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전체 선택해제
총 280건 검색
본문검색 결과만 보기
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장애보정생존년수(DALY)를 활용한 우리 나라 고혈압의 질병부담 측정
윤석준, 하범만, 김창엽 한국보건행정학회 보건행정학회지 13 Pages
한국보건행정학회 보건행정학회지 2001, Vol.11 No.3 89-101 (13 pages)
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성과 종교교육에 대한 대순진리회의 관점과 실제
한국종교교육학회 종교교육학연구 2013, 제 42권 2 27-48 (22 pages)
인간은 교육을 통해서 인간다워진다. 그런데 문제는 인간이 배우는 모든 지식과 규범이 항상 옳고 바른 것이 아니라는 점이다. 특히 교육에 있어서의 성차별은 남녀불평등은 물론이고 사회의 모든 불평등 상황을 반영하는 결과로서 나타난다. 성차별은 사회 전체의 복지와 발전에 큰 걸림돌이 되고 있으며, 비인간적이고 반도덕적인 것으로 간주하는 추세가 점점 일반화 되고 있다. 따라서 성의 개념을 올바르게 인식하고, 남녀차별에 의한 성불평등을 합리적이고 효과적으로 해결하기 위해서 반드시 필요한 것이 교육이다. 본 논문은... -
종교적 사유와 에로스(eros) 개념-인간 존재의 유한성을 중심으로
한국종교교육학회 종교교육학연구 2020, 제 64권 15 245-254 (10 pages)
이 연구의 목적은 종교 본연의 가치와 역할을 에로스(eros)라는 철학적 개념과 연계하여 논의한다. 또한 플라톤의 철학적 사유에서 중심적인 역할을 담당하는 에로스 개념을 근간으로 하여 논의의 주제를 인간 존재의 유한성 문제와 종교의 역할이라는 관계로 확대하여 전개한다. 이 연구의 내용은 다음과 같았다. 첫째, 에로스 개념은 현재의 상태를 비판적으로 성찰하는 성격을 지녔다. 둘째, 에로스적 사유는 단절된 두 개의 대상을 하나로 묶는 작업으로서의 성격을 지녔다. 셋째, 에로스적 사유의 성격에는 이중적이면서도... -
국내 의학 임상진료지침의 개발 현황과 근거기반 간호학 적용방안
조희숙 한국근거기반간호학회 근거와 간호 4 Pages
한국근거기반간호학회 근거와 간호 2014, 제 2권 제 1호 1 1-4 (4 pages)
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Predictive validity of the gait scale in the Performance Oriented Mobility Assessment for stroke survivors
Seung-heon An, Young-ju Jee, Dong-geon Lee, Sun-hae Song, Gyu-chang Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 8 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2016, 제 5권 제 1호 1 1-8 (8 pages)
Objective: The present study was to investigate the discrimination capacity of the Performance Oriented Mobility Assessment-Gait Scale (POMA-GS), for predicting falls in stroke survivors. Design: Retrospective cohort study. Methods: Data including the characteristics and number of falls of 52 chronic stroke patients from a rehabilitation center were collected. The number of falls each subject had experienced in the previous year were investigated through interviews. The subjects were divided... -
자율성 증진 교육활동이 유아의 자율행동에 미치는 영향
조현지(Cho Hyun-Ji) 한국교원대학교 유아교육연구소 한국유아교육연구 26 Pages
한국교원대학교 유아교육연구소 한국유아교육연구 2013, 제 15권 제 2호 3 51-76 (26 pages)
본 연구는 자율성을 증진할 수 있는 교육활동을 계획하여 실행하는 것이 유아의 자율행동에 어떠한 영향을 미치는지 알아보는데 목적이 있다. 연구 대상은 대전광역시에 소재한 2개의 공립유치원에 재원중인 만 4세, 만 5세 유아 34명(만 4세 9명, 만 5세 25명)이었다. 실험집단은 17명(만 4세 5명, 만 5세 12명), 통제집단은 17명(만 4세 4명, 만 5세 13명)이었다. 연구 도구는 유아 자율행동을 측정하기 위해 이학선(2007)에 의해 개발된 「유아 자율행동 검사」도구를 사용하였다. 실험집단은 유치원의 일과활동과 관련되며 자율성... -
Prevalence of severe fever with thrombocytopenia syndrome virus in ticks from Deogyusan National Park
Young Sun Jo, Jun Gu Kang, Jeong Byoung Chae, Yun Kyung Cho, Weon Hwa Jheong, Yong Kwan Kim, Ji Young Won, Joon Seok Chae 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 130 280-281 (2 pages)
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Hepatitis E virus as an emerging zoonotic pathogen
Woo-Jung Park, Byung-Joo Park, Hee-Seop Ahn, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Han-Sang Yoo, In-Soo 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 1호 1 1-11 (11 pages)
Hepatitis E outbreaks are a serious public health concern in developing countries. The disease causes acute infections, primarily in young adults. The mortality rate is approximately 2%; however, it can exceed 20% in pregnant women in some regions in India. The causative agent, hepatitis E virus (HEV), has been isolated from several animal species, including pigs. HEV genotypes 3 and 4 have been isolated from both humans and animals, and are recognized as zoonotic pathogens. Seroprevalence... -
