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Optimization of scan delay for multi-phase computed tomography by using bolus tracking in normal canine kidney
Hyun Cho, Da-Hae Lee, Ah-Young Cha, Dong-Eun Kim, Dong-Woo Chang, Jihye Choi 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 2호 15 290-295 (6 pages)
the injection protocol used in this study, the optimal scan delay times for renal arterial, corticomedullary, and nephrographic phases were 5, 10, and 30 sec after triggering at 100 HU of aortic enhancement using the bolus-tracking technique. The bolus-tracking technique is useful in multi-phase renal CT study as it compensates for different transit times to the kidney among different animals, requires a small dose of contrast media, and does not require additional patient radiation exposure. -
All blood, No stool: enterohemorrhagic Escherichia coli O157:H7 infection
Jang W. Yoon, Carolyn J. Hovde 대한수의학회 Journal of Veterinary Science 14 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 3호 1 219-232 (14 pages)
Enterohemorrhagic Escherichia coli serotype O157:H7 is a pathotype of diarrheagenic E. coli that produces one or more Shiga toxins, forms a characteristic histopathology described as attaching and effacing lesions, and possesses the large virulence plasmid pO157. The bacterium is recognized worldwide, especially in developed countries, as an emerging food-borne bacterial pathogen, which causes disease in humans and in some animals. Healthy cattle are the principal and natural reservoir of E.... -
General pharmacological profiles of bee venom and its water soluble fractions in rodent models
Hyun-Woo Kim, Young-Bae Kwon, Tae-Won Ham, Dae-Hyun Roh, Seo-Yeon Yoon, Seuk-Yun Kang, Il-Suk Yang, Ho-Jae Han, Hye-Jung Lee, Al 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 4호 5 309-318 (10 pages)
on the rodent central nervous, cardiovascular, respiratory and gastrointestinal system. Subcutaneous BV and its fractions treatment did not produce any significant effects on general physiological functions at the highest dose tested (200-fold and 100-fold doses higher than that used clinically, respectively) except writhing test. These results demonstrate that doses of BV or BV subfractions in the therapeutic range or higher can be used as safe antinociceptive and anti-inflammatory agents. -
Application of pulsed Doppler ultrasound for the evaluation of small intestinal motility in dogs
Yong-joo An, Heechun Lee, Dongwoo Chang, Youngwon Lee, Jai-ki Sung, Mincheol Choi, Junghee Yoon 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2001, 제 2권 제 1호 12 71-74 (4 pages)
The purpose of this study was to verify whether small intestinal peristalsis could be observed and quantitatively assessed using pulsed-Doppler ultrasound. Pulsed-Doppler ultrasound was used to evaluate small intestinal peristalsis after a meal in ten normal dogs and ten sedated dogs. The small intestinal peristalses were measured 0, 1, 3, 6, 9, 12, and 24 hours after a 24-hour fast and after feeding. The number of small intestinal peristalsis were 0.133/min, 0.100/min, 0.033/min, 0.167/min,... -
Construction of a live attenuated Salmonella strain expressing FanC protein to prevent bovine enterotoxigenic Escherichia coli and evaluation of its immunogenicity in mice
Gayeon Won , Hee Jung Kim , John Hwa Lee 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2017, 제 57권 제 1호 2 9-15 (7 pages)
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Ardipusilloside-I stimulates gastrointestinal motility and phosphorylation of smooth muscle myosin by myosin light chain kinase
ZhiliXu, HanyeLiang, MingboZhang, XiaojunTao, DeqiangDou, LipingHu, TingguoKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 5 609-616 (8 pages)
on gastro emptying and intestinal transit in constipation-predominant rats were observed, and the MLCK expression in jejuna of constipated rats was determined by western blot. The results showed that, ardipusilloside-I increased the contractility of IJS in a dose-dependent manner and reversed the low contractile state (LCS) of IJS induced by low Ca2+, adrenaline, and atropine respectively. There were synergistic effects on contractivity of IJS between ardipusilloside-I and ACh, high Ca2+, and... -
