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2571.

Thiobenzamide S-oxidation in Perfused Rat Liver Ex Vivo Determination of Hepatic Flavin-Containing Monooxygenase Activity

Woon-GyeChung, Hyung-KeunRoh, Young-NamCha 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 15 591-595 (5 pages)

Woon-GyeChung, Hyung-KeunRoh, Young-NamCha 저
...
- 1,500원
An ex vivo assay determining the flavin-containing monooxygenase (FMO) activity in perfused rat liver has been developed by assessing the rate of thiobenzamide S-oxide (TBSO) formation from the infused thiobenzamide (TB). The hepatotoxicity by TB or TBSO was not a critical factor for maintaining the FMO activity for up to 50 min. The FMO activity expressed in nmoles TBSO produced/g liver/min was the same for the recycling and non-recycling perfusion. This implies that reduction of the oxidized...
2572.

Regulatory Mechanisms of Angiotensin II on the Na+/H+ Antiport System in Rabbit Renal Proximal Tubule Cells. I. Stimulatory Effects of ANG II on Na+ Uptake

HoJaeHan, HyunJuKoh, SooHyunPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 8 413-423 (11 pages)

HoJaeHan, HyunJuKoh, SooHyunPark 저
...
- 4,000원
that of control). The stimulatory effect of ANG II on Na+ uptake was amiloride-sensitive and inhibited by losartan (ANG II receptor subtype 1 antagonist) and not by PD123319 (ANG II receptor subtype 2 antagonist). 2) Pertussis toxin (PTX) alone inhibited Na+ uptake by 85.52⁑3.52% of that of control. In addition, PTX pretreatment prevented the ANG II-induced stimulation of Na+ uptake. 8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP), forskolin, and isobutylmethylxanthine (IBMX) alone...
2573.

Induction of Apoptosis by Bile Acids in HepG2 Human Hepatocellular Carcinoma Cells

JinHyenBaek, Jung-AeKim, Chang-MoKang, YongSooLee, Kyu-WonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 14 107-115 (9 pages)

JinHyenBaek, Jung-AeKim, Chang-MoKang, YongSooLee, Kyu-WonKim 저
...
- 3,000원
We studied the effects of bile acids on the induction of apoptosis in HepG2 human hepatocellular carcinoma cells. Treatment with either ursodeoxycholic acid (UDCA) or lithocholic acid (LCA) resulted in a dose- and time-dependent decrease in cell viability assessed by MTT assay. Both UDCA and LCA also induced genomic DNA fragmentation, a hallmark of apoptosis, indicating that the mechanism by which these bile acids induce cell death was through apoptosis. Cycloheximide, a protein synthesis...
2574.

Mechanism of Action of Pancreatic Polypeptide (PP) on Pancreatic Exocrine Secretion in Isolated Rat Pancreas

YunLyulLee, HyeokYilKwon, HyungSeoPark, HyoungJinPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 11 83-90 (8 pages)

YunLyulLee, HyeokYilKwon, HyungSeoPark, HyoungJinPark 저
...
- 3,000원
Aim of this study was to investigate if pancreatic polypeptide (PP) reduced the insulin action via the intra-pancreatic cholinergic nerves in the isolated rat pancreas. The pancreas was isolated from rats and perfused with intra-arterial infusion of modified Krebs-Henseleit solution containing 2.5 mM glucose at a flow rate of 1.2 ml/min. Simultaneous intra-arterial infusion of insulin (100 nM) resulted in potentiation of the pancreatic flow rate and amylase output which were stimulated by...
2575.

瘦攀代理症性異常兒의 腦波所見例 14及6周波陽性棘波複合體에 關하여

明好鎭 대한신경정신의학회 신경정신의학 3 Pages

대한신경정신의학회 신경정신의학 1963, 제 2권 제 1호 18 81-83 (3 pages)

明好鎭 저
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- 1,500원
2576.