SNP genetic polymorphisms of MDR-1, CYP1A2 and CYPB11 genes in four canine breeds upon toxicological evaluation
Rosa Gagliardi, Silvia Llambí, M. Victoria Arruga 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 4 273-280 (8 pages)
The fields of pharmacogenetics and pharmacogenomics have become increasingly promising regarding the clinical application of genetic data to aid in prevention of adverse reactions. Specific screening tests can predict which animals express modified proteins or genetic sequences responsible for adverse effects associated with a drug. Among the genetic variations that have been investigated in dogs, the multidrug resistance gene (MDR) is the best studied. However, other genes such as CYP1A2 and... -
Genetic diversity of Korean Bacillus anthracis isolates from soil evaluated with a single nucleotide repeat analysis
Sang Hoon Kim, Kyoung Hwa Jung, Se Kye Kim, Seong-Joo Kim, Ji-Cheon Kim, Soo Young Cho, Jin Choul Chai, Young Seek Lee, Yun Ki K 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 4호 12 457-465 (9 pages)
Bacillus (B.) anthracis, the etiological agent of anthrax, is one of the most genetically monomorphic bacteria species in the world. Due to the very limited genetic diversity of this species, classification of isolates of this bacterium requires methods with high discriminatory power. Single nucleotide repeat (SNR) analysis is a type of variable-number tandem repeat assay that evaluates regions with very high mutation rates. To subtype a collection of 21 isolates that were obtained during a... -
Tissue distribution of sialic acid-linked influenza virus receptors in beagle dogs
Zhang-Yong Ning, Xin-Tao Wu, Yan-Fen Cheng, Wen-Bao Qi, Yu-Fu An, Heng Wang, Gui-Hong Zhang*, Shou-Jun Li* 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 3호 1 219-222 (4 pages)
Reports of influenza A virus infections in dogs has received considerable attention from veterinarians, virologists, and epidemiologists. Interaction between influenza viral hemagglutinin and cell oligosaccharides containing sialic acid residues results in infection. Sialic acids have an a-2,3-linkage to the penultimate galactose in the avian influenza virus receptor and an a-2,6-linkage in the human receptor. To date, there are no detailed data on the tissue distribution or histological... -
The Effects of Korean Red Ginseng (Ginseng Radix Rubra) on Liver Regeneration after Partial Hepatectomy in Dogs
Young-sam Kwon, Kwang-ho Jang, In-ho Jang 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2003, 제 4권 제 1호 13 83-92 (10 pages)
We investigated the effects of the oral administration of Korean red ginseng (KRG) on morphologic change and function of liver in dogs. Fifteen adult mongrel dogs (n=15) were divided into three groups: a control group (40% hepatectomy, untreated), a 250 group (40% hepatectomy, 250 mg/kg of KRG, PO), and a 500 group (40% hepatectomy, 500 mg/kg of KRG, PO). The liver regeneration, histologic findings, CBC (WBC, RBC, PCV, and PLT), and liver function tests (AST, ALT, GGT, ALP, LDH, and T-bil) were... -
Original Article : Establishment of a live vaccine strain against fowl typhoid and paratyphoid
Sun Hee Cho , Young Jin Ahn , Tae Eun Kim , Sun Joong Kim , Won Huh , Young Sik Moon , Byung Hyung Lee , Jae Hong Kim , 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 6 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2015, 제 55권 제 4호 5 241-246 (6 pages)
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Isolation, characterization, and evaluation of Bacillus thuringiensis isolated from cow milk
