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341.

Zn2+ Modulates the Responses of Rat Dorsal Horn Neuron to C-Fiber Stimulation and Excitatory Amino Acids

ChangHoonAhn, HongKeeShin, JinHyukKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 3 445-453 (9 pages)

ChangHoonAhn, HongKeeShin, JinHyukKim 저
...
- 3,000원
Zinc contained in the neurons of central nervous system is activity-dependently released and then attenuates NMDA (N-methyl-D-aspartate)-induced neurotoxicity while augmenting non-NMDA-induced neurodegeneration. Zinc also has been reported to produce antinociceptive action on the inflammation- and nerve injury-induced hyperalgesia in the behavioral test. In this study, we investigated the effects of zinc on the responses of dorsal horn cells to NMDA, kainate and graded electrical stimulation of...
342.

Stationary Outward and Transient Ca2+-Dependent Currents in Hamster Oocytes

Yang-MiKim, Jae-HeeHan, Jong-SuKim, Seong-GeunHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 9 403-408 (6 pages)

Yang-MiKim, Jae-HeeHan, Jong-SuKim, Seong-GeunHong 저
...
- 3,000원
(I-V) relation was a mirror image of that of ICa. Either blockade of ICa by Co2⁢ or replacement of Ca2⁢ with Sr2⁢ abolished Ito without change in I∞. Intracellular EGTA (10 mM) inhibited Ito but not I∞. suggesting strongly that generation of Ito requires intracellular Ca2⁢. Apamin (1 nM) abolished selectively Ito, indicating that Ito is Ca2⁢-dependent K⁢ current. On the other hand, I∞ was Ca2⁢- independent. Both Ito and I∞ were completely inhibited b...
343.

Endotoxin-induced Acute Lung Injury is Mediated by PAF Produced via Remodelling of Lyso PAF in the Lungs

YoungManLee, TeoanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 6 219-226 (8 pages)

YoungManLee, TeoanKim 저
...
- 3,000원
In order to elucidate the role of platelet activating factor (PAF) in the acute lung injury induced by endotoxin (ETX), activities of phospholipase A2, lyso PAF acetyltransferase and oxidative stress by neutrophilic respiratory burst were probed in the present study. To induce acute lung injury, 100μg of E.coli ETX (type 0127; B8) was instilled directly into the tracheae of Sprague-Dawley rats. Five hours after the ETX instillation, induction of acute lung injury was confirmed by lung leak...
344.

Developmental Changes of Gustatory Neurons in Nucleus of Solitary Tract in Rats

MiwonKim, WonjaeKim, CharlotteMistretta 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 1 169-175 (7 pages)

MiwonKim, WonjaeKim, CharlotteMistretta 저
...
- 3,000원
did not show any significant differences during the postnatal 3 weeks. The time constant, however, decreased during the development. Duration of action potential measured at half maximum amplitude was longer in younger age groups. Both the maximum rate of rise and the maximum rate of fall in the action potential increased during the first 3 weeks postnatal. Electrophysiologically more than half neurons were type III. In summary, it is suggested that developmental changes in electrophysiological...
345.

Responses of Dorsal Horn Neurons to Peripheral Chemical Stimulation in the Spinal Cord of Anesthetized Cats

SungJunJung, JooMinPark, JoonHoLee, JiHyeLee, Su-YongEun, SangJeongKim, Won-IlLim, SunHeeCho, JunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 3 15-24 (10 pages)

SungJunJung, JooMinPark, JoonHoLee, JiHyeLee, Su-YongEun, SangJeongKim, Won-IlLim, SunHeeCho, JunKim 저
...
- 3,000원
Although nociceptive informations are thought to be processed via different neural mechanisms depending on the types of stimuli, sufficient data have not been accumulated yet. We performed a series of experiments to elucidate the possible neural mechanisms as to chemical stimuli such as formalin, capsaicin and ATP. Single unit activity of wide dynamic range (WDR) neurons and high threshold cells were recorded extracellularly from the lumbosacral enlargement of cat spinal cord before and after...
346.

