자료유형
발행기관
- 대한생리학회-대한약리학회(18)
- 대한약리학회(4)
- 대한생리학회(3)
- 한국약제학회(3)
- 한국응용약물학회(3)
- 대한소아신장학회(2)
- 대한약학회(2)
- 대한임상약리학회(2)
- 한국임상약학회(2)
- 대한통증학회(1)
- 대한흉부외과학회(1)
- 한국기초간호학회(1)
- 한국의학물리학회(1)
- 한국정보처리학회(1)
간행물
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(18)
- 대한약리학잡지(4)
- 대한생리학회지(3)
- ARCHIVES OF PHARMACAL RESEARCH : A PUBLICATION OF THE PHARMACEUTICAL SOCIETY OF KOREA(2)
- BIOMOLECULES & THERAPEUTICS(2)
- 대한소아신장학회지(2)
- 약제학회지(2)
- 임상약리학회지= THE JOURNAL OF KOREAN SOCIETY FOR CLINICAL PHARMACOLOGY AND THERAPEUTICS(2)
- 한국임상약학회지(2)
- JOURNAL OF KOREAN BIOLOGICAL NURSING SCIENCE(1)
- JOURNAL OF PHARMACEUTICAL INVESTIGATION(1)
- THE JOURNAL OF APPLIED PHARMACOLOGY : THE OFFICIAL JOURNAL OF THE KOREAN SOCIETY OF APPLIED PHARMACO(1)
- 대한통증학회지(1)
- 대한흉부외과학회지(1)
- 의학물리(1)
- 정보처리학회논문지. THE KIPS TRANSACTIONS. PART C PART C(1)
전체 선택해제
총 44건 검색
본문검색 결과만 보기
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Effects of Ticlopidine on the Bioavailability and Pharmacokinetics of Nicardipine after Oral and Intravenous Administration
문홍섭, 최준식, 방준석, Moon. Hong-Seop, Choi. Jun-Shik, Bang. Joon-Seok 한국임상약학회 한국임상약학회지 8 Pages
한국임상약학회 한국임상약학회지 2012, Vol.22 No.1 1-8 (8 pages)
항혈소판제인 티크로피딘과 항고혈압제인 니칼디핀과의 약동학적 상호작용 연구를 위하여 티크로피딘 (3 또는 10 mg/kg)과 니칼디핀의 경구 (4 mg/kg) 및 정맥 (12 mg/kg) 투여하여 본 연구를 시행하였다. 연구방법: 티크로피딘이 cytochrome P450 (CYP) 3A4 활성과 P-glycoprotein (P-gp)의 활성에 미치는 영향도 평가하였다. 결 과: 티크로피딘과 니칼디핀의 병용투여 시 티크로피딘이 니칼디핀의 약물동태 파라미터에 미치는 결과는 다음과 같다. 티크로피딘은 CYP3A4 효소의 활성을 저해 하였으나 P-gp활성에는 영향을 미치지... -
흰쥐에서 Cyclosporine의 약동학적 지표에 대한 Nicardipine의 영향
김희규, 강주섭, 이창호, 신인철 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 6 Pages
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 1998, Vol.6 No.4 389-394 (6 pages)
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Inhibitory Effect of Nicardipine on hERG Channel
Chung. Eun-Yong, Cho. Hea-Young, Cha. Ji-Hun, Kwon. Kyoung-Jin, Jeon. Seol-Hee, Jo. Su-Hyun, Kim. Eun-Jung, Kim. Hye-Soo, Chung. Hye-Ju 한국응용약물학회 Biomolecules & therapeutics 6 Pages
한국응용약물학회 Biomolecules & therapeutics 2010, Vol.18 No.4 448-453 (6 pages)
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급성대동맥해리에 대한 혈압강하요법으로서의 Nicardipine.HCI 주사액(Perdipine$^{circledR}$)의 유효성 및 안전성을 검토하기 위한 다기관 공동, 공개 제4상 임상시험
안혁, 김경환, 문인성, 박장상, 고용복 대한흉부외과학회 大韓胸部外科學會誌 7 Pages
대한흉부외과학회 大韓胸部外科學會誌 2002, Vol.35 No.4 267-273 (7 pages)
때 119$pm$12mrnHg, 69$pm$grnmHg, 86$pm$BmmHg로 의미있게 감소하였음을 확인하였다. Nicardipine 투여 종료 시에측정한 수축기 혈압, 이완기혈압, 평균혈압은 각각 119$pm$ 15mmHg, 70$pm$ 14mmHg, 86$pm$ 13mmHg로 3일째 측정한 혈압과 비교하였을 때 의미있는 상승 혹은 하강현상은 관찰되지 않았고 비교적 혈압 하강 상태가 잘 유지되고 있음을 알 수 있었다. 지속적 정맥 투여 중 부작용은 뚜렷하게 관찰할 수 없었다. 결론: 대동맥 박리에 동반된 고혈압에서 nicardipine을 사용하여 만족할만한 혈압하강 효과를 얻었으며, 뚜렷한... -
Effects of Oral Epigallocatechin Gallate on the Pharmacokinetics of Nicardipine in Rats
Choi. Jun-Shik, Burm. Jin-Pil 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 5 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2009, Vol.32 No.12 1721-1725 (5 pages)
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Relaxant and anti-inflammatory effect of two thalidomide analogs as PDE-4 inhibitors in pregnant rat uterus
