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본문검색 결과만 보기
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Effect of low intensity pulsed ultrasound in activating the mitogen-activated protein kinase signaling pathway and inhibition inflammation cytokine synthesis in chondrocytes
Eun-Jung Kim, Gye-Yeop Kim 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2014, 제 3권 제 1호 6 33-37 (5 pages)
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Cadmium induces apoptosis in primary rat osteoblasts through caspase and mitogen-activated protein kinase pathways
Hongyan Zhao, Wei Liu, Yi Wang, Nannan Dai, Jianhong Gu, Yan Yuan, Xuezhong Liu, Jianchun Bian, Zong-Ping Liu 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 7 297-306 (10 pages)
of p38-mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases (ERK)1/2 and c-jun N-terminal kinase (JNK) in OBs. Pretreatment with the caspase inhibitor, N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone, ERK1/2 inhibitor (U0126), p38 inhibitor (SB203580) and JNK inhibitor (SP600125) abrogated Cd-induced cell apoptosis. Furthermore, Cd-treated OBs exhibited signs of oxidative stress protection, including increased antioxidant enzymes superoxide dismutase and glutathione... -
Water soluble tomato concentrate regulates platelet function via the mitogen-activated protein kinase pathway
Dahye Jeong , Muhammad Irfan , Evelyn Saba , Sung Dae Kim , Seung Hyung Kim , Man Hee Rhee 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 8 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2016, 제 56권 제 2호 2 67-74 (8 pages)
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2-(4-Hydroxyphenyl)-5-(3-Hydroxypropenyl)-7-Methoxybenzofuran, a Novel Ailanthoidol Derivative, Exerts Anti-Inflammatory Effect through Downregulation of Mitogen-Activated Protein Kinase in Lipopolysaccharide-Treated RAW 264.7 Cells
HyeonJinKim, Jong-GabJun, Jin-KyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.3 6 217-222 (6 pages)
of prostaglandin (PG) E2 and the expression of inducible NO synthase and cyclooxygenase (COX)-2 induced by LPS, and inhibited the release of LPS-induced pro-inflammatory cytokines from RAW264.7 cells. The underlying mechanism of compound 4 on anti-inflammatory action was correlated with the down-regulation of mitogen-activated protein kinase and activator protein-1 activation. Compound 4 is potentially an effective functional chemical candidate for the prevention of inflammatory diseases. -
Blockade of p38 Mitogen-activated Protein Kinase Pathway Inhibits Interleukin-6 Release and Expression in Primary Neonatal Cardiomyocytes
Han-JungChae, Hyun-KiKim, Wan-KuLee, Soo-WanChae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 7 319-325 (7 pages)
The induction of interleukin-6 (IL-6) using combined proinflammatory agents (LPS/IFN-γ or TNF-α/ IFN-γ) was studied in relation to p38 mitogen-activated protein kinase (MAPK) and NF-κB transcriptional factor in primary neonatal cardiomyocytes. When added to cultures of cardiomyocytes, the combined agents (LPS/IFN-γ or TNF-α/IFN-γ) had stimulatory effect on the production of IL-6 and the elevation was significantly reduced by SB203580, a specific p38 MAPK inhibitor. SB203580 inhibited... -
Transgenic Rice Plants Expressing an Active Tobacco Mitogen-activated Protein Kinase Kinase Induce Multiple Defense Responses
한국식물병리학회 The Plant Pathology Journal 9 Pages
