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01.

Decreased expression of Toll-like receptor 4 and 5 during progression of prostate transformation in transgenic adenocarcinoma of mouse prostate mice

Ju-Hee Han, Jong-Hwan Park, Bo-Yeon Kim, Seo-Na Chang, Tae-Hyoun Kim, Jae-Hak Park, Dong-Jae Kim 대한수의학회 Journal of Veterinary Science 7 Pages

대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 5 281-287 (7 pages)

Ju-Hee Han, Jong-Hwan Park, Bo-Yeon Kim, Seo-Na Chang, Tae-Hyoun Kim, Jae-Hak Park, Dong-Jae Kim 저
...
- 3,000원
of prostate cancer. Toll-like receptors (TLRs) recognize microbial moieties or endogenous molecules and play an important role in the triggering and promotion of inflammation. In this study, we examined whether expression of TLR4 and TLR5 was associated with progression of prostate transformation in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. The expression of TLR4 and TLR5 was evaluated by immunohistochemisty in formalin-fixed paraffin-embedded prostate tissue from wild-type...
02.

Time-dependent proteomic and genomic alterations in Toll-like receptor-4-activated human chondrocytes: increased expression of lamin A/C and annexins

SeungHeeHa, HyoungKyuKim, NguyenThiTuyetAnh, NariKim, KyungSooKo, ByoungDooRhee, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 8 531-546 (16 pages)

SeungHeeHa, HyoungKyuKim, NguyenThiTuyetAnh, NariKim, KyungSooKo, ByoungDooRhee, JinHan 저
...
- 4,500원
Activation of Toll-like receptor-4 (TLR-4) in articular chondrocytes increases the catabolic compartment and leads to matrix degradation during the development of osteoarthritis. In this study, we determined the proteomic and genomic alterations in human chondrocytes during lipopolysaccharide (LPS)-induced inflammation to elucidate the underlying mechanisms and consequences of TLR-4 activation. Human chondrocytes were cultured with LPS for 12, 24,and 36 h to induce TLR-4 activation. The...
03.

Toll-like Receptor 2 is Dispensable for an Immediate-early Microglial Reaction to Two-photon Laser-induced Cortical Injury In vivo

HeeraYoon, YongHoJang, SangJeongKim, SungJoongLee, SunKwangKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 9 461-466 (6 pages)

HeeraYoon, YongHoJang, SangJeongKim, SungJoongLee, SunKwangKim 저
...
- 3,000원
Microglia, the resident macrophages in the central nervous system, can rapidly respond to patho-logical insults. Toll-like receptor 2 (TLR2) is a pattern recognition receptor that plays a fundamental role in pathogen recognition and activation of innate immunity. Although many previous studies have suggested that TLR2 contributes to microglial activation and subsequent pathogenesis following brain tissue injury, it is still unclear whether TLR2 has a role in microglia dynamics in the resting...
04.

FSL-1, a Toll-like Receptor 2/6 Agonist, Induces Expression of Interleukin-1α in the Presence of 27-hydroxycholesterol

WeonHeo, Sun-MiKim, Seong-KugEo, Byung-YongRhim, KoanhoiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 5 475-480 (6 pages)

WeonHeo, Sun-MiKim, Seong-KugEo, Byung-YongRhim, KoanhoiKim 저
...
- 3,000원
inflammatory cytokines via Toll-like receptors (TLR) in monocytic cells. Treatment of THP-1 monocytic cells with 27-hydroxycholesterol (27OHChol) resulted in induction of gene transcription of TLR6 and elevated level of cell surface TLR6. Addition of FSL-1, a TLR6 agonist, to 27OHChol-treated cells resulted in transcription of the IL-1α gene and enhanced secretion of the corresponding gene product. However, cholesterol did not affect TLR6 expression, and addition of FSL-1 to cholesterol-treated...
05.

Multiple Signaling Molecules are Involved in Expression of CCL2 and IL-1b in Response to FSL-1, a Toll-Like Receptor 6 Agonist, in Macrophages

KeunsooWon, Sun-MiKim, Sae-ALee, Byung-YongRhim, Seong-KugEo, KoanhoiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 11 447-453 (7 pages)

KeunsooWon, Sun-MiKim, Sae-ALee, Byung-YongRhim, Seong-KugEo, KoanhoiKim 저
...
- 3,000원
TLR6 forms a heterodimer with TLR2 and TLR4. While proinflammatory roles of TLR2 and TLR4 are well documented, the role of TLR6 in inflammation is poorly understood. In order to understand mechanisms of action of TLR6 in inflammatory responses, we investigated the effects of FSL-1, the TLR6 ligand, on expression of chemokine CCL2 and cytokine IL-1Ղ and determined cellular factors involved in FSL-1-mediated expression of CCL2 and IL-1Ղ in mononuclear cells. Exposure of human monocytic...
06.