The Effect of Electroconvulsive Shock and Cholinergic Drugs on Anterograde Amnesia in Albino Rats

Geon-Ho Bahn, Hwan-Il Chang 대한신경정신의학회 신경정신의학 11 Pages

대한신경정신의학회 신경정신의학 1993, 제 32권 제 4호 9 534-544 (11 pages)

Geon-Ho Bahn, Hwan-Il Chang 저
...
- 4,000원
본 연구는 전기경련충격에 의한 장기적인 전진성 기억장애에 대한 동물모형의 개발과 콜린계 약물이 전기경련충격에 의한 기억장애에 미치는 효과를 알아보고자 실시하였다. 흰쥐에 전기경련 충격을 반복하여 시행한 후 왕복회피상자에서 피동성 도피학습一파지시 험간격을 달리하여 파지시험 결과를 측정하였고, 콜린계 약물들을 용량 및 시기별로 투여하여 파지시험 결과에 미치는 영향을 관찰하여 다음과 같은 결과를 얻었다. 1) 단일 전기경련충격을 받은 집단은 파지기능에 거의 영향을 받지 않았다. 2) 7회에 걸쳐 전기경련충격을...
2577.

Phenobarbital이 마우스의 酒精代謝에 미치는 影響

許光烈 대한신경정신의학회 신경정신의학 6 Pages

대한신경정신의학회 신경정신의학 1982, 제 21권 제 4호 16 687-692 (6 pages)

許光烈 저
...
- 3,000원
2578.

Role of Nitric Oxide as an Antioxidant in the Defense of Gastric Cells

김혜영(Hye-young Kim), 이은주(Eun-joo Lee), 김경환(Kyung Hwan Kim) 대한약리학회 대한약리학잡지 10 Pages

대한약리학회 대한약리학잡지 1996, 제 32권 제 3호 10 389-398 (10 pages)

김혜영(Hye-young Kim), 이은주(Eun-joo Lee), 김경환(Kyung Hwan Kim) 저
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- 3,000원
Gatric mucosa is exposed to toxic, reactive oxygen species generated within the lumen. Nitric oxide protected acetaminophen-induced hepatotoxicity by maintaining glutathione homeostasis. The present study examined the role of nitric oxide in mediating hydrogen peroxide - induced damage to gastric cells. Hydrogen peroxide was generated by glucose oxidase acting on β-D-glucose. L-arginine, NG-nitro-L-arginine methyl ester, or NG-nitro-L-arginine were treated to the cells with glucose/glucose...
2579.

Effects of Extracellular Ca++on PKC or cAMP-stimulated Increases in LH Release and LHβSubunit mRNA Levels in Rat Anterior Pituitary Cells

박덕배(Deok-bae Park), 김창미(Chang-mee Kim), 천민석(Min-seok Cheon), 유경자(Kyung-za Ryu) 대한약리학회 대한약리학잡지 10 Pages

대한약리학회 대한약리학잡지 1996, 제 32권 제 3호 6 347-356 (10 pages)

박덕배(Deok-bae Park), 김창미(Chang-mee Kim), 천민석(Min-seok Cheon), 유경자(Kyung-za Ryu) 저
...
- 3,000원
We examined the effects of EGTA and verapamil on phorbol ester-and forskolin-stimulated LH releases and LHβ subunit mRNA levels in order to verify the role of extracellular Ca++ on PKC- or cAMP-induced increases in LH release and LHβ subunit mRNA levels in cultured anterior pituitary cells of rat. Forskolin-stimulated LHβ subunit mRNA levels as well as LH release were all suppressed by prevention of Ca++ mobilization from extracellular environment, after the treatment of EGTA as a Ca++...
2580.

Pharmacological Action Mechanism(s) of Vasodilator Effect of Calcitonin Gene-related Peptide in Rat Basilar Arteries

임병용(Byung Yong Rhim), 홍선화(Sun Hwa Hong), 김치대(Chi Dae Kim), 이원석(Won Suk Lee), 김동헌(Dong Heon Kim), 홍기환(Ki Whan Hong) 대한약리학회 대한약리학잡지 12 Pages

대한약리학회 대한약리학잡지 1996, 제 32권 제 1호 5 39-50 (12 pages)

임병용(Byung Yong Rhim), 홍선화(Sun Hwa Hong), 김치대(Chi Dae Kim), 이원석(Won Suk Lee), 김동헌(Dong Heon Kim), 홍기환(Ki Whan Hong) 저
...
- 4,100원
In the present study, we observed change in intracellular Ca2+([Ca2+]i) as measured with the fluorescent Ca2+-indicator fura-2 in association with force development of the rat basilar arteries during activation byK+ depolarizing solution and U46619, a thromboxane analogue, in the absence and the presence of calcitonin-gent related peptide (CGRP). CGRP (30 and 100 nM) caused a concentration-dependent inhibition of U46619-induced contraction with decrease in [Ca2+]i, whereas it did not exert any...

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