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An angiotensin II type 1 receptor blocker attenuates TRAIL resistance in human lung cancer via inhibition of autophagy flux
Mohammad Rasheduzzaman, Jeong Min Hong, Uddin Nazim, Hong hua Yin, You Jin Lee, Jae Won Seol, Sang Youel Park 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 235 338-339 (2 pages)
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Inhibition of Apoptosis is Responsible for the Acquired Resistance of K562 Cells to Cisplatin
Lee. Soo-Yong, Kim. Dong-Hyun 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 7 Pages
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 2004, Vol.12 No.2 85-91 (7 pages)
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Screening and Isolation of Antibiotics Resistance Inhibitors from Herb Materials. V.- Resistance Inhibition by Acorenone from Acorus gramineus Solander
Kim. Hye-Kyung, Moon. Kyung-Ho, Lee. Chung-Kyu 한국생약학회 Natural product sciences 4 Pages
한국생약학회 Natural product sciences 2000, Vol.6 No.1 36-39 (4 pages)
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Screening and Isolation of Antibiotic Resistance Inhibitors from Herb Materials. I.-Resistance Inhibition of 21 Korean Plants
Kim. Hye-Kyung, Park. Soo-Wan, Park. Joong-Nam, Moon. Kyung-Ho, Lee. Chung-Kyu 한국생약학회 Natural product sciences 5 Pages
한국생약학회 Natural product sciences 1995, Vol.1 No.1 50-54 (5 pages)
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Inhibition of Seed Germination and Induction of Systemic Disease Resistance by Pseudomonas chlororaphis O6 Requires Phenazine Production Regulated by the Global Regulator, GacS
Kang. Beom-Ryong, Han. Song-Hee, Zdor. Rob E., Anderson. Anne J., Spencer. Matt, Yang. Kwang-Yeol, Kim. Yong-Hwan, Lee. Myung-Chul, Cho. 한국미생물생명공학회 Journal of microbiology and biotechnology 8 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2007, Vol.17 No.4 586-593 (8 pages)
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Overcoming 5-Fu Resistance of Colon Cells through Inhibition of Glut1 by the Specific Inhibitor WZB117
Liu. Wei, Fang. Yong, Wang. Xiao-Tong, Liu. Ju, Dan. Xing, Sun. Lu-Lu 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 5 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.17 7037-7041 (5 pages)
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Modulation of Drug Resistance in Ovarian Cancer Cells by Inhibition of Protein Kinase C-alpha (PKC-α) with Small Interference RNA (siRNA) Agents
Zhao. Li-Jun, Xu. Heng, Qu. Jun-Wei, Zhao. Wan-Zhou, Zhao. Yi-Bing, Wang. Jin-Hua 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 6 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2012, Vol.13 No.8 3631-3636 (6 pages)
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Screening and Isolation of Antibiotic Resistance Inhibitors from Herb Materials-Resistance Inhibition of Volatile Components of Korean Aromatic Herbs
Lee. Chung-Kyu, Kim. Hye-Kyung, Moon. Kyung-Ho, Shin. Kuk-Hyun 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 5 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 1998, Vol.21 No.1 62-66 (5 pages)
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Simultaneous Inhibition of CXCR4 and VLA-4 Exhibits Combinatorial Effect in Overcoming Stroma-Mediated Chemotherapy Resistance in Mantle Cell Lymphoma Cells
Kim. Yu-Ri, Eom. Ki-Seong 대한면역학회 Immune network : official journal of the Korean association of immunobiologists 11 Pages
대한면역학회 Immune network : official journal of the Korean association of immunobiologists 2014, Vol.14 No.6 296-306 (11 pages)
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Naringininduces Autophagy and Growth Inhibition by Down Regulating PI3K/Akt/mTOR Andactivating MAPK Pathway in AGS Cancer Cell
Suchismita Raha, Gyeong Eun Hong, Silvia Yumnam, Ho Jeong Lee, Venu Venkatarame Gowda Saralamma, Jeong Doo Heo, Sang Joon Lee, Gon Sup 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 136 209-210 (2 pages)
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Tumor associated macrophages provide the survival resistance of tumor cells to hypoxic microenvironmental condition through IL-6 receptor-mediated signals
Joong Sun Kim, Wol Soon Jo, Soo Kyung Jeung, Hae June Lee, Chang jong Moon, Sung Ho Kim 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 307 359-360 (2 pages)
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Inhibition of autophagy by hinokitiol enhances TRAIL- induced tumor cell death through augmentation of apoptotic signaling
Ji Hong Moon, Sung Wook Kim, Ju Hee Lee, Jae Won Seol, Nazim Uddin, Rasheduzzaman, Sang Youel Park 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 255 332-332 (1 pages)
