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산부식 후 타액오염이 교정용 접착제의 결합강도에 미치는 영향
김현덕(Hyun-Deog Kim), 김종성(Jong-Sung Kim, ), 김정기(Jong-Ghee Kim) 대한치과교정학회 The Korean Journal of Orthodontics 8 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1996, 제 26권 제 3호 9 309-316 (8 pages)
본 연구는 산부식 법랑질의 타액오염 효과를 오염 시간별 전단결합강도를 통해 알아보고자 주사 전자현미경으로 표면 변화를 관찰하고자 하였다. 타액오염 시간이 전단결합강도에 미치는 영향을 관찰하기 위하여 38% 인산용액으로 15초와 60초 산부식한 후 타액으로 0초, 1초, 20초, 60초동안 오염시켜 세척과 건조 후 주사전자현미경으로 부식면을 검경하였으며, 교정용 레진을 이용하여 브라켓 접착 후 전단결합강도를 측정하고 통계 처리하여 다음과 같은 결과를 얻었다. 1. 타액에 오염시키지 않은 15초 산부식 군과 60초 산부식 군... -
Potentiation of decursinol angelate on pentobarbital-induced sleeping behaviors via the activation of GABAA-ergic systems in rodents
JaeHoonWoo, Tae-WooHa, Jae-SeonKang, JinTaeHong, Ki-WanOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 4 27-36 (10 pages)
Angelicae Gigantis Radix (AGR, Angelica gigas ) has been used for a long time as a traditional folk medicine in Korea and oriental countries. Decursinol angelate (DCA) is structurally isomeric decursin, one of the major components of AGR. This study was performed to confirm whether DCA augments pentobarbital-induced sleeping behaviors via the activation of GABAA-ergic systems in animals. Oral administration of DCA (10, 25 and 50 mg/kg) markedly suppressed spontaneous locomotor activity. DCA also... -
Epigallocatechin-3-gallate rescues LPS-impaired adult hippocampal neurogenesis through suppressing the TLR4-NF-κB signaling pathway in mice
Kyung-JooSeong, Hyun-GwanLee, MinSukKook, Hyun-MiKo, Ji-YeonJung, Won-JaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 6 41-51 (11 pages)
Adult hippocampal dentate granule neurons are generated from neural stem cells (NSCs) in the mammalian brain, and the fate specification of adult NSCs is precisely controlled by the local niches and environment, such as the subventricular zone (SVZ), dentate gyrus (DG), and Toll-like receptors (TLRs). Epigallocatechin-3-gallate (EGCG) is the main polyphenolic flavonoid in green tea that has neuroprotective activities, but there is no clear understanding of the role of EGCG in adult neurogenesis... -
Effects of Local Pancreatic Renin-Angiotensin System on the Microcirculation of Rat with Severe Acute Pancreatitis
ZhijianPan, LingFeng, HaochengLong, HuiWang, JiaruiFeng, FeixiangChen 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.4 1 299-307 (9 pages)
Severe acute pancreatitis (SAP) is normally related to multiorgan dysfunction and local complications. Studies have found that local pancreatic renin-angiotensin system (RAS) was significantly upregulated in drug-induced SAP. The present study aimed to investigate the effects of angiotensin II receptors inhibitor valsartan on dual role of RAS in SAP in a rat model and to elucidate the underlying mechanisms. 3.8% sodium taurocholate (1 ml/kg) was injected to the pancreatic capsule in order for... -
Nitric Oxide-Induced Apoptosis of Human Dental Pulp Cells Is Mediated by the Mitochondria-Dependent Pathway
MinYoungPark, YeonJinJeong, GiChangKang, Mi-HwaKim, SunHunKim, Hyun-JuChung, JiYeonJung, WonJaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 3 25-32 (8 pages)
