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Open Access : Xanthomonas oryzae pv. oryzae RpfE Regulates Virulence and Carbon Source Utilization without Change of the DSF Production
한국식물병리학회 The Plant Pathology Journal 10 Pages
한국식물병리학회 The Plant Pathology Journal 2013, 29권 4호 2 364-373 (10 pages)
It has been known that most regulation of pathogenicity factor (rpf ) genes in xanthomonads regulates virulence in response to the diffusible signal factor, DSF. Although many rpf genes have been functionally characterized, the function of rpfE is still unknown. We cloned the rpfE gene from a Xanthomonas oryzae pv. oryzae (Xoo) Korean race KACC10859 and generated mutant strains to elucidate the role of RpfE with respect to the rpf system. Through experiments using the rpfE-deficient mutant... -
Effect of Salinity, Temperature and Carbon Source on the Growth and Development of Sclerotia of Sclerotinia sclerotiorum Isolated from Semi-arid Environment
한국식물병리학회 The Plant Pathology Journal 10 Pages
한국식물병리학회 The Plant Pathology Journal 2008, 24권 4호 6 407-416 (10 pages)
of temperature, solute potential and carbon source on the mycelial growth, sclerotia development, and apothecium production of an isolate of Sclerotinia sclerotiorum. Mycelial growth rate was greatest at 25oC on potato dextrose agar (PDA) medium amended with up to 2% NaCl (ψs ≤ 1.91 MPa) and thereafter, growth rate declined. The least number of sclerotia were produced at 20oC on both PDA and malt extract agar (MEA) amended with 8% NaCl (ψs=6.62 MPa). With increasing temperature and decreasing... -
Carbon Doping of TiO2 for Visible Light Photo Catalysis - A review
K. Palanivelu, Ji Sun Im, Young-Seak Lee 한국탄소학회 Carbon Letters 11 Pages
한국탄소학회 Carbon Letters 2007, Vol.8 No.3 6 214-224 (11 pages)
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Carl Gustav Jung s Perception of the Chinese Religious Thought in His Works
한국종교교육학회 종교교육학연구 2004, 제 19권 7 139-153 (15 pages)
체게 융은 현대 정신분석학을 확립시킨 지그문트 프로이드와 결별한 이후에 독자적으로 인간의 심층적인 내면을 다양하게 탐구하였다. 융은 자신의 심층적인 내면을 직접 분석하였을 뿐만 아니라 자신의 임상적인 연구가 보편적인 현상인가를 직접 경험하기 위해서 인간의 심층적인 내면을 아직도 깊게 경험하면서 살고 있는 아프리카, 인도, 그리고 북미의 인디안들의 삶의 현장을 찾기도 하였다. 그 결과 융은 인간의 심층에는 프로이트가 약간 언급은 하였지만 깊게 연구해 들어가지 않았던 집단적인 무의식이 인간의 삶 속에서 작용해... -
The Problem of Conceptual Play and Liberation in Buddhist Education
Yongpyo Kim 한국종교교육학회 종교교육학연구 13 Pages
한국종교교육학회 종교교육학연구 2009, 제 29권 2 19-31 (13 pages)
The present study deals with the problem of substantial metaphysic as conceptual play(prapañca) and the way of Liberation from the perspective of Buddhist Education. Our frame of reference is the Prajñā-Mādhyamika. Human illusion is said to be the product of dualistic discrimination. Buddhist understands the structure of dualistic thinking as a connection between substantial metaphysics and the cycle of birth and death. Discriminative mind is in close connection with... -
Anti-inflammatory effects of low-level laser in burn wound models in rats
Eun-Jeong Kim, Se-Hun Kim 물리치료재활과학회 Physical Therapy Rehabilitation Science 6 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2017, 제 6권 제 4호 3 170-175 (6 pages)
Objective: The anti-inflammatory effects of low-level laser in burn wound model in rats were investigated. Design: Randomized controlled trial. Methods: The rats were assigned to three experimental groups. Group I received second-degree burn wounds; Group II received dressing film and low-level laser (1.2 J/cm2) treatment after a burn wound; Group III received dressing film and low-level laser (2.3 J/cm2) treatment after a burn wound. After inducing a deep second-degree burn wound, the wound was... -
The use of laser Doppler blood flow to assess the effect of acute administration of vitamin D on micro vascular endothelial function in people with diabetes
Jerrold Petrofsky, Faris Alshammari, Iman Akef Khowailed, Riya Lodha, Pooja Deshpande, Praveen Rajaram, Mahendra Gaikwad, Vidhi Vadera 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2013, 제 2권 제 2호 1 63-69 (7 pages)
