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951.

Sensitivity of Rabbit Cerebral Artery to Serotonin is Increased with the Moderate Increase of Extracellular K+

SukHyoSuh, SungJinPark, JaiYoungChoi, JaeHoonSim, YoungChulKim, SungJoonKim, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 6 695-703 (9 pages)

SukHyoSuh, SungJinPark, JaiYoungChoi, JaeHoonSim, YoungChulKim, SungJoonKim, InsukSo, KiWhanKim 저
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- 3,000원
mM or 12 mM. On the contrary, the contractions induced by serotonin were significantly increased with the elevation of [K⁢]O. The contractions were also significantly increased by the treatment with nitro-L-arginine (10⁣4 M for 20 minutes). In the nitro-L-arginine treated arteries, the contractions induced by serotonin were significantly increased with the elevation of [K⁢]O from 6 mM to 12 mM. K⁢-induced relaxation was evoked with the stepwise increment of extracellular...
952.

Effects of Dopamine and Haloperidol on Morphine-induced CREB and AP-1 DNA Binding Activities in Differentiated SH-SY5Y Human Neuroblastoma Cells

Soo-kyungKimGee-younKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 3 671-676 (6 pages)

Soo-kyungKimGee-younKwon 저
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- 3,000원
In the present study, we first examined whether the changes in the DNA binding activities of the transcription factors, cAMP response element binding protein (CREB) and activator protein-1 (AP-1) mediate the long-term effects of morphine in differentiated SH-SY5Y human neuroblastoma cells. The increases in CREB and AP-1 DNA binding activities were time-dependent up to 6 days of morphine treatment (1, 4, and 6 days). However, the significant reduction in the DNA binding activities of CREB and...
953.

Angiotensin-Converting Enzyme Gene Polymorphism is not Associated with Myocardial Infarction in Koreans

SeokChaiDong-RyulSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 13 645-650 (6 pages)

SeokChaiDong-RyulSohn 저
...
- 3,000원
typed by polymerase chain reaction. The I allelic frequency of ACE gene in Korean subjects was irrelavant to myocardial infarction (patients, 65%; control subjects 66%), as was true with the D allele. When compared with other populations, the frequency of D allele in Koreans (0.34) was lower than that in Caucasians, and was close to that of other Oriental populations. The data suggest that the ACE gene polymorphism is not an independent genetic risk factor for myocardial infarction in Koreans.
954.

Further Characterization of Bombesin Like Immunoreactivities from the Skin of Korean Fire-bellied Toad, Bombina orientalis

HyeokYilKwon, HyungSeoPark, MooHoWon, YunLyulLee, HyoungJinPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 12 637-644 (8 pages)

HyeokYilKwon, HyungSeoPark, MooHoWon, YunLyulLee, HyoungJinPark 저
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- 3,000원
Previously, we have isolated authentic bombesin and another bombesin like peptide named bombesin like immunoreactivity (BLI)-K2 from the skin of Korean fire-bellied toad, Bombina orientalis. In the present study, we have newly purified three heterogeneous forms of BLI named BLI-K3, BLI-K4, and BLI-K5 from side fractions obtained in previous isolation of bombesin like peptide. The BLIs were separated into five peaks on a column of C18 preparative HPLC. Among them, three minor peaks containing...
955.

Effects of Small Molecular Antioxidants on Cerulein-induced Acute Pancreatitis in Rat

JooYoungChoiKyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 11 629-635 (7 pages)

JooYoungChoiKyungHwanKim 저
...
- 3,000원
It has been suggested that oxygen free radicals are involved in the initiation process of acute pancreatitis, although its pathogenesis is not clear. This study evaluates the roles of oxygen radicals and the effects of small molecular antioxidants (rebamipide, N-acetyl-cysteine, allopurinol, ㄂-carotene) on the development of cerulein-induced acute pancreatitis. Acute edematous pancreatitis was induced by the intravenous infusion of cerulein at supramaximal dose of 10 ㄍg/kg/hour...
956.