Prediction of pharmacokinetics and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach: A case study of caffeine and ciprofloxacin
Min-HoPark, Seok-HoShin, Jin-JuByeon, Gwan-HoLee, Byung-YongYu, YoungG.Shin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 13 107-115 (9 pages)
optimize the PBPK model for ciprofloxacin. Overall, the increase in Cmax of caffeine by ciprofloxacin was not significant. However, the increase in AUC was observed and was proportional to the administered dose of ciprofloxacin. The predicted DDI and PK results were comparable to observed clinical data published in the literatures. This approach would be helpful in identifying potential key factors that could lead to significant impact on PBPK modeling and simulation for challenging compounds. -
A Review on Renal Toxicity Profile of Common Abusive Drugs
VarunParkashSingh, NirmalSingh, AmteshwarSinghJaggi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 13 347-357 (11 pages)
Drug abuse has become a major social problem of the modern world and majority of these abusive drugs or their metabolites are excreted through the kidneys and, thus, the renal complications of these drugs are very common. Morphine, heroin, cocaine, nicotine and alcohol are the most commonly abused drugs, and their use is associated with various types of renal toxicity. The renal complications include a wide range of glomerular, interstitial and vascular diseases leading to acute or chronic renal... -
Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats
BombiLee, BongjunSur, MijungYeom, InsopShim, HyejungLee, Dae-HyunHahm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 2 379-386 (8 pages)
The purpose of this study was to evaluate whether berberine (BER) administration could attenuate depression- and anxiety-like behaviors and increase corticotrophin-releasing factor (CRF) and tyrosine hydroxylase (TH) expression following chronic morphine withdrawal in rats. Male rats were exposed to chronic, intermittent, escalating morphine (10∼50 mg/kg) for 10 days. After the last morphine injection, depression- and anxiety-like beahvior associated with morphine discontinuation persisted for... -
Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats
MajidAsiabanha, GholamrezaAsadikaram, AmirRahnema, MehdiMahmoodi, GholamhoseinHasanshahi, MohammadHashemi6, MohammadKhaksari 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 2 327-332 (6 pages)
It has been shown that some opium derivatives promote cell death via apoptosis. This study was designed to examine the influence of opium addiction on brain and liver cells apoptosis in male and female diabetic and non-diabetic Wistar rats. This experimental study was performed on normal, opium-addicted, diabetic and diabetic opium-addicted male and female rats. Apoptosis was evaluated by TUNEL and DNA fragmentation assays. Results of this study showed that apoptosis in opium-addicted and... -
The Effects of Glutamate NMDA Receptor Antagonist MK-801 on Gastrointestinal Motility after Middle Cerebral Artery Occlusion in Rats
NasirHussinAmeer, JaeHeeLee, MyoungAeChoi, Guang-ShiJin, MinSunKim, ByungRimPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 6 151-156 (6 pages)
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Heme Oxygenase-1 Induced by Aprotinin Inhibits Vascular Smooth Muscle Cell Proliferation Through Cell Cycle Arrest in Hypertensive Rats
HyoungChulChoi, KwangYounLee, DongHyupLee, YoungJinKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 7 309-313 (5 pages)
Spontaneous hypertensive rats (SHR) are an established model of genetic hypertension. Vascular smooth muscle cells (VSMC) from SHR proliferate faster than those of control rats (Wistar-Kyoto rats; WKY). We tested the hypothesis that induction of heme oxygenase (HO)-1 induced by aprotinin inhibits VSMC proliferation through cell cycle arrest in hypertensive rats. Aprotinin treatment inhibited VSMC proliferation in SHR more than in normotensive rats. These inhibitory effects were associated with... -
(? )-Epigallocatechin Gallate Inhibits the Pacemaker Activity of Interstitial Cells of Cajal of Mouse Small Intestine
