자료유형
발행기관
- 대한생리학회-대한약리학회(12)
- 한국식품영양과학회(8)
- 아시아태평양암예방학회(7)
- 대한약학회(4)
- 한국영양학회(4)
- 대한수의학회(2)
- 동아시아식생활학회(2)
- 대한한방내과학회(1)
- 한국보건기초의학회(1)
- 한국생명과학회(1)
- 한국생약학회(1)
- 한국식품과학회(1)
- 한국응용생명화학회(1)
- 한국통합생물학회(1)
- 한방비만학회(1)
간행물
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(12)
- ASIAN PACIFIC JOURNAL OF CANCER PREVENTION : APJCP(7)
- 한국식품영양과학회지(6)
- ARCHIVES OF PHARMACAL RESEARCH : A PUBLICATION OF THE PHARMACEUTICAL SOCIETY OF KOREA(4)
- NUTRITION RESEARCH AND PRACTICE(3)
- JOURNAL OF VETERINARY SCIENCE(2)
- 동아시아식생활학회지(2)
- ANIMAL CELLS AND SYSTEMS(1)
- JOURNAL OF FOOD SCIENCE AND NUTRITION(1)
- JOURNAL OF MEDICINAL FOOD(1)
- NATURAL PRODUCT SCIENCES(1)
- 대한한방내과학회지(1)
- 대한한방비만학회지(1)
- 생명과학회지(1)
- 한국보건기초의학회지(1)
- 한국식품과학회지(1)
- 한국영양학회지(1)
- 한국응용생명화학회지(1)
전체 선택해제
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Thymoquinone (TQ) regulates cyclooxygenase-2 expression and prostaglandin E2 production through PI3kinase (PI3K)/p38 kinase pathway in human breast cancer cell line, MDA-MB-231
Yu. Seon-Mi, Kim. Song-Ja 한국통합생물학회 Animal cells and systems 6 Pages
한국통합생물학회 Animal cells and systems 2012, Vol.16 No.4 274-279 (6 pages)
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Inorganic sulfur reduces cell proliferation by inhibiting of $ErbB_2$ and $ErbB_3$ protein and mRNA expression in MDA-MB-231 human breast cancer cells
Ha. Ae Wha, Hong. Kyung Hee, Kim. Hee Sun, Kim. Woo Kyoung 한국영양학회 Nutrition research and practice 7 Pages
한국영양학회 Nutrition research and practice 2013, Vol.7 No.2 89-95 (7 pages)
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Extraction of Lignans from Flaxseed and Evaluation of Their Biological Effects on Breast Cancer MCF-7 and MDA-MB-231 Cell Lines
Lehraiki. Abdelali, Attoumbre. Jacques, Bienaime. Christophe, Matifat. Fabrice, Bensaddek. Lamine, Nava-Saucedo. Edmundo, Fliniaux. Ma 한국식품영양과학회 Journal of medicinal food 8 Pages
한국식품영양과학회 Journal of medicinal food 2010, Vol.13 No.4 834-841 (8 pages)
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Lactobacillus acidophilus and Lactobacillus crispatus Culture Supernatants Downregulate Expression of Cancer-testis Genes in the MDA-MB-231 Cell Line
Azam. Rosa, Ghafouri-Fard. Soudeh, Tabrizi. Mina, Modarressi. Mohammad-Hossein, Ebrahimzadeh-Vesal. Reza, Daneshvar. Maryam, Mobasheri 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 5 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.10 4255-4259 (5 pages)
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Fangchinoline Inhibits Cell Proliferation Via Akt/GSK-3beta/cyclin D1 Signaling and Induces Apoptosis in MDA-MB-231 Breast Cancer Cells
Wang. Chang-Dong, Yuan. Cheng-Fu, Bu. You-Quan, Wu. Xiang-Mei, Wan. Jin-Yuan, Zhang. Li, Hu. Ning, Liu. Xian-Jun, Zu. Yong, Liu. Ge-Li, So 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 5 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.2 769-773 (5 pages)
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miR-153 Silencing Induces Apoptosis in the MDA-MB-231 Breast Cancer Cell Line
Anaya-Ruiz. Maricruz, Cebada. Jorge, Delgado-Lopez. Guadalupe, Sanchez-Vazquez. Maria Luisa, Perez-Santos. Jose Luis Martin 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 4 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2013, Vol.14 No.5 2983-2986 (4 pages)