Objective: To assess the effect of vitamin D administration on the skin blood flow response to occlusion and heat. Design: Cross-sectional study. Methods: Twenty age matched subjects; 10 who had diabetes and 10 who were controls were administered 4,000 IU of vitamin D3 for 3 weeks at breakfast. The function of the endothelial cells was evaluated in 2 ways; first, the response to 4 minutes of vascular occlusion of the skin was measured with a laser Doppler flow meter. Second, the skin blood flow... -
Korean Pre-Service English Teachers’ Attitudes toward English as an Academic Lingua Franca
Lee Seongyong, Kim Arum 경인교육대학교 교육연구원 The Journal of Education 16 Pages
경인교육대학교 교육연구원 The Journal of Education 2019, Vol.2 No.2 3 27-42 (16 pages)
ideologies of native English (NE) and provided relatively positive behavioral attitudes and intentions regarding the use of ELFA. Further analysis revealed a strong correlation between intrinsic motivation and ideologies of NE. This result indicates that despite their open-mindedness to ELFA, they still considered the native speaker model to be a norm of learning English. The findings of this study would shed light on the English language policy of higher education institutions in South Korea. -
Ovary and vaginal epithelium dynamics during the estrous cycle in Dasyprocta prymnolopha Wagler, 1831
Artur N. Carreiro, Joã, o A. R. A. Diniz, Joyce G. Souza, Dé, bora V. F. Araú, jo, Rô, mulo F. F. Dias, Liliane M. S. Aze 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 14 446-451 (6 pages)
The objective of the present study was to monitor and characterize morphological alterations in ovaries of agouti (Dasyprocta prymnolopha), reared in captivity, by using abdominal ultrasonography. All animals underwent daily vaginal cytological examination to identify the current cycle phase. For each phase of the estrous cycle, ultrasound examinations were carried out to identify and describe the morphology of both ovaries. Topographic parameters in an ultrasound window were established to... -
Analysis of structure-function relationship in porcine rotavirus A enterotoxin gene
Sharad Saurabh, Shubhankar Sircar, Jobin J. Kattoor, Souvik Ghosh, Nobumichi Kobayashi, Krisztian Banyai, Obli R. VinodhKumar, U 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 1호 6 35-43 (9 pages)
Rotavirus (RV)-infected piglets are presumed to be latent sources of heterologous RV infection in humans and other animals. In RVs, non-structural protein 4 (NSP4) is the major virulence factor with pleiotropic properties. In this study, we analyzed the nsp4 gene from porcine RVs isolated from diarrheic and non-diarrheic cases at different levels of protein folding to explore correlations to diarrhea-inducing capabilities and evolution of nsp4 in the porcine population. Full-length nsp4 genes... -
Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical features, magnetic resonance imaging, histopathology, and immunohistochemistry
Joon-Hyeok Jeon, Hae-Won Jung, Hyo-Mi Jang, Jong-Hyun Moon, Ki-Tae Park, Hee-Chun Lee, Ha-Young Lim, Jung-Hyang Sur, By 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 1호 10 75-85 (11 pages)
The purpose of this study was to identify time-related changes in clinical, MRI, histopathologic, and immunohistochemical findings associated with ischemic stroke in dogs. Additionally, the association of cerebrospinal fluid (CSF) and tissue levels of interleukin (IL)-6 with clinical prognosis was assessed. Ischemic stroke was induced by permanent middle cerebral artery occlusion (MCAO) in nine healthy experimental dogs. The dogs were divided into three groups... -
Photodynamic hyperthermal chemotherapy with indocyanine green: a novel cancer therapy for 16 cases of malignant soft tissue sarcoma
Masaki Onoyama, Takeshi Tsuka, Tomohiro Imagawa, Tomohiro Osaki, Saburo Minami, Kazuo Azuma, Kazuhiko Kawashima, Hiroshi Ishi, T 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 13 117-123 (7 pages)
