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41.

Mutation and overexpression of p53 as a prognostic factor in canine mammary tumors

Chung-Ho Lee, Wan-Hee Kim, Ji-Hey Lim, Min-Soo Kang, Dae-Yong Kim and Oh-Kyeong Kweon 대한수의학회 Journal of Veterinary Science 7 Pages

대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 1호 9 63-69 (7 pages)

Chung-Ho Lee, Wan-Hee Kim, Ji-Hey Lim, Min-Soo Kang, Dae-Yong Kim and Oh-Kyeong Kweon 저
...
- 3,000원
= 0.5, p < 0.05). In Kaplan-Meier survival analysis, the p53 index was associated with significantly shortened survival time (p < 0.01). In multivariate analysis, p53 overexpression was only an independent factor for indicator of worse prognosis in canine mammary tumors (p = 0.01). These results demonstrated that p53 gene mutations and protein overexpression using the PAb240 anti-p53 antibody were useful predictors of increased malignant potential and poor prognosis in canine mammary tumors.
42.

Sequence Analysis of Canine LINE-1 Elements and p53 Gene in Canine Transmissible Venereal Tumor

Young-Ki Choi and Chul-Joong Kim 대한수의학회 Journal of Veterinary Science 8 Pages

대한수의학회 Journal of Veterinary Science 2002, 제 3권 제 4호 6 285-292 (8 pages)

Young-Ki Choi and Chul-Joong Kim 저
...
- 3,000원
(ORFs), ORF1 and ORF2. We analysed the ORF2 located in the 5' region to the first exon of oncogene c-myc in canine transmissible venereal tumor (TVT) cell. We also showed the transcription activation was induced by this TVT-LINE sequence using CAT assay. To identify the mutation of tumor suppressor gene, sequence analysis of p53 from TVT cell was performed. We identified the point mutation of 964 nucleotide (T-C) resulting in the change of amino acid (Phe-Ser) of p53 tumor suppressor protein.
43.

Genetic analysis of canine parvovirus vaccine strains in Korea

Dong Kun Yang , Byoung Han Kim , Yeon Hee Kim , Kyung Woo Lee , Sung Suk Choi , Seong Wan Son 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 6 Pages

대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2009, 제 49권 제 3호 9 243-248 (6 pages)

Dong Kun Yang , Byoung Han Kim , Yeon Hee Kim , Kyung Woo Lee , Sung Suk Choi , Seong Wan Son 저
...
- 3,000원
44.

Proteomic Analysis of Colonic Mucosal Tissue from Tuberculous and Ulcerative Colitis Patients

Seong-ChunKwon, KyungJongWon, SeoungHyoJung, KangPaLee, Dong-YoubLee, Eun-SeokPark, BokyungKim, GabJinCheon, KoonHeeHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 7 193-198 (6 pages)

Seong-ChunKwon, KyungJongWon, SeoungHyoJung, KangPaLee, Dong-YoubLee, Eun-SeokPark, BokyungKim, GabJinCheon, KoonHeeHan 저
...
- 3,000원
differentially expressed in TC and UC. Of the over 1,000 proteins isolated, three in TC tissue and two in UC tissue displayed altered expression when compared to normal tissue. Moreover, two proteins were differentially expressed in a comparative analysis between TC and UC. These were identified as mutant Ղ-actin, Ձ-enolase and Charcot-Leyden crystal protein. In particular, the expression of Ձ- enolase was significantly greater in TC compared with normal tissue, but decreased...
45.

Optimized Immunohistochemical Analysis of Cerebellar Purkinje Cells Using a Specific Biomarker, Calbindin D28k

ByungJooKim, SoYeonLee, HyungWooKim, Eun-JungPark, JunKim, SangJeongKim, InsukSo, Ju-HongJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 7 373-378 (6 pages)

ByungJooKim, SoYeonLee, HyungWooKim, Eun-JungPark, JunKim, SangJeongKim, InsukSo, Ju-HongJeon 저
...
- 3,000원
of PC disorders, the method validation of IHC analysis with cerebellar tissue specimens is unclear. Here we present an optimized and validated IHC method using antibodies to calbindin D28k, a specific PC marker in the cerebellum. To achieve the desired sensitivity, specificity, and reproducibility, we modified IHC analysis procedures for cerebellar tissues. We found that the sensitivity of staining varies depending on the commercial source of primary antibody. In addition, we showed that a...
46.

