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The Protective Role of TLR3 and TLR9 Ligands in Human Pharyngeal Epithelial Cells Infected with Influenza A Virus
YanHan, Zhi-jianBo, Ming-yuXu, NanSun, Dan-hongLiu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.3 5 225-231 (7 pages)
In this study we aim to extensively investigate the anti-influenza virus immune responses in human pharyngeal epithelial cell line (Hep-2) and evaluate the protective role of Toll-like receptor (TLR) ligands in seasonal influenza A H1N1 (sH1N1) infections in vitro. We first investigated the expression of the TLRs and cytokines genes in resting and sH1N1 infected Hep-2 cells. Clear expressions of TLR3, TLR9, interleukin (IL)-6, tumour necrosis factor (TNF)-α and interferon (IFN)-β were detected... -
The Relaxing Effect of α-Defensin 1 on the Adrenergic Responses of Rat Bladder
ShinYoungLee, DonKyuKim, KyungDoKim, SoonChulMyung, MooYeolLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 4 143-147 (5 pages)
Defensins, cysteine-rich cationic polypeptides released from neutrophils, are known to have powerful antimicrobial properties. In this study, we sacrificed 30 rats to investigate the effects of Ձ-defensin 1 on detrusor muscle contractions in isolated rat bladder. From the experiments we found relaxing effects of Ձ-defensin 1 on the contractions induced by phenylephrine (PE) but not by bethanechol (BCh) in the detrusor smooth muscles. To determine the mechanisms of the effects of... -
Effects of Ambroxol, S-carboxymethylcysteine, Dextromethorphan and Noscapine on Mucin Release from Airway Goblet Cells
HoJinHeo, HyunJaeLee, ChiSoonYoon, SeungPyongLim, JeongHoSeok, UnKyoSeo, ChoongJaeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.6 2 323-326 (4 pages)
were metabolically radiolabeled and chased for 30 min in the presence of varying concentrations of the above agents to assess the effects on 3H-mucin release. Noscapine stimulated mucin release during 30 min of treatment period in a dose-dependent manner. However, ambroxol, S-carboxymethyl-L-cysteine and dextromethorphan showed no significant effect on mucin release during 30 min of treatment period. We conclude that noscapine can affect mucin release by acting on airway mucin-secreting cells. -
Effects ofSphingosine-1-phosphate, Furosemide and Indomethacin on Mucin Release from Airway Goblet Cells
Ju-OckKim, HyungSooKim, Sun-YoungKim, Seong-SooJeong, HoJinHeo, JeongHoSeok, ChoongJaeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.3 4 155-158 (4 pages)
for 30 min or 24 hr in the presence of varying concentrations of the above agents to assess the effects on 3H-mucin release. Sphingosine-1-phosphate stimulated mucin release during 30 min of treatment period in a dose-dependent manner. However, furosemide and indomethacin showed no effect on both basal and stimulated mucin release during 30 min or 24 hr of treatment period. We conclude that sphingosine-1-phosphate can affect mucin release by directly acting on airway mucin-secreting cells. -
Neuroprotective Effect of 8-OH-DPAT on Long-term Sequelae from Prenatal Ischemia in Rats