KweonYoungKim, SooJinChoi, HyukJinJang, DongChuanZuo, PawanKumarShahi, ShankarPrasadParajuli, CheolHoYeum, PyungJinYoon, SeokChoi, JaeYeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.3 4 111-116 (6 pages)
in a dose-dependent decrease in the frequency and amplitude of pacemaker currents. SQ-22536, an adenylate cyclase inhibitor, and ODQ, a guanylate cyclase inhibitor, did not inhibit the effects of EGCG. EGCG-induced effects on pacemaker currents were not inhibited by glibenclamide, an ATP-sensitive K＋ channel blocker and TEA, a Ca2＋-activated K＋ channel blocker. Also, we found that EGCG inhibited the spontaneous [Ca2＋]i oscillations in cultured ICC. In conclusion, EGCG inhibited the pacemaker... -
Roles of Gonadal Steroids on Exocrine Secretion of Isolated Perfused Rat Pancreas
HyungSeoPark, SeHoonKim, HyoungJinPark, MeeYoungLee, YoungHeeHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.4 5 217-221 (5 pages)
the spontaneous pancreatic fluid and amylase secretion dose-dependently. However, estradiol-17β did not exert any influence on spontaneous pancreatic exocrine secretion. Exogenous secretin, cholecystokinin (CCK), and acetylcholine markedly stimulated pancreatic fluid and amylase secretion. Progesterone initially enhanced secretin-induced amylase secretion, but this stimulatory response declined thereafter to basal value. Moreover, secretin-induced fluid secretion was not affected by infusion of... -
양극성 장애 환자에서 월경 주기에 따른 증상과 Lithium농도의 변화
홍혜경, 정희연, 권영준, 김현 대한신경정신의학회 신경정신의학 8 Pages
대한신경정신의학회 신경정신의학 2004, 제 43권 제 4호 6 393-400 (8 pages)
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A Study on Na+ and Water Reabsorption in the Nephron Segment Beyond Proximal Tubule Measured by Lithium Clearance
Han, O-Soo, Goo, Yong-Sook, Sung, Ho-Kyung 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1991, 제 25권 제 2호 9 189-200 (12 pages)
During the past few years it has been proposed that lithium clearance can be used as a reliable measure for the outflow of tubular fluid from the proximal tubule. This study was aimed to characterize the inflow dependent reabsorption of Na in renal tubule beyond the proximal tubule. For this purpose, lithium clearance was used as a measure for the inflow from the proximal tubule and the changes in reabsorption fraction of Na and water were determined in rabbits. Rabbits were pretreated with... -
지하철 승강장 화재시 안전성 평가
임경범, 김종윤, 이동호 한국웰니스학회 한국웰니스학회지 10 Pages
한국웰니스학회 한국웰니스학회지 2010, 제 5권 1호 9 103-112 (10 pages)
최근 도시의 구조는 과밀화와 대규모화로 인해 생활공간의 편의성을 추구하여 수도권을 중심으로 새로운 공간에 대한 활용이 요구되고 있는 추세이 다. 이러한 추세에 따라 도시공간의 효율적인 이용 을 위해 지하공간의 활용이 증가함에 따라 이에 따른 공간적 화재 안전성에 대한 연구가 진행되어 왔다. 초기의 지하철은 대도시의1)교통난의 해소를 기 본목표로 설정하였기 때문에 수송효율을 우선시 하여 승객의 안전성 및 역사 내의 쾌적성 문제는 부차적인 문제로 취급되어져 왔다. 하지만 생활수 준 및 의식수준의 선진화로 사회적... -
방사선치료에서 투과선량을 이용한 체내선량 검증프로그램 개발
황의중, 백태성, 윤명근, Hwang. Ui-Jung, Baek. Tae Seong, Yoon. Myonggeun 한국의학물리학회 의학물리 8 Pages
한국의학물리학회 의학물리 2014, Vol.25 No.1 23-30 (8 pages)
방사선치료에서는 환자 체내에 전달된 선량이 원래 의도한 데로 분포되는 지 확인하기 위하여 균질한 팬텀을 이용한 정도 관리를 치료 전에 주로 시행하고 있다. 하지만 균질한 팬텀을 이용한 정도 관리는 표면이 불규칙적이고 불균질한 인체에 대한 선량분포를 완전히 보증해 주지는 못하고 있다. 본 연구에서는 환자를 투과하는 선량의 분포를 측정하여 역으로 환자체내 선량 분포를 계산하는 투과선량 기반 체내선량 검증프로그램을 개발하였다. 투과선량은 주방사선과 산란방사선으로 이루어져 있는데, 본 연구에서는... -
조사문 선량 분포와 Monte Carlo 계산을 이용한 삼차원 선량 재구성에 관한 연구
박달, 여인환, 김대용, 안용찬, 허승재 한국의학물리학회 의학물리 9 Pages
한국의학물리학회 의학물리 2000, Vol.11 No.2 91-99 (9 pages)
to primary dose ratio)를 이용하여 계산한다. 이 방법을 시험하기 위해 여러 종류의 균질 혹은 비균질 팬톰의 조사문 선량 분포를 Monte Carlo 전산모사로 계산한 뒤 팬톰 내부의 선량 분포를 재구성하였다. 광자빔은 1.5 MeV의 단일에너지를 사용하였고 Monte Carlo 프로그램은 EGS4를사용하였다. 본 연구의 방법을 사용하여 재구성된 팬톰 내부의 선량 분포와 Monte Carlo로 계산한 팬텀 내부의 선량 분포와 비교하였다. 비교 결과 오차 -4%∼+2% 이내로 일치하였다. 이 방법은 다른 in vivo dosimetry 방법을 대신하여 환자내의... -
The wireless electrocardiogram detection in animal
Gareeballa Osman Adam, Gi Beum Kim, Jin Shang Kim, Shang Jin Kim, Hyung Sub Kang 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 266 337-338 (2 pages)
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Fluoxetine-induced abnormalities of cardiac function
Mun Young Lee, Gi Beum Kim, Hyung Sub Kang, Jin Shang Kim, Shang Jin Kim 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 264 336-337 (2 pages)