V?ctor Manuel Mu?oz-P?rez, Eduardo Fern?ndez-Mart?nez*, H?ctor Ponce-Monter, and Mario I. Ortiz 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 9 429-437 (9 pages)
The aim of this study was to evaluate the relaxant and anti-inflammatory effects of two thalidomide analogs as phosphodiesterase-4 (PDE-4) inhibitors in pregnant rat uterus. Uteri from Wistar female rats were isolated at 19 day of pregnancy. Uterine samples were used in functional studies to evaluate the inhibitory effects of the thalidomide analogs, methyl 3-(4-nitrophthalimido)-3-(3,4-dimethoxyphenyl)-propanoate (4NO2PDPMe) and methyl 3-(4-aminophthalimido)-3-(3,4-dimethoxyphenyl)-propanoate... -
Gintonin facilitates catecholamine secretion from the perfused adrenal medulla
Seung-YeolNa, Ki-HwanKim, Mi-SungChoi, Kang-SuHa, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.6 9 629-639 (11 pages)
a nicardipine (1 μM, a voltage-dependent Ca2+ channel blocker), TMB-8 (1 μM, an intracellular Ca2+ antagonist), and perfusion of Ca2+-free Krebs solution with 5mM EGTA (a Ca2+chelater), while was not affected by sodium nitroprusside (100 μM, a nitrosovasodialtor). Interestingly, LPA (0.3~3 μM, an LPA receptor agonist) also dose-dependently enhanced the CA secretion from the adrenal medulla, but this facilitatory effect of LPA was greatly inhibited in the presence of Ki 14625 (10 μM).... -
Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization
Hyang-AeLee, Sung-AeHyun, Sung-GurlPark, Ki-SukKim, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 15 119-127 (9 pages)
of nicardipine (NIC), isradipine (ISR), and amlodipine (AML) on the cardiac APD in rabbit Purkinje fibers, voltage-gated K+ channel currents (IKr, IKs) and voltage-gated Na+ channel current (INa). The concentration-dependent inhibition of Ca2+ channel currents (ICa) was examined in rat cardiomyocytes; these CCBs have similar potency on ICa channel blocking with IC50 (the half-maximum inhibiting concentration) values of 0.142, 0.229, and 0.227 nM on NIC, ISR, and AML, respectively. However, ISR... -
Possible Involvement of Ca2＋ Activated K＋ Channels, SK Channel, in the Quercetin-Induced Vasodilatation
SeiichiroNishida, HiroyasuSatoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 5 361-365 (5 pages)
Effects of quercetin, a kind of flavonoids, on the vasodilating actions were investigated. Among the mechanisms for quercetin-induced vasodilatation in rat aorta, the involvement with the Ca2＋ activated K＋ (KCa) channel was examined. Pretreatment with NE (5ՌM) or KCl (60 mM) was carried out and then, the modulation by quercetin of the constriction was examined using rat aorta ring strips (3 mm) at 36.5oC. Quercetin (0.1 to 100ՌM) relaxed the NE-induced vasoconstrictions in a... -
Voltage-dependent Ca2＋ Current Identified in Freshly Isolated Interstitial Cells of Cajal (ICC) of Guinea-pig Stomach
YoungChulKim, HikaruSuzuki, Wen-XieXu, HikaruHashitani, WoongChoi, Hyo-YungYun, Seon-MeePark6, SeiJinYoun6, Sang-JeonLee, SangJinLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.6 6 323-330 (8 pages)
