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본문검색 결과만 보기
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단편 서열의 효율적인 가시화를 위한 지놈 브라우저 데이터베이스 설계
박민서, 김우연, 김판규, Park. Min-Seo, Kim. Woo-Yeon, Kim. Pan-Gyu 한국정보과학회 정보과학회논문지. Journal of KIISE. 데이타베이스 7 Pages
한국정보과학회 정보과학회논문지. Journal of KIISE. 데이타베이스 2012, Vol.39 No.1 30-36 (7 pages)
염기서열을 저장하는 파일형식인 SAM(Sequence Alignment/Map)파일로 구성된다. 하지만, 유전자 시퀀싱이 일반화되고 그 양이 증가함에 따라, 많은 양의 짧은 단편서열을 파일시스템으로 관리하는 것보다 지놈 브라우저에 알맞은 새로운 데이터베이스 설계를 활용하는 것이 요구된다. 본 연구에서는 데이터 저장 공간을 줄이고, 큰 용량의 유전체 데이터를 지놈 브라우저에 빨리 전달하고 명확한 가시화를 제공하기 위해 설계한 데이터베이스 구조를 제안한다. 제안한 데이터베이스는 줌 레벨을 고려하고, IOT(Index Organized Tables)와... -
Genetic characterization of bovine viral diarrhea virus strains in Beijing, China and innate immune responses of peripheral blood mononuclear cells in persistently infected dairy cattle
Xiao Gang Weng, Quan Jiang Song, Qiong Wu, Ming Chao Liu, Meng Ling Wang, Jiu Feng Wang 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 4호 13 491-500 (10 pages)
To acquire epidemiological data on the bovine viral diarrhea virus (BVDV) and identify cattle persistently infected (PI) with this virus, 4,327 samples from Holstein dairy cows were screened over a four-year period in Beijing, China. Eighteen BVD viruses were isolated, 12 from PI cattle. Based on genetic analysis of their 5’-untranslated region (5’-UTR), the 18 isolates were assigned to subgenotype BVDV-1m, 1a, 1d, 1q, and 1b. To investigate the innate immune responses in the peripheral-blood... -
Molecular characterization of Korean rabies virus isolates
Dong-Kun Yang*, Young-Nam Park, Gyeong-Soo Hong, Hee-Kyung Kang, Yoon-I Oh, Soo-Dong Cho, Jae-Young Song 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 1호 9 57-63 (7 pages)
The nucleoprotein (N) and glycoprotein (G) of 11 Korean rabies virus (RABV) isolates collected from animals diagnosed with rabies between 2008 and 2009 were subjected to molecular and phylogenetic analyses. Six isolates originated from domestic animals (cattle and dogs) and five were obtained from wild free-ranging raccoon dogs. The similarities in the nucleotide sequences of the N gene among all Korean isolates ranged from 98.1 to 99.8%, while those of the G gene ranged from 97.9 to 99.3%.... -
Pimecrolimus increases the melanogenesis and migration of melanocytes in vitro
PingXu, JieChen, ChengTan, Ren-ShengLai, Zhong-ShengMin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.3 2 287-292 (6 pages)
Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle and to restore the normal function of melanogenesis by residual melanocytes. There are two types of topical calcineurin inhibitors called tacrolimus and pimecrolimus, and are recommended as the first-line treatments in vitiligo. Although pimecrolimus is efficacious for the repigmentation of... -
Cytotoxic Activity and Structure Activity Relationship of Ceramide Analogues in Caki-2 and HL-60 Cells
YongJinKim, EunAeKim, UyDongSohn, ChulBuYim, ChaeukIm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 14 441-447 (7 pages)
B13, a ceramide analogue, is a ceramidase inhibitor and induces apoptosis to give potent anticancer activity. A series of thiourea B13 analogues was evaluated for their in vitro cytotoxic activities against human renal cancer Caki-2 and leukemic cancer HL-60 in the MTT assay. Some compounds (12, 15, and 16) showed stronger cytotoxicity than B13 and C6-ceramide against both tumor cell lines, and compound (12) gave the most potent activity with IC50 values of 36 and 9</SUB>ՌM,... -
Cytotoxic Activity and Three-Dimensional Quantitative Structure Activity Relationship of 2-Aryl-1,8-naphthyridin-4-ones
YongJinKim, EunAeKim, MiLyangChung, ChaeukIm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 16 511-516 (6 pages)
A series of substituted 2-arylnaphthyridin-4-one analogues, which were previously synthesized in our laboratory, were evaluated for their in vitro cytotoxic activity against human lung cancer A549 and human renal cancer Caki-2 cells using MTT assay. Some compounds (11, 12, and 13) showed stronger cytotoxicity than colchicine against both tumor cell lines, and compound 13 exhibited the most potent activity with IC50 values of 2.3 and 13.4</SUB>ՌM, respectively. Three-dimensional... -
Quantitative Structure Activity Relationship between Diazabicyclo[4.2.0]octanes Derivatives and Nicotinic Acetylcholine Receptor Agonists
EunAeKim, KyoungChulJung, UyDongSohn, ChaeukIm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.1 9 55-60 (6 pages)
Three dimensional quantitative structure activity relationship between diazabicyclo[4.2.0]octanes and nicotinic acetylcholine receptor (hՁ4Ղ2 and hՁ3Ղ4) agonists was studied using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA). From 11 CoMFA and CoMSIA models, CoMSIA with steric and electrostatic fields gave the best predictive models (q2=0.926 and 0.945, r2ncv=0.983 and 0.988). This study can be used to develop... -
Human Cerebellar Activation during Painful Cold Stimulation：a Functional Magnetic Resonance Imaging Study
Seung-Schik Yoo, Byung Gil Choi, Chang Uk Lee, Bum Soo Kim, , Su Jung Yoon, Soo Jung Lee, Tae Kim, Jung Jin Kim, Chul Lee, In Ho Paik 대한신경정신의학회 신경정신의학 7 Pages
대한신경정신의학회 신경정신의학 2001, 제 40권 제 4호 16 727-733 (7 pages)
반응을 평가하기 위해 일련의 susceptibility-weighted MR image를 측정하였고 대뇌활동 영 역을 시각화하고 정량화하는 statistical parametric map을 작성하였다. 결 과： 한랭 자극으로 인해 동통을 느끼는 동안 전/후 대상회전(cingulate gyri), 전두엽회(prefrontal gyri), 방사 섬이랑(insula)을 포함하는 대뇌영역뿐만 아니라, 네모소엽(quadrangular lobule), 널판소엽(gracile), 반월 소엽(semilunar lobules)과 같은 몇몇 소뇌영역이 활성화되었다. 결 론： 소뇌의 특정부위는 대뇌와 함께 동통 한랭 자극의 인지 및 처리과정에... -
Incidence of Alternaria Species Associated with Watermelon Leaf Blight in Korea
Oh-Kyu Kwon, A-Ram Jeong, Yong-Jik Jeong, Young-Ah Kim, Jaekyung Shim, Yoon Jeong Jang, Gung Pyo Lee, Chang-Jin Park 한국식물병리학회 The Plant Pathology Journal 10 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 4호 2 329-338 (10 pages)
Alternaria leaf blight is one of the most common dis- eases in watermelon worldwide. In Korea, however, the Alternaria species causing the watermelon leaf blight have not been investigated thoroughly. A total of 16 Alternaria isolates was recovered from diseased water- melon leaves with leaf blight symptoms, which were collected from 14 fields in Korea. Analysis of internal transcribed spacer (ITS) region, glyceraldehyde-3-phos- phate dehydrogenase (GAPDH), and RNA polymerase II second largest...
