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Exploring Ways to Develop a Big Ideas-based Integrated Curriculum: Focusing on the Case of the IB’s PYP
Jung Duk Ohn, Nam Jin Paik 경인교육대학교 교육연구원 The Journal of Education 14 Pages
경인교육대학교 교육연구원 The Journal of Education 2020, Vol.3 No.1 2 13-26 (14 pages)
own meaning(IBO, 2009). In PYP, it is a structured inquiry that enables students to build meanings, test and refine their understanding. Grounded in constructivism, structured inquiry is a learning vehicle for learning by inviting students to formulate their own questions, design their own inquiries, and assess the various means available to support their inquiries. It fosters communication an... application and use in education, the design of the integrated curriculum should be changed. Therefore, this study seeks to explore a case of curriculum design that enables students to think deeply while taking a transdisciplinary approach. For this purpose, we analyzed the PYP of IB, which uses big ideas in transdisciplinary integration, to show why and how big idea-oriented integration can be an alternative to activity-oriented integration. Then we provided implications for the development of... -
Time-course changes in the expression levels of miR-122, -155, and -21 as markers of liver cell damage, inflammation, and regeneration in acetaminophen-induced liver injury in rats
Hyun-Kyu Park, Woori Jo, Hyun-Ji Choi, Sungwoong Jang, Jae-Eun Ryu, Hyo-Ju Lee, Hyojin Lee, Hyejin Kim, Eun-Sil Yu, Woo-Chan Son 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 1호 6 45-51 (7 pages)
group. Error bars indicate standard error of the mean (SEM). Applied Biosystems), miR-21 (rno-miR-21-5p, rat, UAGCUUAUCAGACUGAUGUUGA, Applied Biosystems). For each sample in all treatment groups, the fold change relative to the median vehicle sample was calculated using the comparative Ct method [15]. Pathology Necropsy was performed on all animals, with macroscopic evaluation of the thoracic... that miR-122 is an early and sensitive biomarker of hepatocellular injury at a stage when alanine transaminase, aspartate transaminase, and total bilirubin were not detectable. However, no significant differences in the expression levels of other miRNAs (miR-155 and -21) were observed between treatment and vehicle groups. Collectively, these time-course changes in the expression levels of miRNAs may be useful as markers for clinical decision-making, in the diagnosis and treatment of DILI. -
Sequential alterations of glucocorticoid receptors in the hippocampus of STZ-treated type 1 diabetic rats
Jae Hoon Shin, Je Kyung Seong, Sun Shin Yi* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 2 19-26 (8 pages)
as the standard. Briefly, aliquots containing 80 μg of total protein were boiled in loading buffer containing 150 mM Tris (pH 6.8), 3 mM DTT, 6% sodium dodecyl sulfate, 0.3% bromophenol blue, and 30% glycerol. Aliquots (30 μg) of the protein samples were then loaded onto 10% polyacrylamide gels, and the proteins were transferred onto nitrocellulose membranes (Pall Corporation, USA) after... Type 1 diabetes is a common metabolic disorder accompanied by increased blood glucose levels along with glucocorticoid and cognitive deficits. The disease is also thought to be associated with environmental changes in brain and constantly induces oxidative stress in patients. Therefore, glucocorticoid-mediated negative feedback mechanisms involving the glucocorticoid receptor (GR) binding site are very important to understand the development of this disease. Many researchers have used... -
Effects of conditioned media from human amniotic epithelial cells on corneal alkali injuries in rabbits
Tae-Hyun Kim, Young-Woo Park, Jae-Sang Ahn, Jeong-Taek Ahn, Se-Eun Kim, Man-Bok Jeong, Min-Su Seo, Kyung-Sun Kang, Kang-Moon Seo 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 1호 9 61-67 (7 pages)
USA), and 10% fetal bovine serum (FBS; Thermo Fisher Scientific, USA). The HAECs were cultured until fully confluent in the standard culture media. The cells were then washed three times with PBS and further cultured with K-SFM without FBS or growth factors for 48 h. The media were collected, filtered through a 0.20-μm syringe filter (Minisart Plus; Sartorius, Germany), and stored at 4 o C... cells (HAECs) on the corneal wound healing process. Eighteen rabbits (36 eyes) were used and randomly assigned to three groups according treatment: CM from HAECs (group 1), vehicle alone (group 2), and saline (group 3). Corneal alkali injuries were induced with 1 N sodium hydroxide. Each reagent used for treatment evaluation was injected into the dorsal bulbar subconjunctiva and the area of the corneal epithelial defect was measured every other day. Two animals from each group were euthanized at... -
Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice
Jin-Joo Hue, Ki Nam Lee, Jae-Hwang Jeong, Sang-Hwa Lee, Young Ho Lee, Seong-woon Jeong, Sang Yoon Nam, Young Won Yun, Beom Jun L 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 3호 3 189-195 (7 pages)
o C temperature and 35∼65% relative humidity. Animal experiments were performed in accordance with Standard Operation Procedures of Laboratory Animals that were approved by Institutional Animal Care and Use Committee of Laboratory Animal Research Center at Chungbuk National University. Experimental design Mice weighing an average of about 47 g were divided into 4 groups, including vehicle... This study was to investigate the anti-obesity effects of diglyceride (DG)-conjugated linoleic acid (CLA) containing 22% CLA as fatty acids in C57BL/6J ob/ob male mice. There were four experimental groups including vehicle control, DG, CLA, and DG-CLA. The test solutions of 750 mg/kg dose were orally administered to the mice everyday for 5 weeks. CLA treatments significantly decreased mean body weight in the obese mice throughout the experimental period compared to the control (p ＜ 0.01). All... -
