자료유형
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- 대한생리학회-대한약리학회(158)
- 대한생리학회(53)
- 대한약리학회(42)
- 대한수의학회(17)
- 한국생약학회(4)
- 대한약학회(2)
- 물리치료재활과학회(2)
- 한국기초간호학회(2)
- 고려인삼학회(1)
- 대한신경정신의학회(1)
- 대한한의학회(1)
- 대한흉부외과학회(1)
- 한국보건기초의학회(1)
- 한국응용약물학회(1)
- 한국탄소학회(1)
- 한방비만학회(1)
간행물
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(158)
- 대한생리학회지(53)
- 대한약리학잡지(42)
- KOREAN JOURNAL OF VETERINARY RESEARCH(구 대한수의학회지)(11)
- JOURNAL OF VETERINARY SCIENCE(5)
- 생약학회지(4)
- ARCHIVES OF PHARMACAL RESEARCH : A PUBLICATION OF THE PHARMACEUTICAL SOCIETY OF KOREA(2)
- JOURNAL OF KOREAN BIOLOGICAL NURSING SCIENCE(2)
- PHYSICAL THERAPY REHABILITATION SCIENCE(2)
- CARBON LETTERS(1)
- JOURNAL OF GINSENG RESEARCH(1)
- THE JOURNAL OF APPLIED PHARMACOLOGY : THE OFFICIAL JOURNAL OF THE KOREAN SOCIETY OF APPLIED PHARMACO(1)
- 대한수의학회 학술대회발표집(1)
- 대한한방비만학회지(1)
- 대한한의학회지(1)
- 대한흉부외과학회지(1)
- 신경정신의학(1)
- 한국보건기초의학회지(1)
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Influence of Nicorandil on Catecholamine Release in the Perfused Rat Adrenal Medulla
Young-YoupKoh, Eun-SookLee, Hae-JeongNo, , Seong-ChangWoo, Joong-WhaChung, Yoo-SeungSeoh, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.3 4 97-106 (10 pages)
The present study was attempted to investigate the effect of nicorandil, which is an ATP-sensitive potassium (KATP) channel opener, on secretion of catecholamines (CA) evoked by cholinergic stimulation and membrane depolarization from the isolated perfused rat adrenal glands. The perfusion of nicorandil (0.3∼3.0 mM) into an adrenal vein for 90 min produced relatively dose-and time-dependent inhibition in CA secretion evoked by ACh (5.32 mM), high K+ (a direct membrane depolarizer, 56 mM), DMPP... -
Differential Activation of Ras/Raf/MAPK Pathway between Heart and Cerebral Artery in Isoproterenol-induced Cardiac Hypertrophy
HyunjuKim, NariKim, HyunJoo, JaeBoumYoum, WonSunPark, MohamedWarda, SunghyunKang, VuThiThu, TranMinhKhoa, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.5 7 299-304 (6 pages)
Cardiac hypertrophy contributes an increased risk to major cerebrovascular events. However, the molecular mechanisms underlying cerebrovascular dysfunction during cardiac hypertrophy have not yet been characterized. In the present study, we examined the molecular mechanism of isoproterenol (ISO)-evoked activation of Ras/Raf/MAPK pathways as well as PKA activity in cerebral artery of rabbits, and we also studied whether the activations of these signaling pathways were altered in cerebral artery,... -
Expression of Nitric Oxide Synthase and Endothelin-1 in Human Uterine Artery from Full-Term Pregnancies
Ook-HwanChoi, SunHeeLee, EunJinKim, KoanHoiKim, ByungYongRhim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.3 6 165-172 (8 pages)
The aim of this study was to determine the roles of ET-1 and NO on uterine blood flow in pregnancy. Uterine arteries were isolated from 17 nonpregnant and 12 pregnant women. Nonpregnant group included patients with median age of 48.6⁑2.3 years who underwent hysterectomy, because of myoma. Pregnant group included patients with median age of 31.3⁑1.4 years undergoing cesarean delivery. ET-1 and ET-2 induced concentration-dependent contraction in isolated nonpregnant and pregnant... -
Regulation of L-type Calcium Channel Current by Somatostatin in Guinea-Pig Gastric Myocytes
YoungChulKim, JaeHoonSim, SangJinLee, TongMookKang, SungJoonKim, SeungRyulKim, SeiJinYoun, SangJeonLee, Wen-XieXu6, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 5 103-108 (6 pages)
(SS) on calcium channel current (IBa) in guinea-pig gastric myocytes, IBa was recorded by using whole-cell patch clamp technique in single smooth muscle cells. Nicardipine (1μM), a L-type Ca2+ channel blocker, inhibited IBa by 98⁑1.9% (n=5), however IBa was decreased in a reversible manner by application of SS. The peak IBa at 0 mV were decreased to 95⁑1.1, 92⁑1.9, 82⁑4.0, 66⁑5.8, 10⁑2.9% at 1010, 109, 108, 107, 105 M of SS,... -
Buffering Contribution of Mitochondria to the [Ca2+]i Increase by Ca2+ Influx through Background Nonselective Cation Channels in Rabbit Aortic Endothelial Cells
