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Effects of Interleukin-1β and Tumor Necrosis Factor-α on the Release of Collagenase and Gelatinase from Osteoblasts
Jong-GabEun, Dong-HeonBaek, Se-WonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 6 269-274 (6 pages)
et al, 1987) or induce osteoclast-independent collagenolysis (Jilka & Ham- ilton, 1985). A study by Rifas et al (1989) confirmed the lack of osteoblastic collagenase activity even after stimu- lation by IL-1 or other bone resorbing factors in human. However, numerous studies have reported that IL-1 could increase procollagenase levels extracted from mouse calvarial cultures (Delaisse et al,... A large number of factors such as osteotropic hormones, cytokines, or growth factors are related to the bone remodeling which is characterized by the coupling of osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Recent investigations have indicated that cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) play a potential role in the bone resorption associated with a variety of pathological conditions such as inflammatory osteolytic disease....