한국식물병리학회 The Plant Pathology Journal 2008, 24권 4호 2 375-383 (9 pages)
a tobacco MAPK kinase, is the upstream kinase of both salicylic acidinduced protein kinase and wound-induced protein kinase. In addition, expression of NtMEK2DD, a constitutively active mutant of NtMEK2, is known to induce multiple defense responses in tobacco. In this study, transgenic rice plants that contained an active or inactive mutant of NtMEK2 under the control of a steroid inducible promoter were generated and used to determine if a similar MAPK cascade is involved in disease resistance... -
Mini-Reviews : The Mitogen-Activated Protein Kinase Signal Transduction Pathways in Alternaria Species
한국식물병리학회 The Plant Pathology Journal 12 Pages
한국식물병리학회 The Plant Pathology Journal 2012, 28권 3호 1 227-238 (12 pages)
Mitogen-activated protein kinase (MAPK) cascades are conserved signaling modules in the eukaryotic cells. They are involved in many major cell processes in fungi such as stress responses, vegetative growth, pathogenicity, secondary metabolism and cell wall integrity. In this review, we summarized the advances of research on the MAPK signaling pathways in Alternaria species. As major phytopathogenic fungi, Alternaria species reduce crop production. In contrast to the five MAPK pathways known in... -
Effects of Mining-impacted Polished Rice on the Glutathione Peroxide and Glutathione S-transferaseActivities, and Oxidative Stress-induced Apoptosis Signal Regulating Kinase 1, p38 Mitogen-activated Protein Kinase Isomer, and Jun N-terminal Kinase in Human
Lee. Ji-Ho, Jeong. Eun-Jung, Im. Geon-Jae, Kim. Won-Il 한국응용생명화학회 Journal of the Korean Society for Applied Biological Chemistry 6 Pages
한국응용생명화학회 Journal of the Korean Society for Applied Biological Chemistry 2012, Vol.55 No.2 327-332 (6 pages)
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Effects of Curcumin on Apoptosis and Oxidoinflammatory Regulation in a Rat Model of Acetic Acid-Induced Colitis: The Roles of c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase
Topcu-Tarladacalisir. Yeter, Akpolat. Meryem, Uz. Yesim Hulya, Kizilay. Gulnur, Sapmaz-Metin. Melike, Cerkezkayabekir. Aysegul, Omurlu 한국식품영양과학회 Journal of medicinal food 10 Pages
한국식품영양과학회 Journal of medicinal food 2013, Vol.16 No.4 296-305 (10 pages)
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The Anti-Inflammatory Effect of Kaempferol in Aged Kidney Tissues: The Involvement of Nuclear Factor-${kappa}B$ via Nuclear Factor-Inducin Kinase/$I{kappa}B$ Kinase and Mitogen-Activated Protein Kinase Pathway
Park. Min-Ju, Lee. Eun-Kyeong, Heo. Hyoung-Sam, Kim. Min-Sun, Sung. Bok-Young, Kim. Mi-Kyung, Lee. Jae-Won, Kim. Nam-Deuk, Anton. Stephe 한국식품영양과학회 Journal of medicinal food 8 Pages
한국식품영양과학회 Journal of medicinal food 2009, Vol.12 No.2 351-358 (8 pages)
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A Salt Stress-activated Mitogen-activated Protein Kinase in Soybean Is Regulated by Phosphatidic Acid in Early Stages of the Stress Response
Im. Jong Hee, Lee. Hyoungseok, Kim. Jitae, Kim. Ho Bang, Kim. Seyoung, Kim. B. Moon, An. Chung Sun 한국식물학회 Journal of plant biology 7 Pages
한국식물학회 Journal of plant biology 2012, Vol.55 No.4 303-309 (7 pages)
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Mitogen-Activated Protein Kinase Is Involved in the Symbiotic Interaction between Bradyrhizobium japonicum USDA110 and Soybean