Excitability scores of goats administered ascorbic acid and transported during hot-dry conditions
J. O. Ayo, N. S. Minka, M. Mamman1 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 2호 6 127-131 (5 pages)
loaded point. The animals were fed and watered as they had been immediately prior to the journey. Vehicle design, loading, and journey time A standard Bedford, pick-up van made in England and popularly used in the Guinea Savannah zone of Nigeria, was used to transport the animals. The floor of the vehicle was made of thick wooden planks, and the inner compartment measured 5.5 m× 1.5 m× 1.5 m... In this study, we investigated the effect of ascorbic acid (AA) administration on goat excitability due to transportation. Ten goats administered AA (p.o.) at 100 mg/kg of body weight before transportation served as the experimental group, and seven goats administered only 10 ml/kg of sterile water (p.o.) served as controls. Excitability scores were recorded for each goat; when weighed, before, immediately after, and 3 h after 8 h of transportation. A score of one to four was allocated to each... -
Repeated dose toxicity of alfa-cypermethrin in rats
S Manna, D Bhattacharyya, TK Mandal, S Das 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 3호 9 241-245 (5 pages)
as a vehicle is not available. Therefore, the present study was undertaken to determine the oral median lethal dose of α-CP dissolved in DMSO and to investigate the subacute toxicity (30 days) of α-CP. Materials and Methods Materials Alfa-cypermethrin (α-CP, >99% pure, Gharda Chemicals Ltd. Bombay). Animals and experimental design Ninety [90] adult Wistar rats of both sexes (equal sex ratio;... The present study was performed to investigate the subacute effect of α-cypermethrin (α-CP) in rats. Alfa-cypermethrin a synthetic pyrethroid insecticide, dissolved in dimethyl sulfoxide (DMSO) and oral LD50 was investigated after administering orally different doses in rats and was determined as 145 mg/kg. Other groups of rats were given repeated daily oral dose (1/10 LD50 ) of α-CP for 30 days. The animals were sacrificed on 31st day. Activities of various enzymes, cytochrome P450 and b5... -
Effects of Tributyltin Chloride on the Reproductive System in Pubertal Male Rats
Wook-joon Yu, Sang-yoon Nam, Young-chul Kim, Beom-jun Lee, Young-won Yun 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2003, 제 4권 제 1호 5 29-34 (6 pages)
were no differences of statistical significance and standard deviation among groups in body weights. Study design:There were six experimental groups :Corn oil for negative control,methyltestosterone (MET,10 mg/kg B.W./day) for positive control, TBT chloride (5, 10, and 20 mg/kg B.W./day), and combined treatment of TBT chloride (Aldrich Chemical Co.Inc.,WI,USA.,96% pure) and fluta- mide (10mg/kg... to six different groups; negative control receiving vehicle, positive control receiving methyltestosterone (10 mg/kg B.W.), TBT chloride (5 mg/kg B.W., 10 mg/kg B.W., and 20 mg/kg B.W.), and a combination of TBT chloride (10 mg/kg B.W.) and flutamide (10 mg/kg B.W). The animals were treated with test compounds by oral gavage daily for 10 days and sacrificed on the next day of the final treatment. The treatment with TBT chloride at the doses of 10 and 20 mg/kg B.W. significantly decreased seminal... -
Comparative in vivo biodistributions of nanoparticles and polymers of 177lutetium-labeled hyaluronic acids in mice during 28 days
Chunmei Lin , Ju-yeon Jeong , Jung-min Yon , Seul Gi Park , Lee Wha Gwon , Jong-geol Lee , In-jeoung Baek , Sang-soep Na 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2017, 제 57권 제 2호 5 105-111 (7 pages)
were conducted at the Korea Atomic Energy Research Institute (Korea). Statistical assays Means and standard errors (SEM) were calculated for the radioactivity of HAs from blood and organs at each evalua- tion interval. Statistical differences between groups were ana- lyzed by one-way analysis of variance followed by Tukey’s multiple comparison test. Statistical significance was estab- lished at p... -
Antioxidant Effects of Pyrogallol in Neural Cells and Mice Brain
Jisub Moon, Heesun Gwak, Tae-Hee Lee, Eun Suk An, Yun-Bae Kim, Dongsun Park 한국교원대학교 뇌기반교육연구소 Brain, Digital, & Learning 12 Pages
한국교원대학교 뇌기반교육연구소 Brain, Digital, & Learning 2019, 제 9권 제 3호 2 113-124 (12 pages)
12 h light/dark cycle. The animals were fed standard rodent chow and purified water ad libitum. After acclimation to the laboratory environment for one week, the mice were assigned to treatment groups (n = 6/group).Pyrogallol at 1.0,3.2,or 10 mg/kg/day, or vehicle (purified water), were administered orally for 7 days. All of experimental procedures were carried out in accordance with the Standard... Polyphenols can easily react with reactive oxygen species (ROS) resulting in powerful antioxidant activity. Pyrogallol is a polyphenol found in a variety of fruits and vegetables. Therefore, plants containing pyrogallol can be used for their antioxidant, anti-bacterial, anti-fungal, anti-allergic, and anti-inflammatory properties. However, its effectiveness as an antioxidant is still a matter of debate because pyrogallol is also a superoxide anion generator and induces superoxide anion-mediated...