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- 대한생리학회-대한약리학회(158)
- 대한생리학회(53)
- 대한약리학회(42)
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- 대한생리학회지(53)
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H2 Receptor-Mediated Relaxation of Circular Smooth Muscle in Human Gastric Corpus: the Role of Nitric Oxide (NO)
SangEokLee, DaeHoonKim, YoungChulKim, Joung-HoHan, WoongChoi, ChanHyungKim, HyeWonJeong, Seon-MeePark, SeiJinYun, Song-YiChoi6, RohyunSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.5 11 425-430 (6 pages)
n=3, 4, 4, 4, and 2, respectively). ..PAGE:3 Histamine-Induced Tonic Rela xation in Human Stomach 427 Fig. 1. Effect of histamine on spontaneous phasic and tonic contractions of circular smooth muscle of human gastric corpus. (A) In human gastric corpus, histamine (10 μM) produced tonic relaxation of circular smooth muscle. However, it returned to basal contraction in a few minutes. In... (4,3-A) quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase (sGC), did inhibit histamine-induced tonic relaxation. In particular, histamine-induced tonic relaxation was converted to tonic contraction by pretreatment with L-NAME. Ranitidine, the H2 receptor blocker, inhibited histamine-induced tonic relaxation. These findings suggest that histamine produced relaxation in circular smooth muscle of human gastric smooth muscle through H2 receptor and NO/sGC pathways. -
Nitric Oxide-mediated Relaxation by High K＋ in Human Gastric Longitudinal Smooth Muscle
YoungChulKim, WoongChoi, Hyo-YoungYun, RohyunSung, RaYoungYoo, Seon-MeePark, SeiJinYun, Mi-JungKim, Young-JinSong, Wen-XieXu, SangJinLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 12 405-414 (10 pages)
target of NO released from nNOS neurons. And this NO signals are transmitted to smooth muscle in GI tract [31,32]. From these findings we could conclude that high K ＋ produced muscle relaxation by activation of VDCCL, which was ascribed to NO/sGC-de- pendent pathways of ICC in longitudinal muscle layer. In this study, we observed NO-mediated relaxation in longitudinal muscle. And high K ＋... This study was designed to elucidate high-K＋ induced response of circular and longitudinal smooth muscle from human gastric corpus using isometric contraction. Contraction from circular and longitudinal muscle stripes of gastric corpus greater curvature and lesser curvature were compared. Circular smooth muscle from corpus greater curvature showed high K＋ (50 mM)-induced tonic contraction. On the contrary, however, longitudinal smooth muscle strips showed high K＋ (50 mM)-induced sustained... -
Relaxation Patterns of Human Gastric Corporal Smooth Muscle by Cyclic Nucleotides Producing Agents
YoungChulKim, WoongChoi, RohyunSung, HeonKim, RaYoungYou, Seon-MeePark, SeiJinYoun, Mi-JungKim, Young-JinSong, Wen-XieXu, SangJinLee, Hyo-Y 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 15 503-510 (8 pages)
of human gastric motility. In summary, our present re sults indicated that FSK, ISO and SNP, which are known as cyclic nucleotide activators, have an inhibitory effect on human gastric corporal smooth muscle contractility through inhibiting VDCC L. ACKNOWLEDGEMENTS This work was supported by the research grant of the Chungbuk National Un iversity in 2007. REFERENCES Andersson R, Nilsson K.... of corporal circular smooth muscle in human stomach. Gastric circular smooth muscle showed regular spontaneous contraction, and FSK, ISO and SNP inhibited its phasic contraction and basal tone in a concentration-dependent manner. High K＋ (50 mM) produced sustained tonic contraction, and ACh (10ՌM) produced initial transient contraction followed by later sustained tonic contraction with superimposed phasic contractions. FSK, ISO and SNP inhibited high K＋-induced tonic contraction and also... -
Relaxation Effect of Synthetic Ceramide Analogues in Cat Esophageal Smooth Muscle Cells
DooWonLee, SunYoungPark, JungSuRyu, SungHyoKim, ChaeUkIm, SuHangChoi, SeEunLee, SungKwonKo, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 2 137-142 (6 pages)
C; myr-PKC, N-myristoylated peptides; SMC, smooth muscle cells; PMA, Phorbol 12 myristate 13-acetate. Corresponding to: Uy Dong Sohn, Department of Pharmacology, College of Pharmacy, Chung Ang University, 221, Heuksuk-dong, Dongjak-gu, Seoul 156-756, Korea. (Tel) 82-2-820-5614, (Fax) 82-2- 824-8018, (E-mail) udsohn@cau.ac.kr Relaxation Effect of Synthetic Ceramide Analogues in Cat Esophageal... a role in mediating contraction of cat esophageal smooth muscle cells. We examined the effect of synthesized ceramide analogues on the C2-ceramide and ACh-induced contraction in esophageal smooth muscle cells isolated with collagenase. CY3523, CY3525, or CY3723 inhibited C2-ceramide induced contraction, in a time dependent manne. Each analogue also inhibited the contraction in concentration dependent manners. CY 3523, CY 3525, and CY 3723 had no effect to the contraction induced by PMA. The... -