Lee. Hyoung-Seok, Kim. Ji-Tae, Im. Jong-Hee, Kim. Ho-Bang, Oh. Chang-Jae, An. Chung-Sun 한국식물학회 Journal of plant biology 6 Pages
한국식물학회 Journal of plant biology 2008, Vol.51 No.4 291-296 (6 pages)
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Effects of Curcumin, the Active Ingredient of Turmeric(Curcuma longa), on Regulation of Glutamate-induced Toxicity and Activation of the Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) in HT22 Neuronal Cell
Lee. Sang-Hyun, Yun. Young-Gab 한국생약학회 Natural product sciences 5 Pages
한국생약학회 Natural product sciences 2009, Vol.15 No.1 32-36 (5 pages)
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Nuruk Extract Inhibits Lipopolysaccharide-Induced Production of Nitrite and Interleukin-6 in RAW 264.7 Cells Through Blocking Activation of p38 Mitogen-Activated Protein Kinase
Kim. Jong-Eun, Jung. Sung-Keun, Lee. Sang-Jin, Lee. Ki-Won, Kim. Gye-Won, Lee. Hyong-Joo 한국미생물생명공학회 Journal of microbiology and biotechnology 4 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2008, Vol.18 No.8 1423-1426 (4 pages)
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Differential Alterations of Endotoxin-induced Cytokine Expression and Mitogen-activated Protein Kinase Activation by Mercury in Mouse Kidney
Kim. Sang-Hyun, Kim. Dae-Keun, Shin. Tae-Yong, Choi. Cheol-Hee 한국독성학회 Journal of toxicology and public health : an official journal of the Korean Society of Toxicology 7 Pages
한국독성학회 Journal of toxicology and public health : an official journal of the Korean Society of Toxicology 2004, Vol.20 No.3 233-239 (7 pages)
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Mitogen-Activated Protein Kinase Signal Transduction in Solid Tumors
Lei. Yuan-Yuan, Wang. Wei-Jia, Mei. Jin-Hong, Wang. Chun-Liang 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 10 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.20 8539-8548 (10 pages)
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Taxol-Induced Apoptosis and Nuclear Translocation of Mitogen-Activated Protein (MAP) Kinase in HeLa Cells
Kim. Sung-Su, Kim. Yoon-Suk, Jung. Yon-Woo, Choi. Hyun-Il, Shim. Moon-Jeong, Kim. Tae-Ue 생화학분자생물학회 Journal of biochemistry and molecular biology 6 Pages
생화학분자생물학회 Journal of biochemistry and molecular biology 1999, Vol.32 No.4 379-384 (6 pages)
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The mitogen-activated protein kinase phosphatase-1 (MKP-1) gene is a potential methylation biomarker for malignancy of breast cancer
Chen. Fang-Ming, Chang. Hsueh-Wei, Yang. Sheau-Fang, Huang. Ya-Fang, Nien. Pei-Yung, Yeh. Yao-Tsung, Hou. Ming-Feng 생화학분자생물학회 Experimental & molecular medicine : EMM 7 Pages
생화학분자생물학회 Experimental & molecular medicine : EMM 2012, Vol.44 No.5 356-362 (7 pages)
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Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor $via$ mitogen-activated protein kinase
Jung. Gyung-Ah, Shin. Bong-Shik, Jang. Yeon-Sue, Sohn. Jae-Bum, Woo. Seon-Rang, Kim. Jung-Eun, Choi. Go, Lee. Kyung-Mi, Min. Bon-Hong, Le 생화학분자생물학회 Experimental & molecular medicine : EMM 11 Pages
생화학분자생물학회 Experimental & molecular medicine : EMM 2011, Vol.43 No.10 550-560 (11 pages)
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c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) are involved in Mycobacterium tuberculosis-induced expression of Leukotactin-1
