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Spontaneous Oscillatory Rhythm in Retinal Activities of Two Retinal Degeneration (rd1 and rd10) Mice
YongSookGoo, KunNoAhn, YeongJunSong, SuHeokAhn, SeungKeeHan, SangBaekRyu, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 13 415-422 (8 pages)
photoreceptor layer is seen in rd10 mice. Also, we compared the oscillatory rhythm in RGC spikes and field potential in two photoreceptor degen- eration mice; rd1 and rd10 mice to understand the neural code used by the two diseased retinas to communicate with the brain. This understanding wi ll facilitate to set new se- lection criteria for responsiveness to electrical stimulus in rd10 mice... Previously, we reported that besides retinal ganglion cell (RGC) spike, there is ∼10 Hz oscillatory rhythmic activity in local field potential (LFP) in retinal degeneration model, rd1 mice. The more recently identified rd10 mice have a later onset and slower rate of photoreceptor degeneration than the rd1 mice, providing more therapeutic potential. In this study, before adapting rd10 mice as a new animal model for our electrical stimulation study, we investigated electrical characteristics of... -
Production of transgenic pigs using a pGFAP-CreERT2/EGFP LoxP inducible system for central nervous system disease models
Seon-Ung Hwang, Kiyoung Eun, Junchul David Yoon, Hyunggee Kim, Sang-Hwan Hyun 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 13 434-445 (12 pages)
disease modeling, pharmaceutical toxicity testing, and regenerative medicine. In this study, we constructed two vector systems by using the promoter of the pig glial fibrillary acidic protein (pGFAP) gene, which is an astrocyte cell marker. We established donor TG fibroblasts with pGFAP- T2 /LCMV- LoxP and evaluated the effect of the transgenes on TG-somatic cell nuclear transfer (SCNT) embryo... disease modeling, pharmaceutical toxicity testing, and regenerative medicine. In this study, we constructed two vector systems by using the promoter of the pig glial fibrillary acidic protein (pGFAP) gene, which is an astrocyte cell marker. We established donor TG fibroblasts with pGFAP-CreERT2/LCMV-EGFPLoxP and evaluated the effect of the transgenes on TG-somatic cell nuclear transfer (SCNT) embryo development. Cleavage rates were not significantly different between control and transgene-donor... -
In vitro toxicity of melamine against Tetrahymena pyriformis cells
Zhengfang Wang, Liben Chen, Rashad Al-Kasir, Bo Han* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 1호 5 27-34 (8 pages)
were prepared by adding 0.001, 0.005, 0.01, 0.05, and 0.1 g of melamine to 20 mL of basic liquid culture medium to give melamine concentrations of 0.05, 0.25, 0.5, 2.5, and 5 mg/mL, respectively. Two replicas of each test culture medium were prepared. In addition, three negative control culture media containing no melamine were prepared. All flasks were autoclaved at 103 kPa and 121 o C for... This study assessed the toxicity of melamine against the unicellular eukaryotic system of Tetrahymena (T.) pyriformis exposed to 0, 0.05, 0.25, 0.5, 2.5, and 5 mg/mL of melamine. Cell growth curves of different cultures, the half maximum inhibition concentration (IC50) value of melamine, and morphological changes in cells were obtained via optical and transmission electron microscopic observation. The effects of eleven melamine concentrations, 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 and 5... -
생명과학 학습에서 디지털 콘텐츠의 유형에 따라 생성된 과학적 의문의 분석
권승혁, 엄증태, 권용주 한국교원대학교 뇌기반교육연구소 Brain & Learning 11 Pages
한국교원대학교 뇌기반교육연구소 Brain & Learning 2014, 제 4권 제 2호 1 1-11 (11 pages)
: The Relationships between the Patterns of Elementary School Teachers` Explanations and the Patterns of Elementary School Students` Questions on Scientific Phenomena. Journal of Korean Elementary Science Education,26(2),149-160. van Someren,M. W.,Barnard, Y. F.,& Sandberg, J.A. C. (1994).The think aloud method: A practical guide to modeling cognitive processes. San Diego, CA: Academic press. -
Lactobacillus casei strain C1 attenuates vascular changes in spontaneously hypertensive rats
WeiBoonYap, FaisalMalauAhmad, YiChengLim, SatirahZainalabidin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.6 8 621-628 (8 pages)
