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전체 선택해제
총 71건 검색
본문검색 결과만 보기
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The Stimulatory Effect of Essential Fatty Acids on Glucose Uptake Involves Both Akt and AMPK Activation in C2C12 Skeletal Muscle Cells
SoYeonPark, MinHyeKim, JoungHoonAhn, SuJinLee, JongHoLee, WonSikEum, SooYoungChoi, HyeokYilKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.3 9 255-261 (7 pages)
of its downstream molecules, acetyl-CoA carboxylase (ACC) was markedly induced by EFA, but not OA. In addition, EFA-stimulated 2-NBDG uptake was significantly inhibited by the pre-treatment of a specific AMPK inhibitor, adenine 9-β-D-arabinofuranoside (araA). These data suggest that the restoration of suppressed insulin signaling at PA-induced insulin resistant condition and AMPK activation are involved at least in the stimulatory effect of EFA on glucose uptake in C2C12 skeletal muscle cells. -
Effect of Lutein on L-NAME-Induced Hypertensive Rats
JiHoonSung, YoungSooJo, SuJinKim, JeongSooRyu, MyungChulKim, HyunJuKo, SangSooSim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 12 339-345 (7 pages)
We investigated the antihypertensive effect of lutein on NG-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Daily oral administration of L-NAME (40 mg/kg)-induced a rapid progressive increase in mean arterial pressure (MAP). L-NAME significantly increased MAP from the first week compared to that in the control and reached 193.3±9.6 mmHg at the end of treatment. MAP in the lutein groups was dose-dependently lower than that in the L-NAME group. Similar results were... -
(-)-Epigallocatechin-3-gallate Modulates the Differential Expression of Survivin Splice Variants and Protects Spermatogenesis During Testicular Torsion
NadaAl-Ajmi, MayAl-Maghrebi, WaleedMohammedRenno 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 2 259-265 (7 pages)
The anti-apoptotic effect of (-)-epigallocatechin-3-gallate (EGCG) during unilateral testicular torsion and detorsion (TT/D) was established in our previous study. In mice, the smallest inhibitor of apoptosis, survivin, is alternatively spliced into three variants, each suggested to have a unique function. Here, we assessed how EGCG exerts its protective effect through the expression of the different survivin splice variants and determined its effect on the morphology of the seminiferous tubules... -
Anti-Oxidative and Anti-Inflammatory Effects of QGC in Cultured Feline Esophageal Epithelial Cells
MyeongJaeLee, HyunJuSong, JunYeongJeong, SunYoungPark, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 12 81-87 (7 pages)
Quercetin-3-O-Ղ-D-glucuronopyranoside (QGC) is a flavonoid glucoside extracted from Rumex Aquaticus Herba. In the present study, anti-oxidative and anti-inflammatory effects of QGC were tested in vitro. Epithelial cells obtained from cat esophagus were cultured. When the cells were exposed to acid for 2 h, cell viability was decreased to 36%. Pretreatment with 50 ՌM QGC for 2 h prevented the reduction in cell viability. QGC also inhibited the productions of intracellular ROS by... -
Protective Effects of Oleic Acid Against Palmitic Acid-Induced Apoptosis in Pancreatic AR42J Cells and Its Mechanisms
JoungHoonAhn, MinHyeKim, HyungJooKwon, SooYoungChoi, HyeokYilKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 7 43-50 (8 pages)
