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Acute Toxicity Study on Fermented Ginkgo Epicarp in ICR Mice
Ha Young Kim, Hong Kook Kim, Byeong Soo Kim 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 77 225-226 (2 pages)
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Acute Toxicity Study of Recombinant Granulocyte-Macrophage Colony Stimulating Factor (LBD-005) in ICR mice
Kim. Hyoung-Chin, Song. Si-Whan, Cha. Shin-Woo, Shin. Chun-Chul, Ha. Chang-Su, Han. Sang-Seop 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 5 Pages
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 1993, Vol.1 No.2 270-274 (5 pages)
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Acute Toxicity Study of Recombinant Human Interferon ${alpha}A$ (LBD-007) in ICR Mice
Kim. Hyoung-Chin, Song. Si-Whan, Cha. Shin-Woo, Shin. Chun-Chul, Ha. Chang-Su, Han. Sang-Seop 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 4 Pages
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 1993, Vol.1 No.2 266-269 (4 pages)
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A PRELIMINARY STUDY ON THE ACUTE TOXICITY OF TARTRAZINE IN RABBIT AND GUINEA PIG
유태종, Yu. Tai-Jong 한국응용생명화학회 한국농화학회지 4 Pages
한국응용생명화학회 한국농화학회지 1970, Vol.13 No.3 257-260 (4 pages)
식용색소(食用色素) Tartrazine을 토끼의 경우 $7.5{sim}50mg/kg$, 몰모트의 경우 $1,000{sim}2,000mg/$수(首)를 경구(經口) 또는 복막주사(腹膜注射), 정맥주사(靜脈注射)로 투여(投與)하여 그 동물(動物)에 있어서의 색소(色素)의 독성(毒性)을 관찰조사(觀察調査)하였다. 혈청(血淸)은 화학분석(化學分析)하였고 각各 장기(臟器)는 현미경적(的) 관찰(觀察)을 통(通)하여 조사(調査)하였다. 그 결과(結果) 사용(使用)한 양(量)의 색소(色素)로서 대부분(大部分)의 장기(臟器)가 충혈(充血) 또는 출혈(出血)되였고 특(特)히... -
Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats
Kim. Yong-Soon, Baek. Min-Won, Sung. Jae-Hyuck, Ryu. Hyun-Youl, Kim. Jin-Sik, Cho. Hyun-Sun, Choi. Byung-Gil, Song. Min-Sub, Song. Moon- 한국독성학회 Toxicological research 8 Pages
한국독성학회 Toxicological research 2009, Vol.25 No.3 132-139 (8 pages)
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Chemoradiation Related Acute Morbidity in Carcinoma Cervix and Correlation with Hematologic Toxicity: A South Indian Prospective Study
Kumaran. Aswathy, Guruvare. Shyamala, Sharan. Krishna, Rai. Lavanya, Hebbar. Shripad 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 4 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.11 4483-4486 (4 pages)
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Acute Toxicity and General Pharmacological Action of QGC EXT
JongMiLee, WiJoonIm, YoonJinNam, KyungHoonOh, JaeChunLim, WanKyunnWhang, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.1 8 49-57 (9 pages)
It has been shown that QGC isolated and purified from Rumecis folium found protective effects of gastritis and esophagitis which EXT is an ethanol extract of it. We examined acute toxicity and the general pharmacological action of QGC EXT to search for any side effects of it in rats, mice, guinea pigs, and cats. In a single dose toxicity study, QGC EXT didn't show toxicological effects in rats and mice, and the LD50 was over 5 g/kg in both animals, and there were also no changes in weight, feed... -
A Single Oral Dose Toxicity Study of Bamboo Leaf Water Extract in Sprague-Dawley Rats
Shin. Dong-Ho, Jang. Pan-Gu, Oh. Ki-Seok, Kim. Jae-Ha, Chung. Hee-Jong, Kim. Jong-Choon 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 4 Pages
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 2003, Vol.11 No.3 200-203 (4 pages)
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A Single Oral Dose Toxicity Study of Plant Sterol Ester in Sprague-Dawley Rats
Kim. Jong-Choon, Kim. Kab-Sig, Chung. Dae-Won, Chung. Moon-Koo 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 4 Pages
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 2000, Vol.8 No.2 167-170 (4 pages)
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Acute Hematotoxicity induced by diazinon in SD rats
Su Hyeon Kim, Sang Hee Jeong, Sang Jung Park, Sang In Lee, Chae Ryeong Yi, Si Wan Han, Jae Eun Kim 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 330 388-389 (2 pages)
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A 2-week Dose Range Finding Study of KMRC01, Salmonella flagellin-derived TLR 5 agonist, administered by intramuscular injection in Cynomolgus Monkeys
Hong Soo Lee, Son Il Pak, Doo Wan Cho, Woo Jong Lee, Chi Min Choi, Dong Hun Jung, Su Cheol Han 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 180 309-309 (1 pages)
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Toxicity of crude and detoxified Tityus serrulatus venom in anti-venom-producing sheep
Marina G. Ferreira, Clara G. Duarte, Maira S. Oliveira, Karen L. P. Castro, Ma?lson S. Teixeira, L?lian P. G. Reis, Jos? A. Zamb 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 4호 5 467-477 (11 pages)