The properties of voltage dependent Ca2＋ current (VDCC) were investigated in interstitial cells of Cajal (ICC) distributed in the myenteric layer (ICC-MY) of guinea-pig antrum. In tissue, ICC-MY showed c-Kit positive reactions and produced driving potentials with the amplitude and frequency of about 62 mV and 2 times min−1, respectively, in the presence of 1</SUP>ՌM nifedipine. Single ICC-MY isolated by enzyme treatment also showed c-Kit immunohistochemical reactivity. These... -
Characterization of Ionic Currents in Human Neural Stem Cells
ChaeGilLim, Sung-SooKim, HaeyoungSuh-Kim, Young-DonLee, SeungCheolAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 1 131-136 (6 pages)
The profile of membrane currents was investigated in differentiated neuronal cells derived from human neural stem cells (hNSCs) that were obtained from aborted fetal cortex. Whole-cell voltage clamp recording revealed at least 4 different currents: a tetrodotoxin (TTX)-sensitive Na+ current, a hyperpolarization-activated inward current, and A-type and delayed rectifier-type K+ outward currents. Both types of K+ outward currents were blocked by either 5 mM tetraethylammonium (TEA) or 5 mM... -
Regulation of Ba2+-Induced Contraction of Murine Ureteral Smooth Muscle
YoungChulKim, MooYeolLee, Wun-JaeKim, SoonChulMyung, WoongChoi, ChanHyungKim, Wen-XieXu, SeungRyulKim6, SangJinLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 7 207-213 (7 pages)
1μM nicardipine, a blocker of dehydropyridine-sensitive voltage-dependent L-type Ca2+ channels (VDCCL) in smooth muscle membrane. This Ba2+-induced phasic contraction was significantly enhanced by 10μM cyclopiazonic acid (CPA) in the frequency and amplitude. Finally, regulation of Ba2+-induced contraction was studied by FSK and ISO which are known as adenylyl cyclase activator and β-adrenergic receptor agonist, respectively. These drugs significantly suppressed the frequency and amplitude of... -
Influence of ω-Conotoxin GVIA, Nifedipine and Cilnidipine on Catecholamine Release in the Rat Adrenal Medulla
Byung-SikYu, Byeong-CheolKim, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.1 4 21-30 (10 pages)
The present study was designed to establish comparatively the inhibitory effects of cilnidipine (CNP), nifedipine (NIF), and ω-conotoxin GVIA (CTX) on the release of CA evoked by cholinergic stimulation and membrane depolarization from the isolated perfused model of the rat adrenal medulla. CNP (3 μM), NIF (3μM), and CTX (3μM) perfused into an adrenal vein for 60 min produced greatly inhibition in CA secretory responses evoked by ACh (5.32⁓103 M), DMPP (104 M for 2 min),... -
Regulation of L-type Calcium Channel Current by Somatostatin in Guinea-Pig Gastric Myocytes
YoungChulKim, JaeHoonSim, SangJinLee, TongMookKang, SungJoonKim, SeungRyulKim, SeiJinYoun, SangJeonLee, Wen-XieXu6, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 5 103-108 (6 pages)