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ER81-shRNA Inhibits Growth of Triple-negative Human Breast Cancer Cell Line MDA-MB-231 In Vivo and in Vitro
Chen. Yue, Zou. Hong, Yang. Li-Ying, Li. Yuan, Wang. Li, Hao. Yan, Yang. Ju-Lun 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 8 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2012, Vol.13 No.5 2385-2392 (8 pages)
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shRNA Mediated RHOXF1 Silencing Influences Expression of BCL2 but not CASP8 in MCF-7 and MDA-MB-231 Cell Lines
Ghafouri-Fard. Soudeh, Abdollahi. Davood Zare, Omrani. Mirdavood, Azizi. Faezeh 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 5 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2012, Vol.13 No.11 5865-5869 (5 pages)
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Antiproliferative Properties of Methanolic Extract of Nigella sativa against the MDA-MB-231 Cancer Cell Line
Dilshad. Ahmad, Abulkhair. Omalkhair, Nemenqani. Dalal, Tamimi. Waleed 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 4 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2012, Vol.13 No.11 5839-5842 (4 pages)
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Induction of Apoptotic Cell Death by Ursolic Acid through Mitochondrial Death Pathway and Extrinsic Death Receptor Pathway in MDA-MB-231 Cells
Kim. Kyung-Hun, Seo. Hye-Sook, Choi. Han-Seok, Choi. In-Hwa, Shin. Yong-Cheol, Ko. Seong-Gyu 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 10 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2011, Vol.34 No.8 1363-1372 (10 pages)
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Adiponectin Induces Growth Arrest and Apoptosis of MDA-MB231 Breast Cancer Cell
Kang. Jee Hyun, Lee. Yoon Young, Yu. Byung Yeon, Yang. Beom-Seok, Cho. Kyung-Hwan, Yoon. Do Kyoung, Roh. Yong Kyun 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 7 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2005, Vol.28 No.11 1263-1269 (7 pages)
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Inhibition of the Interleukin-11-STAT3 Axis Attenuates Hypoxia-Induced Migration and Invasion in MDA-MB-231 Breast Cancer Cells
Ji-HongLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.5 6 391-396 (6 pages)
or a neutralizing antibody attenuated hypoxic MDA-MB-231 breast cancer cell migration and invasion through down-regulation of matrix metalloproteinases (MMPs) and activation of epithelial-to-mesenchymal transition (EMT) related gene expression. In addition, hypoxia-induced IL-11 increased STAT3 phosphorylation and STAT3 knockdown suppressed hypoxic MDA-MB-231 breast cancer cell invasion due to reduced MMP levels and reprogrammed EMT-related gene expression. These results suggest that one of the... -
Radish (Raphanus sativus L. leaf) ethanol extract inhibits protein and mRNA expression of $ErbB_2$ and $ErbB_3$ in MDA-MB-231 human breast cancer cells
Kim. Woo-Kyoung, Kim. Ji-Hae, Jeong. Da-Hee, Chun. Young-Hee, Kim. Sun-Hee, Cho. Kang-Jin, Chang. Moon-Jeong 한국영양학회 Nutrition research and practice 6 Pages
한국영양학회 Nutrition research and practice 2011, Vol.5 No.4 288-293 (6 pages)