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Upregulation of death receptor 5 mediated by telmisartan enhances TRAIL-mediated apoptosis via inhibition of autophagy flux in lung cancer
Mohammad Rasheduzzaman, Jeong Min Hong, Uddin Nazim, Hong hua Yin, You Jin Lee, Jae Won Seol, Sang Youel Park 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 233 337-337 (1 pages)
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Transforming growth factor-beta induced epithelial- mesenchymal transition abolished without TGF-beta condition: Cancer stem cell properties and cisplatin resistance in lungcancer cell lines
Seong Kwan Kim, Jin A Park, Sang Hyun Cho, Weijia Zheing, Jeong Min Choi, Ho Chul Shin 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 232 336-337 (2 pages)
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Combination of Sinensetin and Cisplatin Sensitizes Gastric Cancer Cells to Cell Growth Inhibition
Anjugam Paramanantham, Venu Venkatarame Gowda Saralamma, Ho Jeong Lee, Suchismita Raha, Seong Min Kim, Sang Eun Ha, Jeong Doo Heo, Sang 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 216 328-328 (1 pages)
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Inhibition of IAP’s and Activation of p53 leads to Caspase-dependent Apoptosis in Gastric Cancer Cells treated with Scutellarein
Venu Venkatarame Gowda Saralamma, Ho Jeong Lee, Suchismita Raha, Seong Min Kim, Anjugam Paramanantham, Sang Eun Ha, Jeong Doo Heo, Sang 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 213 325-326 (2 pages)
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Phenotypic and genotypic antimicrobial resistance and virulence genes of Salmonella enterica isolated from pet dogs and cats
Songsak Srisanga, Sunpetch Angkititrakul, Patcharee Sringam, Phuong T. Le Ho, An T. T. Vo, Rungtip Chuanchuen 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 3호 3 273-281 (9 pages)
blaTEM gene in both was horizontally transferred. Of the plasmid-mediated quinolone resistance genes tested, only qnrS (4.9%) was detected. Most Salmonella isolates harbored invA (100%), prgH (91.8%), and sipB (91%). Positive associations between resistance and virulence genes were observed for blaPSE-1/orgA, cmlA/span, tolC, and sul1/tolC (p ＜ 0.05). The results suggest that companion dogs and cats are potential sources of S. enterica strains that carry resistance and virulence genes and that... -
Use of aglepristone for the treatment of P4 induced insulin resistance in dogs
Enrico Bigliardi*, Carla Bresciani, Daniela Callegari, Francesco Di Ianni, Giorgio Morini, Enrico Parmigiani, Ezio Bianchi 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 2호 13 267-271 (5 pages)
Insulin resistance (IR) in dogs is suspected when hyperglycemia is present despite administration of insulin doses greater than 1.0 to 1.5 UI/kg. IR is caused by increases in counter regulatory hormones concentrations (glucagon, glucocorticoids, catecholamines and growth hormone). This study was conducted to investigate the use of aglepristone (RU 46534), a P4 receptor antagonist, for the treatment of IR diabetes mellitus in bitches during the luteal phase. All animals were treated with porcine... -
Prevalence and antibiotic resistance of mastitis pathogens isolated from dairy herds transitioning to organic management
Young Kyung Park, Lawrence K. Fox*, Dale D. Hancock, Wade McMahan, Yong Ho Park* 대한수의학회 Journal of Veterinary Science 3 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 1호 15 103-105 (3 pages)
udder health and antibiotic resistance of mastitis pathogens isolated from dairies upon conversion from conventional to organic management over a 3-year period was studied. Coagulase-negative staphylococci (CNS) were the most prevalent mastitis pathogens isolated. CNS were significantly less resistant to b-lactam antibiotics when isolated from milk after the herd transitioned to organic management. Cessation of the use of antimicrobial therapies in dairies in combination with organic management... -
Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells
Hyun Sun Cho, Seung Hee Chang, Youn Sun Chung, Ji Young Shin, Sung Jin Park, Eun Sun Lee, Soon Kyung Hwang, Jung Taek Kwon, Aras 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 1호 4 23-28 (6 pages)
in both time-/concentration- dependent manners. The inhibition of ERK using PD98059 synergistically enhanced the TET-induced apoptosis of A549 cells whereas the inhibition of Akt using LY294002 had a less significant effect. Taken together, our results suggest that TET: i) selectively inhibits the proliferation of lung cancer cells by blocking Akt activation and ii) increases apoptosis by inhibiting ERK. The treatment of lung cancers with TET may enhance the efficacy of chemotherapy and... -
