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Ca2+ is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line
SoonhongPark, SangKyunKu, HyeWonJi, Jong-HoonChoi, DongMinShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.3 9 249-255 (7 pages)
as a model and showed that Ca2+ may have a role in regulating Wnk kinase in the HSG cell line. Through this study, we found that the HSG cell line expressed molecules participating in the WNK-OSR1-NKCC pathway, such as Wnk1, Wnk4, OSR1, SPAK, and NKCC1. The HSG cell line showed an intracellular Ca2+ concentration ([Ca2+]i) increase in response to hypotonic stimulation, and the response was synchronized with the phosphorylation of OSR1. Interestingly, when we inhibited the hypotonically induced... -
Role of Cerebrospinal Fluid Biomarkers in Clinical Trials for Alzheimer’s Disease Modifying Therapies
Ju-HeeKang, Na-YoungRyoo, DongWunShin, JohnQTrojanowski, LeslieM.Shaw 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 1 447-456 (10 pages)
for go/no-go decision making as well as surrogate markers for disease severity or progression. Furthermore, CSF biomarkers can be used as a tool to enrich patients for clinical trials with prospect of increasing statistical power and reducing costs in drug development. However, the standardization of technical aspects of analysis of these biomarkers is an essential prerequisite to the clinical uses. To accomplish this, global efforts are underway to standardize CSF biomarker measurements and a... -
Modeling of the Parathyroid Hormone Response after Calcium Intake in Healthy Subjects
JaeEunAhn, SangilJeon, JongtaeLee, SeunghoonHan, Dong-SeokYim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.3 4 217-223 (7 pages)
mechanistic model for the parathyroid hormone (PTH) response after calcium intake and indirectly compare the difference in oral calcium absorption from PTH responses. PTH and Ca2+ concentrations were collected from 24 subjects from a clinical trial performed to evaluate the safety and calcium absorption of Geumjin Thermal Water in comparison with calcium carbonate tablets in healthy subjects. Indirect response models (NONMEM Ver. 7.2.0) were fitted to observed Ca2+ and PTH data, respectively, in... -
Neurovascular Mechanisms in Stroke, Neurodegeneration and Recovery
EngH.Lo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.5 1 223-230 (8 pages)
The emerging concept of the“neurovascular unit”may enable a powerful paradigm shift for neuroscience. Instead of a pure focus on the“neurobiology”of disease, an opportunity now exists to return to a more integrative approach. The neurovascular unit emphasizes that signaling between vascular and neuronal compartments comprise the basis for both function and dysfunction in brain. Hence, brain disorders are not just due to death of neurons, but instead manifested as cell signaling perturbations... -
Inhibition of Sarcoplasmic Reticulum Ca2+ Uptake by Pyruvate and Fatty Acid in H9c2 Cardiomyocytes: Implications for Diabetic Cardiomyopathy
EunHeeLee, HyeKyungLee, HaeWonKim, Young-HoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.4 2 195-202 (8 pages)
High extracellular glucose concentration was reported to suppress intracellular Ca2 clearing through altered sarcoplasmic reticulum (SR) function. In the present study, we attempted to elucidate the effects of pyruvate and fatty acid on SR function and reveal the mechanistic link with glucose-induced SR dysfunction. For this purpose, SR Ca2-uptake rate was measured in digitonin-permeabilized H9c2 cardiomyocytes cultured in various conditions. Exposure of these cells to 5 mM... -
The Role of Nitric Oxide for the Regulation of Vascular Tone in Health and Disease
Thiemermann, Christoph 대한생리학회 대한생리학회지 9 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 2호 1 187-195 (9 pages)
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Characteristics of Synthesized Red Cells Using Bovine Hemoglobin as Oxygen Carrier
Cho, Eng-Haeng, Hah, Jong-Sik, Kim, Ku-Ja 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 1호 4 37-44 (8 pages)
The encapsulation of the Purified bovine hemoglobin with Phospholipids obtained from egg folk was performed using a rotary vacuum evaporator. The prepared Hb-containing liposome (hemosome) had good properties as artificial red blood cell. The shape and size of the hemosomes were measured by a phase contrast microscope and image analyzer. The function of the hemosome as oxygen carrier was tested by measuring oxygen saturation curve with blood gas analyzer and infusing it into rats. The prepared... -
플라즈마 개질기를 이용한 모사타르 나프탈렌 제거 특성
김성천, 고진환, 전영남 한국열환경공학회 열환경공학 11 Pages
한국열환경공학회 열환경공학 2012, 제 9권 2호 2 9-19 (11 pages)