(SS) on calcium channel current (IBa) in guinea-pig gastric myocytes, IBa was recorded by using whole-cell patch clamp technique in single smooth muscle cells. Nicardipine (1μM), a L-type Ca2+ channel blocker, inhibited IBa by 98⁑1.9% (n=5), however IBa was decreased in a reversible manner by application of SS. The peak IBa at 0 mV were decreased to 95⁑1.1, 92⁑1.9, 82⁑4.0, 66⁑5.8, 10⁑2.9% at 1010, 109, 108, 107, 105 M of SS,... -
Mechanism of Leptin-Induced Potentiation of Catecholamine Secretion Evoked by Cholinergic Stimulation in the Rat Adrenal Medulla
Dong-YoonLim, Deok-HoChoi, Moo-JinKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.4 9 227-235 (9 pages)
The aim of the present study was to examine the effect of leptin on CA release from the isolated perfused model of the rat adrenal gland, and to establish its mechanism of action. Leptin (1∼100 ng/ml), when perfused into an adrenal vein of the rat adrenal gland for 60 min, enhanced a dose-dependently the secretory responses of CA evoked by ACh (5.32⁓103 M), DMPP (104 M) and McN-A-343 (104 M), although it alone has weak effect on CA secretion. However, it did not... -
Postischemic Treatment with Aminoguanidine Inhibits Peroxynitrite Production in the Peroxynitrite Production in the Rat Hippocampus Following Transient Forebrain Ischemia
Yun-SikChoi, Yeo-HongYoon, JuEunLee, Kyung-OkCho, SeongYunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 1 1-5 (5 pages)
Transient forebrain ischemia results in the delayed neuronal death in the CA1 area of the hippocampus. The present study was performed to determine effects of aminoguanidine, a selective iNOS inhibitor, on the generation of peroxynitrite and delayed neuronal death occurring in the hippocampus following transient forebrain ischemia. Transient forebrain ischemia was produced in the conscious rats by four-vessel occlusion for 10 min. Treatment with aminoguanidine (100 mg/kg or 200 mg/kg, i.p.) or... -
Effect of Ca2+-channel Blockers on Norepinephrine Release in the Rat Hippocampal Slice and Synaptosome
SukWonKim, KyuYongJung, BongKyuChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 4 87-92 (6 pages)
blockers in norepinephrine (NE) release from rat hippocampus. Slices and synaptosomes were incubated with [3H]-NE and the releases of the labelled products were evoked by 25 mM KCl stimulation. Nifedipine, diltiazem, nicardipine, flunarizine and pimozide did not affect the evoked and basal release of NE in the slice. But, diltiazem, nicardipine and flunarizine decreased the evoked NE release with a dose-related manner without any change of the basal release from synaptosomes. Also, a large dose... -
Modulation of L-type Ca2+ Channel Currents by Various Protein Kinase Activators and Inhibitors in Rat Clonal Pituitary GH3 Cell Line
YoungMinBae, Hye-JungBaek, HanaCho, YungEEarm, Won-KyungHo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 4 139-146 (8 pages)
L-type Ca2 channels play an important role in regulating cytosolic Ca2 and thereby regulating hormone secretions in neuroendocrine cells. Since hormone secretions are also regulated by various kinds of protein kinases, we investigated the role of some kinase activators and inhibitors in the regulation of the L-type Ca2 channel currents in rat pituitary GH3 cells using the patch-clamp technique. Phorbol 12,13-dibutyrate (PDBu), a protein kinase C (PKC) activator, and... -