Chang Hee Kweon , Sang Yoon Choi , Hyog Young Kwon , Eun Hye Kim , Hyun Mi Kang , Jin San Moon , Geum Chag Jang , Hee So 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 8 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2012, 제 52권 제 3호 4 169-176 (8 pages)
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Microbiology,Immunology : Characterization of Yersinia ruckeri isolated from the farm-cultured eel Anguilla japonica in Korea
Seong Joon Joh , Chang Hee Kweon , Min Jeong Kim , Min Su Kang , Hwan Jang , Jun Hun Kwon 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2010, 제 50권 제 1호 5 29-35 (7 pages)
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CT characteristics of normal canine pulmonary arteries and evaluation of optimal contrast delivery methods in CT pulmonary angiography
JooHyunJung, JinHwaChang, JungHeeYoon, MinCheolChoi 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 8 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2007, 제 47권 제 2호 17 247-254 (8 pages)
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골격성 III급 부정교합자의 편악수술과 양악수술후 재발경향에 관한 비교연구
김정록(Jeong-Rog Kim), 손우성(Woo-Sung Son) 대한치과교정학회 The Korean Journal of Orthodontics 13 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1995, 제 25권 제 5호 10 613-625 (13 pages)
본 연구는 골격성 III급 부정교합 환자에서 술전 상태와 수술방법 사이의 관계 및 악교정 수술후 재발경향을 조사하기 위하여 시행하였다. 연구 대상으로는 악교정수술을 받은 31명(남자 17명, 여자 14명)을 선택하였고, 이중 20명은 편악수술, 11명은 양악 수술을 시행하였으며, 평균연령은 22.5세였다. 각 대상에서 술전, 수술직후, 1년 이상 경과 후의 측모두부방사선 규격사진을 채득하여, 투사도를 작성하고, 분석하여 다음과 같은 결과를 얻었다. 1. 하악만을 수술한 군보다 양악 동시수술군에서 하악체의 길이가 4.24mm, 하안모... -
저열량 식이요법을 한 폐경 전 비만 여성의 휴식 대사량에 대한 마황과 오수유의 효과
김수진(Su Jin Kim), 김호준(Ho Jun Kim), 고병표(Byung Pyo Ko), 김형도(Hyung Do Kim), 김진아(Jin Ah Kim), 박정미(Jeong Mi Park), 최승기(Seung Ki Choi), 전우현(Uo 한방비만학회 대한한방비만학회지 10 Pages
한방비만학회 대한한방비만학회지 2004, 제 4권 제 1호 5 45-54 (10 pages)
본 논문은 저열량 식이요법을 한 폐경 전 비만 여성의 휴식 대사량에 대한 마황과 오수유의 효과에 대하여 연구한 논문으로 주요내용으로는 마황과 오수유가 표한(表寒), 이한(裏寒)을 흩뜨리는 대표적인 한약재로 궁극적으로 대사량 저하 상태를 개선시키고 체중감소 효과가 있을 것으로 판단되어 선택하였다. 건강한 비만 여성 90명을 대상으로 8주간 저열량 식이요법을 시행하면서 조제된 마황과 오수유를 복용하게 하여 확인한 결과, 마황은 초기 4주간에 휴식 대사량에 유의한 증가의 효과를 보였고 체중, 체지방율의 유의한 감소를... -
비만처방에서의 안전한 마황사용 지침
송미영(Mi Young Song), 김호준(Ho Jun Kim), 이명종(Myeong Jong Lee) 한방비만학회 대한한방비만학회지 11 Pages
한방비만학회 대한한방비만학회지 2006, 제 6권 제 2호 2 17-27 (11 pages)
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피하지방 감량에 있어 경피침주요법의 유효성 및 안전성 평가
송미영(Mi Young Song), 박지훈(Ji Hun Park), 이정호(Jung Ho Lee), 김호준(Ho Jun Kim), 이명종(Myeong Jong Lee) 한방비만학회 대한한방비만학회지 15 Pages
한방비만학회 대한한방비만학회지 2007, 제 7권 제 1호 7 71-85 (15 pages)
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2000년 이후 비만치료에 사용되는 처방(處方) 및 본초(本草)에 대한 문헌연구
황미자(Mi Ja Hwang), 신현대(Hyun Dae Shin), 송미연(Mi Yeon Song) 한방비만학회 대한한방비만학회지 16 Pages
한방비만학회 대한한방비만학회지 2007, 제 7권 제 1호 5 39-54 (16 pages)
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오미자(五味子) 클로로포름 분획물이 이상지질혈증 생쥐의 지질대사 및간 조직 유전자 변화에 미치는 영향
신윤리(Yoon Ri Shin), 김영균(Young Kyun Kim), 김경민(Kyoung Min Kim) 한방비만학회 대한한방비만학회지 12 Pages
한방비만학회 대한한방비만학회지 2015, 제 15권 제 2호 6 111-122 (12 pages)
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초등학생의 완벽주의와 발표불안이 학교생활적응에 미치는 영향
강호용, 신지영, 이순옥, 천성문 한국교육치료학회 교육치료연구 20 Pages
한국교육치료학회 교육치료연구 2012, Vol.4 No.1 6 93-112 (20 pages)
본 연구의 목적은 완벽주의와 발표불안이 초등학생의 학교생활적응에 미치는 영향을 알아보고자 하 는 것이다. 이 연구를 위하여 부산시에 거주하는 남녀 초등학생 606명을 대상으로 완벽주의, 발표불 안, 학교생활적응을 측정하였다. 회수된 설문지의 분석을 위해 SPSS 12.0통계 프로그램을 사용하여, 상관분석, 중다회귀분석을 실시하였다. 본 연구의 결과는 다음과 같다. 첫째, 초등학생의 완벽주의의 모든 하위영역과 발표불안의 모든 하위영역 간에 대체로 높은 유의미 한 정적 상관관계를 나타내었으며, 완벽주의의 하위영역 모두... -
Effects of exercise on obesity-induced mitochondrial dysfunction in skeletal muscle
