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281.

Minimal Amount of Insulin Can Reverse Diabetic Heart Function Sarcoplasmic Reticulum Ca2+ Transport and Phospholamban Protein Expression

HaeWonKim, YongSunCho, YunSongLee, EunHeeLee, HeeRanLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 7 175-182 (8 pages)

HaeWonKim, YongSunCho, YunSongLee, EunHeeLee, HeeRanLee 저
...
- 3,000원
In the present study, the underlying mechanisms for diabetic functional derangement and insulin effect on diabetic cardiomyopathy were investigated with respect to sarcoplasmic reticulum (SR) Ca2⁢-ATPase and phospholamban at the transcriptional and translational levels. The maximal Ca2⁢ uptake and the affinity of Ca2⁢-ATPase for Ca2⁢ were decreased in streptozotocin-induced diabetic rat cardiac SR, however, even minimal amount of insulin could reverse both parameters....
282.

The Effects of Sera from Amyotrophic Lateral Sclerosis Patients on Neuromuscular Transmission and Calcium Channels in Mice

HaiDunYan, JimokKim, SungJunJung, JunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 17 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 13 101-117 (17 pages)

HaiDunYan, JimokKim, SungJunJung, JunKim 저
...
- 4,600원
Amyotrophic lateral sclerosis (ALS) is a degenerative neuromuscular disease of unknown etiology in which the upper and lower motor neurons are progressively destroyed. Recent evidences support the role of autoimmune mechanisms in the pathogenesis of ALS. This study investigated the effects of sera from ALS patients on neuromuscular transmission in phrenic nerve-hemidiaphragm preparations and on calcium currents of single isolated dorsal root ganglion (DRG) cells in mice. Mice were injected with...
283.

Role of Phospholipase A2 in Hypoxia-Induced Renal Cell Injury

WonRakChoi, SunHeeKo, SuInCho, JaeSukWoo, JinSupJung, SangHoLee, YongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 12 93-100 (8 pages)

WonRakChoi, SunHeeKo, SuInCho, JaeSukWoo, JinSupJung, SangHoLee, YongKeunKim 저
...
- 3,000원
The present study was designed to assess the roles of PLA2 activation and arachidonic acid (AA) metabolites in hypoxia-induced renal cell injury. Hypoxia increased LDH release in a dose-dependent manner in rabbit renal cortical slices, and this increase was significant after 20-min hypoxia. The hypoxia-induced LDH release was prevented by amino acids, glycine and alanine, and extracellular acidosis (pH 6.0). Buffering intracellular Ca2⁢ by a chelator, but not omission of Ca2⁢ in the...
284.

Regulation of Magnesium Release by cAMP during Chemical Hypoxia in the Rat Heart and Isolated Ventricular Myocytes

JinShangKimAntonioScarpa 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 8 59-68 (10 pages)

JinShangKimAntonioScarpa 저
...
- 3,000원
Chemically induced hypoxia has been shown to induce a depletion of ATP. Since intracellular free Mg2⁢ ([Mg2⁢]i) appears to be tightly regulated following cellular energy depletion, we hypothesized that the increase in [Mg2⁢]i would result in Mg2⁢ extrusion following hormonal stimulation. To determine the relation between Mg2⁢ efflux and cellular energy state in a hypoxic rat heart and isolated myocytes, [Mg2⁢]i, ATP and Mg2⁢ content were measured by...
285.

Altered Cerebral Vasomotion with Decreased CGRP Level in Pial Arteries of Spontaneously Hypertensive Rats

KwangHoLee, JaeMoonChoi, KiWhanHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 5 573-580 (8 pages)

KwangHoLee, JaeMoonChoi, KiWhanHong 저
...
- 3,000원
The study aims to identify the mechanism (s) underlying the altered vasodilatory responses of the pial artery of spontaneously hypertensive rats (SHR) under a hypothesis that calcitonin gene-related peptide (CGRP) exerts a modulator role in the autoregulation of cerebral blood flow (CBF). The animals were divided into four groups: 1) Sprague-Dawley rats (SDR), 2) Wistar rats (WR), 3) SHR with high blood pressure (BP≥150 mmHg), and 4) SHR with normotensive BP (≤150 mmHg). The lower limit of...
286.

