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381.

Cilostazol attenuates kainic acid-induced hippocampal cell death

Young-SeopPark, ZhenJin, EunAeJeong, Chin-okYi, JongYoulLee, InSungPark, GuSeobRoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 7 63-70 (8 pages)

Young-SeopPark, ZhenJin, EunAeJeong, Chin-okYi, JongYoulLee, InSungPark, GuSeobRoh 저
...
- 3,000원
of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss. Cilostazol pretreatment reduced KA-induced seizure scores and hippocampal neuron death. In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation. These observations suggest that cilostazol may have beneficial therapeutic effects on seizure activity and other neurological diseases associated with...
382.

Alleviation of ascorbic acid-induced gastric high acidity by calcium ascorbate in vitro and in vivo

Joon-KyungLee, Sang-HyukJung, Sang-EunLee, Joo-HuiHan, EunjiJo, Hyun-SooPark, Kyung-SunHeo, DeasunKim, Jeong-SookPark, Chang-SeonMyung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 4 35-42 (8 pages)

Joon-KyungLee, Sang-HyukJung, Sang-EunLee, Joo-HuiHan, EunjiJo, Hyun-SooPark, Kyung-SunHeo, DeasunKim, Jeong-SookPark, Chang-SeonMyung 저
...
- 3,000원
juice pH, total acid output, and pepsin secretion in an in vivo rat model, as well as pharmacokinetic parameters. Calcium ascorbate and ascorbic acid had similar antioxidant activity. However, the gastric fluid pH was increased by calcium ascorbate, whereas total acid output was increased by ascorbic acid. In the rat pylorus ligation-induced ulcer model, calcium ascorbate increased the gastric fluid pH without changing the total acid output. Administration of calcium ascorbate to rats given a...
383.

Morroniside on anti-inflammation activities in rats following acute myocardial infarction

BangxingYu, GuoxingZhang, YiAn, WenWang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 2 17-21 (5 pages)

BangxingYu, GuoxingZhang, YiAn, WenWang 저
...
- 1,500원
Our previous studies have confirmed that morroniside has neuroprotective effects. However, the effects of morroniside on cardiac myocardium remain unknown. Rats were anaesthetized with 10% chloral hydrate (0.35~0.4 mL/kg) and an acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD). Following AMI, morroniside was administered intragastrically for 3 consecutive days at doses of 45, 90 and 180 mg/kg, respectively. Lactate dehydrogenase (LDH) and...
384.

Role of inflammasomes in inflammatory autoimmune rheumatic diseases

Young-SuYi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 15 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 1 1-15 (15 pages)

Young-SuYi 저
...
- 4,400원
Inflammasomes are intracellular multiprotein complexes that coordinate anti-pathogenic host defense during inflammatory responses in myeloid cells, especially macrophages. Inflammasome activation leads to activation of caspase-1, resulting in the induction of pyroptosis and the secretion of pro-inflammatory cytokines including interleukin (IL)-1β and IL-18. Although the inflammatory response is an innate host defense mechanism, chronic inflammation is the main cause of rheumatic diseases, such...
385.

Dual control of the vestibulosympathetic reflex following hypotension in rats

SangEonPark, Yuan-ZheJin, ByungRimPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 13 675-686 (12 pages)

SangEonPark, Yuan-ZheJin, ByungRimPark 저
...
- 4,100원
Orthostatic hypotension (OH) is associated with symptoms including headache, dizziness, and syncope. The incidence of OH increases with age. Attenuation of the vestibulosympathetic reflex (VSR) is also associated with an increased incidence of OH. In order to understand the pathophysiology of OH, we investigated the physiological characteristics of the VSR in the disorder. We applied sodium nitroprusside (SNP) to conscious rats with sinoaortic denervation in order to induce hypotension....
386.