Effects of Prostaglandin F2α on Membrane Potentials and K+ Currents in Rabbit Middle Cerebral Arterial Cells
NariKim, JinHan, WonGueKim, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.4 5 301-309 (9 pages)
The purpose of our investigation was to examine the effects of prostaglandin F2α (PGF2α) on membrane potentials, Ca2-activated K (KCa) channels, and delayed rectifier K (KV) channels using the patch-clamp technique in single rabbit middle cerebral arterial smooth muscle cells. PGF2α significantly hyperpolarized membrane potentials and increased outward whole-cell K currents. PGF2α increased open-state probability of KCa channels without the change of the open and... -
The Role of K+ Channels on Spontaneous Action Potential in Rat Clonal Pituitary GH3 Cell Line
HyewhonRhim, Hye-JungBaek, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 1 81-90 (10 pages)
repolarization process and produced membrane depolarization in all tested cells. This effect was observed even in TEA-untreated cells and was not mimicked by higher concentration of TEA (30 mM). Also this barium-induced membrane depolarization effect was still observed after L-type Ca2 channel was blocked by nicardipine (10μM). These results suggest that barium-sensitive current is important in SAP repolarization process and barium itself may have some depolarizing effect in GH3 cells. -
Mechanism of Vasoactive Intestinal Polypeptide-Induced Catecholamine Secretion from the Rat Adrenal Medulla
Dong-YoonLim, Jae-BongHeo, Cheol-HeeChoi, Geon-HanLim, Yong-GyoonLee, Song-HoonOh, Il-SikKim, Jong-InKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 6 443-454 (12 pages)
pretreatment with atropine or chlorisondamine. The releasing effects of CA evoked by either VIP or ACh were depressed by pretreatment with nicardipine, TMB-8, and the perfusion of Ca2-free medium. Moreover, VIP- as well as ACh-evoked CA secretory responses were markedly inhibited under the presence of (Lys1, Pro2.5, Arg3.4, Tyr6)-VIP or naloxone. CA secretory responses induced by ACh and high K (5.6⁓102 M) were potentiated by infusion of VIP (3⁓106M for 5... -
토끼 단일 심근세포에서 대사억제시 Inward Rectifier(IK1)의 변화 Effect of Metabolic Inhibition on Inward Rectifier K Current in Single Rabbit Ventricular Myocytes
정유정, 호원경, 엄융의, YuJeongChung, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 15 741-748 (8 pages)
In the present study, we have investigated the effect of metabolic inhibition on the inward rectifier K current (IK1). Using whole cell patch clamp technique we applied voltage ramp from 80 mV to 140 mV at a holding potential of 30 mV and recorded the whole cell current in single ventricular myocytes isolated from the rabbit heart. The current-voltage relationship showed N-shape (a large inward current and little outward current with a negative slope) which is a... -