Original Article : Virulence factors, antimicrobial resistance patterns, and genetic characteristics of hydrogen sulfide-producing Escherichia coli isolated from swine
Hyun Eui Park , Min Kyoung Shin , Hong Tae Park , Seung Won Shin , Myunghwan Jung , Young Bin Im , Han Sang Yoo 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2015, 제 55권 제 3호 7 191-197 (7 pages)
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Original Article : Comparison of antibiotic resistance profiles for Escherichia coli isolated from wild boar and domestic pig fecal samples
Sung J. Yoo , Sun Young Sunwoo , Sang Won Seo , Young S. Lyoo , 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 6 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2015, 제 55권 제 1호 6 41-46 (6 pages)
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Relationship between biofilm formation and the antimicrobial resistance in the Staphylococcus spp. isolated from animal and air
Yeon Soo Seo , Deog Young Lee , Mi Lan Kang , Won Jung Lee , Han Sang Yoo 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 6 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2009, 제 49권 제 3호 7 231-236 (6 pages)
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Microbiology,Immunology : Antimicrobial resistance of Staphylococcus aureus isolated from domestic and imported raw meat in Korea
HeeJinHeo, BokKyungKu, DongHwaBae, CheongKyuPark, YoungJuLee 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2008, 제 48권 제 1호 11 75-81 (7 pages)
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Inhibition of human breast carcinoma by BLC (Sargassum fulvellum) and BLC/HEN Egg in vitro and in vivo
EunHyeJo, SungDaeCho, NamShikAhn, JiWonJung, SeRanYang, JoonSukPark, JaeWoongHwang, SungHoonLee, JungRanPark, SunJungKim, HyunKy 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2005, 제 45권 제 1호 12 85-91 (7 pages)
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Inhibition of voltage-dependent K+ current in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic drug propafenone
Jin Ryeol An, Hongliang Li, Mi Seon Seo, Won Sun Park 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 13 597-605 (9 pages)
2 Hz progressively increased the propafenone-induced inhibition of the Kv current. Furthermore, the inactivation recovery time constant was increased after the application of propafenone, suggesting that the inhibitory action of propafenone on Kv current is partially use-dependent. Pretreatment with Kv1.5, Kv2.1 or Kv7 inhibitor did not change the inhibitory effect of propafenone on the Kv current. Together, these results suggest that propafenone inhibits the vascular Kv channels in a dose- and... -
Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing’s syndrome
MinaKim, Hae-AhmLee, Hyun-MinCho, Seol-HeeKang, EunjoLee, InKyeomKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 3 23-33 (11 pages)
attenuated dexamethasone (DEX)-induced lipogenesis in HepG2 cells. The transcriptional activity of Fasn was decreased by pretreatment with VPA. In addition, pretreatment with VPA decreased DEX-induced binding of GR to the glucocorticoid response element (GRE). Treatment with VPA increased the acetylation of GR in ACTH-infused rats and DEX-induced HepG2 cells. Taken together, these results indicate that HDAC inhibition attenuates hepatic steatosis through GR acetylation in experimental CS. -
Developmental changes in GABAA tonic inhibition are compromised by multiple mechanisms in preadolescent dentate gyrus granule cells
SudipPit, GyuSeungLee, JinBongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 15 695-702 (8 pages)
The sustained tonic currents (Itonic) generated by γ-aminobutyric acid A receptors (GABAARs) are implicated in diverse age-dependent brain functions. While various mechanisms regulating Itonic in the hippocampus are known, their combined role in Itonic regulation is not well understood in different age groups. In this study, we demonstrated that a developmental increase in GABA transporter (GAT) expression, combined with gradual decrease in GABAAR α5 subunit, resulted in various Itonic in the... -
Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: a pilot study
HyunSeokBang, DaeYunSeo, YoungMinChung, DoHyungKim, Sam-JunLee, SungRyulLee, Hyo-BumKwak, TaeNyunKim, MinKim, Kyoung-MoOh, YoungJinSon, San 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 10 651-656 (6 pages)