a broadband light source, and local chemotherapy after surgical tumor resection. This triple therapy was called photodynamic hyperthermal chemotherapy (PHCT). In all cases, the surgical margin was insufficient. In one feline case, PHCT was performed without surgical resection. PHCT was performed over an interval of 1 to 2 weeks and was repeated three to 21 times. No severe side effects, including severe skin burns, necrosis, or skin suture rupture, were observed in any of the animals. No disease... -
An overview of calf diarrhea - infectious etiology, diagnosis, and intervention
Yong-il Cho, Kyoung-Jin Yoon* 대한수의학회 Journal of Veterinary Science 17 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 1 1-17 (17 pages)
Calf diarrhea is a commonly reported disease in young animals, and still a major cause of productivity and economic loss to cattle producers worldwide. In the report of the 2007 National Animal Health Monitoring System for U.S. dairy, half of the deaths among unweaned calves was attributed to diarrhea. Multiple pathogens are known or postulated to cause or contribute to calf diarrhea development. Other factors including both the environment and management practices influence disease severity or... -
Development of in vitro produced porcine embryos according to serum types as macromolecule
Jungmin Son, Don Buddika Oshadi Malaweera, Eunsong Lee, Sangtae Shin, Jongki Cho 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 3호 11 315-321 (7 pages)
This study was conducted to establish an in vitro maturation (IVM) system by selection of efficient porcine serum during porcine in vitro production. To investigate the efficient porcine serum (PS), different types of PS [newborn pig serum, prepubertal gilt serum (PGS), estrus sow serum, and pregnancy sow serum] were used to supplement IVM media with or without gonadotrophin (GTH) and development rates of parthenogenetic activation (PA) and in vitro fertilization (IVF) embryos were then... -
Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway
Sijun Deng, Hui Yuan, Jine Yi, Yin Lu, Qiang Wei, Chengzhi Guo, Jing Wu, Liyun Yuan, Zuping He 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 3호 7 281-289 (9 pages)
To investigate the effects of gossypol acetic acid (GA) on proliferation and apoptosis of the macrophage cell line RAW264.7 and further understand the possible underlying mechanism responsible for GA-induced cell apoptosis, RAW264.7 cells were treated with GA (25∼35 μmol/L) for 24 h and the cytotoxicity was determined by MTT assay, while apoptotic cells were identified by TUNEL assay, acridine orange/ethidium bromide staining and flow cytometry. Moreover, mitochondrial membrane potential... -
Effects of administration of IH901, a ginsenoside intestinal metabolite, on muscular and pulmonary antioxidant functions after eccentric exercise
Nam-Jin Lee, Jung-Won Lee, Jong- Hwan Sung, Yeoung-Gyu Ko, Seongsoo Hwang, Jong-Koo Kang 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 3호 3 249-256 (8 pages)
This study was conducted to investigate whether administration of IH901, a ginseng intestinal metabolite, ameliorates exercise-induced oxidative stress while preserving antioxidant defense capability in rat skeletal muscles and lung. Eight adult male Sprague-Dawley rats per group were randomly assigned to the resting control, exercise control, resting with IH901 (25, 50, and 100 mg/kg) consumption (R/IH901), or exercise with IH901 (25, 50, and 100 mg/kg) consumption (E/IH901) group. The trained... -
Radiation up-regulates the expression of VEGF in a canine oral melanoma cell line
Irene Flickinger*, Barbara C Rütgen, Wilhelm Gerner, Ivana Calice, Alexander Tichy, Armin Saalmüller, Miriam Kleiter 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 2호 13 207-214 (8 pages)