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Anthocyanin의 Delphinidin이 MDA-MB-231 유방암세포에 미치는 영향
장혜연, 이송희, 안인정, 이해님, 김혜리, 박영석, 박병권, 김병수, 김상기, 조성대, 남정석, 최창순, 정지윤, Jang. Hye-Yeon, Lee. Song-Hee, An. In-Jung, Lee. Hae-Nim, Kim. Hye-Ri, Park. Youn 한국식품영양과학회 한국식품영양과학회지 7 Pages
한국식품영양과학회 한국식품영양과학회지 2014, Vol.43 No.2 231-237 (7 pages)
본 연구에서는 블루베리에 포함된 anthocyanin 중 delphinidin이 인간 유래의 MDA-MB-231 유방암세포의 성장을 억제시키고 apoptosis를 유발하는지 살펴보고 in vivo 실험에서도 항암효과가 나타나는지 확인하였다. 그 결과 cell viability를 보기 위한 MTT assay에서는 농도 의존적으로 암세포의 성장을 억제시켰으며, apoptosis의 확인을 위한 DAPI stain에서 농도 의존적으로 chromatin condensation이 유의적으로 증가하는 것을 확인하였다. 또한 western blot에서 암 억제 유전자인 p53 단백질이 증가하였고, anti-apoptotic 분자인... -
적양배추 추출물이 인체 유방암 세포 MDA-MB-231의 세포사멸에 미치는 영향
남미경, 강금지, Nam. Mi Kyung, Kang. Keum Jee 한국식품영양과학회 한국식품영양과학회지 9 Pages
한국식품영양과학회 한국식품영양과학회지 2013, Vol.42 No.1 8-16 (9 pages)
본 연구는 체내 세포배양을 통한 적양배추 추출물의 항유방암 효과를 검정하기 위해 세포활성, 세포사멸, ROS 축적 및 세포사멸 관련 유전자 발현을 분석하였다. 적양배추 추출물을 0.5, 0.75, 1.0, 1.25, 1.5, 1.75 및 2.0 mg/mL의 농도로 24시간 처리하여 세포 생존율(MTT assay)을 분석한 결과 농도 의존적으로 감소되었다(p<0.05). 또한 세포사멸/괴사분석(Hoechst33342/ethidium bromide 염색법), flow cytometry assay, ROS 측정(DCF-DA 염색법) 등의 세포 화학적 방법을 통해 분석한 결과 처리 농도가 증가할수록 세포사멸이... -
신선초 추출물이 인체 유방암 세포 MDA-MB-231의 세포 사멸에 미치는 영향
정유진, 강금지, Jeong. Yu-Jin, Kang. Keum-Jee 한국식품영양과학회 한국식품영양과학회지 8 Pages
한국식품영양과학회 한국식품영양과학회지 2011, Vol.40 No.12 1654-1661 (8 pages)
AKE의 농도별 처리가 인체 유방암 세포 MDA-MB-231의 세포사멸에 미치는 영향을 확인하기 위하여 세포 화학적인 방법인 MTT 분석, 이중 핵 염색법(Hoechst 33342/EtBr staining), FACS를 통하여 세포사멸을 관찰하였다. MTT 분석 결과, 150 ${mu}g$/mL 처리 군에서 대조군에 대비하여 약 50%의 세포사멸을 나타내었으며 세포사멸이 농도 의존적으로 증가되었고(p<0.05), 이중 핵 염색법을 이용하여 세포사의 구분 결과 능동적 세포예정사인 apoptosis가 농도 의존적으로 급격히 증가하였으며(p<0.05), 특히 150 ${mu}g$/mL... -
Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity
LichThiNguyen, Yeon-HeeLee, AshishRanjanSharma, Jong-BongPark, SupriyaJagga, GarimaSharma, Sang-SooLee, Ju-SukNam 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 8 205-213 (9 pages)
and GADD45 signaling activities. We also observed that quercetin induced protein level, transcriptional activity and nuclear translocation of Foxo3a. Knockdown of Foxo3a caused significant reduction in the effect of quercetin on cell apoptosis and cell cycle arrest. In addition, treatment of JNK inhibitor (SP 600125) abolished quercetin-stimulated Foxo3a activity, suggesting JNK as a possible upstream signaling in regulation of Foxo3a activity. Knockdown of Foxo3a and inhibition of JNK activity... -
Antiestrogen, Trans-Tamoxifen Modulation of Human Breast Cancer Cell Growth
Lee. Hyung-Ok, Sheen. Yhun-Yhong 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 7 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 1997, Vol.20 No.6 572-578 (7 pages)
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The p90rsk-mediated signaling of ethanol-induced cell proliferation in HepG2 cell line
HanSangKim, Su-JinKim, JinhyungBae, YiyiWang, SunYoungPark, YoungSilMin, HyunDongJe, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.6 5 595-603 (9 pages)
