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1201.

Characterization of ETB Receptor-mediated Relaxation in Precontracted Mesenteric Artery from Streptozotocin-induced Diabetic Rats

YangKiEom, KoanHoiKim, ByungYongRhim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.5 8 305-313 (9 pages)

YangKiEom, KoanHoiKim, ByungYongRhim 저
...
- 3,000원
from streptozotocin (STZ)-induced diabetic rats, which was not shown from control rats or in other arterial segments from diabetic rats. Accordingly, the goal of this study was to investigate in what way STZ-induced diabetes altered reactivity of the mesenteric arterial bed and to examine the causal relaxation, if any, between this ETB receptor-mediated relaxation and endothelial paracrine function, especially nitric oxide (NO) production. The relaxation induced by ETB agonists was not observed...
1202.

Morphine-induced Modulation of Nociceptive Spinal Dorsal Horn Neuronal Activities after Formalin-induced Inflammatory Pain

JooMinPark, KangWuLi, SungJunJung, JunKim, SangJeongKim, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 2 77-86 (10 pages)

JooMinPark, KangWuLi, SungJunJung, JunKim, SangJeongKim, 저
...
- 3,000원
of the nociceptive spinal dorsal horn neuronal activities before and after formalin-induced inflammatory pain. Intradermal injection of formalin induced time-dependent changes in the spontaneous activity of nociceptive dorsal horn neurons. In naïve cats before the injection of formalin, iontophoretically applied morphine attenuated the naturally and electrically evoked neuronal responses of dorsal horn neurons. However, neuronal responses after the formalin-induced inflammation were...
1203.

Effects of PCB Congeners in Rodent Neuronal Cells in Culture

Sun-YoungKimJae-HoYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 2 9-16 (8 pages)

Sun-YoungKimJae-HoYang 저
...
- 3,000원
a significant increase of total protein kinase C (PKC) activity at phobol 12,13-dibutyrate ([3H]PDBu) binding assay, indicating that non-coplanar PCBs are more neuroactive than coplanar PCBs in neuronal cells. PKC isozymes were immunoblotted with the selected monoclonal antibodies. PKC-α, δ, and ε were activated with non-coplanar PCB exposure. Receptor for activated C kinase-1 (RACK-1), anchoring protein for activated PKC, was more induced with exposure to coplanar PCBs than non-coplanar PCBs...
1204.

Hyperthermia-induced Apoptosis is Independent upon DNA Strand Breaks in Human Lymphoid Cells

HwaJinJung, WonHyeKa, JeeNaHwang, YoungRokSeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 9 345-350 (6 pages)

HwaJinJung, WonHyeKa, JeeNaHwang, YoungRokSeo 저
...
- 3,000원
a wide number of cell lines. In this study, we asked whether DNA strand breaks are responsible for this phenomenon. Using the highly sensitive comet assay for DNA damage detection, we were unable to demonstrate DNA breaks immediately after heat shock in Raji human lymphoid cells. It showed that DNA breaks were not necessary for hyperthermic apoptosis, since its activity is indicative of DNA lesions. Here, we present a suggestion that a protein(s) is the major target for heat shock apoptosis. We...
1205.

Economical Sweating Function in Africans: Quantitative Sudomotor Axon Reflex Test

Jeong-BeomLee, Jun-SangBae, Jeong-HwanChoi, Joo-HyunHam, Young-Ki 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 4 21-25 (5 pages)

Jeong-BeomLee, Jun-SangBae, Jeong-HwanChoi, Joo-HyunHam, Young-Ki 저
...
- 1,500원
to the dissimilar central and peripheral sweating mechanisms operating in people from both groups. In the present study, acetylcholine (ACh), the primary transmitter for the sudomotor functions, was iontophoretically administered to South Koreans and Africans to determine the characteristic sudorific responses of their acclimatized biologic make-up to their respective environments. Using quantitative sudomotor axon reflex test (QSART), direct (DIR) and axon reflex (AXR) responses were evaluated....
1206.

Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis

ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 3 131-142 (12 pages)

ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 저
...
- 4,100원
reduced affinity for spermine and persists in the absence of polyamines. Though the unitary current-voltage relation shows some inward rectification, it is insufficient to account for that seen under whole cell recording. Channels open and shut under single channel recording, and changes of Popen appear to generate inward rectification. In D172H, the reduction in affinity for spermine is greater when His is protonated at low pHi. The effective valency for spermine is reduced from 3.09⁑0.07...
1207.

Increase of Intracellular Ca2+ Concentration Induced by Lysophosphatidylcholine in Murine Aortic Endothelial Cells

MeiHongZhu, SungJinPark, HyunJinKim, DongKiYang, SukHyoSuh, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 5 93-100 (8 pages)

MeiHongZhu, SungJinPark, HyunJinKim, DongKiYang, SukHyoSuh, InsukSo, KiWhanKim 저
...
- 3,000원
measuring intracellular Ca2⁢ concentration ([Ca2⁢]i) with fura 2-AM and reverse transcription-polymerase chain reaction (RT-PCR). LPC increased [Ca2⁢]i under the condition of 1.5 mM [Ca2⁢]o but did not show any effect under the nominally Ca2⁢-free condition. Even after the store depletion with 30μM 2,5-di-tert- butylhydroquinone (BHQ) or 30μM ATP, LPC could still increase the [Ca2⁢]i under the condition of 1.5 mM [Ca2⁢]o. The time required to increase...
1208.

Nimodipine as a Potential Pharmacological Tool for Characterizing R-Type Calcium Currents

SeogBaeOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.6 8 511-519 (9 pages)

SeogBaeOh 저
...
- 3,000원
of nimodipine (＞10μM) further reduced the "residual" currents in DRG neurons from α1E knock-out mice, after blocking L-, N- and P/Q-type Ca currents with 10μM nimodipine, 1μM ω-conotoxin GVIA and 200 nM ω-agatoxin IVA, indicating inhibitory effects of nimodipine on R-type Ca currents. Nimodipine (＞10μM) also produced the inhibition of both low-voltage-activated calcium channel currents in DRG neurons and α1B and α1E subunit based Ca channel currents in heterologous system....
1209.

G Protein-Coupled Receptor Signaling in Gastrointestinal Smooth Muscle

UyDongSohn, DongSeokKim, KarnamSMurthy 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 1 287-297 (11 pages)

UyDongSohn, DongSeokKim, KarnamSMurthy 저
...
- 4,000원
(MLC) kinase and phosphorylation of MLC. The types of contraction and signaling mechanisms mediating contraction differ depending on the region. The involvement of these different mechanisms varies depending on the source of Ca2⁢ and the kinetic of Ca2⁢ mobilization. Ca2⁢ mobilizing agonists stimulate different phospholipases (PLC-β, PLD and PLA2) to generate one or more Ca2⁢ mobilizing messengers (IP3 and AA), and diacylglycerol (DAG), an activator of protein kinase C...
1210.

Enhancement of Cyclosporine-Induced Oxidative Damage of Kidney Mitochondria by Iron

Yoon-YoungJang, Eun-SookHan, Chung-SooLee, Young-KiKim, Jin-HoSong, Yong-KyooShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 12 631-640 (10 pages)

Yoon-YoungJang, Eun-SookHan, Chung-SooLee, Young-KiKim, Jin-HoSong, Yong-KyooShin 저
...
- 3,000원
The present study investigated the stimulatory effects of iron (or ascorbate) on cyclosporine-induced kidney mitochondrial damage. Damaging effect of 50 μM cyclosporine plus 20 μM Fe2⁢ on mitochondrial lipids and proteins of rat kidney and hyaluronic acid was greater than the summation of oxidizing action of each compound alone, except sulfhydryl oxidation. Cyclosporine and 100 μM ascorbate showed an enhanced damaging effect on lipids but not on proteins. The peroxidative action of...

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