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Ketoprofen 첩포제(Ketotop : )의 경피적용에 따른 혈장농도 및 피부자극의 검토
임동석, 장인진, 유재학, 은희철, 신상구, Yim. Dong-Seok, Jang. In-Jin, Yoo. Jae-Hak, Eun. Hee-Chul, Shin. Sang-Goo 대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 7 Pages
대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 1994, Vol.2 No.1 41-47 (7 pages)
연구는 matrix type으로 개발한 Ketoprofen 경피적용 첩포제의 임상적 유용성을 검토하기 위한 일환으로 기존의 습포제형 침포제로 일본에서 시판되고 있는 M제품을 대조약물로, 이들제형의 경피흡수율 및 피부자극성을 비교 검토하였다. 방 법 : 12명의 건강한 성인남성 지원자를 대상으로 무작위 교차시험을 시행하였다. 시험제제 및 대조제제 3매(각 30mg함유 첩포제)를 상체 배면에 24시간 적용하였으며, 두 제제의 피부자극 정도를 검토키 위한 기준척도로 동일 크기의 surgical plaster를 동시에 부착하였다. 혈장 keoprofen 농도의... -
Enantioseparation of Flurbiprofen and Ketoprofen in Patches and in Urine Excretions by Achiral Gas Chromatography
Paik. Man-Jeong, Nguyen. Duc-Toan, Kim. Kyoung-Rae 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 7 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2004, Vol.27 No.12 1295-1301 (7 pages)
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Candida rugosa 리파제를 이용한 광학적으로 순수한 S-(+)-Ketoprofen의 생산
김민곤, 최순자, 최원아, 김철호, 정봉현 한국생물공학회 한국생물공학회지 5 Pages
한국생물공학회 한국생물공학회지 1999, Vol.14 No.2 225-229 (5 pages)
연구에서는 광학적으로 순수한 S-(+)-ketoprofen을 얻기 위한 효소적 분할공정을 개발하는 것을 그 내용으로 하고 있다. 결과에 의하면 Candida rugosa 유래의 lipase는 음이온 교환수지에 의해 두 가지 형태의 효소로 분리되었으며 특히 첫 번째 peak의 lipaserk (S)-enantiomer에 대해 선택성이 매우 높은 것으로 나타났다. 온도 pH, 첨가제의 영향에 대해서 조사한 결과 높은 활성을 유지하면서 광학적으로 순수한 (S)-ketoprofen을 얻는 조건을 찾지는 못하였으나, $37^{circ}C$의 온도에서 선택성이 높았으며 ethylen glyco과 같은... -
구강외과영역의 염증성질환에 대한 PROFENID (Ketoprofen)의 치험성적에 관하여
이춘근, 김규식, 민병일, 김종원, 남일우, 양동규, Rhee. Chun-Geun, Kim. Gyu-Sik, Min. Byeong-Il, Kim. Jong-Won, Nam. Il-U, Yang. Dong-Kyu 대한치과의사협회 大韓齒科醫師協會誌 4 Pages
대한치과의사협회 大韓齒科醫師協會誌 1977, Vol.15 No.1 59-62 (4 pages)
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The effect of intrinsic foot muscle training on medial longitudinal arch and ankle stability in patients with chronic ankle sprain accompanied by foot pronation
Kyoung A Chung, Eun-sang Lee, Seung-won Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 6 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2016, 제 5권 제 2호 4 78-83 (6 pages)
Objective: The purpose of this study was to investigate whether the intrinsic foot muscle training method can improve the medial longitudinal arch in patients with chronic ankle injury and with pronated feet, as well as to investigate for the most effective exercise method for these patients. Design: Randomized controlled trial. Methods: Thirty men and women with pronated feet had participated in this study and were allocated to either the short foot exercise group (SFEG) or the towel curl... -
Analgesic efficacy of oral firocoxib in ovariohysterectomized cats
Prangtip Phuwapattanachart, Naris Thengchaisri 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 2호 7 175-182 (8 pages)
The postoperative analgesic effects of firocoxib in ovariohysterectomized cats were observed. Twenty-four cats were divided into 3 groups: control (no medicine), firocoxib-1 (1 mg/kg/day) and firocoxib-3 (3 mg/kg/day). Colorado pain scale scores (CPSS), composite pain scores (CPS), and buccal mucosal bleeding times (BMBT) were recorded in blinded fashion before induction and 2, 5, 8, 24, 30, and 48 h post-operation. The average CPSS (mean ± SEM) over 2 to 48 h post-operation in firocoxib-3 (0.4... -
Stress and pain response after oligofructose induced-lameness in dairy heifers
Hedie A. Bustamante, Alfredo R. Rodr?guez, Daniel E. Herzberg, Marianne P. Werner 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 4호 3 405-411 (7 pages)
Lameness is one of the most painful conditions that affects dairy cattle. This study was conducted to evaluate clinical signs and plasma concentration of several pain and stress biomarkers after oligofructose-induced lameness in dairy heifers. Lameness was induced using an oligofructose overload model in 12 non-pregnant heifers. Clinical parameters and blood samples were obtained at 48 and 24 h and at 6, 12, 24, 36 and 48 h after induction of lameness. Clinical parameters included heart rate,... -
Total hip replacement in two dogs with unsuccessful femoral head ostectomy
Su-Young Heo, Jae-Won Seol, Hae-Beom Lee 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 1호 18 131-134 (4 pages)
An English setter (case 1) and a Tibetan mastiff (case 2) presented with intermittent weight-bearing lameness on the right hind limb when trotting. The dogs had a history of femoral head and neck ostectomy (FHNO). Orthopedic examination revealed pain and crepitus on the right hip joint. The dogs underwent total hip replacement (THR). At the 2-year (case 1) and 1-year (case 2) follow-up, both dogs had resumed normal activity without lameness. The muscle mass and range... -
Effect of Harderian adenectomy on the statistical analyses of mouse brain imaging using positron emission tomography
Minsoo Kim, Sang-Keun Woo, Jung Woo Yu, Yong Jin Lee, Kyeong Min Kim, Joo Hyun Kang, Kidong Eom, Sang-Soep Nahm* 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 18 157-161 (5 pages)
Positron emission tomography (PET) using 2-deoxy-2-[F] fluoro-D-glucose (FDG) as a radioactive tracer is a useful technique for in vivo brain imaging. However, the anatomical and physiological features of the Harderian gland limit the use of FDG-PET imaging in the mouse brain. The gland shows strong FDG uptake, which in turn results in distorted PET images of the frontal brain region. The purpose of this study was to determine if a simple surgical procedure to remove the Harderian gland prior to... -
In vitro effects of meloxicam on the number, Foxp3 expression, production of selected cytokines, and apoptosis of bovine CD25+CD4+ and CD25−CD4+ cells
Tomasz Maślanka*, Jerzy Jan Jaroszewski 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 2호 3 125-134 (10 pages)
The purpose of this study was to evaluate the effect of meloxicam (MEL) on selected immune parameters of bovine CD25CD4+, CD25CD4+, and CD25−CD4+ cells. Peripheral blood mononuclear cells (PBMCs) collected from 12-month-old heifers were treated with MEL at a concentration corresponding to the serum level of this medication following administration at the recommended dose (MEL 5 × 10 M) and at a concentration 10 times lower (MEL 5 × 10 M). After 12 and 24 h of incubation with the drug,...


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