Jun-WonHeo, Mi-HyunNo, Dong-HoPark, Ju-HeeKang, DaeYunSeo, JinHan, P.DarrellNeufer, Hyo-BumKwak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 1 567-577 (11 pages)
Obesity is known to induce inhibition of glucose uptake, reduction of lipid metabolism, and progressive loss of skeletal muscle function, which are all associated with mitochondrial dysfunction in skeletal muscle. Mitochondria are dynamic organelles that regulate cellular metabolism and bioenergetics, including ATP production via oxidative phosphorylation. Due to these critical roles of mitochondria, mitochondrial dysfunction results in various diseases such as obesity and type 2 diabetes.... -
Elucidation of the profound antagonism of contractile action of phenylephrine in rat aorta effected by an atypical sympathomimetic decongestant
EldinaRizvi, GoranJankovi, MiroslavM.Savi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 4 385-395 (11 pages)
Vasoconstrictive properties of sympathomimetic drugs are the basis of their widespread use as decongestants and possible source of adverse responses. Insufficiently substantiated practice of combining decongestants in some marketed preparations, such are those containing phenylephrine and lerimazoline, may affect the overall contractile activity, and thus their therapeutic utility. This study aimed to examine the interaction between lerimazoline and phenylephrine in isolated rat aortic rings,... -
Association study between OCTN1 functional haplotypes and Crohn’s disease in a Korean population
EunSukJung, HyoJinPark, KyoungAeKong, JiHaChoi, JaeHeeCheon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 2 11-17 (7 pages)
Crohn’s disease (CD) is a chronic inflammatory bowel disease with multifactorial causes including environmental and genetic factors. Several studies have demonstrated that the organic cation/carnitine transporter 1 (OCTN1) nonsynonymous variant L503F is associated with susceptibility to CD. However, it was reported that L503F is absent in Asian populations. Previously, we identified and functionally characterized genetic variants of the OCTN1 promoter region in Koreans.In that study, four... -
Metabotropic glutamate receptor dependent long-term depression in the cortex
SukjaeJoshuaKang, Bong-KiunKaang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.6 1 557-564 (8 pages)
Metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD), a type of synaptic plasticity, is characterized by a reduction in the synaptic response, mainly at the excitatory synapses of the neurons. The hippocampus and the cerebellum have been the most extensively studied regions in mGluR-dependent LTD, and Group 1 mGluR has been reported to be mainly involved in this synaptic LTD at excitatory synapses. However, mGluR-dependent LTD in other brain regions may be involved in the... -
Screening of Genetic Polymorphisms of CYP3A4 and CYP3A5 Genes
JinSolLee, HyunSubCheong, LyoungHyoKim, JiOnKim, DooWonSeo, YoungHoonKim, MyeonWooChung, SoonYoungHan, HyoungDooShin, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.6 1 479-484 (6 pages)
Given the CYP3A4 and CYP3A5’s impact on the efficacy of drugs, the genetic backgrounds of individuals and populations are regarded as an important factor to be considered in the prescription of personalized medicine. However, genetic studies with Korean population are relatively scarce compared to those with other populations. In this study, we aimed to identify CYP3A4/5 polymorphisms and compare the genotype distributions among five ethnicities. To identify CYP3A4/5 SNPs, we first performed... -
Synaptic Plasticity in Mouse Models of Autism Spectrum Disorders
