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2591.

생체의 Polyamine-분석을 위하여 FNBT-유도체를 이용하는 간편하고 특이적이며 예민한 Isocratic RP-HPLC 분석법과 재생성 흰쥐-간의 Polyamine-대사의 변동에 관한연구

최상현(Sang-Hyun Choi), 김형건(Hyung-Gun Kim), 박홍익(Hong-Ik Park), 전보권(Boe-Gwun Chun) 대한약리학회 대한약리학잡지 8 Pages

대한약리학회 대한약리학잡지 1988, 제 24권 제 2호 9 233-240 (8 pages)

최상현(Sang-Hyun Choi), 김형건(Hyung-Gun Kim), 박홍익(Hong-Ik Park), 전보권(Boe-Gwun Chun) 저
...
- 3,000원
복잡한 시료-전처리과정을 배제하여 간편하고 선택적이며 예민한 polyamine 측정방법으로써 4-fluoro-3-nitrobenzotrifluoride (FNBT)유도체 및 단일이동상을 이용하는 역상의 고속액체 크로마토 그래피 (HPLC) 방법과 아울러 이 방법을 이용한 흰쥐의 재생성간내 polyamine대사의 변동에 관한 관찰-결과를 요약하면 다음과 같다. 1. 간내-polyamine은 0.4M perchloric acid에 추출한 후 Spragg와 Hutchings의 방법에 따라서 FNBT로 N-2 -nitro-4 -trifluoromethylphenyl polyamine (NTP-polyamine) 유도체를 만들고 이를HPLC로 분석...
2592.

Lidocaine이 아미노산 신경전도물질의 유리, 수용체 결합, 및 섭취에 미치는 효과에 관한 시험관내 실험에 관한 연구

오안민(An-Min Oh), 정동균(Dong-Kyun Cheong), 모리 마사까즈(Masakazu Mori) 대한약리학회 대한약리학잡지 14 Pages

대한약리학회 대한약리학잡지 1988, 제 24권 제 1호 3 17-30 (14 pages)

오안민(An-Min Oh), 정동균(Dong-Kyun Cheong), 모리 마사까즈(Masakazu Mori) 저
...
- 4,300원
Lidocaine 투여에 의한 전신경련의 작용기전을 추구하고자 흰쥐의 전체뇌를 또는 선조체, 해마, 및 중뇌를 부위별로 적출하여 synaptosomes를 마련하고 20μM veratrine또는 5μM K+ 첨가에 의한 신경 전달물질 (Aspartic acid, Glutamic acid, GABA, Norepinephrine)의 유리촉진작용에 미치는 lidocaine, propranolol, norepinephrine 또는 serotonin의 억제효과를 관찰하였고 [3H]M와 [3H]-glutamic acid의 synaptosomes로의 섭취에 미치는 lidocaine의 영향도 관찰하였다. 아울러 crude synaptic membrane을 이용하여 [3H]-GABA와...
2593.

백서(白鼠) 뇌조직(腦組織)에서 Morphine의 Saturable Binding에 미치는 전해질(電解質)의 영향(影響)

고복현(Bok-Hyun Ko), 채수완(Soo Wan Chae), 조규박(Kyu Park Cho) 대한약리학회 대한약리학잡지 12 Pages

대한약리학회 대한약리학잡지 1982, 제 18권 제 2호 4 33-44 (12 pages)

고복현(Bok-Hyun Ko), 채수완(Soo Wan Chae), 조규박(Kyu Park Cho) 저
...
- 4,100원
전해질농도(電解質濃度)를 달리하고 morphine, naloxone 또는 morphine+naloxone을 가(加)하거나 가(加)하지 않은 modified Krebs-Henseleit bicarbonate buffer용액(溶液)에 흰쥐의 뇌절편(腦切片)을 incubate하여 저온처리(低溫處理)와 media내(內) 전해질조성(電解質組成)이 (3H)-morphine의 saturable binding에 미치는 영향(影響)을 관찰(觀察)하여 다음과 같은 성적(成績)을 얻었다. 1) 저온처리(低溫處理)는 (3H)-morphine의 saturable binding을 현저(顯著)히 증가(增加)시켰고, maximal saturable binding은 증가(增加)시키나...
2594.

Endothelium-dependent Contraction of Aorta in One-kidney, One-clip Goldblatt Hypertensive Rat

Jeon, Byeong-Hwa, Lee, Kug-Hee, Kim, Hoe-Suk, Kim, Se-Hoon, Chang, Seok-Jong 대한생리학회 대한생리학회지 10 Pages

대한생리학회 대한생리학회지 1996, 제 30권 제 2호 9 269-278 (10 pages)

Jeon, Byeong-Hwa, Lee, Kug-Hee, Kim, Hoe-Suk, Kim, Se-Hoon, Chang, Seok-Jong 저
...
- 3,000원
The mechanism of impaired endothelium-dependent relaxation in the aorta of one-kidney, one clip Goldblatt hypertensive (1K,1C-GBH) rats was investigated. 8 week-old Wistar-Kyoto (WKY) rats were made hypertensive by left renal artery stenosis with contralateral nephrectomy. Endothelium-dependent relaxation was significantly reduced in 1K,1C-GBH rats as compared with WKY rats. However, the relaxation by sodium nitroprusside in 1K,1C-GBH rats was not reduced as compared with WKY rats. The...
2595.