To evaluate radiosensitivity and the effects of radiation on the expression of vascular endothelial growth factor (VEGF) and VEGF receptors in the canine oral melanoma cell line, TLM 1, cells were irradiated with doses of 0, 2, 4, 6, 8 and 10 Gray (Gy). Survival rates were then determined by a MTT assay, while vascular endothelial growth factor receptor (VEGFR)-1 and -2 expression was measured by flow cytometry and apoptotic cell death rates were investigated using an Annexin assay.... -
Butyrate regulates leptin expression through different signaling pathways in adipocytes
Mohamed Mohamed Soliman*, Mohamed Mohamed Ahmed, Alaa-eldin Salah-eldin, Abeer Abdel-Alim Abdel-Aal 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 4호 3 319-323 (5 pages)
maintains energy homeostasis by promoting reduced food intake and increasing energy expenditure. Leptin expression and secretion is regulated by various factors including hormones and fatty acids. Butyrate is a short-chain fatty acid that acts as source of energy in humans. We determined whether this fatty acid can play a role in leptin expression in fully differentiated human adipocytes. Mature differentiated adipocytes were incubated with or without increasing concentrations of butyrate. RNA... -
Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice
Jin-Joo Hue, Ki Nam Lee, Jae-Hwang Jeong, Sang-Hwa Lee, Young Ho Lee, Seong-woon Jeong, Sang Yoon Nam, Young Won Yun, Beom Jun L 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 3호 3 189-195 (7 pages)
This study was to investigate the anti-obesity effects of diglyceride (DG)-conjugated linoleic acid (CLA) containing 22% CLA as fatty acids in C57BL/6J ob/ob male mice. There were four experimental groups including vehicle control, DG, CLA, and DG-CLA. The test solutions of 750 mg/kg dose were orally administered to the mice everyday for 5 weeks. CLA treatments significantly decreased mean body weight in the obese mice throughout the experimental period compared to the control (p < 0.01). All... -
Testicular morphology and cauda epididymal sperm reserves of male rats exposed to Nigerian Qua Iboe Brent crude oil
I. Reginald Obidike, Igwebuike U. Maduabuchi, Shoyinka S.V. Olumuyiwa 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 1호 1 1-5 (5 pages)
Potential negative effects of exposure to Nigerian Qua Iboe Brent crude oil on the reproductive system of male rats was investigated. Forty Sprague-Dawley rats were used for the experiment. Exposure to Nigerian Qua Iboe Brent crude oil was achieved via oral administration of increasing doses (0.1, 0.2, and 0.4 ml/rat) every other day for 4 weeks. Cauda epididymal sperm reserves and relative weights of the testes as well as histological features of the testes of rats that received the crude oil... -
Gamma-ray irradiation stimulates the expression of caveolin-1 and GFAP in rat spinal cord: a study of immunoblot and immunohistochemistry
Meejung Ahn, Heechul Kim, Jeong Tae Kim, Jeeyoung Lee, Jin Won Hyun, Jae Woo Park, Taekyun Shin 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 4호 1 309-314 (6 pages)
per each time point) were analyzed by Western blot and immunohistochemistry. Western blot analysis showed that the expression of caveolin-1 was significantly increased at day 1 PI (p < 0.05), and returned to the level of normal control rats on days 4 and 9 PI. Immunohistochemistry showed that caveolin-1 immunoreactivity was enhanced in some glial cells, vascular endothelial cells, and neurons in the spinal cords. The increased expression of glial fibrillary acidic protein (GFAP), a marker for an... -
Protective effect of the isoflavone equol against DNA damage induced by ultraviolet radiation to hairless mouse skin
Sitarina Widyarini 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 3호 2 217-223 (7 pages)
Equol, an isoflavonoid metabolite produced from the dietary isoflavone daidzein by the gut microflora in mammals, has been found to protect not only against ultraviolet (UV) radiation-induced cutaneous inflammation and photoimmune suppression, but also have antiphotocarcinogenic properties in mice. Because the state of DNA damage has been correlated with suppression of the immune system and photocarcinogenesis, we have therefore examined the potential of equol to offer protection from... -