beneficial effects on exercise-induced skeletal muscle damage markers including the levels of cortisol, B-type natriuretic peptide (BNP), myoglobin, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) in resistance-trained men. Sixteen healthy participants were randomly assigned to resistance training (RT) or RT+UA groups (n=8 per group). Participants were trained according to the RT program (60~80% of 1 repetition, 6 times/week), and the UA group was... -
Inhibition of K+ outward currents by linopirdine in the cochlear outer hair cells of circling mice within the first postnatal week
ShinWookKang, JiWoongAhn, SeungCheolAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 13 251-257 (7 pages)
known blocker of K+ currents activated at negative potentials (I K,n), did cause inhibition at varying degree (severe, moderate, mild) in K+ outward currents of heterozygous (+/cir ) or homozygous (cir /cir ) mice OHCs in the concentration range between 1 and 100 μM, while it was apparent only in one ICR mice OHC out of nine OHCs at 100 μM. Although the half inhibition concentrations in heterozygous (+/cir ) or homozygous (cir /cir ) mice OHCs were close to those reported in I K,n, biophysical... -
Cardamonin inhibits agonist-induced vascular contractility via Rho-kinase and MEK inhibition
HyunDongJe, JiHoonJeong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 9 69-74 (6 pages)
regardless of endothelial nitric oxide synthesis. Furthermore, cardamonin significantly inhibited the fluoride-induced increase in pMYPT1 level and phenylephrine-induced increase in pERK1/2 level, suggesting inhibition of Rho-kinase and MEK activity and subsequent phosphorylation of MYPT1 and ERK1/2. This study provides evidence that the relaxing effect of cardamonin on agonist-induced vascular contraction regardless of endothelial function involves inhibition of Rho-kinase and MEK activity. -
Epigallocatechin-3-Gallate (EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative Stress
BoZhang, BingWang, ShuhuaCao, YongqiangWang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.6 3 491-497 (7 pages)
TBI-induced oxidative stress was remarkably impaired by EGCG treatment, which elevated the activities of SOD and GSH-PX. Conversely, EGCG significantly reduced the contents of MDA after TBI. In addition, EGCG decreased TBI-induced NADPH oxidase activation through inhibition of p47phox translocation from cytoplasm to plasma membrane. These data demonstrate that EGCG treatment may be an effective therapeutic strategy for TBI and the underlying mechanism involves inhibition of oxidative stress. -
Trichostatin A Modulates Angiotensin II-induced Vasoconstriction and Blood Pressure Via Inhibition of p66shc Activation
GunKang, YuRanLee, HeeKyoungJoo, MyoungSooPark, Cuk-SeongKim, SungaChoi, ByeongHwaJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 10 467-472 (6 pages)
cells (VSMCs). In cultured rat aortic VSMCs, Ang II increased p66shc phosphorylation, which was inhibited by the Ang II receptor type I (AT1R) inhibitor, valsartan (10 μM), but not by the AT2R inhibitor, PD123319. TSA (1∼10 μM) inhibited Ang II-induced p66shc phosphorylation in VSMCs and in HEK293T cells expressing AT1R. Taken together, these results suggest that TSA treatment inhibited vasoconstriction and hypertension via inhibition of Ang II-induced phosphorylation of p66shc through AT1R. -
Phasic and Tonic Inhibition are Maintained Respectively by CaMKII and PKA in the Rat Visual Cortex
KayoungJoo, ShinHeeYoon, Duck-JooRhie, , Hyun-JongJang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 11 517-524 (8 pages)
of tonic inhibition relied on protein kinase A activity. Depolarization of membrane potential (5 min of 0 mV holding) potentiated phasic inhibition via Ca2+ and CaMKII but tonic inhibition was not affected. Thus, phasic and tonic inhibition seem to be independently maintained and regulated by different signaling cascades in the same cell. These results suggest that neuromo-dulatory signals might differentially regulate phasic and tonic inhibition in response to changes in brain states. -
Reversal of Cisplatin Resistance by Epigallocatechin Gallate Is Mediated by Downregulation of Axl and Tyro 3 Expression in Human Lung Cancer Cells
Kyung-ChanKim, ChuHeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 8 61-66 (6 pages)
non-small cell lung cancer is constrained by the resistance to drug. To overcome chemo-resistance, various modified treatment including combination therapy has been used, but overall survival has not been improved yet. In this study, chemo-resistant lung cancer cells, A549/Cis and H460/Cis, were developed by long-term exposure of cells to cisplatin and the proliferative capability of these resistant cells was verified to be reduced. We found cytotoxic effect of epigal-locatechin gallate (EGCG),...