Microarray Analysis of Differentially Expressed Genes in the Brains of Tubby Mice

JeongHoLee, ChulHoonKim, DongGooKim, YoungSooAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.2 4 91-98 (8 pages)

JeongHoLee, ChulHoonKim, DongGooKim, YoungSooAhn 저
...
- 3,000원
by a loss-of-function mutation in the tub gene and are shared with several human syndromes, suggesting the importance of tubby protein in central nervous system (CNS) functioning. Although evidence suggests that tubby may act as a transcription factor mediating G-protein coupled receptor (GPCR) signaling, any downstream gene regulated by tubby has yet to be identified. To explore potential target genes of tubby with region-specific transcription patterns in the brain, we performed a microarray...
47.

Discrepancy between in vitro and in vivo Effect of Gαs Gene Mutation on the mRNA Expression of TRH Receptor

SeungjoonPark, InmyungYang, SungvinYim, JoohoChung, JeechangJung, KyechangKo, YoungseolKim, YoungkilChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 13 101-108 (8 pages)

SeungjoonPark, InmyungYang, SungvinYim, JoohoChung, JeechangJung, KyechangKo, YoungseolKim, YoungkilChoi 저
...
- 3,000원
strong and prolonged contraction in trachealis musc1e strip. Strong tonic contraction by P AF was attenuated
48.

Enhanced Coupling of M1 Muscarinic Receptors to Activation of Phospholipase C upon Mutation of a Transposed Amino Acid Triplet Repeat

Seok-YongLee, Ki-WugSung, Ok-NyuKim, Sang-BokLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 3 19-25 (7 pages)

Seok-YongLee, Ki-WugSung, Ok-NyuKim, Sang-BokLee 저
...
- 3,000원
we found mutation of the LYTTYL sequence of M1 receptors to the corresponding M2 receptor LYTLYT sequence demonstrated markedly enhanced the stimulation of phosphoinositide (PI) hydrolysis by carbachol without a change in its coupling to increased cyclic AMP formation. In this work, thus, the enhanced stimulation of PI hydrolysis in the LYTLYT M1 receptor mutant was further investigated. The stimulation of PI hydrolysis by carbachol was enhanced in the mutant M1 receptor, and this change was not...
49.

Comparative Proteomic Analysis for a Putative Pyridoxal Phosphate-Dependent Aminotransferase Required for Virulence in Acidovorax citrulli

Jongchan Lee, Lynn Heo, Sang-Wook Han 한국식물병리학회 The Plant Pathology Journal 8 Pages

한국식물병리학회 The Plant Pathology Journal 2021, 37권 6호 16 673-680 (8 pages)

Jongchan Lee, Lynn Heo, Sang-Wook Han 저
...
- 3,000원
in watermelon when introduced via germinated-seed inoculation as well as leaf infiltration. Comparative proteomic analysis predicted the cellular mechanisms related to PpdaAc. Apart from causing virulence, the PpdaAc may have significant roles in energy production, cell membrane, motility, chemo- taxis, post-translational modifications, and iron-related mechanisms. Therefore, it is postulated that PpdaAc may possess pleiotropic effects. These results provide new insights into the functions of a...
50.

Whole-Genome Characterization of Alfalfa Mosaic Virus Obtained from Metagenomic Analysis of Vinca minor and Wisteria sinensis in Iran: with Implications for the Genetic Structure of the Virus

Zohreh Moradi, Mohsen Mehrvar 한국식물병리학회 The Plant Pathology Journal 13 Pages

한국식물병리학회 The Plant Pathology Journal 2021, 37권 6호 11 619-631 (13 pages)

Zohreh Moradi, Mohsen Mehrvar 저
...
- 4,200원
In the population genetic analysis based on the CP gene sequences, all 107 AMV isolates fell into two main clades (A, B) and isolates of clade A were further divided into three groups with significant subpopulation differentiation. The results indicated moderate genetic variation within and no clear geographic or genetic structure between the studied populations, implying moderate gene flow can play an important role in differentiation and distri- bution of genetic diversity among populations....

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