is known to be an important downstream kinase of p44/42 MAPK. We investigated the role of p90rsk on ethanol-induced cell proliferation of HepG2 cells. HepG2 cells were treated with 10~50 mM of ethanol with or without ERK and p90rsk inhibitors. Cell viability was measured by MTT assay. The expression of pERK1, NHE1 was measured by Western blots. The phosphorylation of p90rsk was measured by ELISA kits. The expression of Bcl-2 was measured by qRT-PCR. When the cells were treated with 10~30 mM of... -
3D-QSAR Analyses on the Inhibitory Activity of [(2-Phenylindol-3-yl)-methylene]propanedinitrile Analogues against Breast Cancer Cell and the Ligand Design of Active Molecules
Soung. Min-Gyu, Myung. Pyung-Keun, Sung. Nack-Do 한국응용생명화학회 한국응용생명화학회지 6 Pages
한국응용생명화학회 한국응용생명화학회지 2009, Vol.52 No.1 28-33 (6 pages)
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Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells
Yun-HeeBae, JongHyoRyu, Hyun-JooPark, KwangRokKim, Hee-JunWee, Ok-HeeLee, Hye-OckJang, Moon-KyoungBae, Kyu-WonKim, Soo-KyungBae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 6 291-297 (7 pages)
activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis. We found that curcumin treatment resulted in an induction of apoptosis in MDA-MB-231 cells, together with downregulation of Notch1 and its downstream target, Hes1. This reduction in Notch1 expression was determined to be due to the decreased activity of endogenous mutant p53. We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1... -
Lysophosphatidic acid enhances breast cancer cells-mediated osteoclastogenesis
Ju-Suk Nam, Ashish Ranjan Sharma, Lich Thi Nguyen, Supriya Jagga, Yeon-Hee Lee, Garima Sharma, Sang-Soo Lee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 4 503-511 (9 pages)
in both MDA-MB-231 and MDA-MB-468, however, IL-11 was induced only in MDA-MB-231, suggesting differential LPARs participation in the expression of these cytokines. Expression of IL-8 but not IL-11 was suppressed by inhibitors of PI3K, NFkB, ROCK and PKC pathways. In the case of PKC activation, it was observed that PKCd and PKCμ might regulate LPA-induced expression of IL-11 and IL-8, respectively, by using specific PKC subtype inhibitors. Finally, conditioned Medium from LPA-stimulated breast... -
Potentiation of decursinol angelate on pentobarbital-induced sleeping behaviors via the activation of GABAA-ergic systems in rodents
JaeHoonWoo, Tae-WooHa, Jae-SeonKang, JinTaeHong, Ki-WanOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 4 27-36 (10 pages)
Angelicae Gigantis Radix (AGR, Angelica gigas ) has been used for a long time as a traditional folk medicine in Korea and oriental countries. Decursinol angelate (DCA) is structurally isomeric decursin, one of the major components of AGR. This study was performed to confirm whether DCA augments pentobarbital-induced sleeping behaviors via the activation of GABAA-ergic systems in animals. Oral administration of DCA (10, 25 and 50 mg/kg) markedly suppressed spontaneous locomotor activity. DCA also... -
4-(Tert-butyl)-2,6-bis(1-phenylethyl)phenol induces pro-apoptotic activity
JunHoKim, YunmiLee, Mi-YeonKim, JaeYoulCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 4 253-259 (7 pages)