the immunogens used. This study was conducted to evaluate the toxic and immunogenic activities of crude and detoxified Tityus serrulatus (Ts) venom in sheep during the production of anti-scorpionic anti-venom. Sheep were categorized into three groups: G1, control, immunized with buffer only; G2, immunized with crude Ts venom; and G3, immunized with glutaraldehyde-detoxified Ts venom. All animals were subjected to clinical exams and supplementary tests. G2 sheep showed mild clinical changes, but... -
In vitro toxicity of melamine against Tetrahymena pyriformis cells
Zhengfang Wang, Liben Chen, Rashad Al-Kasir, Bo Han* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 1호 5 27-34 (8 pages)
This study assessed the toxicity of melamine against the unicellular eukaryotic system of Tetrahymena (T.) pyriformis exposed to 0, 0.05, 0.25, 0.5, 2.5, and 5 mg/mL of melamine. Cell growth curves of different cultures, the half maximum inhibition concentration (IC50) value of melamine, and morphological changes in cells were obtained via optical and transmission electron microscopic observation. The effects of eleven melamine concentrations, 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 and 5... -
Histopathological retrospective study of canine renal disease in Korea, 2003∼2008
Ji-Young Yhee, Chi-Ho Yu, Jong-Hyuk Kim, Keum-Soon Im, Seung-Ki Chon, Jung-Hyang Sur* 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2010, 제 11권 제 4호 1 277-283 (7 pages)
in this study. Tissue histopathology was performed using light microscopy with hematoxylin and eosin stains. Masson's trichrome, Congo Red, and Warthin starry silver staining were applied in several individual cases. Glomerular diseases (22.9%), tubulointerstitial diseases (8.6%), neoplastic diseases (8.6%), conditions secondary to urinary obstruction (24.3%), and other diseases (35.7%) were identified. Glomerulonephritis (GN) cases were classified as acute proliferative GN (5.7%), membranous GN... -
Pathological features of bone marrow transplantation-related toxicity in a mouse
Yong-Hoon Kim, Chang-Su Ha, Hyun-Sook Lee, Sun-Hwa Lim, Kyoung-Sik Moon, Moon-Koo Chung, Hwa-Young Son* 대한수의학회 Journal of Veterinary Science 3 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 4호 15 361-363 (3 pages)
In this case report, we present a mock-transduced bone marrow (BM) transplantation in a mouse, which was found moribund and autopsied to evaluate pathogenesis. Macroscopically, red discoloration of systemic organs was observed. Hematological values revealed a decrease in white blood cells, red blood cells, hematocrit, hemoglobin, and platelets, but an increase in reticulocytes. In BM cytology, hematopoietic cell lines were severely depleted. Histopathologically, hemorrhage in the cerebellar... -
Comparative study on the aflatoxin B1 degradation ability of rumen fluid from Holstein steers and Korean native goats
Santi Devi Upadhaya, Ha Guyn Sung, Chan Hee Lee, Se Young Lee, Sun Woo Kim, Kyung Jin Cho, Jong K. Ha* 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 1호 5 29-34 (6 pages)
The aflatoxin B1 degrading abilities of two different ruminants were compared in this study. One set of experiments evaluated the aflatoxin B1 degradation ability of different rumen fluid donors (steers vs. goats) as well as the rumen fluid filtration method (cheese cloth filtered vs. 0.45 Ռm Millipore) in a 2 × 2 factorial arrangement. Additional studies examined aflatoxin B1 degradation by collecting rumen fluid at different times (0, 3, 6, 9 and 12 h) after feeding. Cannulated... -
Effects of L-NAME, a non-specific nitric oxide synthase inhibitor, on AlCl3-induced toxicity in the rat forebrain cortex
Ivana D. Stevanović*, Marina D. Jovanović, Ankica Jelenković, Miodrag Čolić, Ivana Stojanović, Mil 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 1호 3 15-22 (8 pages)
The present experiments were done to determine the effectiveness of a non-specific nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), on oxidative stress parameters induced by aluminium chloride (AlCl3) intrahippocampal injections in Wistar rats. Animals were sacrificed 3 h and 30 d after treatments, heads were immediately frozen in liquid nitrogen and forebrain cortices were removed. Crude mitochondrial fraction preparations of forebrain cortices were used for the... -
Protective and therapeutic effects of an extract mixture of alder tree, labiate herb, milk thistle green bean-rice bran fermentation, and turnip against ethanol-induced toxicity in the rat