Mechanism of Catecholamine Secretion Evoked by Lithium from the Isolated Perfused Rat Adrenal Gland
임동윤(Dong-Yoon Lim), 김철(Cheol Kim), 오형근(Hyeong-Geun Oh) 대한약리학회 대한약리학잡지 16 Pages
대한약리학회 대한약리학잡지 1996, 제 32권 제 3호 7 357-372 (16 pages)
adrenal vein for 2 hours in every experiments. Li-Krebs-evoked CA secretory responses were depressed significantly under loading with Ca++-free medium. This CA secretion evoked by lithium loading was also reduced markedly by the pretreatment with nicardipine (10-6 M), TMB-8 (10-5 M) and chlorisondamine (10-6 M) for 20 min, respectively, while was not affected by preloading with a pirenzepine (2 × 10-6 M)-containing Krebs. Na+ pump inhibition by pretreatment with ouabain (10-4 M) for 20 min did... -
흰쥐 관류부신에서 Pentazocine의 카테콜아민 분비작용의 기전
임동윤(Dong-Yoon Lim), 김봉한(Bong-Han Kim), 허재봉(Jae-Bong Heo), 최철희(Cheo-Hee Choi), 김진호(Jin-Ho Kim), 장영(Young Jang), 이재준(Jae-Joon Lee) 대한약리학회 대한약리학잡지 14 Pages
대한약리학회 대한약리학잡지 1994, 제 30권 제 3호 4 299-312 (14 pages)
× 10-6 M), nicardipine (10-6 M) 및 TMB-8(10-5 M)등의 전처치로 뚜렷이 억제되었으나 pirenzepine (2과 10-6 M)의 전처치에 의해서는 영향을 받지 않았다. Ca++-free Krebs 용액으로 30분간 관류한 후에 pentazocine의 CA 분비작용은 현저한 감소를 나타냈었다. Pentazocine (1.75 × 10-4 M)을 20분간 관류시킨 후에 ACh (5.32 × 10-3 M)과 DMPP (10-4 M)에 의한 CA 분비작용이 의의 있게 감약되었다. 이상과 같은 연구결과를 종합하면, pentazocine은 횐쥐 적출 관류부신에 투여시 현저한 CA 분비작용을 일으키고 있는 칼슘의존성... -
흰쥐 관류부신에서 Histamine 수용체 활성화가 Catecholamine 분비작용에 미치는 영향
임동윤(Dong-Yoon Lim), 노상현(Sang-Hyun Rho) 대한약리학회 대한약리학잡지 14 Pages
대한약리학회 대한약리학잡지 1993, 제 29권 제 1호 5 43-56 (14 pages)
CA 분비작용은 chlorisondamine, diphenhydrarmine, ranitidine, Ca++-free Krebs 용액의 관류, nicardipine 및 TMB-8 등의 전처치로 유의하게 억제 되었으나 pirenzepine의 전처치에 의해서는 별다른 영향을 받지 않았다. 더우기 histamine (6.8 × 10-5M)으로 30분간 관류시킨 후에 ACh (50μg)의 CA 분비작용이 상당히 억제됨을 나타내었다. 이상과 같은 연구 결과로 보아 histamine은 흰쥐 적출관류 부신에서 현저한 CA 분비작용을 나타내었으며 칼슘 의존성이었다. 이러한 CA 분비작용은 H1- 및 H2- 양수용체의 활성화를 통해서... -
Effect of Blood Pressure on the Endothelium-Dependent Contraction in Rat Aorta
Jeon, Byeong-Hwa, Kim, Hoe-Suk, Kim, Se-Hoon, Chang, Seok-Jong 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 1호 3 21-32 (12 pages)
contraction by acetylcholine and blood pressure was studied in spontaneously hypertensive rats (SHR), one-kidney, one clip Goldblatt hypertension (1K,1C-GBH) rats, and Wistar-Kyoto rats (WKY). SHR were treated orally with enalapril or nicardipine in order to prevent development of hypertension or suppress the developed hypertension. 1K,1C-GBH rats were made by renal artery stenosis with contralateral nephrectomy in 8 week-WKY. 1. Endothelium-dependent contractions by acetylcholine (10-6 ~ 10-5... -
Effect of Various Divalent Ions on the Calcium Current of Adrenal Medullary Chromaffin Cells in the Rat
Kim, Jun, Leem, Chae-Hun, Kim, Sang-Jeong 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 2호 2 113-122 (10 pages)
of culture, mean ±S.E.M.) and the kinetic parameters were not altered along the culture duration. Nicardipine (10 μM) blocked the current almost completely. Among treated divalent cations such as Cd2+, Co2+, Ni2+, Zn2+ and ,Mn2+, Cd2+ was the most potent blocker on VDCC. When the depolarizing step pulse from -80 mV to 10 mV was applied, the equilibrium dissociation constant (Kd) of Cd2+ was 39 μM, Kd of Co2+ was 100 μM and Kd of Ni2+];was];780μM. The principal findings of this study are as... -