of C6 glioma, MDA-MB-231, LoVo, and HCT-15 cells. KTH-13-t-Bu induced morphological changes in C6 glioma cells in a dose-dependent manner. KTH-13-t-Bu also increased the level of early apoptotic cells stained with annexin V-FITC. Furthermore, KTH-13-t-Bu increased the levels of cleaved caspase-3 and -9. In contrast, KTH-13-t-Bu upregulated the levels of pro- and cleaved forms of caspase-3, -8, and -9 and Bcl-2. Phospho-STAT3, phospho-Src, and phospho-AKT levels were also diminished by KTH13-t-Bu... -
Cryptotanshinone inhibits TNF-α-induced LOX-1 expression by suppressing reactive oxygen species (ROS) formation in endothelial cells
XiaoliRan, WenwenZhao, WenpingLi, JingshanShi, XiupingChen 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.4 4 347-355 (9 pages)
Cryptotanshinone (CPT) is a natural compound isolated from traditional Chinese medicine Salvia miltiorrhiza Bunge. In the present study, the regulatory effect and potential mechanisms of CPT on tumor necrosis factor alpha (TNF-α) induced lectin-like receptor for oxidized low density lipoprotein (LOX-1) were investigated. Human umbilical vein endothelial cells (HUVECs) were cultured and the effect of TNF-α on LOX-1 expression at mRNA and protein levels was determined by Real-time PCR and... -
Inhibition of Cancer Cell Migration by Compounds from Garlic Extracts
김은경, 윤성지, 하정민, 진인혜, 김영환, 김선근, 박다정, 최영환, 윤식, 김치대, 배순식, Kim. Eun-Kyoung, Yun. Sung-Ji, Ha. Jung-Min, Jin. In-Hye, Kim. Young-Whan, Kim. Sun-Gun, Pa 한국생명과학회 생명과학회지 8 Pages
한국생명과학회 생명과학회지 2011, Vol.21 No.6 767-774 (8 pages)
세포의 이동을 억제함을 확인하였다. 그러나 ICMG-27은 mouse embryonic fibroblast (MEF) 세포에서 IGF-1에 의한 이동에는 영향을 주지 않았다. 이러한 ICMG-27은 OVCA-3, SKOV-3와 MDA-MB-231 세포와 같은 암세포에서 모두 IGF-1에 의한 이동을 억제함을 관찰하였다. 마지막으로 세포이동을 일으키는 인자에 따른 ICMG-27의 영향을 확인한 것으로, IGF-1, lysophosphatidic acid (LPA), sphingosine-1-phosphate (S1P), leukotriene B4 (LTB4) 그리고, angiotensinII (AngII)에 의한 OVCAR-3 세포의 이동을 모두 억제하였다. 이러한 결... -
Gambogenic Acid Induction of Apoptosis in a Breast Cancer Cell Line
Zhou. Jing, Luo. Yan-Hong, Wang. Ji-Rong, Lu. Bin-Bin, Wang. Ke-Ming, Tian. Ye 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 5 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2013, Vol.14 No.12 7601-7605 (5 pages)
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Estrogen Modulation of Human Breast Cancer Cell Growth
Lee. Hyung-Ok, Sheen. Yhun-Yhong 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 6 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 1997, Vol.20 No.6 566-571 (6 pages)
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Tarantula cubensis extract alters the degree of apoptosis and mitosis in canine mammary adenocarcinomas
Nilgun Gultiken, Tolga Guvenc, Duygu Kaya, Ali Reha Agaoglu, Serhan Serhat Ay, Ibrahim Kucukaslan, Birten Emre, Murat Findik, Sa 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 2호 11 213-219 (7 pages)
B-cell lymphoma 2 (Bcl-2) was found to be higher in pre-treatment compared to post-treatment tissues (p ＜ 0.01) whereas Ki-67 expression was lower in post-treatment tissues (p ＜ 0.01). No significant differences in fibroblast growth factor or vascular endothelial growth factor expression were observed between pre- and post-treatment tissues (p ＞ 0.05). The apoptotic index was determined to be low before treatment and increased during treatment. These results suggest that TCE may be effective... -