Rifampicin Inhibits the LPS-induced Expression of Toll-like Receptor 2 via the Suppression of NF-κB DNA-binding Activity in RAW 264.7 Cells

SeongKeunKim, YoungMiKim, ChungEunYeum, Song-HyoJin, GueTaeChae, Seong-BeomLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 11 475-482 (8 pages)

SeongKeunKim, YoungMiKim, ChungEunYeum, Song-HyoJin, GueTaeChae, Seong-BeomLee 저
...
- 3,000원
a receptor for rifampicin, and NF-ՊB p65, suggesting pregnane X receptor interferes with NF-ՊB binding to DNA. Taken together, our results demonstrate that rifampicin inhibits LPS-induced TLR2 expression, at least in part, via the suppression of NF-ՊB DNA-binding activity in RAW 264.7 cells. Thus, the present results suggest that the rifampicin-mediated inhibition of TLR2 via the suppression of NF-ՊB DNA- binding activity may be a novel mechanism of the immune-suppressive...
07.

Ligand Recognition by the Toll-like Receptor Family

Jin. Mi-Sun, Lee. Jie-Oh 한국통합생물학회 Animal cells and systems 8 Pages

한국통합생물학회 Animal cells and systems 2009, Vol.13 No.1 1-8 (8 pages)

Jin. Mi-Sun, Lee. Jie-Oh 저

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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08.

Ellagic acid가 대식세포의 면역조절작용에 미치는 영향과 Toll-like receptor 4 관련 작용기전 연구

남궁승, 김예진, 김태성, 손은화, NamKoong. Seung, Kim. Ye-Jin, Kim. Taeseong, Sohn. Eun-Hwa 한국자원식물학회 韓國資源植物學會誌 7 Pages

한국자원식물학회 韓國資源植物學會誌 2012, Vol.25 No.5 561-567 (7 pages)

남궁승, 김예진, 김태성, 손은화, NamKoong. Seung, Kim. Ye-Jin, Kim. Taeseong, Sohn. Eun-Hwa 저

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
- 무료
본 연구는 EA에 의한 대식세포의 활성화를 매개로 한 항암효과와 항암작용과 관련된 대식세포의 면역조절효과를 확인하였다. 연구 결과 EA에 의해 RAW264.7세포 및 peritoneal macrophage 모두에서 항암효과가 증가하였으며, 증가된 대식세포의 항암효과는 TLR4 signaling을 blocking하는 CLI-095을 함께 처리하였을 때 일부 감소되었다. 이는 EA에 의한 항암 효과가 부분적으로 TLR4를 경유하는 기전으로 나타나는 것을 의미한다. 또한, EA에 대한 대식세포의 NO 분비조절효과를 측정하였으며, EA는 대식세포의 NO 생성을 증가시켰으나,...
09.

말의 정상안과 재발성 포도막염이 있는 안구에서의 Toll-like Receptor-2, -4, -9 발현 비교

이나영, Yi. Na-Young, Salmon. Jacklyn, Gilger. Brian 한국임상수의학회 Journal of veterinary clinics 4 Pages

한국임상수의학회 Journal of veterinary clinics 2009, Vol.26 No.6 520-523 (4 pages)

이나영, Yi. Na-Young, Salmon. Jacklyn, Gilger. Brian 저

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
- 무료
Real-time PCR assay 통해 정상안과 재발성 포도막염이 있는 안구에서의 TLR-2, -4, -9의 mRNA 발현 차이를 정량적으로 비교하였다. 말의 재발성 포도막염 시에는 모양체, 홍채에서 정상인 경우에 비해 4-12 배의 TLR-2 와 TLR-9 mRNA 발현증가를 보였으며, 맥락막 및 망막에서는 2-6 배의 TLR-2, -4, -9 mRNA 발현 증가를 보였다. 본 연구 결과는 Toll-like receptor 2, -4, -9이 말의 재발성 포도막염의 병리기전에 영향을 미치고 있음을 시사한다. 하지만 재발성 포도막염 시의 Toll-like receptor 2, -4, -9의 구체적 역할을...
10.

Reactive Oxygen Species-Induced Expression of B cell Activating Factor (BAFF) Is Independent of Toll-like Receptor 4 and Myeloid Differentiation Primary Response Gene 88

Kim. Hyun-Sun, Moon. Eun-Yi 한국응용약물학회 Biomolecules & therapeutics 7 Pages

한국응용약물학회 Biomolecules & therapeutics 2009, Vol.17 No.2 144-150 (7 pages)

Kim. Hyun-Sun, Moon. Eun-Yi 저

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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