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Prolyl 4 Hydroxylase: A Critical Target in the Pathophysiology of Diseases
RaviKant, AnjanaBali, NirmalSingh, AmteshwarSinghJaggi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.2 1 111-120 (10 pages)
Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well in the systemic circulation. Over a period of time, a number of prolyl hydroxylase inhibitors and activators have been developed. By employing the pharmacological tools and transgenic knock out animals, the critical role of these enzymes has been established in the... -
Regulation of Ca2+ Signaling in Pulmonary Hypertension
AmyL.Firth, JunYeonWon, WonSunPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 1 1-8 (8 pages)
Understanding the cellular and molecular mechanisms involved in the development and progression of pulmonary hypertension (PH) remains imperative if we are to successfully improve the quality of life and life span of patients with the disease. A whole plethora of mechanisms are associated with the development and progression of PH. Such complexity makes it difficult to isolate one particular pathway to target clinically. Changes in intracellular free calcium concentration, the most common... -
Neurovascular Mechanisms in Stroke, Neurodegeneration and Recovery
EngH.Lo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.5 1 223-230 (8 pages)
manifested as cell signaling perturbations at the neurovascular interface. In this mini-review, we will examine 3 examples of this hypothesis: neurovascular mechanisms involved in the thrombolytic therapy of stroke, the crosstalk between neurogenesis and angiogenesis, and the link between vascular dysfunction and amyloid pathology in Alzheimer's disease. An understanding of cell-cell and cell-matrix signaling at the neurovascular interface may yield new approaches for targeting CNS disorders. -
느릅나무 근피드레싱이 쥐에 유발된 욕창의 섬유아세포성장인자와 혈관내피성장인자에 미치는 효과
나연경 한국기초간호학회 Journal of Korean Biological Nursing Science 7 Pages
한국기초간호학회 Journal of Korean Biological Nursing Science 2013, Volume 15, No 4 12 257-263 (7 pages)
일에서 2008년 60.8일로 증가하였다(Nam & Lim, 2012). 또한 2005년 전국 가정전문간호사업소를 대상으로 가정 간호 서비스를 분석한 결과 욕창치료로 가정전문간호사가 방문한 사례가 1인당 월 29.5회로 가장 많은 것으로 나타나 욕창관리의 중요성이 부각되었다(Ryu, Park, Kim, Kwon, & Kang, 2008). 욕창관리를 받는 가정 간호 대상자 중 40.2%가 3-4단계의 욕창이었으며, 간호중재 방법으로 습포드레싱, 항생제 연고 도포 및 느릅나무 근피 드레싱과 같은 민간요법을 사용하고 있는 것으로 확인되었다(Kim, Cho, & Park, 1997; Kim &...