LeeyupChung, AlexraL.Bey, Yong-HuiJiang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 1 369-378 (10 pages)
Analysis of synaptic plasticity together with behavioral and molecular studies have become a popular approach to model autism spectrum disorders in order to gain insight into the pathosphysiological mechanisms and to find therapeutic targets. Abnormalities of specific types of synaptic plasticity have been revealed in numerous genetically modified mice that have molecular construct validity to human autism spectrum disorders. Constrained by the feasibility of technique, the common regions... -
TRPC-Mediated Current Is Not Involved in Endocannabinoid-Induced Short-Term Depression in Cerebellum
WonseokChang, JooMinPark, JunKim, SangJeongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 9 139-144 (6 pages)
It has been reported that activation of metabotropic glutamate receptor 1 (mGluR1) can mediate endocannabinoid-induced short-term depression of synaptic transmission in cerebellar parallel fiber (PF)-Purkinje cell (PC) synapse. mGluR1 has signaling pathways involved in intracellular calcium increase which may contribute to endocannabinoid release. Two major mGluR1-evoked calcium signaling pathways are known: (1) slow-kinetic inward current carried by transient receptor potential canonical (TRPC)... -
Microarray Analysis of Gene Expression Profiles in Response to Treatment with Melatonin in Lipopolysaccharide Activated RAW 264.7 Cells
JuYeonBan, BumSikKim, SooCheolKim, DongHwanKim, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.1 4 23-30 (8 pages)
Melatonin, which is the main product of the pineal gland, has well documented antioxidant and immune-modulatory effects. Macrophages produce molecules that are known to play roles in inflammatory responses. We conducted microarray analysis to evaluate the global gene expression profiles in response to treatment with melatonin in lipopolysaccharide (LPS) activated RAW 264.7 macrophage cells. In addition, eight genes were subjected to real-time reverse transcription polymerase chain reaction... -
P2X and P2Y Receptors Mediate Contraction Induced by Electrical Field Stimulation in Feline Esophageal Smooth Muscle
YoungRaeCho, HyeonSoonJang, WonKim, SunYoungPark, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 10 311-316 (6 pages)
It is well-known that electrical field stimulation (EFS)-induced contraction is mediated by a cholinergic mechanism and other neurotransmitters. NO, ATP, calcitonin gene-related peptide (CGRP), and substance P are released by EFS. To investigate the purinergic mechanism involved in the EFS-induced contraction, purinegic receptors antagonists were used. Suramine, a non-selective P2 receptor antagonist, reduced the contraction induced by EFS. NF023 (10−7∼10−4 M), a selective P2X... -
Effects of Saccharin Intake on Hippocampal and Cortical Plasticity in Juvenile and Adolescent Rats
Jong-SilPark, SangBaeYoo, JinYoungKim, SungJoongLee, Seog-BaeOh, Joong-SooKim, Jong-HoLee, KyungpyoPark, JeongWonJahng, Se-YoungChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.2 8 113-118 (6 pages)
The sensory system is developed and optimized by experiences given in the early phase of life in association with other regions of the nervous system. To date, many studies have revealed that deprivation of specific sensory experiences can modify the structure and function of the central nervous system; however, the effects of sensory overload remains unclear. Here we studied the effect of overloading the taste sense in the early period of life on the synaptic plasticity of rat hippocampus and... -