SeoulLee, TieYuanZhang, GunTaeKim, HeeSooKim, JongDooLee, JeongWonJahng, DongGooKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 3 293-297 (5 pages)
The role of 5-hydroxytryptamine (5-HT)1A receptor activity in prenatal ischemia was studied, by injecting 8-hydroxy-dipropylaminotetraline (8-OH-DPAT; 50μg/kg, s.c.), a 5-HT1A agonist on gestation day 17, and 30 min later inducing transient ischemia by ligating the uterine vessels for 30 min. On postnatal day 95, rats that had experienced prenatal ischemia showed impaired motor coordination and reduced concentration of 5-HT in the cerebellum compared with Sham-operated controls. In addition,... -
일본군 위안부 생존자들의 외상 후 스트레스 장애에 관한 연구
민성길, 이창호, 김주영, 심은지 대한신경정신의학회 신경정신의학 9 Pages
대한신경정신의학회 신경정신의학 2004, 제 43권 제 6호 18 740-748 (9 pages)
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침투성 상피암세포주와 비침투성 상피암세포주의 TGF alpha에 대한 반응의 차이
손영숙(Young-Sook Son), 최명재(Myoung-Jae Chey), Elaine Fuchs, 정명희(Myung Hee Chung), 박찬웅(Chan Woong Park) 대한약리학회 대한약리학잡지 10 Pages
대한약리학회 대한약리학잡지 1993, 제 29권 제 1호 14 139-148 (10 pages)
SCC 12와 SCC 13 세포주는 피부의 상피암 조직에서 유래되었다. 본 연구에서는, 세포배양으로 in vivo 피부의 거의 모든 특징들을 재현할 수 있는 raft 배양법을 이용하여, 두 종류의 상피 암세포주의 진피 침투성 정도를 비교해 보았다. SCC 12 세포주의 raft 배양에서는, collagen matrix로 침투하는 많은 세포군들이 관찰되었고, 또한 기저세포와 유사한 세포들이 분화층 중간에 관찰되었다. 그러나 SCC 13 세포주의 raft 배양에서는 침투성 세포들이 전혀 관찰되지 않았다. 어떤 인자가 SCC 12 세포주의 침투성에 관여하였는지를... -
Fe++및 H2O2에 의한 hyaluronic acid 분해에 있어서 ascorbic acid의 역할
이정수(Jung-Soo Lee), 정명희(Myung-Hee Chung), 임정규(Jung-Kyoo Lim), 박찬웅(Chan-Woong Park), 차인준(In-Joon Cha) 대한약리학회 대한약리학잡지 17 Pages
대한약리학회 대한약리학잡지 1985, 제 21권 제 1호 6 62-78 (17 pages)
Hydroxyl raical(OH⋅)을 생성하는 것으로 알려진 iron-catalyzed Haber-Weiss rocation에서 superoxide anion (O2-⋅)은 주로 Fe+++을 Fe++로 환원시키는 데에 작용하는 것으로 추정하고 있다. 이러한 OH⋅ 의 역할은 다른 환원제들에 의하여 대체가 가능할 것으로 추측되며 생물계의 환원제의 하나로써 ascorbate가 관심의 대상이 되고 있다. 이에 따라 본 연구에서는 Fe++와 H2O2 존재하에서 OH⋅ 을 생성하는 ascorbate 의 역할을 hyaluronic acid의 변성과 methional로 부터 ethylene 생성에 대한 효과로써... -
Reconstruction of the anterior maxilla with implants using customized zirconia abutments and all-ceramic crowns: a clinical case report
Sang-ki Byun, Yung-bin Lee, Woohyun Park, Mi-kyung Jo, Seung-yong Jeon 대한치과이식임플란트학회 Journal of Dental Implant Research 6 Pages
대한치과이식임플란트학회 Journal of Dental Implant Research 2015, 제 34권 2호 3 46-51 (6 pages)
implant placement was performed in #11 immediately after the patient lost #11 due to trauma because the patient had sufficient bone height and thickness and no pathologic conditions. One-mm labial and lingual distances between the implant andthe bone were observed with no sign of dehiscences, and GBR or tissue grafts were not required. The final impression, which was taken 5 months after the placement, confirmed the formation of interdental papillae and labial gingiva. The final restoration with... -
인접 자연치를 침범한 임플란트와 침범받은 자연치의 임상적 예후
구정귀, 윤필영, 최용훈, 이양진, 안교진, 이희진, 김영균 대한치과이식임플란트학회 Journal of Dental Implant Research 10 Pages
대한치과이식임플란트학회 Journal of Dental Implant Research 2015, 제 34권 1호 3 12-21 (10 pages)
임플란트는 치조골, 인접치 및 대합치의 상태에 따라 식립 위치가 결정된다. 치조골의 상태에 따라 식립각도에 제한이 있는 경우가 있 으며, 주변 인접치의 해부학적 배열 상태에 따라 임플란트 식립 위치 및 각도를 고려해야 한다1).
