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High-Order QAM에 적합한 반송파 동기회로 설계 - I부. 넓은 주파수 포착범위를 가지는 위상검출기 설계 및 분석
김기윤, 조병학, 최형진, Kim. Ki-Yun, Cho. Byung-Hak, Choi. Hyung-Jin 대한전자공학회 電子工學會論文誌. Journal of the Institute of Electronics Engineers of Korea. TC, 통신 7 Pages
대한전자공학회 電子工學會論文誌. Journal of the Institute of Electronics Engineers of Korea. TC, 통신 2001, Vol.38 No.4 11-17 (7 pages)
논문에서는 High-Order QAM(Quandrature Amplitude Modulation)을 적용하는 모뎀에서 강인하고 넓은 범위의 주파수 포착 범위를 가지는 극성판단(Polarity Decision) 반송파 동기용 PD(Phase Detector) 알고리즘을 제안하고 이에 대한 평균 출력특성(S-curve)과 분산특성을 수학적으로 유도하여 기존의 DD(Decision Directed)방식과 비교 분석한다. 기존의 DD 방식의 선형영역은 256 QAM의 경우 $3.5^{circ}{sim}3.5^{circ}$ 이었으나 제안한 알고리즘의 선형영역은 ${gamma}-17.9$에서 $36^{circ}{sim}36^{circ}$ 의 넓은 구간을 가진다.... -
NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts
VuThiThu, HyoungKyuKim, LeThanhLong, ToThanhThuy, NguyenQuangHuy, SoonHaKim, NariKim, KyungSooKo, ByoungDooRhee, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 10 305-314 (10 pages)
beneficially control biological processes via cooperative or specific modulation of TNF TGF1, and Smad2 expression [57,58]. Moreover, inflammation-mediated mitochondrial alterations play a critical role in inflammation-linked diseases [42,59]. Li- miting inflammation and consequent mitochondrial function modulation may offer promising therapeutic targets for treatment of ischemic disease. As... of tumor necrosis factor alpha (TNFα), TGFβ1, and pSmad2, and markedly decreased Dcn expression levels, were observed in LPS-stimulated H9C2 cells. Interestingly, NecroX-5 supplementation effectively attenuated the increased expression levels of TNFα, TGFβ1, and pSmad2, as well as the decreased expression of Dcn. Thus, our data demonstrate potential anti-inflammatory and anti-fibrotic effects of NecroX-5 against cardiac HR injuries via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway. -
Modulation of Pituitary Somatostatin Receptor Subtype (sst1-5) mRNA Levels by Growth Hormone (GH)-Releasing Hormone in Purified Somatotropes
SeungjoonPark, HeesoonPark, MinaLee, SookjinSohn, EunheeKim, JeechangJung, LawrenceA.Frohman, RhondaD.Kineman 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.2 5 79-84 (6 pages)
and its ac- tions are likely mediated by activation of AC. GHRH showed stimulatory action on sst1 and sst2 mRNA levels and inhibitory action on sst3, sst4, and sst5 mRNA levels. The differential modulation of these SRIF receptor sub types suggests that they exert independent and highly selective roles in the modulation of pituitary function. ACKNOWLEDGMENT This work was supported by grant No.... We have previously reported that expression of the somatostatin receptor subtypes, sst1-5, is differentially regulated by growth hormone (GH)-releasing hormone (GHRH) and forskolin (FSK), in vitro. GHRH binds to membrane receptors selectively located on pituitary somatotropes, activates adenylyl cyclase (AC) and increases sst1 and sst2 and decreases sst5 mRNA levels, without significantly altering the expression of sst3 and sst4. In contrast FSK directly activates AC in all pituitary cell types... -
pH-dependent modulation of intracellular free magnesium ions with ion- selective electrodes in papillary muscle of guinea pig
Shang-Jin Kim, In-Gook Cho, Hyung-Sub Kang, Jin-Shang Kim 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 1호 5 31-36 (6 pages)
NH4Cl. All the experiments were at constant [pH]o of 7.4. For the control, the choline chloride was added to the Thyroid solution. ..PAGE:5 pH-dependent modulation of intracellular free magnesium ions 35 increase in [Mg 2+]i. Nevertheless, the acidification-induced modulation in the [Mg 2+]i coupled with HCO 3 such as Mg 2+/HCO 3 cotransport in sarcolemma and mitochondrial membrane [29] and with H... A change in pH can alter the intracellular concentration of electrolytes such as intracellular Ca2+ and Na+ ([Na+]i) that are important for the cardiac function.For the determination of the role of pH in the cardiac magnesium homeostasis, the intracellular Mg 2+ concentration ([Mg 2+]i), membrane potential and contraction in the papillary muscle of guinea pigs using ion-selective electrodes changing extracellular pH ([pH]o)or intracellular pH ([pH ]i )were measured in this study. A high... -
Calcium Ions are Involved in Modulation of Melittin-induced Nociception in Rat: II. Effect of Calcium Chelator
HongKeeShin, KyungHeeLee, ChulHyunCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.6 1 297-302 (6 pages)
test. Pain 66: 271-277, 1996 Lee KH, Kim JS, Kim JH, Shin HK. Spinal serotonin receptors are involved in the modulation of the melittin-induced nocicep- tion in the rat. Korean J Physiol Pharmacol 9(Suppl I): S163, 2005 Lee KH, Shin HK, Kim JS, Kim JH. Effects of intrathecal and intraplantar injection of calcium channel antagonists on melit- tin-induced mechanical hyperalgesia in rats. Korean... Melittin, a major component of bee venom, produces a sustained decrease in mechanical threshold, and an increase in spontaneous flinchings and paw thickness, which are characteristics similar to those induced by whole bee venom. Melittin-induced nociception has been known to be modulated by the changes in the activity of excitatory amino acid receptors, voltage-dependent calcium channels, cyclooxygenase and serotonin receptors. The present study was undertaken to investigate the role of calcium... -
Calcium Ions are Involved in Modulation of Melittin-induced Nociception in Rat: I. Effect of Voltage-gated Calcium Channel Antagonist