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Association between endotoxin levels in dust from indoor swine housing environments and the immune responses of pigs
Katharine Roque, Kyung Min Shin, Ji Hoon Jo, Gyeong Dong Lim, Eun Seob Song, So Jung Shin, Ravi Gautam, Jae Hee Lee, Yeon Gyeong Kim, Ah 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 2 331-338 (8 pages)
Indoor animal husbandry environments are inevitably contaminated with endotoxins. Endotoxin exposure is associated with various inflammatory illnesses in animals. This cross-sectional study evaluated the relationship between the degree of endotoxin exposure and the cellular and humoral immune profiles of fattening pigs. Blood samples were taken from the jugular vein of 47 pigs from ten pig farms in Korea. Whole blood cell counts and plasma immunoglobulin (Ig) classes were determined.... -
Reactive oxygen species-mediated unfolded protein response pathways in preimplantation embryos
Ihsan Ali, Syed Zahid Ali Shah, Yi Jin, Zhong-Shu Li, Obaid Ullah, Nan-Zhu Fang 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 1호 1 1-9 (9 pages)
Excessive production of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress-mediated responses are critical to embryonic development in the challenging in vitro environment. ROS production increases during early embryonic development with the increase in protein requirements for cell survival and growth. The ER is a multifunctional cellular organelle responsible for protein folding, modification, and cellular homeostasis. ER stress is activated by a variety of factors including... -
Effect of BL-21 (Wei-Yu) acupoint stimulation on gastric motility following preanesthetic treatment in dogs
Hee-Young Kim, Oh-Kyeong Kwon, Tchi-Chou Nam 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2000, 제 1권 제 2호 11 133-138 (6 pages)
In acupuncture practice of animals, preanesthetics sometimes are needed. The purpose of this study was to select the ideal chemical restraint at acupuncture for gastric motility. Nine healthy mixed breed dogs weighed 10-21 kg and aged 1-3 years old were used in this study. Two EMG surface electrodes were placed between the seromuscular and the mucosal layer of pylorus. Twenty minutes after feeding normal gastric motility was recorded for 60 minutes using physiograph (Narco-Biosystem). Then... -
소청룡탕 추출물의 당뇨병 질환에서 위장관 운동 기능 개선에 관한 연구
배진수, 김익성, 서병도, 김병주 한방비만학회 대한한방비만학회지 7 Pages
한방비만학회 대한한방비만학회지 2017, 제 17권 제 2호 1 61-67 (7 pages)
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The Effects of Eupatilin (Stillen�) on Motility of Human Lower Gastrointestinal Tracts
Seung-BumRyoo, Heung-KwonOh, SungAYu, , SangHuiMoon, EunKyungChoe, , TaeYoungOh, KyuJooPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.5 5 383-390 (8 pages)
of eupatilin. The amplitude, AUC, and frequency of tension recordings from circular and longitudinal smooth muscle strips and bowel segments of the ileum and colon were significantly decreased after admission of eupatilin. Eupatilin elicited dose-dependent decreases during segmental tension recordings. In conclusion, eupatilin (StillenⓇ) showed inhibitory effects on the human ileum and colon. We propose that this drug may be useful for treating diseases that increase bowel motility, but... -
Neurotensin Enhances Gastric Motility in Antral Circular Muscle Strip of Guinea-pig
TaeYongKoh, SungJoonKim, SangJinLee, TongMookKang, JaeYeoulJun, JaeHoonSim, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 7 227-234 (8 pages)
Many reports suggest that neurotensin (NT) in the gastrointestinal tract may play a possible role as a neurotransmitter, a circulating hormone, or a modulator of motor activity. NT exerts various actions in the intestine; it produces contractile and relaxant responses in intestinal smooth muscle. This study was designed to investigate the effect of NT on motility of antral circular muscle strips in guinea-pig stomach. To assess the role of Ca2 influx in underlying mechanism, slow waves... -
경련과 뇌 혈액 관류장애를 동반한 Zipeprol 남용 6례
김종우, 장환일, 오동재 대한신경정신의학회 신경정신의학 7 Pages
대한신경정신의학회 신경정신의학 1994, 제 33권 제 2호 21 496-502 (7 pages)
