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전체 선택해제
총 378건 검색
본문검색 결과만 보기
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Increased Activity of Large Conductance Ca2+-Activated K+ Channels in Negatively-Charged Lipid Membranes
JinBongParkPanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 15 529-539 (11 pages)
The effects of membrane surface charge originated from lipid head groups on ion channels were tested by analyzing the activity of single large conductance Ca2-activated K (maxi K) channel from rat skeletal muscle. The conductances and open-state probability (Po) of single maxi K channels were compared in three types of planar lipid bilayers formed from a neutral phosphatidylethanolamine (PE) or two negatively-charged phospholipids, phosphatidylserine (PS) and phosphatidylinositol... -
Molecular Pharmacological Interaction of Phenylbutazone to Human Neutrophil Elastase
KooilKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 14 385-393 (9 pages)
Human neutrophil elastase (HNElastase, EC 3.4.21.37), a causative factor of inflammatory diseases, was purified by Ultrogel AcA54 gel filtration and CM-Sephadex ion exchange chromatography. HNElastase was inhibited by phenylbutazone in a concentration dependent manner up to 0.4 mM, but as the concentration increased, the inhibitory effect gradually diminished. Binding of phenylbutazone to the human neutrophil elastase caused strong Raman shifts at 200, 440, and 1194 cm1. The peak at 1194... -
The Inhibitory Mechanism of Aloe Glycoprotein (NY945) on the Mediator Release in the Guinea Pig Lung Mast Cell Activated with Antigen-Antibody Complexes
JaiYoulRo, ByungChulLee, MyungHeeChung, SeungKiLee, ChungKiSung, KyungHwanKim, YoungInPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 13 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 15 119-131 (13 pages)
using the enzyme digestion， the rough and the discontinuous density percoll gradient method. Mast cells were sensitized with IgG1 (anti-OA) and challenged with ova1bumin. Histamine was assayed by fluorometric ana1yzer， 1eukotrienes by radioimmunoassay. The phospholipase D activity was assessed by the production of 1abe1ed phosphatidy1alcoho1. The amount of mass 1， 2-diacy1g1ycero1 (DAG) was measured by the eH]DAG produced when pre1abe1ed with eH]myristic acid. The phosph01ipid methy1ation was... -
α-Adrenergic and Cholinergic Receptor Agonists Modulate Voltage- Gated Ca2+ Channels
Seung-YeolNah, Jae-HaKim, Cheon-HoKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 3 485-493 (9 pages)
We investigated the effect of α-adrenergic and cholinergic receptor agonists on Ca2 current in adult rat trigeminal ganglion neurons using whole-cell patch clamp methods. The application of acetylcholine, carbachol, and oxotremorine (50 ㄍM each) produced a rapid and reversible reduction of the Ca2 current by 17⁑6%, 19⁑3%, and 18⁑4%, respectively. Atropine, a muscarinic antagonist, blocked carbachol- induced Ca2 current inhibition to 3⁑1%.... -
Human Cerebellar Activation during Painful Cold Stimulation：a Functional Magnetic Resonance Imaging Study
Seung-Schik Yoo, Byung Gil Choi, Chang Uk Lee, Bum Soo Kim, , Su Jung Yoon, Soo Jung Lee, Tae Kim, Jung Jin Kim, Chul Lee, In Ho Paik 대한신경정신의학회 신경정신의학 7 Pages
대한신경정신의학회 신경정신의학 2001, 제 40권 제 4호 16 727-733 (7 pages)
연구목적： 본 연구에서는 기능적 자기공명영상법(fMRI)을 이용하여 동통 한랭 자극 동안의 소뇌 활동정도를 알아보 았다. 방 법： 6명의 건강한 자원자들을 선발하여 1.5 Tesla MR scanner 안에 누워 있는 동안 그들의 좌측 손에 0~3℃의 얼음주머니를 올려놓아 동통 한랭 자극을 주었다. 자극과 연관된 BOLD(blood oxygenation level dependent) 반응을 평가하기 위해 일련의 susceptibility-weighted MR image를 측정하였고 대뇌활동 영 역을 시각화하고 정량화하는 statistical parametric map을 작성하였다. 결 과： 한랭 자극으로... -
흰쥐 뇌에서 항정신병약물이 C-fos 발현에 미치는 영향
김광수, 박원명, 박재홍 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 1996, 제 35권 제 2호 19 442-451 (10 pages)
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腦脊髓液内의 Norepinephrine，Epinephrine 및 Dopamine 의 定量法
孫昌福, 高炳鶴, 白汝基 대한신경정신의학회 신경정신의학 8 Pages
대한신경정신의학회 신경정신의학 1982, 제 21권 제 3호 26 495-502 (8 pages)
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주정이 흰쥐 뇌 Synaptosomal Membrane의 Ca2+-ATPase 활성도에 미치는 영향
대한신경정신의학회 신경정신의학 1988, 제 27권 제 3호 7 504-512 (9 pages)
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Oxidative Stress and HSP70 Expression Upon Cerebral Isehemia-Reperfusion in Mongolian Gerbil
박영미(Young-Mee Park), 김철훈(Chul-Hoon Kim), 도윤정(Yun-Jeong Do), 최은미(Eun-Mi Choi), 안영수(Young-Soo Ahn) 대한약리학회 대한약리학잡지 12 Pages
대한약리학회 대한약리학잡지 1996, 제 32권 제 3호 5 335-346 (12 pages)
A critical role of oxygen-derived free radicals has been implicated in ischemia/reperfusion (I/R)-induced brain damage. In this study, we have produced experimental I/R to the brains of Mongolian gerbil (Meriones unguiculatus) by a transient occlusion and release of the common carotid arteries. We have attempted to determine whether the oxidative stress is generated upon I/R and whether this oxidative stress is linked to the cell damage. Since hippocampus has been suggested as one of the most...