Changes in Cytosolic Ca2+ but not in cGMP Contents May be more Important to Nitric Oxide-Mediated Relaxation in Depolarized Vascular Smooth Muscle
HyunSeokLeeKiChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 8 63-68 (6 pages)
NO response in vascular smooth muscle (Gilbert et al， 1991). Fur thermore， Chang et al. (1997) reported that UV light-induced relaxation involves in hyperpolarizing action in vascular smooth muscle. 1n contrast， pho toactivated caged NO-mediated relaxation does not decline on repeated exposure to light， indicating that certain amounts of NO can be released from the caged molecules by... -
Effect of Blood Pressure on Contractility of Vascular Smooth Muscle and Endothelium-Dependent Relaxation
Suh, Suk-Hyo, Park, Yee-Tae, Lee, Dong-Chul, Seo, Pil-Won, Kim, Ki-Whan 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 10 279-290 (12 pages)
to phenylephrine and serotonin between the high pressure-exposed vessels and the low pressure-exposed vessels. However, the endothelium-dependent relaxation to acetylcholine and nitroprusside-induced relaxation showed significant differences between the high pressure- exposed and the low pressure-exposed subclavian arteries. From the above results, we suggest that the contractility of vascular... phenylephrine and serotonin between the high pressure-exposed vessels and the low pressure-exposed vessels. However, the endothelium-dependent relaxation to acetylcholine and nitroprusside-induced relaxation showed significant differences between the high pressure-exposed and the low pressure-exposed subclavian arteries. From the above results, we suggest that the contractility of vascular smooth muscle is unchanged by the elevated pressure per se. However, the endothelium-dependent relaxation... -
Cyclic AMP Dependent Down Regulation in the Relaxation of Smooth Muscle Cells of Cat Esophagitis
Shin. Chang-Yell, Lee. Yul-Pyo, Song. Hyun-Ju, Je. Hyun-Dong, Sohn. Uy-Dong 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 8 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2007, Vol.30 No.6 715-722 (8 pages)
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Ardipusilloside-I stimulates gastrointestinal motility and phosphorylation of smooth muscle myosin by myosin light chain kinase
ZhiliXu, HanyeLiang, MingboZhang, XiaojunTao, DeqiangDou, LipingHu, TingguoKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 5 609-616 (8 pages)
al It is well known that the smooth muscle contraction and relaxation of smooth muscle mainly relates to the reversible Ca 2+- calmodulin dependent phosphorylation of myosin light chains by myosin light chain kinase (MLCK) [5]. So the modulation of myosin provides an important index to evaluate the effects of modulators. In vertebrate tissues, MLCK is regulated by Ca 2+- calmodulin, which is... a natural triterpenoid saponin, which was isolated from Ardisia pusilla A. DC. The aim of the study was to evaluate the stimulation of ardipusilloside-I on gastrointestinal motility in vitro and in vivo. The experiment of smooth muscle contraction directly monitored the contractions of the isolated jejunal segment (IJS) in different contractile states, and the effects of ardipusilloside-I on myosin were measured in the presence of Ca2+-calmodulin using the activities of 20 kDa myosin light chain... -
The Inhibitory Mechanism of Gentamicin on Electrical Field Stimulation Response in Rat Bladder Smooth Muscle
ChangHoMin, YiYiWang, JinhyungBae, JungHoonHan, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 11 473-478 (6 pages)
did not affect the gentamicin-induced in- hibitory effect on muscle relaxation at different frequencies. Therefore gentamicin induced muscle relaxation on EFS re- sponse in rat bladder smooth muscle is not mediated by the activation of adrenergic, cholinergic and serotonergic receptor. Effect of chelerythrine, ML-9 and Y27632 on EFS in rat bladder smooth muscle treated with gentamicin Fig. 3... To see the inhibitory mechanism of gentamicin in response to electrical field stimulation (EFS) using the rat bladder smooth muscle, atropine or guanethidine was treated but had no effect. Methylsergide, a non-selective 5-HT1, 5-HT2 receptor antagonist was also treated but had on effect. Kinase inhibitors, such as chelerythrine (PKC inhibitor), ML-9 (MLCK inhibitor), or Y27632 (rho kinase inhibitor) were pretreated before gentamicin treatment, but did not have effect. For U73122, a phospholipase...