in accordance with enhanced expression of Dgat2 gene. These results indicate that restoration of anti-apoptotic/pro-apoptotic protein balance from apoptosis toward cell survival is involved in the cytoprotective effects of OLA against PAM-induced apoptosis in pancreatic AR42J cells. In addition, OLA-induced increase in TAG accumulation and up-regulation of Dgat2 and Cpt1 gene expressions may be possibly associated in part with the ability of OLA to protect cells from deleterious actions of PAM. -
일측 전정기관 손상 흰쥐에서 전정안구반사와 내측전정신경핵의 c-Fos 단백질발현에 대한 전정기관의 전기자극 효과 Effect of Electrical Stimulation of the Vestibular System on Vestibuloocular Reflex and c-Fos Expression in the Medial Vestibular Nuclei of Unilateral Labyrinthectomized Rats
박병림, 황호룡, 이문영, 김민선, ByungRimPark, HoRyongHwang, MoonYongLee, MinSunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.3 6 275-284 (10 pages)
hs. However, ES group showed the symmetry of c-Fos expression after 6 hs, which was significantly early recovery in ES group. All these findings suggest that electrical stimulation ameliorates recovery of vestibuloocular reflex following ULX by the restoration of the balance of the resting activity between bilateral medial vestibular nuclei. In addition, c-Fos expression in the medial vestibular nuclei could be used as a marker of vestibular compensation since c-Fos expression is closely related... -
고도경주의 문화재보존과 활용 - 경주 월성과 쪽샘지구 신라고분을 중심으로 -
한국대학박물관협회 고문화 2013, 제81집 3 61-85 (25 pages)
경주는 한국을 대표하는 역사도시이자 관광도시로서 인식되고 있으나 실제로 도시의 이미지를 대표하는 무수한 문화재와 역사적인 경관은 제대로 정비되어 있지 못하다. 2004년 <고도보존에 관한 특별법>의 제정을 계기로 경주시에서는 ‘경주역사문화도시조성사업 기본계획’을 수립하고 역사적 문화환경을 효율적으로 보존하고, 주민생활과 재산상 피해를 최소화시킬 수 있는 다양한 정책을 추진하게 되었다. 현재, 경주시의 역사문화도시조성사업은 2035년까지 추진되는데, 가장 중심이 되는 문화유산 정비사업은 신라왕경의 골격... -
당뇨병성 신증의 발생에 있어서 산화성 스트레스의 역할
장연진(Yeon Jin Jang), 박형섭(Hyoung-sup Park), 김현식(Hyoun Sik Kim), 홍혜남(Hea Nam Hong), 김미경(Mi Kyung Kim) 대한약리학회 대한약리학잡지 8 Pages
대한약리학회 대한약리학잡지 1995, 제 31권 제 1호 10 95-102 (8 pages)
당뇨병성 신증은 만성 당뇨병에서 흔히 동반되는 심각한 합병증이나 그 발생기전은 확실히 밝혀져 있지 않다. 본 연구에서는 암, 노화, 염증등 여러 가지 질환의 발생에 관여한다고 알려진 산화성 스트레스의 증가가 당뇨병성 신증의 발생에 관여하는지를 알아 보았다. 쥐에서 신증의 유발을 용이하게 하기 위해 먼저 한쪽 신장을 적출한후 스트렙토조토신을 주사하여 당뇨병을 유발하였다(NEPH-STZ). 당뇨병 유발 8주후, NEPH-STZ쥐들은 심한 고혈당증, 단백뇨, 고혈압의 증상을 보였으며 신장조직은 보상성 비대와 함께... -
Endothelium-dependent Contraction of Aorta in One-kidney, One-clip Goldblatt Hypertensive Rat
Jeon, Byeong-Hwa, Lee, Kug-Hee, Kim, Hoe-Suk, Kim, Se-Hoon, Chang, Seok-Jong 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 2호 9 269-278 (10 pages)
The mechanism of impaired endothelium-dependent relaxation in the aorta of one-kidney, one clip Goldblatt hypertensive (1K,1C-GBH) rats was investigated. 8 week-old Wistar-Kyoto (WKY) rats were made hypertensive by left renal artery stenosis with contralateral nephrectomy. Endothelium-dependent relaxation was significantly reduced in 1K,1C-GBH rats as compared with WKY rats. However, the relaxation by sodium nitroprusside in 1K,1C-GBH rats was not reduced as compared with WKY rats. The... -
A Novel Therapeutic Measure for Metabolic Acidosis with Amino Acids
Kim, Jun, Goo, Yong-Sook, Kim, Sang-Jeong, Park, Sang-Chul, Koh, Chang-Soon 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 1호 9 89-98 (10 pages)
In hypoxic tissue conditions, pyruvate can not enter the Krebs cycle and lactic acid, produced from pyruvate, accumulates to induce lactic acidosis. Pyruvate, However, can also be converted to alanine by glutamate pyruvate transaminase, that could be enhanced by glutamate. Therefore, it would be a fundamental measure to treat the lactic acidosis in tissue hypoxic conditions when one can convert the accumulated lactic acid, through pyruvate, to alanine. To test the above hypothesis, we induced a...