Frequencies of Micronuclei in Peripheral Lymphocytes in Korean Populations after Chronic Low-dose Radiation Exposure
Mi-Young An and Tae-Hwan Kim 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2002, 제 3권 제 3호 11 213-218 (6 pages)
The purpose of this study was to estimate predictive markers of intrinsic radiosensitivity in individuals who were exposed to occupational or environmental radiation. Throughout this process, the actual biohazard risks and base-line chromosome damage were evaluated in human population. Further studies were carried out to provide evidence for the existence of individual variations in age-dependent responses through micronuclei (MN) assay. Spontaneous frequencies not only vary greatly between... -
Safety and outcomes of subconjunctival allogenic mesenchymal stem cell transplantation in canine experimental corneal defects
Ju Won Kim , So Young Lee , Hee Myung Park 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 6 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2012, 제 52권 제 3호 2 157-162 (6 pages)
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Clinics : Latex agglutination test based prevalence of Toxoplasma gondii in native Korean cattle
Kun Ho Song , Myung Jo You , Bae Keun Park , Duck Hwan Kim , Eun Sik Song , Sang Il Jung 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 3 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2011, 제 51권 제 1호 9 59-61 (3 pages)
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미적 교육으로서의 음악교육에 대한 철학적 관점의 비평적 조망
주대창(Dae Chang Ju) 한국음악교육학회 음악교육연구 21 Pages
한국음악교육학회 음악교육연구 2014, 제 43권 제 2호 5 93-113 (21 pages)
음악교육철학 분야에서 미적 교육은 가장 중요한 이슈의 하나로 다루어지고 있다. 그러나 그 기원과 철학적 의도에 대해 충분한 검토가 이루어지지 않은 실정이다. 본 연구는 미학을 탄생시킨 바움가르텐, 그것의 목적론적 활용을 추구한 칸트, 그리고 그의 사고를 이어받아 미적 교육이라는 교육적 아이디어를 가시화 한 쉴러를 하나의 철학적 체계 안에서 살펴보았다. 이를 통하여 오늘날 음악교육에서 내세우는 철학적 근거로서의 미적 교육이 본래의 철학적 의도와 일치하지 않으며, 그러한 무의식적 변질이 음악교육의 당위성을... -
Participation of COX-1 and COX-2 in the contractile effect of phenylephrine in prepubescent and old rats
GustavoGuevara-Balcazar, IsraelRamirez-Sanchez, ElviaMera-Jimenez, IvanRubio-Gayosso, MariaEugeniaAguilar-Najera, MariaC.Castillo-Her 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 6 407-413 (7 pages)
Vascular reactivity can be influenced by the vascular region, animal age, and pathologies present. Prostaglandins (produced by COX-1 and COX-2) play an important role in the contractile response to phenylephrine in the abdominal aorta of young rats. Although these COXs are found in many tissues, their distribution and role in vascular reactivity are not clear. At a vascular level, they take part in the homeostasis functions involved in many physiological and pathologic processes (e.g., arterial... -
Facilitation of AMPA receptor-mediated steady-state current by extrasynaptic NMDA receptors in supraoptic magnocellular neurosecretory cells
YoonHyoungPai, ChaeSeongLim, Kyung-AhPark, HyunSilCho, Gyu-SeungLee, YongSupShin, Hyun-WooKim, ByeongHwaJeon, SeokHwaYoon, JinBongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.4 12 425-432 (8 pages)
In addition to classical synaptic transmission, information is transmitted between cells via the activation of extrasynaptic receptors that generate persistent tonic current in the brain. While growing evidence supports the presence of tonic NMDA current (INMDA) generated by extrasynaptic NMDA receptors (eNMDARs), the functional significance of tonic INMDA in various brain regions remains poorly understood. Here, we demonstrate that activation of eNMDARs that generate INMDA facilitates the... -
The effects of intra-articular resiniferatoxin on monosodium iodoacetate-induced osteoarthritic pain in rats
YoungkyungKim, Eun-hyeKim, KyuSangLee, KoeunLee, , SungHoPark, , SookHyunNa, CheolwoongKo6, JunesunKim, YoungWookYooon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 16 129-136 (8 pages)
