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Clinical Study on the Iron Absorption from Heme-Iron Polypeptide and Nonheme-Iron
Nam. Tae-Sik, Shim. Ji-Yeon, Kim. Byung-Ju, Rah. So-Young, Park. Kwang-Hyun, Kim. Seon-Young, Mun. Eun-Gyeng, Jeong. Young-Ju, Han. Myun 한국영양학회 Nutritional sciences 6 Pages
한국영양학회 Nutritional sciences 2006, Vol.9 No.4 295-300 (6 pages)
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투석법에 의한 Heme-iron의 분리
강인규, 인만진, 오남순, Kang. In-Kyu, In. Man-Jin, Oh. Nam-Soon 한국응용생명화학회 한국농화학회지 4 Pages
한국응용생명화학회 한국농화학회지 2003, Vol.46 No.2 130-133 (4 pages)
mM이상의 농도에서는 30.0-32.5%로 증가하였다. 투석용액의 pH 높을수록 heme-iron의 용해도가 증가하여 투석막을 통한 heme-iron의 세출이 많아졌다. Peptide의 제거율은 투석막이 2kDa에서 5kDa로 커질 때 74.5%에서 87.5%의 큰 폭으로 증가하였으며, heme-iron의 회수율은 투석막의 크기에 따라 감소하여 2kDa에서는 86.5%, 15kDa에서는 79.6%, 25kDa에서 63.1%로 급감하였다. 투석법에 의해 분리, 건조된 heme-iron제품의 heme-iron과 peptide의 함량은 각각 21.7%와 77.0%이었으며, HP ratio는 28.2%, 수율은 6,5%이었다. -
고농도 Heme-iron의 생산을 위한 Hemoglobin의 가수분해 및 분리 조건
강인규, 인만진, 오남순, Kang. In-Kyu, In. Man-Jin, Oh. Nam-Soon 한국응용생명화학회 한국농화학회지 5 Pages
한국응용생명화학회 한국농화학회지 2001, Vol.44 No.4 219-223 (5 pages)
14.5%인 경우는 pH $4.0{sim}6.0$에서 $12.1{sim}19.5%$였으며, DH가 24.3%인 경우는 pH $3.0{sim}5.0$에서 $34.7{sim}36.4%$로 가수분해도가 높을수록 고농도 heme-iron의 분리시 최적 PH 범위가 산성 영역으로 이동되었으며, 이 영역의 pH에서 peptide의 용해도 증가로 분리도가 증가되었다. 가수분해액으로부터 분리된 heme-iron의 분자량은 약 1 kDa정도로 hematin과 유사한 분리패턴을 보였다. Pilot scale로 제조한 고농도 heme-iron 제품에서의 heme-iron 함량은 27.1%, heme-iron/peptide 비는 38.7%, 생산수율은 9.3%이었다. -
Potential Application of the Recombinant Escherichia coli-Synthesized Heme as a Bioavailable Iron Source
Kwon. Oh-Hee, Kim. Su-Sie, Hahm. Dae-Hyun, Lee. Sang-Yup, Kim. Pil 한국미생물생명공학회 Journal of microbiology and biotechnology 6 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2009, Vol.19 No.6 604-609 (6 pages)
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Effect of canine mesenchymal stromal cells overexpressing heme oxygenase-1 in spinal cord injury
Seung Hoon Lee, Yongsun Kim, Daeun Rhew, Ahyoung Kim, Kwang Rae Jo, Yongseok Yoon, Kyeung Uk Choi, Taeseong Jung, Wan Hee Kim, O 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 3호 15 377-386 (10 pages)
..PAGE:1 Original Article J Vet Sci 2017, 18(3), 377-386ㆍhttps://doi.org/10.4142/jvs.2017.18.3.377 JVS Received 23 Mar. 2016, Revised 4 Jul. 2016, Accepted 26 Aug. 2016 *Corresponding author: Tel: +82-2-880-1248; Fax: +82-2-888-2866; E-mail: ohkweon@snu.ac.kr Journal of Veterinary Scienceㆍⓒ 2017 The Korean Society of Veterinary Science. All Rights Reserved. This is an Open Access article... Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that modulates the immune response and oxidative stress associated with spinal cord injury (SCI). This study aimed to investigate neuronal regeneration via transplantation of mesenchymal stromal cells (MSCs) overexpressing HO-1. Canine MSCs overexpressing HO-1 were generated by using a lentivirus packaging protocol. Eight beagle dogs with experimentally-induced SCI were divided into GFP-labeled MSC (MSC-GFP) and HO-1-overexpressing MSC... -
Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells
Mi-KyoungKim, Hyun-JooPark, , Su-RyunKim, , YoonKyungChoi, Soo-KyungBae, Moon-KyoungBae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.4 4 327-334 (8 pages)