Caffeine and 2-Aminoethoxydiphenyl Borate (2-APB) Have Different Ability to Inhibit Intracellular Calcium Mobilization in Pancreatic Acinar Cell
KyungJinChoi, KabSungKim, SeHoonKim, DongKwanKim, HyungSeoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.2 7 105-111 (7 pages)
Inositol 1,4,5-trisphosphate receptors (InsP3Rs) modulate Ca2＋ release from intracellular Ca2＋ store and are extensively expressed in the membrane of endoplasmic/sarcoplasmic reticulum and Golgi. Although caffeine and 2-aminoethoxydiphenyl borate (2-APB) have been widely used to block InsP3Rs, the use of these is limited due to their multiple actions. In the present study, we examined and compared the ability of caffeine and 2-APB as a blocker of Ca2＋ release from intracellular Ca2＋ stores... -
Forskolin Changes the Relationship between Cytosolic Ca2＋ and Contraction in Guinea Pig Ileum
KoonHeeHan, GapJinCheon, DongSooYeon, SeongChunKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 8 189-194 (6 pages)
This study was designed to clarify the mechanism of the inhibitory effect of forskolin on contraction, cytosolic Ca2＋ level ([Ca2＋]i), and Ca2＋ sensitivity in guinea pig ileum. Forskolin (0.1 nM∼10ՌM) inhibited high K＋ (25 mM and 40 mM)- or histamine (3ՌM)-evoked contractions in a concentration- dependent manner. Histamine-evoked contractions were more sensitive to forskolin than high K＋- evoked contractions. Spontaneous changes in [Ca2＋]i and contractions were inhibited by... -
Matrix Metallopeptidase 2 Gene Polymorphism is Associated with Obesity in Korean Population
DongHeeHan, SuKangKim, SungwookKang, Bong-KeunChoe, KeonSikKim, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.3 6 125-128 (4 pages)
The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) of matrix metallopeptidase 2 (MMP2) are associated with obesity. MMP2 is an enzyme with proteolytic activity against matrix and nonmatrix proteins, particularly basement membrane constituents. To identify the relationship between polymorphisms of MMP2 and overweight/obese, we genotyped 5 SNPs (rs17242319, rs1053605, rs243849, rs2287074, and rs10775332) of the coding region of MMP2 using the Golden Gate assay on... -
Assessment of Relationship between Fyn-related Kinase Gene Polymorphisms and Overweight/Obesity in Korean Population
MiYoungJung, BumShikKim, YounJungKim, InSongKoh, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.2 8 83-86 (4 pages)
The fyn-related kinase (FRK) belongs to the tyrosine kinase family of protein kinases. Recent studies have shown that Frk affects pancreatic beta cell number during embryogenesis and promotes beta cell cytotoxic signals in response to streptozotocin. To investigate the genetic association between FRK polymorphisms and the risk of obesity in Korean population, single nucleotide polymorphisms (SNPs) in the FRK gene region were selected and analyzed. The body mass index (BMI) was calculated, and... -
A1 Receptor-mediated Protection against Amyloid Beta-induced Injury in Human Neuroglioma Cells
YongWoonCho, HyunJuJung, YongKeunKim, JaeSukWoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.2 1 37-43 (7 pages)
Adenosine has been reported to provide cytoprotection in the central nervous systems as well as myocardium by activating cell surface adenosine receptors. However, the exact target and mechanism of its action still remain controversial. The present study was performed to examine whether adenosine has a protective effect against Aβ-induced injury in neuroglial cells. The astrocyte-derived human neuroglioma cell line, A172 cells, and Aβ25∼35 were employed to produce an experimental Aβ-induced...