Natriuresis Induced by Intracerebroventricular Diazepam in Rabbits

Jeong-TaeKohYoung-JohngKook 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 3 555-563 (9 pages)

Jeong-TaeKohYoung-JohngKook 저
...
- 3,000원
after 3 min. The plasma level of atrial natriuretic peptide (ANP) increased 7-fold, the peak coinciding with the natriuresis and diuresis. Muscimol, a GABAergic agonist, 1.0 ㄍg/kg given icv, elicited marked antidiuresis and antinatriuresis, accompanied by decreases in systemic blood pressure and renal hemodynamics. When icv 0.3 ㄍg/kg muscimol was given 3 min prior to 30 ㄍg/kg of diazepam icv, urinary flow and Na excretion rates did not change significantly, while systemic...
287.

Effect of the Inhibition of Platelet Activating Factor on Oxidative Lung Injury Induced by Interleukin-1α

YoungManLeeYoon-YubPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 13 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 10 479-491 (13 pages)

YoungManLeeYoon-YubPark 저
...
- 4,200원
In order to know the pathogenesis of adult respiratory distress syndrome (ARDS) in association with the oxidative stress by neutrophils, the role of platelet activating factor (1-0-alkyl-2-acetyl-sn- glycero-3-phosphocholine, PAF) was investigated during acute lung injury induced by interleukin- 1α (IL-1) in rats. An insufflation of IL-1 into the rat's trachea increased the acetyltransferase activity in the lung and the increase of PAF content was followed. As evidences of acute lung injury by...
288.

Mechanism of Vasoactive Intestinal Polypeptide-Induced Catecholamine Secretion from the Rat Adrenal Medulla

Dong-YoonLim, Jae-BongHeo, Cheol-HeeChoi, Geon-HanLim, Yong-GyoonLee, Song-HoonOh, Il-SikKim, Jong-InKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 6 443-454 (12 pages)

Dong-YoonLim, Jae-BongHeo, Cheol-HeeChoi, Geon-HanLim, Yong-GyoonLee, Song-HoonOh, Il-SikKim, Jong-InKim 저
...
- 4,100원
The present study was attempted to investigate the effect of vasoactive intestinal polypeptide (VIP) on secretion of catecholamines (CA) and to establish whether there is the existence of a noncholinergic mechanism in adrenomedullary CA secretion from the isolated perfused rat adrenal gland. The perfusion into an adrenal vein of VIP (3⁓10⁣6 M) for 5 min or the injection of acetylcholine (ACh, 5.32⁓10⁣3 M) resulted in great increases in CA secretion. Tachyphylaxis to...
289.

In Vitro Cytotoxicity of Novel Platinum(II) Coordination Complexes Containing Diaminocyclohexane and Diphenylphosphines

Jee-ChangJung, Young-KyuKim, Seung-JoonPark, Joo-HoChung, Sung-GooChang, Kyung-TaeLee, Min-SonBaek, Jong-JipPark, Young-SooRho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 15 395-401 (7 pages)

Jee-ChangJung, Young-KyuKim, Seung-JoonPark, Joo-HoChung, Sung-GooChang, Kyung-TaeLee, Min-SonBaek, Jong-JipPark, Young-SooRho 저
...
- 3,000원
We have synthesized new platinum(II) analogs containing 1,2-diaminocyclohexane (dach) as a carrier ligand, 1,3-bis(diphenylphosphino) propane (DPPP) /1,2-bis(diphenylphosphino)ethane (DPPE) as a leaving group and nitrates to improve solubility. In the present study, the cytotoxicity of [Pt(trans-l-dach)(DPPP)]·2NO3 (KHPC-001) and [Pt(trans-l-dach)(DPPE)]·2NO3 (KHPC-002) was evaluated and compared on various P-388 cancer cell lines and porcine kidney cell line (LLC-PK1). The new platinum...
290.

Molecular Pharmacological Interaction of Phenylbutazone to Human Neutrophil Elastase

KooilKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 14 385-393 (9 pages)

KooilKang 저
...
- 3,000원
Human neutrophil elastase (HNElastase, EC 3.4.21.37), a causative factor of inflammatory diseases, was purified by Ultrogel AcA54 gel filtration and CM-Sephadex ion exchange chromatography. HNElastase was inhibited by phenylbutazone in a concentration dependent manner up to 0.4 mM, but as the concentration increased, the inhibitory effect gradually diminished. Binding of phenylbutazone to the human neutrophil elastase caused strong Raman shifts at 200, 440, and 1194 cm⁣1. The peak at 1194...

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