Nitric oxide (NO) is recognized as a mediator and regulator of inflammatory responses. NO is produced by nitric oxide synthase (NOS), and NOS is abundantly expressed in the human dental pulp cells (HDPCs). NO produced by NOS can be cytotoxic at higher concentrations to HDPCs. However, the mechanism by which this cytotoxic pathway is activated in cells exposed to NO is not known. The purpose of this study was to elucidate the NO-induced cytotoxic mechanism in HDPCs. Sodium nitroprusside (SNP), a... -
Effect of Modulation of hnRNP L Levels on the Decay of bcl-2 mRNA in MCF-7 Cells
Mi-HyunLim, Dong-HyoungLee, SeungEunJung, Dong-YeYoun, ChanSunPark, Jeong-HwaLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.1 3 15-20 (6 pages)
It has been shown that CA repeats in the 3'-untranslated region (UTR) of bcl-2 mRNA contribute the constitutive decay of bcl-2 mRNA and that hnRNP L (heterogenous nuclear ribonucleoprotein L) interacts with CA repeats in the 3'-UTR of bcl-2 mRNA, both in vitro and in vivo. The aim of this study was to determine whether the alteration of hnRNP L affects the stability of bcl-2 mRNA in vivo. Human breast carcinoma MCF-7 cells were transfected with hnRNP L-specific shRNA or hnRNP L-expressing vector... -
Ser1778 of 53BP1 Plays a Role in DNA Double-strand Break Repairs
Jung-HeeLee, Hyang-MinCheong, Mi-YoungKang, Sang-YoungKim, YoonsungKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 2 343-348 (6 pages)
53BP1 is an important genome stability regulator, which protects cells against double-strand breaks. Following DNA damage, 53BP1 is rapidly recruited to sites of DNA breakage, along with other DNA damage response proteins, including Ճ-H2AX, MDC1, and BRCA1. The recruitment of 53BP1 requires a tandem Tudor fold which associates with methylated histones H3 and H4. It has already been determined that the majority of DNA damage response proteins are phosphorylated by ATM and/or ATR after DNA... -
Expression of Nitric Oxide Synthase and Endothelin-1 in Human Uterine Artery from Full-Term Pregnancies
Ook-HwanChoi, SunHeeLee, EunJinKim, KoanHoiKim, ByungYongRhim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.3 6 165-172 (8 pages)
The aim of this study was to determine the roles of ET-1 and NO on uterine blood flow in pregnancy. Uterine arteries were isolated from 17 nonpregnant and 12 pregnant women. Nonpregnant group included patients with median age of 48.6⁑2.3 years who underwent hysterectomy, because of myoma. Pregnant group included patients with median age of 31.3⁑1.4 years undergoing cesarean delivery. ET-1 and ET-2 induced concentration-dependent contraction in isolated nonpregnant and pregnant... -
Heat Shock Protein 70이 흰쥐 배양 혈관간 세포에서 관찰되는 TNFα에 의한 지질과산화에 미치는 보호 효과
하헌주(Hun-joo Ha), 박영미(Young Mee Park), 안영수(Young Soo Ahn), 김경환(Kyung Hwan Kim) 대한약리학회 대한약리학잡지 10 Pages
대한약리학회 대한약리학잡지 1995, 제 31권 제 3호 7 323-332 (10 pages)
사구체내 단핵구의 침윤은 면역학적뿐 아니라 비면역학적 사구체 질환 발생 초기에 특징적으로 관찰된다. 단핵구에서 합성되는 대표적인 사이토 카인인 tumor necrosis factor (TNF)α의 합성이 각종 사구체 질환과 관련되어 증가할 뿐 아니라 외부에서 투여한 TNFα는 사구체 질환의 발생과 진행에 수반된 유사한 증세를 초래한다. 따라서 본 연구에서는 사구체 질환의 표적세포인 혈관간 세포를 이용하여 TNFα에 의한 세포독성 기전을 검색하고자 하였다. 표준화된 체걸름법을 이용하여 사구체를 분리한후 collagenase로 처리하여... -
알부민 Gylcation이 약물의 단백질결합에 미치는 영향
배진우(Jin Woo Bae) 대한약리학회 대한약리학잡지 6 Pages
대한약리학회 대한약리학잡지 1995, 제 31권 제 1호 14 135-140 (6 pages)
Glycation이란 단당류의 카보릴기와 아미노산의 입실론 아미노기가 공유결합에 의하여 형성되는 반응으로 이는 단백질의 생리적 기능을 변화시키며 아울러 당뇨합병증을 유발한다. 본 연구에서는 warfarin과 dansylsarcosine의 단백질결합에 미치는 glycation의 영향을 평형투석법을 이용하여 연구하였으며 평형투석은 섭씨 37도의 진탕수조에서 3시간 동안 실시하였다. 약물의 농도가 알부민의 농도보다 높을 경우, 50 ± 16%가 glycation된 알부민은 8.5 ± 5.28% glycation 알부민을 함유한 정상알부민에 비해 약물과의 결합도가...