This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX) would alleviate behavioral signs of arthritic pain in a rat model of osteoarthritis (OA). We also sought to determine the effect of RTX treatment on calcitonin gene-related peptide (CGRP) expression in the spinal cord. Knee joint inflammation was induced by intra-articular injection of monosodium iodoacetate (MIA, 8 mg/50... -
A Novel Nicotinamide Adenine Dinucleotide Correction Method for Mitochondrial Ca2+ Measurement with FURA-2-FF in Single Permeabilized Ventricular Myocytes of Rat
JeongHoonLee, JeongMiHa, ChaeHunLeem 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.4 10 373-382 (10 pages)
Fura-2 analogs are ratiometric fluoroprobes that are widely used for the quantitative measurement of [Ca2+]. However, the dye usage is intrinsically limited, as the dyes require ultraviolet (UV) excitation, which can also generate great interference, mainly from nicotinamide adenine dinucleotide (NADH) autofluorescence. Specifically, this limitation causes serious problems for the quantitative measurement of mitochondrial [Ca2+], as no available ratiometric dyes are excited in the visible range.... -
Extremely Low Frequency Magnetic Field Modulates the Level of Neurotransmitters
YoonHeeChung, YoungJooLee, HoSungLee, SuJinChung, CheolHeeLim, KeonWoongOh, UyDongSohn, EonSubPark, JiHoonJeong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 3 15-20 (6 pages)
This study was aimed to observe that extremely low frequency magnetic field (ELF-MF) may be relevant to changes of major neurotransmitters in rat brain. After the exposure to ELF-MF (60 Hz, 2.0 mT) for 2 or 5 days, we measured the levels of biogenic amines and their metabolites, amino acid neurotransmitters and nitric oxide (NO) in the cortex, striatum, thalamus, cerebellum and hippo-campus. The exposure of ELF-MF for 2 or 5 days produced significant differences in norepinephrine and vanillyl... -
Potassium Currents in Isolated Deiters' Cells of Guinea Pig
JongWooChung, EuiCholNam, WonTaeKim, JaeBoumYoum, ChaeHunLeem 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.6 10 537-546 (10 pages)
Deiters' cells are the supporting cells in organ of Corti and are suggested to play an important role in biochemical and mechanical modulation of outer hair cells. We successfully isolated functionally different K+ currents from Deiters’ cells of guinea pig using whole cell patch clamp technique. With high K+ pipette solution, depolarizing step pulses activated strongly outward rectifying currents which were dose-dependently blocked by clofilium, a class III anti-arrhythmic K+ channel blocker.... -
Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs
YuJiCho, ChinOkYi, ByeongTakJeon, YiYeongJeong, GiMunKang, JungEunLee, GuSeobRoh, JongDeogLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 3 267-274 (8 pages)
A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed to investigate whether curcumin, which is known to have anti-inflammatory and antioxidant properties, could ameliorate radiation-induced pulmonary inflammation and fibrosis in irradiated lungs. Rats were given daily doses of intragastric curcumin (200 mg/kg) prior to a single irradiation and for 8 weeks after radiation. Histopathologic findings demonstrated that macrophage... -
Electrophysiological and Histologic Evaluation of the Time Course of Retinal Degeneration in the rd10 Mouse Model of Retinitis Pigmentosa
SeolAJae, KunNoAhn, JiYoungKim, JeHoonSeo, HyongKyuKim, YongSookGoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.3 8 229-235 (7 pages)
Among several animal models of retinitis pigmentosa (RP), the more recently developed rd10 mouse with later onset and slower rate of retinal degeneration than rd1 mouse is a more suitable model for testing therapeutic modalities. We therefore investigated the time course of retinal degeneration in rd10 mice before adopting this model in our interventional studies. Electroretinogram (ERG) recordings were carried out in postnatal weeks (PW) 3∼5 rd10 (n=23) and wild-type (wt) mice (n=26). We... -