Mechanism of Epibatidine-Induced Catecholamine Secretion in the Rat Adrenal Gland
Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.3 8 259-270 (12 pages)
the pretreatment with atropine, chlorisondamine, pirenzepine, nicardipine, TMB-8, and perfusion of Ca2-free Krebs solution containing EGTA, while was not affected by diphenhydramine. Moreover, the CA secretion evoked by ACh for 1st period (0∼4 min) was greatly potentiated by the simultaneous perfusion of epibatidine (1.5⁓108 M), but followed by time-dependently gradual reduction after 2nd period. The CA release evoked by high potassium (5.6⁓108 M) for 1st period... -
Rijndael 알고리즘을 이용한 물리 계층 ATM 셀 보안 기법
임성렬, 정기동, Im. Sung-Yeal, Chung. Ki-Dong 한국정보처리학회 정보처리학회논문지. The KIPS transactions. Part C Part C 12 Pages
한국정보처리학회 정보처리학회논문지. The KIPS transactions. Part C Part C 2006, No.0 83-94 (12 pages)
남아 있는 신조직무게를 비교하여 보면 24주째 0.25% sodium 식이군, 0.25% sodium 식이 enalapril군, 0.25% sodium 식이 nicardipine군에서 16주째 0.49% sodium 식이군, 0.49% sodium 식이 enalapril군, 0.49% sodium 식이 nicardipine 군보다 의의있게 신조직무게가 증가됨을 관찰할 수 없었다. 5) 0.25% sodium 식이군은 0.49% sodium 식이군과 비교하여 MES의 현저한 감소를 보였고 (0.25% sodium식이군: 12주; $1.97{pm}0.02$, 24주; $2.06{pm}0.03$ vs. 0.49% sodium 식이군: 12주; $2.29{pm}0.09$, 16주; <TEX>$2.55{pm}0. -
심바스타틴과 니카르디핀과의 약동학적 상호작용
최병철, 최준식, Choi. Byung-Chul, Choi. Jun-Shik 한국임상약학회 한국임상약학회지 5 Pages
한국임상약학회 한국임상약학회지 2009, Vol.19 No.1 32-36 (5 pages)
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흰쥐 부신수질 크로마핀세포의 칼슘통로 유형
Goo. Yong-Sook 한국의학물리학회 의학물리 12 Pages
한국의학물리학회 의학물리 2001, Vol.12 No.1 59-70 (12 pages)
패치클람프 테크닉을 적용하여 여러 종류의 칼슘통로가 존재한다는 것이 알려져 있으나 아직 종이 달라짐에 따라 다른 칼슘통로가 존재하는 지 여부가 확실하지 않다. 그러므로 본 연구에서는 흰쥐 부신수질 크로마핀 세포를 대상으로 하여 단일 세포 패치클람프 테크닉을 적용하여 이 세포에 존재하는 다양한 칼슘통로의 존재를 확인하고자 하였다. L형 칼슘통로 억제제인 nicardipine, N형 칼슘통로 억제제인 $omega$-CgTx GVIA, P형 칼슘통로 억제제인 $omega$-AgaTx IVA를 사용하여 L형, N형, P형 칼슘통로가 흰쥐 부신수질 세포에... -
인체 혈장 중 니카르디핀의 정량을 위한 HPLC 분석법 검증 및 단일 용량 투여에 의한 약물동태 연구
임호택, 조성희, 이헌우, 박완수, 류재환, 최영욱, 용철순, 이경태, Im. Ho-Taek, Cho. Sung-Hee, Lee. Heon-Woo, Park. Wan-Su, Rew. Jae-Hwan, Choi. Young-Wook, Yong. Chul-S 한국약제학회 藥劑學會誌 5 Pages
한국약제학회 藥劑學會誌 2005, Vol.35 No.6 461-465 (5 pages)
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Influences of Several Vasodilators on the Pain Threshold in Healthy Men
박명, 최훈, 마시모 다께시, 야기 마사하루, 사사키 시게타, 토미 카츠지, 요시야 이쿠토, Pak. Myong, Choe. Huhn, Mashimo. Takashi, Yagi. Masaharu, Sasaki. Shigeta, Tomi. Katsuji 대한통증학회 大韓痛症學會誌 5 Pages
대한통증학회 大韓痛症學會誌 1990, Vol.3 No.2 144-148 (5 pages)
정상인에서 Guanethidine Nicardipine Nitroglycerine Prostaglandin $E_1$을 피하주사하고 지속적인 복사열을 주사한 후에 Pain Meter NYT-5를 이용하여 동통역치를 측정하였다. 통증역치는 Guanethidine과 Nicardipine에 의해 상승되었으며 Nitroglycerine에 의해서는 거의 변화가 없고 Prostaglandin $E_1$에 의해서는 감소되었다. 이러한 변화는 지각신경섬유의 말단 감각수용체에 대한 감수성이 이들 혈관확장제에 대하여 서로 다른 작용을 나타내는것 같다. -
칼슘 길항제인 Nilvadipine과 Diltiazem의 고혈압 치료효과의 비교 관찰