Electrophysiological Responses of δ -Opioid Receptor Expressed on HEK293 Cells

Kim, Jin-Hyuk, Koh, Young-Ik, Chin, He-Min, Lee, Yong-Sung, Cho, Yeul-Hee, Kim, Kee-Soon 대한생리학회 대한생리학회지 8 Pages

대한생리학회 대한생리학회지 1995, 제 29권 제 2호 12 301-308 (8 pages)

Kim, Jin-Hyuk, Koh, Young-Ik, Chin, He-Min, Lee, Yong-Sung, Cho, Yeul-Hee, Kim, Kee-Soon 저
...
- 3,000원
hybrid) cDNA library. Also studied were effects of 8-bromo-cyclic AMP and naloxone on DPDPE-induced changes in the voltage sensitive outward current. The voltage sensitive outward currents were recorded using perforated patch technique at room temperature. In the non-transformed HEK293 cells, DPDPE did not alter voltage sensitive outward current, indicating that no native δ-Opioid receptor had been developed. However, (1 μM) DPDPE remarkably increased the voltage sensitive outward current in...
2596.

Contractile and Electrical Responses of Guinea-pig Gastric Smooth Muscle to Bradykinin

Kim, Chul-Soo, Jun, Jae-Yeoul, Kim, Sung-Joon, So, In-Suk, Kim, Ki-Whan 대한생리학회 대한생리학회지 10 Pages

대한생리학회 대한생리학회지 1995, 제 29권 제 2호 5 233-242 (10 pages)

Kim, Chul-Soo, Jun, Jae-Yeoul, Kim, Sung-Joon, So, In-Suk, Kim, Ki-Whan 저
...
- 3,000원
The nonapeptide bradykinin has been shown to exhibit an array of biological activities including relaxation/contraction of various smooth muscles. In order to investigate the effects of bradykinin on the contractility and the electrical activity of antral circular muscle of guinea-pig stomach, the isometric contraction and membrane potential were recorded. Also, using standard patch clamp technique, the Ca2+-activated K currents were recorded to observe the change in cytosolic Ca2+...
2597.

Effects of Insulin and IGFS on Growth and Functional Differentiation in Primary Cultured Rabbit Kidney Proximal Tubule Cells -Growth and membrane transport-

Han, Ho-Jae, Park, Kwon-Moo, 대한생리학회 대한생리학회지 12 Pages

대한생리학회 대한생리학회지 1995, 제 29권 제 2호 1 191-202 (12 pages)

Han, Ho-Jae, Park, Kwon-Moo, 저
...
- 4,100원
The purpose of this study was to compare effects of insulin and IGFs on growth, apical membrane enzyme activities and membrane transport systems of primary cultured rabbit kidney proximal tubule cells. Results were as follows: 1. Insulin and IGF-I produced significant growth stimulatory effects at 5 X 10-10M. IGF-II(5 X 10 -10 M) did not stimulate significant cell growth. 2. Insulin stimulated the phosphorylation of a 97 KD protein. It was difficult to determine whether this band represents...
2598.

Effects of In Vitro Exposure to Silica on Bioactive Mediator Release by Alveolar Macrophages

Lee, Ji-Hee 대한생리학회 대한생리학회지 12 Pages

대한생리학회 대한생리학회지 1995, 제 29권 제 1호 1 1-12 (12 pages)

Lee, Ji-Hee 저
...
- 4,100원
a positive control fur the PAF assay increased PAF release by 19 % of total serotonin release. Furthermore, silica also resulted in significant enhancement of the PAF release compared with that in unstimulated (control) cells, i.e., 17.7±5.8% and 24.0±4.9% of total serotonin release at 5 mg/ml and 10 mg/ml silica, respectively, which represents the release of nanomole levels of PAF. Lastly, IL-1 production by alveolar macrophages was analysed following their stimulation with lipopolysaccharide...
2599.

Effects of Lemakalim, a Potassium Channel Opener, on the Contractility and Electrical Activity of the Antral Circular Muscle in Guinea-Pig Stomach

Kim, Sung-Joon, Jun, Jae-Yeoul, Choi, Youn-Baik, Kim, Ki-Whan, Kim, Woo-Gyeum 대한생리학회 대한생리학회지 14 Pages

대한생리학회 대한생리학회지 1994, 제 28권 제 1호 4 37-50 (14 pages)

Kim, Sung-Joon, Jun, Jae-Yeoul, Choi, Youn-Baik, Kim, Ki-Whan, Kim, Woo-Gyeum 저
...
- 4,300원
Synthetic potassium channel openers (KCOs) are agents capable of opening K-channels in excitable cells. These agents are known to have their maximal potency in the smooth muscle tissue, especially in the vascular smooth muscle. Much attention has been focused on the type of K-channel that is responsible for mediating the effects of KCOs. As the KCO-induced changes are antagonized by glibenclamide, an KATP (ATP-sensitive K-channel) blocker in the pancreatic β-cell, KATP was suggested to be the...
2600.

Effect of Dopamine on the Ca2+-dependent K+ currents in Isolated Single Gastric Myocytes of the Guinea-pig

Rhee, Poong-Lyul, Lee, Sang-Jin, Kim, Sung-Joon, So, In-Suk, Hwang, Sang-Ik, Kim, Ki-Whan 대한생리학회 대한생리학회지 12 Pages

대한생리학회 대한생리학회지 1993, 제 27권 제 2호 3 139-150 (12 pages)

Rhee, Poong-Lyul, Lee, Sang-Jin, Kim, Sung-Joon, So, In-Suk, Hwang, Sang-Ik, Kim, Ki-Whan 저
...
- 4,100원
We have reported that dopamine potentiates spontaneous contractions dose-dependently in guinea-pig antral circular muscle strips (Hwang et al, 1991). To clarify the underlying excitatory mechanism of dopamine on the gastric smooth muscle, the effects of dopamine on voltage-dependent Ca2+ currents and Ca2+ -dependent K+ currents were observed in enzymatically dispersed guinea-pig gastric myocytes using the whole-cell voltage-clamp technique. Experiments were also done using isometric tension...

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