자료유형
발행기관
- 대한생리학회-대한약리학회(232)
- 대한수의학회(29)
- 대한약리학회(18)
- 대한생리학회(8)
- 대한신경정신의학회(8)
- 한국식물병리학회(5)
- 한국기초간호학회(2)
- 대한결핵및호흡기학회(1)
- 대한방사선종양학회(1)
- 대한치과이식임플란트학회(1)
- 물리치료재활과학회(1)
- 생화학분자생물학회(1)
- 한국동물번식학회(1)
- 한국미생물생명공학회(1)
- 한국발생생물학회(1)
- 한국청각언어재활학회(1)
- 한국탄소학회(1)
간행물
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(232)
- 대한약리학잡지(18)
- JOURNAL OF VETERINARY SCIENCE(17)
- 대한생리학회지(8)
- 신경정신의학(8)
- 대한수의학회 학술대회발표집(7)
- KOREAN JOURNAL OF VETERINARY RESEARCH(구 대한수의학회지)(5)
- THE PLANT PATHOLOGY JOURNAL (5)
- JOURNAL OF KOREAN BIOLOGICAL NURSING SCIENCE(2)
- AUDIOLOGY AND SPEECH RESEARCH(1)
- BMB REPORTS(1)
- CARBON LETTERS(1)
- JOURNAL OF DENTAL IMPLANT RESEARCH(1)
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY(1)
- PHYSICAL THERAPY REHABILITATION SCIENCE(1)
- REPRODUCTIVE & DEVELOPMENTAL BIOLOGY(1)
- 결핵 및 호흡기 질환(1)
- 대한방사선종양학회지(1)
- 발생과 생식(1)
전체 선택해제
총 312건 검색
본문검색 결과만 보기
-
A novel variant of t-PA resistant to plasminogen activator inhibitor-1; expression in CHO cells based on In Silico experiments
Davami. Fatemeh, Sardari. Soroush, Majidzadeh-A. Keivan, Hemayatkar. Mahdi, Barkhordari. Farzaneh, Enayati. Somayeh, Adeli. Ahmad, Mahb 생화학분자생물학회 BMB reports 6 Pages
생화학분자생물학회 BMB reports 2011, Vol.44 No.1 34-39 (6 pages)
-
Efficacy of horse chestnut leaf extract ALH-L1005 as a matrix metalloproteinase inhibitor in ligature-induced periodontitis in canine model
Se Eun Kim, Tae Hyun Kim, Shin Ae Park, Won Tae Kim, Young Woo Park, Jae Sang Ahn, Manbok Jeong, Min-Young Kim, Kangmoon Seo 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 2호 15 245-251 (7 pages)
Matrix metalloproteinases (MMPs) are the main proteinases associated with periodontal tissue destruction and remodeling. Therefore, inhibition of host-derived MMPs has a key role in the prevention and reduction of periodontitis progression. Horse chestnut (Aesculus hippocastanum L.) extracts have been used as treatments for inflammatory disease, traditionally. This study assessed the clinical effect as a MMP inhibitor of horse chestnut leaf extract ALH-L1005 on periodontitis. ALH-L1005 was... -
Plasminogen Activator Inhibitor-1 Antisense Oligodeoxynucleotides Abrogate Mesangial Fibronectin Accumulation
JehyunPark, JiYeonSeo, HunjooHa 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 6 385-390 (6 pages)
Excessive extracellular matrix (ECM) accumulation is the main feature of chronic renal disease including diabetic nephropathy. Plasminogen activator inhibitor (PAI)-1 is known to play an important role in renal ECM accumulation in part through suppression of plasmin generation and matrix metalloproteinase (MMP) activation. The present study examined the effect of PAI-1 antisense oligodeoxynucleotide (ODN) on fibronectin upregulation and plasmin/MMP suppression in primary mesangial cells cultured... -
Effect of Amrinone, a Selective Inhibitor of Phosphodiesterase III, on PMNs-induced
ByungKwonOh, HyoungKiKim, SooRanChoi, JinHoSong, EonSubPark, Byung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 7 43-50 (8 pages)
Ischemia followed by reperfusion in the presence of polymorphonuclear leukocytes (PMNs) results in a marked cardiac contractile dysfunction. Amrinone, a specific inhibitor of phosphodiesterase 3, has an antioxidant activity against PMNs. Therefore, we hypothesized that amrinone could attenuate PMNs-induced cardiac dysfunction by suppression of reactive oxygen species (ROS) produced fby PMNs. In the present study, we examined the effects of amrinone on isolated ischemic (20 min) and reperfused... -
Effects of Pretreatment of Serotonin Synthesis Inhibitor p-chlorophenylalanine on Lipopolysaccharide-induced Anorexia in Rats
So-youngPark, ByungSuckKim, SeoungSookBack 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 3 133-138 (6 pages)