A Computational Model of Cytosolic and Mitochondrial [Ca2+] in Paced Rat Ventricular Myocytes
JaeBoumYoum, SeongWooChoi, ChangHanJang, HyoungKyuKim, ChaeHunLeem, NariKim, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 23 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.4 5 217-239 (23 pages)
We carried out a series of experiment demonstrating the role of mitochondria in the cytosolic and mitochondrial Ca2+ transients and compared the results with those from computer simulation. In rat ventricular myocytes, increasing the rate of stimulation (1∼3 Hz) made both the diastolic and systolic [Ca2+] bigger in mitochondria as well as in cytosol. As L-type Ca2+ channel has key influence on the amplitude of Ca2+-induced Ca2+ release, the relation between stimulus frequency and the... -
Neuroprotective Effect of Visnagin on Kainic Acid-induced Neuronal Cell Death in the Mice Hippocampus
Min-SooKwon, Jin-KooLee, Soo-HyunPark, Yun-BeomSim, Jun-SubJung, Moo-HoWon, Seon-MiKim, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 2 257-263 (7 pages)
Visnagin (4-methoxy-7-methyl-5H-furo[3,2-g][1]-benzopyran-5-one), which is an active principle extracted from the fruits of Ammi visnaga, has been used as a treatment for low blood-pressure and blocked blood vessel contraction by inhibition of calcium influx into blood cells. However, the neuroprotective effect of visnagin was not clearly known until now. Thus, we investigated whether visnagin has a neuroprotective effect against kainic acid (KA)-induced neuronal cell death. In the cresyl violet... -
Electrically-evoked Neural Activities of rd1 Mice Retinal Ganglion Cells by Repetitive Pulse Stimulation
SangBaekRyu, JangHeeYe, JongSeungLee, YongSookGoo, ChiHyunKim, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 6 443-448 (6 pages)
For successful visual perception by visual prosthesis using electrical stimulation, it is essential to develop an effective stimulation strategy based on understanding of retinal ganglion cell (RGC) responses to electrical stimulation. We studied RGC responses to repetitive electrical stimulation pulses to develop a stimulation strategy using stimulation pulse frequency modulation. Retinal patches of photoreceptor-degenerated retinas from rd1 mice were attached to a planar multi-electrode array... -
Role of Glucocorticoids in Fasting-induced Changes in Hypothalamic and Pituitary Components of the Growth Hormone (GH)-axis
EunheeKim, SangheeSeo, HyunjuChung, SeungjoonPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.5 1 217-224 (8 pages)
To directly test if elevated glucocorticoids are required for fasting-induced regulation of growth hormone (GH)-releasing hormone (GHRH), GHRH receptors (GHRH-R) and ghrelin receptors (GHS-R) expression, male rats were bilaterally adrenalectomized or sham operated. After 7 days, animals were fed ad libitum or fasted for 48 h. Bilateral adrenalectomy increased hypothalamic GHRH to 146% and decreased neuropeptide Y (NPY) mRNA to 54% of SHAM controls. Pituitary GHRH-R and GHS-R mRNA levels were... -
Protein Kinase C-mediated Neuroprotective Action of (-)-epigallocatechin-3-gallate against Aβ1-42-induced Apoptotic Cell Death in SH-SY5Y Neuroblastoma Cells
SujeongJang, KyoungWanYou, Song-HeeKim, SungJunPark, Han-SeongJeong, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 1 163-169 (7 pages)
The neurotoxicity of amyloid β (Aβ) is associated with an increased production of reactive oxygen species and apoptosis, and it has been implicated in the development of Alzheimer's disease. While (-)-epigallocatechin-3-gallate (EGCG) suppresses Aβ-induced apoptosis, the mechanisms underlying this process have yet to be completely clarified. This study was designed to investigate whether EGCG plays a neuroprotective role by activating cell survival system such as protein kinase C (PKC),... -
Effects of Phenylephrine on the Excitability of Medial Vestibular Nuclear Neurons in Rats