..PAGE:1 327 Korean J Physiol Pharmacol Vol 19: 327 －334, July, 2015 http://dx.doi.org/10.4196/kjpp.2015.19.4.327 pISSN 1226-4512 eISSN 2093-3827 ABBREVIATIONS: HO-1, heme oxygenase-1; HUVECs, human umbilical vein endothelial cells; SnPP, tin protoporphryin-IX; Nrf2, nuclear factor erythroid-derived 2 related factor 2; ARE, antioxidant response element; OX1R, orexin-1 receptor; OX2R, orexin-2... The cytoprotective enzyme heme oxygenase-1 (HO-1) influences endothelial cell survival, proliferation, inflammatory response, and angiogenesis in response to various angiogenic stimuli. In this study, we investigate the involvement of HO-1 in the angiogenic activity of orexin-A. We showed that orexin-A stimulates expression and activity of HO-1 in human umbilical vein endothelial cells (HUVECs). Furthermore, we showed that inhibition of HO-1 by tin (Sn) protoporphryin-IX (SnPP) reduced... -
Ischemia/reperfusion Lung Injury Increases Serum Ferritin and Heme Oxygenase-1 in Rats
Yoon-YubPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 7 181-187 (7 pages)
..PAGE:1 Korean J Physiol Pharmacol Vol 13: 181 －187, June, 2009 181 ABBREVIATIONS: ALI, acute lung injury; ARDS, acute respiratory distress syndrome; HO-1, heme oxygenase-1; BAL, bronchoalveolar lavage. Received April 24, 2009, Revised May 11, 2009, Accepted May 25, 2009 Corresponding to: Yoon-Yub Park, Department of Physiology, School of Medicine, Catholic University of Daegu, 3056-6,... Intestinal ischemia/reperfusion (I/R) is one of common causes of acute lung injury (ALI). Early and accurate diagnosis of patients who are like to develop serious acute respiratory distress syndrome (ARDS) would give a therapeutic advantage. Ferritin and heme oxygenase-1 (HO-1) are increased by oxidative stress and are potential candidates as a predictive biomarker of ARDS. However, the mechanisms responsible for the increases of ferritin and HO-1, and their relationship to ALI, are unclear. In... -
Induction of Heme Oxygenase-1 by Traditional Herb Mix Extract Improves MKN-74 Cell Survival and Reduces Stomach Bleeding in Rats by Ethanol and Aspirin in vivo
YoungJinKang, HyungSukMoon, HyeJungKim, HanGeukSeo, JaeHeunLee, KiChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.2 4 65-70 (6 pages)
..PAGE:1 Korean J Physiol Pharmacol Vol 11: 65- 70, April, 2007 INTRODUCTION Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin are widely used,but major limitations to their cli- nical administration are serious side effects associated with oxidative stress such as acute hemorrhagic erosions,aggra- vating effect on stress ulceration, and interference with healing ofpreexisting gastric... Chinese herb medicines have traditionally been used to treat or alleviate the symptom of various diseases. The rationale for use of certain herbs to certain disorder is now getting unveiled by modern technology. In the present study, we investigated whether herb mix extract (HMX), which is alleged to be useful for gastric ulcer, protects stomach from oxidative stress. Rats were allowed to normal diet with and without HMX (1, 5, 10 mg/kg) for 30 days. To induce gastric ulcer, ethanol (75%, 1.5... -
Coordinate Regulation of Vibrio vulnificus Heme Receptor HupA Expression by Cyclic AMP-receptor Protein and Ferric Uptake Regulator
Kim. Sun-Pyo, Lee. Gang-Wook, Kim. Choon-Mee, Shin. Sung-Heui 대한미생물학회 Journal of bacteriology and virology : JBV 11 Pages
대한미생물학회 Journal of bacteriology and virology : JBV 2012, Vol.42 No.4 294-304 (11 pages)