Effect of C1 Esterase Inhibitor on the Cardiac Dysfunction Following Ischemia and Reperfusion in the Isolated Perfused Rat Heart

Geon-YoungLee, Yong-KyooShin, Yoon-YoungJang, Jin-HoSong, Dae-JoongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 6 579-586 (8 pages)

Geon-YoungLee, Yong-KyooShin, Yoon-YoungJang, Jin-HoSong, Dae-JoongKim 저
...
- 3,000원
Complement-mediated neutrophil activation has been hypothesized to be an important mechanism of reperfusion injury. It has been proposed that C1 esterase inhibitor (C1 INH) may prevent the complement- dependent activation of polymorphonuclear leukocytes (PMNs) that occurs within postischemic myocardium. Therefore, The effect of C1 INH was examined in neutrophil dependent isolated perfused rat heart model of ischemia (I) (20 min) and reperfusion (R) (45 min). Administration of C1 INH (5 mg/Kg)...
347.

Role of K+ Channels to Resting Membrane Potential of Rabbit Middle Cerebral Arterial Smooth Muscle Cells

NariKim, JinHan, EuiyongKim, Yun-HeeKim, Jae-HongSim, Soo-CheonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 2 547-554 (8 pages)

NariKim, JinHan, EuiyongKim, Yun-HeeKim, Jae-HongSim, Soo-CheonKim 저
...
- 3,000원
reduced the membrane currents, abolished STOCs, and decreased the open probability of single KCa channel. When KV currents were isolated, the application of 4-AP (5 mM) depolarized the RMP. The important aspect of our results is that KCa channel is responsible for the generation of the STHPs in the membrane potential and plays an important role in the regulation of the RMP and KV channel is also responsible for the regulation of the RMP in rabbit middle cerebral arterial smooth muscle cells.
348.

Effect of Ethanol on Na+-Pi Uptake in Opossum Kidney Cells Role of Membrane Fluidization and Reactive Oxygen Species

InHoPark, MoonYoungHwang, JaeSukWoo, JinSupJung, YongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 10 529-538 (10 pages)

InHoPark, MoonYoungHwang, JaeSukWoo, JinSupJung, YongKeunKim 저
...
- 3,000원
This study was undertaken to examine the effect of ethanol on Na⁢-dependent phosphate (Na⁢-Pi) uptake in opossum kidney (OK) cells, an established renal proximal tubular cell line. Ethanol inhibited Na⁢-dependent component of phosphate uptake in a dose-dependent manner with I50 of 8.4%, but it did not affect Na⁢-independent component. Similarly, ethanol inhibited Na⁢-dependent uptakes of glucose and amino acids (AIB, glycine, alanine, and leucine). Microsomal...
349.

Characteristics of Hypoxic Pulmonary Vasoconstriction of the Rat Study by the Vessel Size and Location in the Lung

Sang-JinLeeKiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 10 321-328 (8 pages)

Sang-JinLeeKiWhanKim 저
...
- 3,000원
Pulmonary blood vessels with diameters of 200∼400 μm produce considerably more force in response to vasoconstrictor drugs than those which are either smaller or larger. We have therefore investigated whether or not hypoxic pulmonary vasoconstriction (HPV) is more powerful in vessels of these diameters. We have also looked at the possibility that vessels from different regions of the lung respond differently. To do this we have grouped vessels according to their location within the lung as...
350.

Opening of ATP-sensitive K+ Channel by Pinacidil Requires Serine/ Threonine Phosphorylation in Rat Ventricular Myocytes

Yong-GeunKwakSoo-WanChae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 7 293-303 (11 pages)

Yong-GeunKwakSoo-WanChae 저
...
- 4,000원
The influences of specific protein phosphatase and protein kinase inhibitors on the ATP-sensitive K⁢ (KATP) channel-opening effect of pinacidil were investigated in single rat ventricular myocytes using patch clamp technique. In cell-attached patches, pinacidil (100 μM) induced the opening of the KATP channel, which was blocked by the pretreatment with H-7 (100 μM) whereas enhanced by the pretreatment with genistein (30 μM) or tyrphostin A23 (10 μM). In inside-out patches, pinacidil...

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