HongKeeShin, KyungHeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.5 6 255-262 (8 pages)
in the modulation of the melittin-induced no- ciception in the rat. Korean J Physiol Pharmacol 9(Suppl I): S163, 2005 Li CY, Zhang XL, Matthews EA, Li KW, Kurwa A, Boroujerdi A, Gross J, Gold MS, Dickenson AH, Feng G, Luo ZD. Calcium channel α2δ1 subunit mediates spinal hyperexcitability in pain modulation. Pain, in press, 2006 Li KC, Chen J. Differential roles of spinal protein kinase C... Melittin-induced nociceptive responses are mediated by selective activation of capsaicin-sensitive primary afferent fibers and are modulated by excitatory amino acid receptor, cyclooxygenase, protein kinase C and serotonin receptor. The present study was undertaken to investigate the peripheral and spinal actions of voltage-gated calcium channel antagonists on melittin-induced nociceptive responses. Changes in mechanical threshold and number of flinchings were measured after intraplantar (i.pl.)... -
Modulation of Ca2+-Activated Potassium Channels by cGMP- Dependent Signal Transduction Mechanism in Cerebral Arterial Smooth Muscle Cells of the Rabbit
JinHan, NariKim, KwangbokLee, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 2 439-444 (6 pages)
445 -453， December， 2000 Modulation of Ca2+ -Activated Potassium Channels by cGMP Dependent Signal Transduction Mechanism in Cerebral Arterial Smooth Muscle Cells of the Rabbit Jin Han， Nari Kim， Kwangbok Lee， and Euiyong Kim Department of Physiology and Biophysics， College of Medicine， Inje University， Busan 614-735， Korea The present investigation tested the hypothesis that the... The present investigation tested the hypothesis that the activation of protein kinase G (PKG) leads to a phosphorylation of Ca2-activated potassium channel (KCa channel) and is involved in the activation of KCa channel activity in cerebral arterial smooth muscle cells of the rabbit. Single-channel currents were recorded in cell-attached and inside-out patch configurations of patch-clamp techniques. Both molsidomine derivative 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1, 50μM) and... -
Modulation of Outward Potassium Currents by Nitric Oxide in Longitudinal Smooth Muscle Cells of Guinea-pig Ileum
Seong-ChunKwon, SeJoongRim, Bok-SoonKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 11 225-232 (8 pages)
J Physiol Pharmacol Vol 2: 225 -232， April， 1998 Modulation of Outward Potassium Currents by Nitric Oxide in Longitudinal Smooth Muscle Cells of Guinea-pig Ileum Seong-Chun Kwon， Se Joong Rim\ and Bok-Soon Kang Department of Physiology and lInteral Medicine， Yonsei University College of Medicine， Seoul 120-752， Korea To investigate the possible involvement of outward potassium (K+)... To investigate the possible involvement of outward potassium (K+) currents in nitric oxide-induced relaxation in intestinal smooth muscle, we used whole-cell patch clamp technique in freshly dispersed guinea-pig ileum longitudinal smooth muscle cells. When cells were held at 60 mV and depolarized from 40 mV to 50 mV in 10 mV increments, sustained outward K+ currents were evoked. The outward K+ currents were markedly increased by the addition of 10 ㄍM sodium... -
Cell proliferation and neuroblast differentiation in the dentate gyrus of high-fat diet-fed mice are increased after rosiglitazone treatment
Dae Young Yoo, Woosuk Kim, Dae Won Kim, Sung Min Nam, Hyo Young Jung, Jong Whi Kim, Choong Hyun Lee, Jung Hoon Choi, Moo-Ho Won, 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 3 27-33 (7 pages)
observed that blocking the BDNF receptor reduces cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus of mice [38]. Thus, our present results indicate that modulation of BDNF levels can alter hippocampal neurogenesis in the dentate gyrus of LFD- and HFD-fed mice. In conclusion, RSG administration decreased the number of Ki67- and DCX-positive cells in the... In this study, we determined how rosiglitazone (RSG) differentially affected hippocampal neurogenesis in mice fed a low-fat diet (LFD) or high-fat diet (HFD; 60% fat). LFD and HFD were given to the mice for 8 weeks. Four weeks after initiating the LFD and HFD feeding, vehicle or RSG was administered orally once a day to both groups of mice. We measured cell proliferation and neuroblast differentiation in the subgranular zone of the dentate gyrus using Ki67 and doublecortin (DCX), respectively,... -
High fat diet confers vascular hyper-contractility against angiotensin II through upregulation of MLCK and CPI-17
JeeInKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 12 99-106 (8 pages)
in vascular smooth muscle cells. Horm Metab Res. 2014;46:126-132. 15. Savineau JP, Marthan R. Modulation of the calcium sensitivity of the smooth muscle contractile apparatus: molecular mechanisms, pharmacological and pathophysiological implications. Fundam Clin Pharmacol. 1997;11:289-299. 16. Somlyo AP, Somlyo AV. Ca 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G... Obesity is a critical risk factor for the hypertension. Although angiotensin II (Ang II) in obese individuals is known to be upregulated in obesity-induced hypertension, direct evidence that explains the underlying mechanism for increased vascular tone and consequent increase in blood pressure (BP) is largely unknown. The purpose of this study is to investigate the novel mechanism underlying Ang II-induced hyper-contractility and hypertension in obese rats. Eight-week old male Sprague-Dawley...