Pharmacological Characterization of Synthetic Tetrahydroisoquinoline Alkaloids, YS 51 and YS 55, on the Cardiovascular System

Ki-ChurlChang, Young-JinKang, Young-SooLee, Won-SeogChong, Hye-SookYun-Choi, Duck-HyongLee, Jae-ChunRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 8 461-469 (9 pages)

Ki-ChurlChang, Young-JinKang, Young-SooLee, Won-SeogChong, Hye-SookYun-Choi, Duck-HyongLee, Jae-ChunRyu 저
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- 3,000원
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines, and many of them, especially with 6,7-disubstitution, demonstrate relatively high affinity for catecholamines. Two -OH groups at 6 and 7 positions are supposed to be essential to exert ㄂-receptor activities. However, it is not clear whether -OH at 6,7 substitution of THIs also shows ㄁-adrenoceptor activities. In the present study, we investigated whether -OH or -OCH3...
957.

The K+ Channels of Colonic Crypts and Their Regulation

R.Greger, K.Hamm, R.Warth, M.Nielsen, B.Wey, D.Ecke, N.Riedemann, U.Gerlach, A.E.Busch, H.C.Englert, M.Hropot, H.J.Lang, M.Bleich 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 1 403-409 (7 pages)

R.Greger, K.Hamm, R.Warth, M.Nielsen, B.Wey, D.Ecke, N.Riedemann, U.Gerlach, A.E.Busch, H.C.Englert, M.Hropot, H.J.Lang, M.Bleich 저
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- 3,000원
958.

In Vitro Cytotoxicity of Novel Platinum(II) Coordination Complexes Containing Diaminocyclohexane and Diphenylphosphines

Jee-ChangJung, Young-KyuKim, Seung-JoonPark, Joo-HoChung, Sung-GooChang, Kyung-TaeLee, Min-SonBaek, Jong-JipPark, Young-SooRho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 15 395-401 (7 pages)

Jee-ChangJung, Young-KyuKim, Seung-JoonPark, Joo-HoChung, Sung-GooChang, Kyung-TaeLee, Min-SonBaek, Jong-JipPark, Young-SooRho 저
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- 3,000원
to improve solubility. In the present study, the cytotoxicity of [Pt(trans-l-dach)(DPPP)]·2NO3 (KHPC-001) and [Pt(trans-l-dach)(DPPE)]·2NO3 (KHPC-002) was evaluated and compared on various P-388 cancer cell lines and porcine kidney cell line (LLC-PK1). The new platinum complexes demonstrated high efficacy on P-388 mouse leukemia cell line as well as cisplatin-resistant (P-388/CDDP) and adriamycin-resistant (P-388/ADR) P-388 cell lines. The intracellular platinum content was measured by a flame...
959.

Comparison of Inodilator Effect of Higenamine, YS49, YS51, Tetrahydroisoquinoline Analogs, and Dobutamine in the Rat

Won-SeogChong, Young-SooLee, Young-JinKang, Duck-HyungLee, Jae-ChunRyu, HyeSookYun-Choi, Ki-ChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 7 323-330 (8 pages)

Won-SeogChong, Young-SooLee, Young-JinKang, Duck-HyungLee, Jae-ChunRyu, HyeSookYun-Choi, Ki-ChurlChang 저
...
- 3,000원
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines. Many of them, especially with 6,7-disubstitution, demonstrate a relatively high affinity for catecholamines. Present study examines the pharmacological action of limited series of THI, using rats' isolated atria and aorta. In addition, a [3H] prazosin displacement binding study with THI compounds was performed, using rat brain homogenates to investigate whether these probes have...
960.

Characteristics of Ca2+ Stores in Rabbit Cerebral Artery Myocytes

SungJoonKim, JinKyungKim, InsukSo, SukHyoSuh, SangJinLee, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 6 313-322 (10 pages)

SungJoonKim, JinKyungKim, InsukSo, SukHyoSuh, SangJinLee, KiWhanKim 저
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- 3,000원
In a myocyte freshly isolated from rabbit cerebral artery, the characteristics of Ca2⁢ release by histamine or caffeine were studied by microspectrofluorimetry using a Ca2⁢-binding fluorescent dye, fura-2. Histamine (5 ㄍM) or caffeine (10 mM) induced a phasic rise of cytoplasmic free Ca2⁢ concentration ([Ca2⁢]c) which could occur repetitively with extracellular Ca2⁢ but only once or twice in Ca2⁢-free bathing solution. Also, the treatment with...

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