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전체 선택해제
총 358건 검색
본문검색 결과만 보기
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Interleukin-17A upregulation influences susceptibility to Riemerella anatipestifer infection
Cherry Fernez, Woo H Kim, Jipseol Jeong, Fahmida Afrin, Rochelle Flores, Wongi Min 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 74 223-224 (2 pages)
a basic knowledge to establish strategies for treatment in pigs. P-014 Interleukin-17A upregulation influences susceptibility to Riemerella anatipestifer infection Cherry Fernandez 1, Woo H Kim 1, Jipseol Jeong 2, Fahmida Afrin 1, Rochelle Flores 1, Wongi Min *1 1College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 660-701, Korea, 2Environmental... -
Palmitic Acid Increased the Amyloid-β Secretion in SK-N-MC via GPR40-Mediated APP and BACE1 Upregulation
Jeong Yeon Kim, Hyun Jik Lee, Ji Young Oh, Sei Jung Lee, Xaykham Onphachanh, Ho Jae Han 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 84 129-129 (1 pages)
SK-N-MC via GPR40-Mediated APP and BACE1 Upregulation Jeong Yeon Kim 1, Hyun Jik Lee 1, Ji Young Oh 1, Sei-Jung Lee 1, Xaykham Onphachanh 1, Ho Jae Han *1 1Department of Veterinary Physiology, BK21 PLUS Creative Research Center, College of Veterinary Medicine, Seoul National University, Seoul, Korea. Introduction: There are accumulating evidence that the patients with metabolic disease such... -
Upregulation of death receptor 5 mediated by telmisartan enhances TRAIL-mediated apoptosis via inhibition of autophagy flux in lung cancer
Mohammad Rasheduzzaman, Jeong Min Hong, Uddin Nazim, Hong hua Yin, You Jin Lee, Jae Won Seol, Sang Youel Park 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 233 337-337 (1 pages)
3 activation. P-180 Upregulation of death receptor 5 mediated by telmisartan enhances TRAIL-mediated apoptosis via inhibition of autophagy flux in lung cancer Mohammad Rasheduzzaman , Jeong-Min Hong, Uddin MD Nazim, Hong-hua Yin, You-Jin Lee, Jae-Won Seol, Sang-Youel Park * Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Iksan, Jeonbuk 54596, South... -
Upregulation of Hypoxia-inducible factor-1a in Calbindin-D9k Knockout mice
Bonn Lee, Chang-hwan Ahn, Eui Bae Jeung 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 191 315-315 (1 pages)
by elevation of SIRT1expression. P-138 Upregulation of Hypoxia-inducible factor-1a in Calbindin-D9k Knockout mice Bonn Lee 1,2, Changhwan Ahn 2, Eui-Bae Jeung *2 1Diagnostic laboratory, Armed Forces Medical Research Institute, Daejeon, Republic of Korea; 2Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju,... -
MDL-12330A potentiates TRAIL-induced apoptosis in gastric cancer cells through CHOP-mediated DR5 upregulation
Sung-ChulLimSongIyHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 5 397-405 (9 pages)
membrane-bound TRAIL through p38 MAPK- and CHOP-mediated DR5 upregulation. Int J Cancer. 2015;136:299-309. 20. Lim JH, Park JW, Choi KS, Park YB, Kwon TK. Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP- dependent and PKC delta-independent mechanism in human malignant tumor cells. Carcinogenesis. 2009;30:729-736. 21. Merino D, Lalaoui N, Morizot A, Solary E,... death whereas at concentrations greater than 20 μM, it increased non-apoptotic cell death. The induction of apoptosis was at least partially regulated by CHOP-mediated DR5 upregulation, as detected by immunoblotting and gene interference assays. More importantly, low concentrations of MDL-12330A effectively enhanced recombinant human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (rhTRAIL)-induced apoptosis and clonogenicity in these gastric cancer cells. This study demonstrates... -
High fat diet confers vascular hyper-contractility against angiotensin II through upregulation of MLCK and CPI-17
JeeInKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 12 99-106 (8 pages)
against angiotensin II through upregulation of mLCK and CPI-17 Jee In Kim* Department of Molecular Medicine, Keimyung University School of Medicine, Daegu 42601, Korea ARTICLE INFO Received September 21, 2016 Revised November 14, 2016 Accepted November 24, 2016 *Correspondence Jee In Kim E-mail: jeein.kim@kmu.ac.kr Key Words Angiontensin II CPI-17 Hypertension MLCK Obesity ABSTRACT Obesity is a... Obesity is a critical risk factor for the hypertension. Although angiotensin II (Ang II) in obese individuals is known to be upregulated in obesity-induced hypertension, direct evidence that explains the underlying mechanism for increased vascular tone and consequent increase in blood pressure (BP) is largely unknown. The purpose of this study is to investigate the novel mechanism underlying Ang II-induced hyper-contractility and hypertension in obese rats. Eight-week old male Sprague-Dawley... -
