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구순구개열 환자의 악교정 수술 시 교정 치료 전략
정현주, 안효원 대한구순구개열학회 대한구순구개열학회지 9 Pages
대한구순구개열학회 대한구순구개열학회지 2020, 제 23권 1호 2 5-13 (9 pages)
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구순 - 치조열 파열환자에서 르포씨 1형 전진 - 전방 전진의 한계점
김동영, 안강민 대한구순구개열학회 대한구순구개열학회지 8 Pages
대한구순구개열학회 대한구순구개열학회지 2017, 제 20권 1호 5 41-48 (8 pages)
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The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats
Jong Soo Han, Young Sil Min, Gil Hyung Kim, Sang-hyun Chae, Yoonjin Nam, Jaehwi Lee, Seok-Yong Lee, Uy Dong Sohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 11 577-584 (8 pages)
Bladder dysfunction is a common complication of diabetes mellitus (DM). However, there have been a few studies evaluating bladder smooth muscle contraction in DM in the presence of pharmacological inhibitors. In the present study, we compared the contractility of bladder smooth muscle from normal rats and DM rats. Furthermore, we utilized pharmacological inhibitors to delineate the mechanisms underlying bladder muscle differences between normal and DM rats. DM was established in 14 days after... -
Pituitary Adenylate Cyclase-activating Polypeptide Inhibits Pacemaker Activity of Colonic Interstitial Cells of Cajal
MeiJinWu, KeunHongKee, JisunNa, SeokWonKim, YouinBae, DongHoonShin, SeokChoi, JaeYeoulJun, Han-SeongJeong, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 6 435-440 (6 pages)
This study aimed to investigate the effect of pituitary adenylate cyclase-activating peptide (PACAP) on the pacemaker activity of interstitial cells of Cajal (ICC) in mouse colon and to identify the underlying mechanisms of PACAP action. Spontaneous pacemaker activity of colonic ICC and the effects of PACAP were studied using electrophysiological recordings. Exogenously applied PACAP induced hyperpolarization of the cell membrane and inhibited pacemaker frequency in a dose-dependent manner (from... -
Effects of Lubiprostone on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Colon
Han-YiJiao, DongHyunKim, JungSukKi, KwonHoRyu, SeokChoi, JaeYeoulJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.4 9 341-346 (6 pages)
Lubiprostone is a chloride (Cl−) channel activator derived from prostaglandin E1 and used for managing constipation. In addition, lubiprostone affects the activity of gastrointestinal smooth muscles. Interstitial cells of Cajal (ICCs) are pacemaker cells that generate slow-wave activity in smooth muscles. We studied the effects of lubiprostone on the pacemaker potentials of colonic ICCs. We used the whole-cell patch-clamp technique to determine the pacemaker activity in cultured colonic... -
A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents
PuneetKaurRhawa, KavinderSingh, NirmalSingh, AmteshwarSinghJaggi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.4 1 279-288 (10 pages)
Ulcerative colitis and Crohn’s disease are a set of chronic, idiopathic, immunological and relapsing inflammatory disorders of the gastrointestinal tract referred to as inflammatory bowel disorder (IBD). Although the etiological factors involved in the perpetuation of IBD remain uncertain, development of various animal models provides new insights to unveil the onset and the progression of IBD. Various chemical-induced colitis models are widely used on laboratory scale. Furthermore, these... -
Mechanisms of Motility Change on Trinitrobenzenesulfonic Acid- Induced Colonic Inflammation in Mice
GabJinCheon, YuanCui, Dong-SooYeon, Seong-ChunKwon, Byong-GonPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 10 437-446 (10 pages)
Ulcerative colitis is an inflammatory bowel disease (IBD) characterized by recurrent episodes of colonic inflammation and tissue degeneration in human or animal models. The contractile force generated by the smooth muscle is significantly attenuated, resulting in altered motility leading to diarrhea or constipation in IBD. The aim of this study is to clarify the altered contractility of circular and longitudinal smooth muscle layers in proximal colon of trinitrobenzen sulfonic acid... -
Proteomic Analysis of Colonic Mucosal Tissue from Tuberculous and Ulcerative Colitis Patients
Seong-ChunKwon, KyungJongWon, SeoungHyoJung, KangPaLee, Dong-YoubLee, Eun-SeokPark, BokyungKim, GabJinCheon, KoonHeeHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 7 193-198 (6 pages)
Changes in the expression profiles of specific proteins leads to serious human diseases, including colitis. The proteomic changes related to colitis and the differential expression between tuberculous (TC) and ulcerative colitis (UC) in colon tissue from colitis patients has not been defined. We therefore performed a proteomic analysis of human TC and UC mucosal tissue. Total protein was obtained from the colon mucosal tissue of normal, TC, and UC patients, and resolved by 2-dimensional... -
The Preventive Effects of Bcl-2 and Bcl-xL on Lovastatin-induced Apoptosis of C6 Glial Cells
JaeWonChoi, JongMinLee, YoungJunOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 1 235-240 (6 pages)
It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented by Bcl-2 or Bcl-xL in C6 glial cells. Overexpression of human Bcl-2 or Bcl-xL prevented lovastatin (25μM)- induced changes such as DNA fragmentation, chromatin condensation, disruption of cell membrane, and cleavage of poly (ADP-ribose) polymerase. Lovastatin-induced inhibition of cell proliferation...