In the present study, we investigated the effect of pretreatment of p-chlorophenylalanine (PCPA), inhibitor of serotonin synthesis, on lipopolysaccharide (LPS)-induced anorexia in rats. First of all, effects of PCPA injection on food intake and body weight in rats were investigated. During 4 days of PCPA injection (300 mg/kg BW once a day), food intake was decreased by 33% and daily gain in body weight was inhibited compared with controls. Twenty-four hours after last PCPA injection, food... -
Combined TGE-SGE Expression of Novel PAI-1-Resistant t-PA in CHO DG44 Cells Using Orbitally Shaking Disposable Bioreactors
Davami. Fatemeh, Barkhordari. Farzaneh, Alebouyeh. Mahmoud, Adeli. Ahmad, Mahboudi. Fereidoun 한국미생물생명공학회 Journal of microbiology and biotechnology 7 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2011, Vol.21 No.12 1299-1305 (7 pages)
-
폐암에서 혈장 Urokinase-Type Plasminogen Activator 및 Type 1 Plasminogen Activator Inhibitor의 의의
박광주, 김형중, 안철민, 이두연, 장준, 김성규, 이원영, Park. Kwang-Joo, Kim. Hyung-Jung, Ahn. Chul-Min, Lee. Doo-Yun, Chang. Joon, Kim. Sung-Kyu, Lee. Won-Young 대한결핵및호흡기학회 결핵 및 호흡기 질환 9 Pages
대한결핵및호흡기학회 결핵 및 호흡기 질환 1997, Vol.44 No.3 516-524 (9 pages)
목 적 : 악성 종양에 있어서 단백질 분해 효소에 의한 세포외기질의 분해는 종양 침습 및 전이에 있어서 중요한 역할을 한다. Urokinase-type plasminogen activator(u-PA)는 이러한 단백질 분해효소 중 하나이며, u-PA의 길항제인 plasminogen activator inhibitor(PAI-1, PAI-2)도 u-PA에 의한 종양조직 자체의 분해를 방어하여 종양의 성장, 침습 및 혈관신생을 촉진하는 역할을 한다. u-PA와 PAI-1은 폐암 등의 종양 조직내의 양이 증가하며, 침습도 및 예후 둥과 유의하게 상관되는 것으로 보고되고 있다. 저자 등은 폐암환자의 혈장... -
JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells
DaeWooChoi, DoKyungKim, YoshikatsuKanai, MichaelF.Wempe, HitoshiEndou, Jong-KeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 4 599-607 (9 pages)
Most normal cells express L-type amino acid transporter 2 (LAT2). However, L-type amino acid transporter 1 (LAT1) is highly expressed in many tumor cells and presumed to support their increased growth and proliferation. This study examined the effects of JPH203, a selective LAT1 inhibitor, on cell growth and its mechanism for cell death in Saos2 human osteosarcoma cells. FOB human osteoblastic cells and Saos2 cells expressed LAT1 and LAT2 together with their associating protein 4F2 heavy chain,... -
Immunotherapy with methyl gallate, an inhibitor of Treg cell migration, enhances the anti-cancer effect of cisplatin therapy
HyunseongKim, GihyunLee, Sung-HwaSohn, ChanjuLee, JungWonKwak, HyunsuBae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 5 261-268 (8 pages)
Foxp3+ CD25+CD4+ regulatory T (Treg) cells are crucial for the maintenance of immunological self-tolerance and are abundant in tumors. Most of these cells are chemo-attracted to tumor tissues and suppress anti-tumor responses inside the tumor. Currently, several cancer immunotherapies targeting Treg cells are being clinically tested. Cisplatin is one of the most potent chemotherapy drugs widely used for cancer treatment. While cisplatin is a powerful drug for the treatment of multiple cancers,... -
CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1α in Hepatoma Cells
Kyoung-HwaLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 13 331-336 (6 pages)
In rapidly growing tumors, hypoxia commonly develops due to the imbalance between O2 con</SUB>sumption and supply. Hypoxia Inducible Factor (HIF)-1Ձ is a transcription factor responsible for tumor growth and angiogenesis in the hypoxic microenvironment; thus, its inhibition is regarded as a promising strategy for cancer therapy. Given that CamKII or PARP inhibitors are emerging anticancer agents, we investigated if they have the potential to be developed as new HIF-1Ձ-targeting...
