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371.

The Pathophysiologic Roles of TRPM7 Channel

HyunSooPark, ChansikHong, ByungJooKim, InsukSo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 2 15-23 (9 pages)

HyunSooPark, ChansikHong, ByungJooKim, InsukSo 저
...
- 3,000원
Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg2＋ and Ca2＋, and its channel activity is negatively regulated by free Mg2＋ and Mg-complexed nucleotides. Recent studies have investigated the relationships between TRPM7 and a number of diseases. TRPM7 regulates cell...
372.

Spontaneous Electrical Activity of Cultured Interstitial Cells of Cajal from Mouse Urinary Bladder

Sun-OuckKim, Han-SeongJeong, SujeongJang, Mei-JinWu, JongKyuPark, Han-YiJiao, JaeYeoulJun, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.6 9 531-536 (6 pages)

Sun-OuckKim, Han-SeongJeong, SujeongJang, Mei-JinWu, JongKyuPark, Han-YiJiao, JaeYeoulJun, Jong-SeongPark 저
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- 3,000원
Interstitial cells of Cajal (ICCs) from the urinary bladder regulate detrusor smooth muscle activities. We cultured ICCs from the urinary bladder of mice and performed patch clamp and intracellular Ca2+ ([Ca2+]i) imaging to investigate whether cultured ICCs can be a valuable tool for cellular functional studies. The cultured ICCs displayed two types of spontaneous electrical activities which are similar to those recorded in intact bladder tissues. Spontaneous electrical activities of cultured...
373.

The Effect of Metformin Treatment on CRBP-I Level and Cancer Development in the Liver of HBx Transgenic Mice

Jo-HeonKim, Md.MorshedulAlam, DoekBaePark, MoonjaeCho, Seung-HongLee, You-JinJeon, Dae-YeulYu, TaeDuKim6, HaYoungKim, ChungGuCho, DaeHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 12 455-461 (7 pages)

Jo-HeonKim, Md.MorshedulAlam, DoekBaePark, MoonjaeCho, Seung-HongLee, You-JinJeon, Dae-YeulYu, TaeDuKim6, HaYoungKim, ChungGuCho, DaeHoLee 저
...
- 3,000원
Retinoids regulate not only various cell functions including proliferation and differentiation but also glucose and lipid metabolism. After we observed a marked up-regulation of cellular retinol-binding protein-I (CRBP-I) in the liver of hepatitis B virus x antigen (HBx)-transgenic (HBx Tg) mice which are prone to hepatocellular carcinoma (HCC) and fatty liver, we aimed to evaluate retinoid pathway, including genes for the retinoid physiology, CRBP-I protein expression, and retinoid levels, in...
374.

Activation of G Proteins by Aluminum Fluoride Enhances RANKL- Mediated Osteoclastogenesis

BoryungPark, Yu-MiYang, Byung-JaiChoi, MinSeukKim, DongMinShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 8 427-433 (7 pages)

BoryungPark, Yu-MiYang, Byung-JaiChoi, MinSeukKim, DongMinShin 저
...
- 3,000원
influx. Notably, co-stimulation of AlF4− with RANKL resulted in enhanced NFATc1 expression and formation of tartrate-resistant acid phosphatase (TRAP) positive multinucleated cells. Additionally, we confirmed that mitogen-activated protein kinase (MAPK) is also activated by AlF4−. Taken together, these results demonstrate that G-protein would be a novel modulator responsible for [Ca2＋]i oscillations and MAPK activation which lead to enhancement of RANKL-mediated osteoclastogenesis.
375.

Effects of Vitamin D on Blood Pressure and Endothelial Function

BokyungMin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 2 385-392 (8 pages)

BokyungMin 저
...
- 3,000원
Vitamin D deficiency is prevalent, primarily due to limited sun exposure, which may be observed in urban areas, or as a result of modern lifestyles. Common myths about vitamin D persist, including that it is mostly obtained from the diet and is only essential for bone and mineral homeostasis. Nonetheless, advances in biomedical science suggest that vitamin D is a hormone that is integral to numerous physiologic functions in most cells and tissues. Therefore, abnormal vitamin D levels may...
376.

Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells

Yun-HeeBae, JongHyoRyu, Hyun-JooPark, KwangRokKim, Hee-JunWee, Ok-HeeLee, Hye-OckJang, Moon-KyoungBae, Kyu-WonKim, Soo-KyungBae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 6 291-297 (7 pages)

Yun-HeeBae, JongHyoRyu, Hyun-JooPark, KwangRokKim, Hee-JunWee, Ok-HeeLee, Hye-OckJang, Moon-KyoungBae, Kyu-WonKim, Soo-KyungBae 저
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- 3,000원
MDA-MB-231 triple-negative human breast cancer cells. The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis. We found that curcumin treatment resulted in an induction of apoptosis in MDA-MB-231 cells, together with downregulation of Notch1 and its downstream target, Hes1. This reduction in Notch1 expression was determined to be due...
377.

(-)-Epigallocatechin-3-gallate Modulates the Differential Expression of Survivin Splice Variants and Protects Spermatogenesis During Testicular Torsion

NadaAl-Ajmi, MayAl-Maghrebi, WaleedMohammedRenno 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 2 259-265 (7 pages)

NadaAl-Ajmi, MayAl-Maghrebi, WaleedMohammedRenno 저
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- 3,000원
The anti-apoptotic effect of (-)-epigallocatechin-3-gallate (EGCG) during unilateral testicular torsion and detorsion (TT/D) was established in our previous study. In mice, the smallest inhibitor of apoptosis, survivin, is alternatively spliced into three variants, each suggested to have a unique function. Here, we assessed how EGCG exerts its protective effect through the expression of the different survivin splice variants and determined its effect on the morphology of the seminiferous tubules...
378.

Cytotoxic Activity and Quantitative Structure Activity Relationships of Arylpropyl Sulfonamides

YuJinHwang, SangMinPark, ChulBuYim, ChaeukIm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.3 9 237-243 (7 pages)

YuJinHwang, SangMinPark, ChulBuYim, ChaeukIm 저
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- 3,000원
29.2 and 20.7 ՌM, for PC-3and HL-60 cells, respectively. Three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis was performed to build highly reliable and predictive CoMSIA models with cross-validated q2 values of 0.816 and 0.702, respectively. Our results suggest that long alkyl chains and a 1R, 2R configuration of the propyl group are important for the cytotoxic activities of arylpropyl sulfonamides. Moreover, the introduction of small hydrophobic groups in the...
379.

Resveratrol Inhibits GABAC Ց Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes

Byung-HwanLee, Sun-HyeChoi, Sung-HeeHwang, Hyeon-JoongKim, Joon-HeeLee, Seung-YeolNah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.2 10 175-180 (6 pages)

Byung-HwanLee, Sun-HyeChoi, Sung-HeeHwang, Hyeon-JoongKim, Joon-HeeLee, Seung-YeolNah 저
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- 3,000원
on the channel activity of homomeric GABAC receptor expressed in Xenopus oocytes injected with cRNA encoding human GABAC Ց subunits. Our data show that the application of GABA elicits an inward peak current (IGABA) in oocytes that express the GABAC receptor. Resveratrol treatment had no effect on oocytes injected with H2O or with GABAC receptor cRNA. Co-treatment with resveratrol and GABA inhibited IGABA in oocytes with GABAC receptors. The inhibition of IGABA by resveratrol was in a...
380.

TRPM7 Is Essential for RANKL-Induced Osteoclastogenesis

Yu-MiYang, Hwi-HoonJung, SungJunLee, Hyung-JunChoi, MinSeukKim, DongMinShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 10 65-71 (7 pages)

Yu-MiYang, Hwi-HoonJung, SungJunLee, Hyung-JunChoi, MinSeukKim, DongMinShin 저
...
- 3,000원
The transient receptor potential melastatin type 7 (TRPM7) channel is a widely expressed non- selective cation channel with fusion to the C-terminal alpha kinase domain and regarded as a key regulator of whole body Mg2+ homeostasis in mammals. However, the roles of TRPM7 during osteoclastogenesis in RAW264.7 cells and bone marrow-derived monocyte/macrophage precursor cells (BMMs) are not clear. In the present study, we investigate the roles of TRPM7 in osteoclastogenesis using methods of small...

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