박대균, 한기훈, 채인호, 이무용, 이명용, 김효수, 손대원, 오병희, 박영배, 최윤식, 이영우, 이명묵, Park. Dae-Gyun, Han. Ki-Hoon, Chai. In-Ho, Rhee. Moo-Yong, Lee. Myoung-Yong, Kim. Hyo 대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 11 Pages
대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 1996, Vol.4 No.2 174-184 (11 pages)
및 nicardipine에 비해 보다 소량으로 작용시간이 길다는 것이 확인되었다. 본 연구는 경도 또는 중등도의 본태성 고혈압으로 진단된 환자군에 대하여 nilvadipine의 혈압 강하 효과와 부작용 등을 평가하기 위해 기존에 그 효과 및 안정성에 대하여 널리 알려진 diltiazem을 이중 맹검법을 이용하여 비교 평가 하였다. 방 법 : 경도 내지 중등도의 고혈압 환자 66명을 무작위로 nilvadipine 치료군과 diltiazem 치료군으로 33명씩 분류하여 위약 투여 2주에 이어 8주간 치료제를 투여하였다. 혈압 강하 효과를 측정하기 위하여 위약 투여... -
고혈압 환자에서 칼슘차단제의 부작용에 관한 시판 후 조사
조홍준, 최현림, 서홍관, 양윤준, 신호철, 김경수, 김영주, 조경환, 이신휘, 정승필, 이정권, 안윤옥, 김영식, Cho. Hong-Jun, Choi. Hyun-Rim, Seo. Hong-Gwan, Yang. Yoon-Joon, Shin. Ho-Cheol, K 대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 8 Pages
대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 1994, Vol.2 No.2 118-125 (8 pages)
투여 후 하지부종의 발생률이 18.1%로, Nicardipine의 0.0%보다 높았다(P<0.05). 그 외 부작용으로는 변비 13예, 소화장애 8예, 오심 6예, 잇몸비후, 안면부종, 피로감이 각각 2예, 탈모증, 불면증, 허약감, 피부질환, 호흡곤란, 손발저림, 발한, 구강건조 등이각각 1예 있었다. 칼슘차단제 투여 후 부작용으로 인한 투약 중단율은 10.0% 였다. 결론 : 칼슘차단제 투여 시 혈관확장과 관련된 부작용의 발생률은 39%로 높았으나 시간경과에 따라 점차 없어져서 발생자중 10%정도에서만 증상이 지속되었으며, 안면홍조, 두통, 하지부종의... -
만성신부전 백서에서 항고혈압제의 종류에 따른 신부전의 진행과 사구체의 형태학적 변화
홍성진, 김교순, 김병길, 박경화, 김기혁, Hong. Sung-Jin, Kim. Kyo-Sun, Kim. Pyung-Kil, Park. Kyung-Hwa, Kim. Kee-Hyuck 대한소아신장학회 대한소아신장학회지 9 Pages
대한소아신장학회 대한소아신장학회지 2002, Vol.6 No.2 169-177 (9 pages)
저자들은 부분 신절제를 이용하여 만성신부전을 유발시킨 후 항고혈압제로 enalapril과 nicardipine을 투여하여 만성신부전의 진행에 미치는 영향을 조사하였다. 대상 및 방법 : 백서에서 5/6 신절제술로 만성신부전을 유발시킨 후 무작위로 대조군, enalapril 투여군(E군), nicardipine 투여군(N군)으로 나누어 4주 간격으로 꼬리 동맥압을 측정하고 12주째 24시간 소변 단백량과 creatinine배설량, 혈청 creatinine을 측정한 후 희생시켜 신조직을 광학현미경과 전자현미경으로 관찰하여 사구체의 형태학적 소견을 조사하였다. 결과 :... -
식이 sodium 제한 및 식이 sodium 제한에 따른 항고혈압제의 투여가 만성신부전증의 진행에 미치는 영향에 관한 실험적 연구
김기혁, 김상윤, 강용주, 맹원재, 김교순, Kim. Kee-Hyuk, Kim. Sang-Yun, Kang. Yong-Joo, Maeng. Won-Jae, Kim. Kyo-Sun 대한소아신장학회 대한소아신장학회지 10 Pages
대한소아신장학회 대한소아신장학회지 1999, Vol.3 No.2 170-179 (10 pages)
sodium 식이군, 0.49% sodium 식이 enalapril군, 0.49% sodium 식이 nicardipine 군보다 의의있게 신조직무게가 증가됨을 관찰할 수 없었다. 5) 0.25% sodium 식이군은 0.49% sodium 식이군과 비교하여 MES의 현저한 감소를 보였고 (0.25% sodium식이군: 12주; $1.97{pm}0.02$, 24주; $2.06{pm}0.03$ vs. 0.49% sodium 식이군: 12주; $2.29{pm}0.09$, 16주; $2.55{pm}0.16$, P<0.05) 12주 이후에 관찰한 MES는 0.25% sodium 식이군, 0.25% sodium 식이 enalapril군, 0.25% sodium 식이 nicardipine군 세군간의 통계적인 차이는 없었다.... -
압축코팅법에 의한 3단계 약물방출형 지속성제제의 제조 및 용출특성
김철수, 권혁노, 차봉진, 권종원, 양중익, 민신홍, Kim. Cheol-Soo, Kwon. Hyeok-Lo, Cha. Bong-Jin, Kwon. Jong-Won, Yang. Joong-Ik, Min. Shin-Hong 한국약제학회 藥劑學會誌 5 Pages
한국약제학회 藥劑學會誌 1992, Vol.22 No.2 133-137 (5 pages)
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Effects of Calcium Channel Blockers On Hyaluronidaseinduced Capillary Vascular Permeability
Halici. Zekai, Suleyman. Halis, Cadirci. Elif 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 9 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2008, Vol.31 No.7 891-899 (9 pages)