YoungChulKim, SangJinLee, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 5 29-36 (8 pages)
To prove the buffering contribution of mitochondria to the increase of intracellular Ca2+ level ([Ca2+]i) via background nonselective cation channel (background NSCC), we examined whether inhibition of mitochondria by protonophore carbonylcyanide m-chlorophenylhydrazone (CCCP) affects endothelial Ca2+ entry and Ca2+ buffering in freshly isolated rabbit aortic endothelial cells (RAECs). The ratio of fluorescence by fura-2 AM (R340/380) was measured in RAECs. Biological state was checked by... -
Efffects of Fluoxetine on ATP-induced Calcium Signaling in PC12 Cells
Yeo-MinLee, HeeJungKim, SunHwaHong, Myung-JunKim, DoSikMin, Duck-Joo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 9 57-63 (7 pages)
Fluoxetine, a widely used anti-depressant compound, has several additional effects, including blockade of voltage-gated ion channels. We examined whether fluoxetine affects ATP-induced calcium signaling in PC12 cells by using fura-2-based digital calcium imaging and assay for [3H]-inositol phosphates (IPs). Treatment with ATP (100μM) for 2 min induced [Ca2]i increases. The ATP-induced [Ca2]i increases were significantly decreased by removal of extracellular Ca2 and... -
Effect of Amrinone, a Selective Inhibitor of Phosphodiesterase III, on PMNs-induced
ByungKwonOh, HyoungKiKim, SooRanChoi, JinHoSong, EonSubPark, Byung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 7 43-50 (8 pages)
Ischemia followed by reperfusion in the presence of polymorphonuclear leukocytes (PMNs) results in a marked cardiac contractile dysfunction. Amrinone, a specific inhibitor of phosphodiesterase 3, has an antioxidant activity against PMNs. Therefore, we hypothesized that amrinone could attenuate PMNs-induced cardiac dysfunction by suppression of reactive oxygen species (ROS) produced fby PMNs. In the present study, we examined the effects of amrinone on isolated ischemic (20 min) and reperfused... -
Cooperation of Gβ and Gαq Protein in Contractile Response of Cat Lower Esophageal Sphincter (LES)
UyDongSohnTaiSangLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 9 349-355 (7 pages)
PLC isozymes, PLC-β1, PLC-β3, and PLC-γ1, but not PLC-β2, PLC-β4, PLC-γ2, PLC-δ1, and PLC-δ2 from both LES and esophageal muscle. ACh produced contraction in a dose dependent manner in LES and esophageal muscle cells obtained by enzymatic digestion with collagenase. PLC-β1 or PLC-β3 antibody incubation reduced contraction in response to ACh in LES but not in esophageal permeabilized cells, but PLC-γ1 antibody incubation did not have an inhibitory effect. The inhibition by PLC-β1 or... -
Comparison of Vasodilator Effects of Platycodin D and D3 in Rats
Dong-YoonLim, Byeong-CheolKim, Eun-BangLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 5 149-155 (7 pages)
adrenergic α1-receptors. Platycodin D also caused vascular relaxation in the isolated aortic strips of the rat via the blockade of adrenergic α1-receptors, in addition to an unknown direct mechanism. However, platycodin D3 did not affect both norepinephrine-induced pressor responses and the isolated rat aortic contractile responses evoked by phenylephrine and high potassium. Based on these results, there seems to be much difference in the mode of action between platycodin D and platycodin D3. -
Dietary Ascorbate Supplementation Reduces Oxidative Tissue Damage and Expression of iNOS in the Kidney of Streptozotocin Induced Diabetic Rats
MyungSeoupChoi, YoonYoungJang, WooSeungLee, JinHoSong, YongKyooShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 8 39-45 (7 pages)
Reactive oxygen species (ROS) have been suggested to be contributory factors in complications of diabetes mellitus. In the present study, we investigated the generation of superoxide, the lipid peroxide level measured as thiobarbituric acid reactive substances, the vasorelaxation of isolated thoracic aorta and the iNOS expression in kidney of streptozotocin induced diabetic rats. Sprague Dawley rats were divided into four groups: control, ascorbate (400 mg/kg rat weight daily in drinking water),...