Physiol Pharmacol 2016;20(6):621-628 Yap WB et al modeling [10]. Structural remodeling is often coupled with impaired vascular reactivity. This phenomenon was clearly demonstrated in rats undergoing chronic nicotine administration [11]. One of the key factors that results in hypertensive vessels and impaired vascular reactivity is low bioavailability of nitric oxide (NO) [12]. Interestingly,... Hypertension can be caused by various factors while the predominant causes include increase in body fluid volume and resistance in the circulatory system that elevate the blood pressure. Consumption of probiotics has been proven to attenuate hypertension; however, the effect is much strain-dependent. In this study, a newly isolated Lactobacillus casei (Lb. casei ) strain C1 was investigated for its antihypertensive properties in spontaneously hypertensive rats (SHR). Lactic acid bacteria (LAB)... -
Direct Corticosteroid Modulation of GABAergic Neurons in the Anterior Hypothalamic Area of GAD65-eGFP Mice
SeungYubShin, TaeHeeHan, SoYeongLee, SeongKyuHan, JinBongPark, FerencErdelyi, GaborSzabo, PanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 7 163-169 (7 pages)
J, Sherman SM. Current clamp and modeling studies of low-threshold calcium spikes in cells of the cat's lateral geniculate nucleus. J Neurophysiol. 1999;81:2360- 2373. 31. Bessaih T, Leresche N, Lambert RC. T current potentiation increases the occurrence and temporal fidelity of synaptically evoked burst firing in sensory thalamic neurons. Proc Natl Acad Sci USA. 2008;105:11376-11381. 32.... Corticosterone is known to modulate GABAergic synaptic transmission in the hypothalamic paraventricular nucleus. However, the underlying receptor mechanisms are largely unknown. In the anterior hypothalamic area (AHA), the sympathoinhibitory center that project GABAergic neurons onto the PVN, we examined the expression of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) of GABAergic neurons using intact GAD65-eGFP transgenic mice, and the effects of corticosterone on the burst... -
Alterations in Membrane Transport Function and Cell Viability Induced by ATP Depletion in Primary Cultured Rabbit Renal Proximal Tubular Cells
SungJuLee, ChaeHwaKwon, YongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.1 3 15-22 (8 pages)
Physiol Pharmacol 3: 93100, 1999 Dagher PC. Modeling ischemia in vitro: selective depletion of adenine and guanine nucleotide pools. Am J Physiol Cell Physiol 279: C1270 1277, 2000 Denis I, Pointillart A, Lieberherr M. Effects of growth hormone and insulin-like growth factor-I on the proliferation and differentiation of cultured pig bone cells and rat calvaria cells. Growth Regul 4: 123 130,... This study was undertaken to elucidate the underlying mechanisms of ATP depletion-induced membrane transport dysfunction and cell death in renal proximal tubular cells. ATP depletion was induced by incubating cells with 2.5 mM potassium cyanide (KCN)/0.1 mM iodoacetic acid (IAA), and membrane transport function and cell viability were evaluated by measuring Na＋-dependent phosphate uptake and trypan blue exclusion, respectively. ATP depletion resulted in a decrease in Na＋-dependent phosphate... -
Effects of Repeated Citalopram Treatments on Chronic Mild Stress- Induced Growth Associated Protein-43 mRNA Expression in Rat Hippocampus
Sang-HaPark, Song-hyenChoi, JiminLee, SeungwooKang, You-ChanShin, Hyun-JuKim, HyunJungKim, SeungKeonShin, Min-SooLee, Kyung-HoShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.3 5 117-124 (8 pages)
the CA1 compared with the levels of CA1 in control rats (Student's t-test, p＜0.001). Similar trend of increases was found in CA3, CA4 and dentate granule cell layer (GCL) of the hippocampus, but the magnitude of increases was lower than that of CA1 (Fig. 1, 2). CMS induced a small but significant decrease of GAP-43 mRNA levels in the GCL, compared to control rats (Fig. 1; Student's t-test,... the dentate granule cell layer (GCL). Repeated citalopram treatment decreased GAP-43 mRNA expression in the GCL compared with unstressed controls, but this decrease was not further potentiated by CMS exposure. Similar decreases in GAP-43 mRNA expression were observed in CA1, CA3 and CA4 areas of the hippocampus only after repeated citalopram treatment in CMS-exposed rats. This result indicates that GAP-43 mRNA expression in the hippocampus may differently respond to acute and chronic stress, and...