Han-SeongJeong, HaeRyongHuh, Myung-JooJang, Seol-HeeHong, SujeongJang, JinPark, Seung-HanLee, Jae-HaKim, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.3 3 131-136 (6 pages)
Coeruleo-vestibular pathway which connects locus coeruleus and vestibular nuclei is noradrenergic. This study was designed to elucidate the effects of phenylephrine on the spontaneous activity of acutely isolated medial vestibular nuclear neurons of rat by whole-cell patch-clamp technique. Sprague-Dawley rats, aged 14 to 16 days, were used. After enzymatic digestion, dissociated medial vestibular neurons were transferred to a recording chamber mounted on an inverted microscope, and spontaneous... -
A Possible Role of Kainate Receptors in C2C12 Skeletal Myogenic Cells
Jae-YongPark, JaeheeHan, Seong-GeunHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 13 375-379 (5 pages)
Ca2 influx appears to be important for triggering myoblast fusion. It remains, however, unclear how Ca2 influx rises prior to myoblast fusion. Recently, several studies suggested that NMDA receptors may be involved in Ca2 mobilization of muscle, and that Ca2 influx is mediated by NMDA receptors in C2C12 myoblasts. Here, we report that other types of ionotropic glutamate receptors, non-NMDA receptors (AMPA and KA receptors), are also involved in Ca2 influx in... -
Stationary Outward and Transient Ca2+-Dependent Currents in Hamster Oocytes
Yang-MiKim, Jae-HeeHan, Jong-SuKim, Seong-GeunHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 9 403-408 (6 pages)
The outward currents elicited in hamster eggs by depolarizing pulses were studied. The currents appeared to comprise at least two components, a transient outward component (Ito) and a steady-state outward component (I∞). Ito was transiently followed by the cessation of inward Ca2 current (ICa), and its current-voltage (I-V) relation was a mirror image of that of ICa. Either blockade of ICa by Co2 or replacement of Ca2 with Sr2 abolished Ito without change in I∞.... -
Effects of Cl Channel Blockers on the Cardiac ATP-sensitive K+ Channel
Yong-GeunKwak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 8 305-313 (9 pages)
To explore whether Cl channel blockers interact with the ATP-sensitive K (KATP) channel, I have examined the effect of two common Cl channel blockers on the KATP channel activity in isolated rat ventricular myocytes using patch clamp techniques. In inside-out patches, 4,4'-diisothio-cyanatostilbene- 2,2'-disulfonic acid (DIDS) and niflumic acid applied to bath solution inhibited the KATP channel activity in a concentration-dependent manner with IC50 of 0.24 and 927μM,... -
Protective Mechanism of Nitric Oxide and Mucus against Ischemia/ Reperfusion-Induced Gastric Mucosal Injury
HyeyoungKim, KwangsooNam, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 13 511-519 (9 pages)
This study investigated the role of nitric oxide on the oxidative damage in gastric mucosa of rats which received ischemia/reperfusion and its relation to mucus. Nitric oxide synthesis modulators such as L-arginine and NG-nitro-L-arginine methyl ester, and sodium nitroprusside, a nitric oxide donor, were injected intraperitoneally to the rats 30 min prior to ischemia/reperfusion which was induced by clamping the celiac artery and the superior mesenteric artery for 30 min and reperfusion for 1... -
흡연이 청각사건관련전위 P300에 미치는 영향
전창만, 김병광, 이창욱, 한상익, 백인호 대한신경정신의학회 신경정신의학 7 Pages
대한신경정신의학회 신경정신의학 1997, 제 36권 제 6호 14 1099-1105 (7 pages)
흡연이 중추신경계에 미치는 영향을 알아보기 위하여 흡연자 24명과 비흡연자 14명을 대상으로 흡연 전 후에 지표학적 전산화 청각 사건관련전위 검사를 시행하고 이를 아직까지 흡연연구에 시도된바 없는 전부위 장력 측정법으로 잠복기를 분석하여 다음과 같은 결과를 얻었다. 1) 흡연군과 비흡연군사이에서 P300의 잠복기를 비교하였을 때, 흡연군에서 흡연전값이 324.0±30.1 흡 연후 값이 309.8±31.5였고 비흡연군에서 흡연전값이 329.6±49.6 흡연후 값이 344±48.3으로 흡연군에 서 비흡연군에 비해 흡연 후에 잠복기가 유의하게... -
암환자 수면 장애의 약물요법:체계적 문헌 고찰
김하경, 김종흔 대한신경정신의학회 신경정신의학 11 Pages
대한신경정신의학회 신경정신의학 2010, 제 49권 제 1호 8 26-36 (11 pages)


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