Cho. Jang-Eun, Park. Sang-Jung, Cho. Sang-Nae, Lee. Hye-Young, Kim. Yoon-Suk 생화학분자생물학회 BMB reports 6 Pages
생화학분자생물학회 BMB reports 2012, Vol.45 No.10 583-588 (6 pages)
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Molecular characterization and immunohistochemical localization of a mitogen-activated protein kinase, Accp38b, from Apis cerana cerana
Zhang. Liang, Meng. Fei, Li. Yuzhen, Kang. Mingjiang, Guo. Xingqi, Xu. Baohua 생화학분자생물학회 BMB reports 6 Pages
생화학분자생물학회 BMB reports 2012, Vol.45 No.5 293-298 (6 pages)
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A novel human KRAB-related zinc finger gene ZNF425 inhibits mitogen-activated protein kinase signaling pathway
Wang. Yuequn, Ye. Xiangli, Zhou. Junmei, Wan. Yongqi, Xie. Huaping, Deng. Yun, Yan. Yan, Li. Yongqing, Fan. Xiongwei, Yuan. Wuzhou, Mo. Xi 생화학분자생물학회 BMB reports 6 Pages
생화학분자생물학회 BMB reports 2011, Vol.44 No.1 58-63 (6 pages)
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Beta-carboline alkaloids harmaline and harmalol induce melanogenesis through p38 mitogen-activated protein kinase in B16F10 mouse melanoma cells
Park. Sun-Young, Kim. Young-Hun, Kim. Young-Hee, Park. Geun-Tae, Lee. Sang-Joon 생화학분자생물학회 BMB reports 6 Pages
생화학분자생물학회 BMB reports 2010, Vol.43 No.12 824-829 (6 pages)
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Suppressive effects of Lithospermum erythrorhizon extracts on lipopolysaccharide-induced activation of AP-1 and NF-κB via mitogen-activated protein kinase pathways in mouse macrophage cells
Han. Kyu-Yeon, Kwon. Taek-Hwan, Lee. Tae-Hoon, Lee. Sung-Joon, Kim. Sung-Hoon, Kim. Ji-Young 생화학분자생물학회 BMB reports 6 Pages
생화학분자생물학회 BMB reports 2008, Vol.41 No.4 328-333 (6 pages)
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SB202190- and SB203580-Sensitive p38 Mitogen-Activated Protein Kinase Positively Regulates Heat Shock- and Amino Acid Analog-Induced Heat Shock Protein Expression
Kim. Sun-Hee, Han. Song-Iy, Oh. Su-Young, Seo. Myoung-Suk, Park. Hye-Gyeong, Kang. Ho-Sung 대한의생명과학회 The Journal of biomedical laboratory sciences 7 Pages
대한의생명과학회 The Journal of biomedical laboratory sciences 2003, Vol.9 No.2 59-65 (7 pages)
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핵 내에서 분리한 Mitogen-Activated Protein (MAP) Kinase의 Transcription Factor에 대한 인산화
김윤석, 김소영, 김태우 대한의생명과학회 The Journal of biomedical laboratory sciences 11 Pages
대한의생명과학회 The Journal of biomedical laboratory sciences 1996, Vol.2 No.2 175-185 (11 pages)
모든 진핵세포에 존재하며 세포의 성장 및 분화에 주로 관계되는 신호전달물질의 하나인 Mitogen-activated protein(MAP)kinase의 mitogen에 의한 핵내 활성화와 기질 인산화에 대해 알아보기 위해 본 실험을 수행하였다. P388세포를 10% fetal bovine serum이 첨가된 DMEM배지에 배양한 후, 혈청이 들어있지 않은 배지에서 24시간 더 배양하고 serum 및 PMA를 농도별로 처리하여 세포성 장을 위한 최적 농도를 확인한 결과 serum은 5-20% 농도에서 세포성장을 촉진시켰고 PMA는 실험한 모든 농도에서 세포성장을 거의 촉진시키지 못하는... -
동물 조직세포로부터 Mitogen-activated Protein (MAP) Kinase의 분리 및 성격규명
김태우, 정동주, 김윤석 대한의생명과학회 The Journal of biomedical laboratory sciences 10 Pages
대한의생명과학회 The Journal of biomedical laboratory sciences 1996, Vol.2 No.1 21-30 (10 pages)
Mitogen-activated protein (MAP) kinase는 여러 세포증식 촉진인자들에 의하여 자신이 인산화됨으로써 활성화되어 다른 protein kinase를 인산화시키는 역할을 하는 세포내 신호전달의 중요한 효소이다. 본 연구에서는 P388 murine leukemia 세포 파쇄액에서 SP sephadex C-50, phenyl superose, Mono Q column을 통하여 MAP kinase를 분리한 결과, 44 kD와 66kD의 isoform을 확인할 수 있었다. 면역 T 세포의 $p56^{kk}$의 N-terminal로부터 유전자 재조합 방법을 통하여 glutathion-s-transferase(GST) fusion protein을 얻은 후...