Multiple Effects of a Novel Epothilone Analog on Cellular Processes and Signaling Pathways Regulated by Rac1 GTPase in the Human Breast Cancer Cells
HongZhang, FanAn, LiTang, RongguoQiu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.2 4 109-120 (12 pages)
in cell motility. UTD2 also reduced the phosphorylation of Akt, which is an important signaling kinase regulating the cell survival through Rac1. Furthermore, UTD2 interrupted the synergy between Rac1 and Raf in focus formation assays. Taken together, these results indicated that UTD2 exerted multiple effects on the actin cytoskeleton and signaling pathways associated with Rac1. This study provided novel insights into the molecular mechanism of the antineoplastic and antimetastatic activities of... -
황기의 유방암 발생 억제효과
소명숙, 김아린 한국보건기초의학회 한국보건기초의학회지 6 Pages
한국보건기초의학회 한국보건기초의학회지 2013, Vol.6 No.3 9 172-177 (6 pages)
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국화과 추출물의 암세포 증식 억제 효과
안인정, 권중기, 이진석, 박하승, 김동찬, 최병준, 이규민, 박용진, 정지윤, An. In-Jung, Kwon. Jung-Ki, Lee. Jin-Seok, Park. Ha-Seung, Kim. Dong-Chan, Choi. Byung-Jun, Lee. K 한국식품영양과학회 한국식품영양과학회지 7 Pages
한국식품영양과학회 한국식품영양과학회지 2012, Vol.41 No.5 584-590 (7 pages)
의존적으로 억제시켰다. 우리나라 여성에서 가장 많이 발생하는 유방암세포인 MDA-MB-231 암세포에서 세포자멸사를 확인하기 위해 DAPI 염색을 수행하였다. MTT assay에서 암세포를 억제시킨 6종의 국화과 추출물중 3종인 한라구절초 전초, 포천구절초 전초, 삼잎국화 지하부 추출물을 처치한 세포에서 핵의 응축이 농도 의존적으로 존재함을 형광현미경으로 확인하였다(${ imes}200$). 세포자멸사에 관련된 단백질의 발현을 알아보기 위해서 western blot으로 확인하였다. 한라구절초 전초, 포천구절초 전초, 삼잎국화 지하부 추출물을... -
일문전(Stephania delavayi Diels.) 메탄올, 부탄올, 에틸아세테이트 분획물의 항산화 및 세포증식억제 효과
이용순, 김경희, 서홍덕, 박대훈, 최연식, 황혜림, 이민재, 최종진, 권명상, 육홍선, Li. Yong-Chun, Kim. Kyoung-Hee, Xu. Hong-De, Park. Dae-Hun, Choi. Yeon-Shik, Hwang. Hye-Rim, L 한국식품영양과학회 한국식품영양과학회지 5 Pages
한국식품영양과학회 한국식품영양과학회지 2009, Vol.38 No.3 297-301 (5 pages)
소거능은 $1,000{mu}g/mL$ 농도에서 부탄올(75.23%)> 메탄올(68.11%)> 에틸아세테이트 (63.58%)> 물(50.13%) 순으로 나타났으며 환원력의 경우 용매 분획물의 농도가 증가함에 따라 환원력이 증가하는 경향을 나타내었다. DPPH 라디칼 소거능 및 환원력 모두 부탄올 분획층에서 좋은 활성을 나타내었다. 항암활성 측정결과 메탄올 추출물과 부탄올 분획물, 에틸 아세테이트 분획물에서 MDA-MB-231 cell과 MCF-7 cell에 대한 세포증식억제효과를 나타내었다. 이상의 결과에서 일문전의 용매 분획물은 항암 후보물질로의 가능성이... -
작두콩 청국장 첨가 고추장의 항산화, tyrosinase 저해 및 암세포 증식 억제 효과
장문익, 김재영, 김운성, 백승화, Chang. Moon-Ik, Kim. Jae-Young, Kim. Un-Sung, Baek. Seung-Hwa 한국식품과학회 한국식품과학회지 6 Pages
한국식품과학회 한국식품과학회지 2013, Vol.45 No.2 221-226 (6 pages)
하여 고추장을 제조한 후, 90일 숙성된 고추장에 대해 생리 활성 그리고 in vitro에서 A549, G361, HT-29 및 MDA-MB-231 등 4종의 암세포에 대한 증식 억제 효과를 조사한 결과는 다음과 같다. 항산화 활성은 50배 희석 수준의 경우, SBC 10 고추장이 85.5%로 SBC 0 고추장(68.4%)보다 약 1.2배 증가되었으며, SBC 첨가량이 많을수록 증가되었다. Tyrosinase 저해 효과는 100배 희석 수준에서 SBC 10 고추장이 40.3%로 SBC 0 고추장(34.0%)보다 약 1.1배 증가되었다. 암세포주인 A549, G361, HT-29 및 MDA-MB-231에 대한 SBC 0, 2, 5, 8... -
황금의 유방암세포주에 대한 항암작용
용형순, 고성규, Yong. Hyung-Soon, Ko. Seong-Gyu 대한한방내과학회 대한한방내과학회지 10 Pages
대한한방내과학회 대한한방내과학회지 2004, Vol.25 No.3 451-460 (10 pages)
및 기전에 대한 연구는 아직 미흡하며, 특히 에스트로젠리셉터를 가지지않은 유방암세포주인 MDA-MB-231에 대한 효과 및 기전에 대한 연구는 아직 발표된바 없어, 이에 대한 연구가 진행되었다. Methods : 인간 유방암세포주 MDA-MB-231 MTT assay를 이용 성장방해비율을 조사하였으며. FACS analysis를 이용 cell cycle analysis를 시행하였고, Western Blot Analysis 및 Annexin V analysis를 시행하였다. Results : MDA-MB-231에 대한 황금의 IC50는 180 ug/ml 이었으며 최대 세포성장억제효과는 $500{mu}g/ml$로 한약재중 비교적 강한...
