used for their antioxidant, anti-bacterial, anti-fungal, anti-allergic, and anti-inflammatory properties. However, its effectiveness as an antioxidant is still a matter of debate because pyrogallol is also a superoxide anion generator and induces superoxide anion-mediated death of several types of cells. In this study, we tried to confirm the antioxidant effects and mechanisms of pyrogallol in... -
MDL-12330A potentiates TRAIL-induced apoptosis in gastric cancer cells through CHOP-mediated DR5 upregulation
Sung-ChulLimSongIyHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 5 397-405 (9 pages)
H. Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis. Oncogene. 2008;27:2055-2063. 10. Szliszka E, Krol W. The role of dietary polyphenols in tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-in- duced apoptosis for cancer chemoprevention. Eur J... MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and induced cell death in a concentration-dependent manner. At a moderate concentration (~20 μM), MDL-12330A mainly induced apoptotic death whereas at concentrations greater than 20 μM, it increased non-apoptotic cell death. The induction of... -
Neuroprotective effect of caffeic acid phenethyl ester in 3-nitropropionic acid-induced striatal neurotoxicity
JiaBak, HeeJungKim, SeongYunKim, Yun-SikChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 7 279-286 (8 pages)
polyphenol compound with hydroxyl groups that are believed to be responsible for its biological activities [13]. For example, CAPE induces anti-inflammatory activity by inhibiting arachidonic acid release from the cell membrane and activation of cyclooxygenase1 and 2 [14,15]. Likewise, CAPE suppressed the level of lipopolysaccharide-induced interleukin-1, interleukin-6, and tumor necrosis... Caffeic acid phenethyl ester (CAPE), derived from honeybee hives, is a bioactive compound with strong antioxidant activity. This study was designed to test the neuroprotective effect of CAPE in 3-nitropropionic acid (3NP)-induced striatal neurotoxicity, a chemical model of Huntington’s disease (HD). Initially, to test CAPE’s antioxidant activity, a 2,2’-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS) antioxidant assay was employed, and CAPE showed a strong direct radicalscavenging eff... -
Epigallocatechin-3-Gallate (EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative Stress
BoZhang, BingWang, ShuhuaCao, YongqiangWang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.6 3 491-497 (7 pages)
stress in neurons. Antioxid Redox Signal . 2009;11: 469-480. 17. Levites Y, Amit T, Youdim MB, Mandel S. Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuropro- tective action. J Biol Chem . 2002;277:30574-30580. 18. Ge R, Zhu Y, Diao Y, Tao L, Yuan W, Xiong XC. Anti-edema effect of epigallocatechin gallat... Traumatic brain injury (TBI) is a major cause of mortality and long-term disability, which can decrease quality of life. In spite of numerous studies suggesting that Epigallocatechin-3- gallate (EGCG) has been used as a therapeutic agent for a broad range of disorders, the effect of EGCG on TBI remains unknown. In this study, a weight drop model was established to evaluate the therapeutic potential of EGCG on TBI. Rats were administered with 100 mg/kg EGCG or PBS intraperitoneally. At different...