Min-Won Baek, Seung-Hyeok Seok, Hui-Young Lee, Dong Jae Kim, Byoung-Hee Lee, Young-Tae Ahn, Kwang-Sei Lim, Chul-Sung Huh, Jae-Ha 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 1호 5 31-37 (7 pages)
drugs were used for treatment for two weeks prior to administering a single oral dose of ethanol (3 g/kg body weight). The herbal extract mixture and yogurt added to the herbal extract mixture were found to provide protection against ethanolinduced toxicity comparable to the commercial drug treatment, according to the serum and histopathological analysis. It was also shown that co-treatment with herbal extract mixture and yogurt against a triple oral dose of ethanol (2 g/kg body weight, over one... -
Repeated dose toxicity of alfa-cypermethrin in rats
S Manna, D Bhattacharyya, TK Mandal, S Das 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 3호 9 241-245 (5 pages)
The present study was performed to investigate the subacute effect of α-cypermethrin (α-CP) in rats. Alfa-cypermethrin a synthetic pyrethroid insecticide, dissolved in dimethyl sulfoxide (DMSO) and oral LD50 was investigated after administering orally different doses in rats and was determined as 145 mg/kg. Other groups of rats were given repeated daily oral dose (1/10 LD50 ) of α-CP for 30 days. The animals were sacrificed on 31st day. Activities of various enzymes, cytochrome P450 and b5... -
Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells
Jin-Hyuk Choi, Jun-Sung Kim, Young-Chul Kim, Yoon-Shin Kim, Nam-Hyun Chung and Myung-Haing Cho 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 1호 3 11-18 (8 pages)
by PM2.5 rather than PM10. PM2.5 induced higher Mth1 mRNA than PM10. In pBR322 DNA treated with PM2.5, production of single strand breakage of DNA was higher than that of PM10. In Western blot analysis, PM2.5 induced more Nrf-2 protein, associated with diverse transcriptional and anti-oxidative stress enzymes, compared to PM10. Our data suggest that PM2.5 rather than PM10 may be responsible for PM-induced toxicity. Additional efforts are needed to establish the environmental standard of PM2.5. -
Acute kidney injury caused by administration of zaltoprofen in a cat
Woon-bum Baek , Hak-hyun Kim , Byeong-teck Kang , Ji-houn Kang , Mhan-pyo Yang 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 3 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2017, 제 57권 제 1호 10 55-57 (3 pages)
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Protective effects of a mineral aqueous solution on toxicity in mouse liver and kidney
In Jae Park , Se Yeoun Cha , Min Kang , Yang Sub So , Ji Yun Bahng , Hyung Kwan Jang 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 6 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2013, 제 53권 제 3호 6 169-174 (6 pages)
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Phenidone, a dual inhibitor of cyclooxygenase and lipoxygenase, inhibits carbon tetrachloride-induced acute liver injury in rats
Hyuop Choi , Dong Hwan Joeng , Bae Dong Jung , Tae Kyun Shin , Myung Bok Wie1 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 5 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2010, 제 50권 제 2호 10 145-149 (5 pages)
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Carbon monoxide releasing molecule-2 protects mice against acute kidney injury through inhibition of ER stress
Md Jamal Uddin, Eun Seon Pak, Hunjoo Ha 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 10 567-575 (9 pages)
Acute kidney injury (AKI), which is defined as a rapid decline of renal function, becomes common and recently recognized to be closely intertwined with chronic kidney diseases. Current treatment for AKI is largely supportive, and endoplasmic reticulum (ER) stress has emerged as a novel mediator of AKI. Since carbon monoxide attenuates ER stress, the objective of the present study aimed to determine the protective effect of carbon monoxide releasing molecule-2 (CORM2) on AKI associated with ER... -
Toxicokinetics of paraquat in Korean patients with acute poisoning
Hak-JaeKim, Hyung-KiKim, HwayoungLee, Jun-SeokBae, Jun-TackKown, Hyo-WookGil, Sae-YongHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 5 35-39 (5 pages)
kinetic study of paraquat (PQ), we investigated 9 patients with acute PQ intoxication. All of them ingested more than 20 ml of undiluted PQ herbicide to commit suicide and arrived at our hospital early, not later than 7 h after PQ ingestion. The urine dithionite test for PQ in all of the nine patients was strongly positive at emergency room. Blood samples were obtained every 30 min for the first 2~3 h and then every 1 or 2 h, as long as the clinical progression was stable among the patients for...


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