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- ASIAN PACIFIC JOURNAL OF CANCER PREVENTION : APJCP(501)
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- KOREAN JOURNAL OF VETERINARY RESEARCH(구 대한수의학회지)(15)
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p53 signaling is involved in leptin-induced growth of hepatic and breast cancer cells
MohanShrestha, Pil-HoonPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.5 6 487-498 (12 pages)
growth and survival of cancer cells depending on experimental environments. In the present study, we examined if p53 signaling is implicated in leptin-induced growth of cancer cells. Herein, we demonstrated that leptin treatment significantly increased p53 protein expression in both hepatic (HepG2) and breast (MCF-7) cancer cells without significant effect on mRNA expression. Enhanced p53 expressionby leptin was mediated via modulation of ubiquitination, in particular ubiquitin specific protease... -
Inhibition of the Interleukin-11-STAT3 Axis Attenuates Hypoxia-Induced Migration and Invasion in MDA-MB-231 Breast Cancer Cells
Ji-HongLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.5 6 391-396 (6 pages)
on MDA-MB-231 breast cancer cells migration and invasion in relation to metastasis under hypoxic conditions has been defined. Inhibition of IL-11 expression or function using small interfering RNA (siRNA) or a neutralizing antibody attenuated hypoxic MDA-MB-231 breast cancer cell migration and invasion through down-regulation of matrix metalloproteinases (MMPs) and activation of epithelial-to-mesenchymal transition (EMT) related gene expression. In addition, hypoxia-induced IL-11 increased STAT3... -
Multiple Effects of a Novel Epothilone Analog on Cellular Processes and Signaling Pathways Regulated by Rac1 GTPase in the Human Breast Cancer Cells
HongZhang, FanAn, LiTang, RongguoQiu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.2 4 109-120 (12 pages)
gene cluster. This study investigated the effects of UTD2 on the actin cytoskeleton and its critical regulators, and the signaling pathways which are essential for cell motility, growth and survival in MCF-7 breast cancer cells. Results showed that UTD2 inhibited the cellular functions of actin cytoskeleton, such as wound-closure, migration and invasion, as well as adhesion. Our study further demonstrated that UTD2 suppressed Rac1 GTPase activation and reduced the activity of PAK1, which is a... -
Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells
Yun-HeeBae, JongHyoRyu, Hyun-JooPark, KwangRokKim, Hee-JunWee, Ok-HeeLee, Hye-OckJang, Moon-KyoungBae, Kyu-WonKim, Soo-KyungBae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 6 291-297 (7 pages)
of breast cancer. Mutant p53 (R280K) is overexpressed in MDA-MB-231 triple-negative human breast cancer cells. The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis. We found that curcumin treatment resulted in an induction of apoptosis in MDA-MB-231 cells, together with downregulation of Notch1 and its downstream target, Hes1. This... -
Avoidant Insecure Attachment as a Predictive Factor for Psychological Distress in Patients with Early Breast Cancer
Sang-Shin Lee, Hyo-Deog Rim, Seung-Hee Won, Jungmin Woo 대한신경정신의학회 Psychiatry Investigation 6 Pages
대한신경정신의학회 Psychiatry Investigation 2018, 제 15권 제 8호 9 805-810 (6 pages)
1 year after surgery in the early breast cancer (BC) population. Methods_One-hundred fourteen participants completed the Hospital Anxiety and Depression Scale (HADS) and the Experiences in Close Relationship (ECR-M36) questionnaire within 1 week (baseline) and at 1-year post-surgery (follow-up). Participants were categorized into the distress and the non-distress groups based on a HADS-total score cut-off of 15. Logistic regression analysis revealed predictive factors of distress at follow-up.... -
Helpful and Unhelpful Messages for Korean Women with Breast Cancer
Hyegyu Lee, Hanna Joo, Hee Sun Park 한국헬스커뮤니케이션학회 헬스커뮤니케이션연구 38 Pages
한국헬스커뮤니케이션학회 헬스커뮤니케이션연구 2017, Vol.16 1 1-38 (38 pages)
We examined helpful and unhelpful messages that 35 Korean women with breast cancer commonly received. Messages providing optimism were the most frequently received type; the majority of the interviewees wanted to receive more of that type. Interviewees considered minimization of disease extent or impact helpful. Another finding unique to Korean culture is that family members express their share of responsibility for, and guilt feelings about, the interviewees being afflicted with breast cancer.... -
Images Say More Than Text: Effects of Pictorial Exemplification in Health News on Promoting Breast Cancer Early Detection Behavior
Yangsun Hong, Woohyun Yoo 한국헬스커뮤니케이션학회 헬스커뮤니케이션연구 31 Pages
한국헬스커뮤니케이션학회 헬스커뮤니케이션연구 2015, Vol.13 2 29-59 (31 pages)
of the highest in the world. As part of the efforts of preventing breast cancer among them, this study examines the potentials of pictorial exemplars: (a) tests the effects of pictorial exemplars in breast cancer news on perceived susceptibility and perceived severity of breast cancer and (b) assesses the effects of perceived susceptibility and perceived severity of breast cancer on intention to perform breast cancer detection behaviors. Ninety-seven South Korean college students participated in... -
The Social Stress-Buffering Role of Exchanging Emotional Support in an Online Breast Cancer Support Group
Woohyun Yoo 한국헬스커뮤니케이션학회 헬스커뮤니케이션연구 39 Pages
한국헬스커뮤니케이션학회 헬스커뮤니케이션연구 2014, Vol.11 4 119-157 (39 pages)
emotional support in an online breast cancer support group. The data used in the analysis resulted from merging computer-aided content analysis of discussion posts, action log data analysis of system usage, and longitudinal survey data collected from 237 participants in an online breast cancer support group. Findings indicated that the expression and reception of emotional support buffered the deleterious effect of unsupportive intimate relationship on breast cancer patients’ coping strategies.


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