Genipin Selectively Inhibits TNF-α-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-γ in Human Endothelial Cells
JungSeokHwa, LidiyaMun, HyeJungKim, HanGeukSeo, JaeHeunLee, JongHwanKwak, Dong-UngLee, KiChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 6 157-162 (6 pages)
by Upregulation of PPAR- γ in Human Endothelial Cells Jung Seok Hwa 1 , Lidiya Mun 2 , Hye Jung Kim 2 , Han Geuk Seo 2 , Jae Heun Lee 2 , Jong Hwan Kwak 3 , Dong-Ung Lee 4,*, and Ki Churl Chang 2,† Departments of 1Urology, 2Pharmacology, School of Medicine, and Institute of Health Sciences, Gyeongsang National University, Jinju 660-290, 3 College of Pharmacy, Sungkyunkwan University, Suwon... Vascular inflammation process has been suggested to be an important risk factor in the development of atherosclerosis. Recently we reported that induction of peroxisome proliferator-activated receptor-Ճ (PPAR-Ճ) selectively inhibits vascular cell adhesion molecule-1 (VCAM-1) but not intercellular cell adhesion molecule-1 (ICAM-1) in tumor necrosis factor (TNF)-Ձ-activated human umbilical vein endothelial cells (HUVEC). In this study, we investigated whether genipin inhibits... -
Knockdown of RCAN1.4 Increases Susceptibility to FAS-mediated and DNA-damage-induced Apoptosis by Upregulation of p53 Expression
YoungSunKim, HongJoonLee, ChorongJang, Ho-ShikKim, , Young-JinCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 12 483-489 (7 pages)
of p53 was responsible for the upregulation of Bax and the increased sensitivity to apoptosis, which could be reversed by p53 knockdown. To explain the observed upregulation of p53, we propose a downregulation of the ubiquitin ligase HDM2, probably translationally. These findings show the importance of appropriate RCAN1.4 expression in the modulation of cell survival and reveal a link between... expression and translocation of Bax to mitochondria. Our results suggest that enhanced expression and activation of p53 was responsible for the upregulation of Bax and the increased sensitivity to apoptosis, which could be reversed by p53 knockdown. To explain the observed upregulation of p53, we propose a downregulation of the ubiquitin ligase HDM2, probably translationally. These findings show the importance of appropriate RCAN1.4 expression in the modulation of cell survival and reveal a link... -
Overexpression of Ref-1 Inhibits Lead-induced Endothelial Cell Death via the Upregulation of Catalase
KwonHoLee, SangKiLee, HyoShinKim, EunJungCho, HeeKyoungJoo, EunJiLee, JiYoungLee, MyoungSooPark, SeokJongChang, Chung-HyunCho, JinBongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 4 431-436 (6 pages)
to the upregulation of catalase. However, the cellular mechanism underlying the Ref-1-mediated upregulation of catalase has yet to be clearly elucidated. Ref-1 has been established to function as a transcriptional co-activator, similarly to AP-1, NF-κB, and Egr-1 (Tell et al., 2005), which are found in the pro- moter region of catalase (Nenoi et al., 2001); thus, the pro- moter activity of... significantly inhibited Pb-induced cell death in the endothelial cells. Also the overexpression of Ref-1 significantly suppressed Pb-induced superoxide and hydrogen peroxide elevation in the endothelial cells. Pb exposure induced the downregulation of catalase, it was inhibited by the Ref-1 overexpression in the endothelial cells. Taken together, our data suggests that the overexpression of Ref-1 inhibited Pb-induced cell death via the upregulation of catalase in the cultured endothelial cells. -
Upregulation of Renin-angiotensin, Endothelin and C-type Natriuretic Peptide in Rat Glomerulus with Bilateral Ureteral Obstruction
EunHuiBae, SooWanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.6 8 343-348 (6 pages)
system in close proximity influences renal structure and function. How- ever, the role of renally produced aldosterone in the glomer- uli is not clear. The changes of RAS components as well Upregulation of Renin-angiotensin, Endothelin and C-type Natriuretic Peptide in Rat Glomer ulus with Bilateral Ureteral Obstruction Eun Hui Bae and Soo Wan Kim Department of Internal Medicine Chonnam... ET-1 were increased, while that of angiotensin converting enzyme 2 was not changed. The expressions of CYP11B2 and angiotensin II receptors were not changed. C-type natriuretic peptide (CNP) expression was increased, while its receptors (natriuretic peptide receptor-B) were not changed. We suggest that the upregulation of local RAS and ET play a role in the progressive glomerular injury, and that the enhanced CNP activity also plays a compensatory role in obstructive uropathy in the glomerulus.