Chronic cerebral hypoperfusion and plasticity of the posterior cerebral artery following permanent bilateral common carotid artery occlusion

Kyung-OkCho, Seul-KiKim, SeongYunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 9 643-650 (8 pages)

Kyung-OkCho, Seul-KiKim, SeongYunKim 저
...
- 3,000원
of the brain vasculature and white matter damage after BCCAo. We found reference memory impairment in Wistar rats, but not in SD rats. Moreover, our LDPI system revealed that Wistar rats had significant hypoperfusion in the brain region supplied by the posterior cerebral artery (PCA). Furthermore, Wistar rats showed more profound CBF reduction in the forebrain region than did SD rats. Post-mortem analysis of brain vasculature demonstrated greater PCA plasticity at all time points after BCCAo in...
387.

Taurine relaxes human radial artery through potassium channel opening action

Kemal Gokhan Ulusoy, Erkan Kaya, Kubilay Karabacak, Melik Seyrek, ?brahim Duvan, Vedat Yildirim, Oguzhan Yildiz 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 6 617-623 (7 pages)

Kemal Gokhan Ulusoy, Erkan Kaya, Kubilay Karabacak, Melik Seyrek, ?brahim Duvan, Vedat Yildirim, Oguzhan Yildiz 저
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- 3,000원
The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, 30 µM) to organ baths. When the precontractions were stable, taurine (20, 40, 80 mM) was added cumulatively. Antagonistic effect of taurine on calcium chloride (10 µM to 10...
388.

JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells

DaeWooChoi, DoKyungKim, YoshikatsuKanai, MichaelF.Wempe, HitoshiEndou, Jong-KeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 4 599-607 (9 pages)

DaeWooChoi, DoKyungKim, YoshikatsuKanai, MichaelF.Wempe, HitoshiEndou, Jong-KeunKim 저
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- 3,000원
Most normal cells express L-type amino acid transporter 2 (LAT2). However, L-type amino acid transporter 1 (LAT1) is highly expressed in many tumor cells and presumed to support their increased growth and proliferation. This study examined the effects of JPH203, a selective LAT1 inhibitor, on cell growth and its mechanism for cell death in Saos2 human osteosarcoma cells. FOB human osteoblastic cells and Saos2 cells expressed LAT1 and LAT2 together with their associating protein 4F2 heavy chain,...
389.

Genistein attenuates isoflurane-induced neurotoxicity and improves impaired spatial learning and memory by regulating cAMP/CREB and BDNF-TrkB-PI3K/Akt signaling

TaoJiang, Xiu-qinWang, ChuanDing, Xue-lianDu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 2 579-589 (11 pages)

TaoJiang, Xiu-qinWang, ChuanDing, Xue-lianDu 저
...
- 4,000원
Anesthetics are used extensively in surgeries and related procedures to prevent pain. However, there is some concern regarding neuronal degeneration and cognitive deficits arising from regular anesthetic exposure. Recent studies have indicated that brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are involved in learning and memory processes. Genistein, a plant-derived isoflavone, has been shown to exhibit neuroprotective effects. The present study...
390.

Effects of exercise on obesity-induced mitochondrial dysfunction in skeletal muscle

Jun-WonHeo, Mi-HyunNo, Dong-HoPark, Ju-HeeKang, DaeYunSeo, JinHan, P.DarrellNeufer, Hyo-BumKwak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 1 567-577 (11 pages)

Jun-WonHeo, Mi-HyunNo, Dong-HoPark, Ju-HeeKang, DaeYunSeo, JinHan, P.DarrellNeufer, Hyo-BumKwak 저
...
- 4,000원
Obesity is known to induce inhibition of glucose uptake, reduction of lipid metabolism, and progressive loss of skeletal muscle function, which are all associated with mitochondrial dysfunction in skeletal muscle. Mitochondria are dynamic organelles that regulate cellular metabolism and bioenergetics, including ATP production via oxidative phosphorylation. Due to these critical roles of mitochondria, mitochondrial dysfunction results in various diseases such as obesity and type 2 diabetes....

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