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Preventive effects of imperatorin on perfluorohexanesulfonate-induced neuronal apoptosis via inhibition of intracellular calcium-mediated ERK pathway
EunkyungLee, So-YoungChoi, Jae-HoYang, YounJuLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.4 9 399-406 (8 pages)
Early life neuronal exposure to environmental toxicants has been suggested to be an important etiology of neurodegenerative disease development. Perfluorohexanesulfonate (PFHxS), one of the major perfluoroalkyl compounds, is widely distributed environmental contaminants. We have reported that PFHxS induces neuronal apoptosis via ERK-mediated pathway. Imperatorin is a furanocoumarin found in various edible plants and has a wide range of pharmacological effects including neuroprotection. In this... -
NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts
VuThiThu, HyoungKyuKim, LeThanhLong, ToThanhThuy, NguyenQuangHuy, SoonHaKim, NariKim, KyungSooKo, ByoungDooRhee, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 10 305-314 (10 pages)
Inflammatory and fibrotic responses are accelerated during the reperfusion period, and excessive fibrosis and inflammation contribute to cardiac malfunction. NecroX compounds have been shown to protect the liver and heart from ischemia-reperfusion injury. The aim of this study was to further define the role and mechanism of action of NecroX-5 in regulating infl ammation and fi brosis responses in a model of hypoxia/reoxygenation (HR). We utilized HR-treated rat hearts and lipopolysaccharide... -
Na+-Ca2+ Exchange Curtails Ca2+ before Its Diffusion to Global Ca2+i in the Rat Ventricular Myocyte
Sung-WanAhnChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 4 95-102 (8 pages)
In the heart, Na-Ca2 exchange (NCX) is the major Ca2 extrusion mechanism. NCX has been considered as a relaxation mechanism, as it reduces global [Ca2]i raised during activation. However, if NCX locates in the close proximity to the ryanodine receptor, then NCX would curtail Ca2 before its diffusion to global Ca2i. This will result in a global [Ca2]i decrease especially during its ascending phase rather than descending phase. Therefore, NCX would... -
임베디드 도로를 위한 차량하중 분석시스템 기초연구
조병완, 윤광원, 박정훈, 김헌, Jo. Byung-Wan, Yoon. Kwang-Won, Park. Jung-Hoon, Kim. Heoun 대한토목학회 大韓土木學會論文集, Journal of the Korean Society of Civil Engineers, D. 교통공학, 도로공학, 시공관리, 정보기술, 지역 및 도시계획, 철 6 Pages
대한토목학회 大韓土木學會論文集, Journal of the Korean Society of Civil Engineers, D. 교통공학, 도로공학, 시공관리, 정보기술, 지역 및 도시계획, 철 2011, Vol.31 127-132 (6 pages)
과적차량은 도로 및 교량 구조물과 도로 횡단 시설물 등에 손상요인으로 작용하며 기존의 단속 시스템은 많은 문제점을 내포하고 있어서 이에 대한 대처방안이 요구되고 있다. 이에 유전자 알고리즘 기법을 적용, 도로자체를 저울로 하여 주행중인 차량의 하중 및 주행정보를 분석한다면 지능형 임베디드 도로 시스템을 통한 효율적인 과적 단속이 이루어 질 수 있다 고 판단된다. 과적차량의 불법 축조작을 통한 단속의 문제점 해결 및 도로의 지능화를 위한 임베디드 차량하중분석 시스템을 위해서는 우선적으로 도로자체의 거동을... -
지능형 과적단속을 위한 시스템 구축 연구
조병완, 윤광원, 박정훈, 최지선, Jo. Byung-Wan, Yoon. Kwang-Won, Park. Jung-Hoon, Choi. Ji-Sun 한국전산구조공학회 한국전산구조공학회논문집 6 Pages
한국전산구조공학회 한국전산구조공학회논문집 2011, Vol.24 No.4 399-404 (6 pages)
과적차량은 도로관련 사회간접자본과 국가 경제적 측면, 교통류, 도로안전 등 다양한 측면에서 악영향을 미치고 있다. 이에 따라, 본 논문에서는 지능형 과적차량 단속시스템 개발을 위하여 유비쿼터스 센서네트워크(USN) 시스템을 구성하였다. 그리고 WIM(Weight-in-motion) 시스템과 달리 도로자체의 변형을 측정하여 주행중인 차량의 축을 감지한 후, 도로 하면에 부착된 변형률센서를 통하여 얻은 신호와 해석방법을 이용하여 차량의 중량을 계산하는 방안을 제시하였다. 또한 유전자알고리즘 기법의 차량하중 분석방법을 위한... -
Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers
Claudia Concha, María Daniella Carretta, Pablo Alarcón, Ivan Conejeros, Diego Gallardo, Alejandra Isabel H 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 2호 7 217-224 (8 pages)
and plasma lactic acid was recorded in these animals. Specifically, a decrease in PAF-induced ROS production was observed 8 h after oligofructose overload, and this was sustained until 48 h post oligofructose overload. A reduction in PAF-induced L-selectin shedding was observed at 16 h and 32 h post oligofructose overload. Overall, the results indicated that neutrophil PAF responses were altered in heifers with ruminal acidosis, suggesting a potential dysfunction of the innate immune response. -
Alteration of Striatal Tetrahydrobiopterin in Iron-Induced Unilateral Model of Parkinson’s Disease
BijayAryal, Jin-KooLee, , HakRimKim, , Hyung-GunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.2 6 129-134 (6 pages)
It has been suggested that transition metal ions such as iron can produce an oxidative injuries to nigrostriatal dopaminergic neurons, like Parkinson’s disease (PD) and subsequent compensative increase of tetrahydrobiopterin (BH4) during the disease progression induces the aggravation of dopaminergic neurodegeneration in striatum. It had been established that the direct administration of BH4 into neuron would induce the neuronal toxicity in vitro. To elucidate a role of BH4 in patho-genesis in... -
Inhibition of Sarcoplasmic Reticulum Ca2+ Uptake by Pyruvate and Fatty Acid in H9c2 Cardiomyocytes: Implications for Diabetic Cardiomyopathy
EunHeeLee, HyeKyungLee, HaeWonKim, Young-HoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.4 2 195-202 (8 pages)
High extracellular glucose concentration was reported to suppress intracellular Ca2 clearing through altered sarcoplasmic reticulum (SR) function. In the present study, we attempted to elucidate the effects of pyruvate and fatty acid on SR function and reveal the mechanistic link with glucose-induced SR dysfunction. For this purpose, SR Ca2-uptake rate was measured in digitonin-permeabilized H9c2 cardiomyocytes cultured in various conditions. Exposure of these cells to 5 mM...
