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601.

Mediation of N-methyl-D-aspartate on Neuropeptide Y Expression Induced by Morphine in Mouse Cerebellum

Gee-younKwon, Soo-kyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.6 4 479-485 (7 pages)

Gee-younKwon, Soo-kyungKim 저
...
- 3,000원
The existence of opioid receptors in mammalian cerebellum except human, has not been clearly understood. In the present study, we found that NPY was inducible by morphine in the mouse cerebellar granular and Purkinje cell layers. We performed in situ RT-PCR and immunohistochemistry to characterize the NPY expression. The increase of NPY gene expression by morphine (30 mg/kg, i.p.) was inhibited by pretreatment with not only naloxone (100 mg/kg, i.p.) but also a noncompetitive NMDA antagonist,...
602.

Altered Electrophysiological Properties of Coronary Artery in Isoprenaline-Induced Cardiac Hypertrophy

NariKim, JinHan, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.5 7 413-421 (9 pages)

NariKim, JinHan, EuiyongKim 저
...
- 3,000원
arterial SMCs underwent significant changes in ultrastructure. The unitary current amplitude and the open-state probability of KCa channel were significantly reduced in hypertrophy without open-time and closed-time kinetic. The concentration-response curve of KCa channel to Ca2⁢ is shifted to the right in hypertrophy. The reduction in the mean single channel current and increase in the open channel noise of KCa channel by TEA were more sensitive in hypertrophy. Kdr current density is...
603.

Lipopolysaccharide Inhibits Proliferation of the Cultured Vascular Smooth Muscle Cells by Stimulating Inducible Nitric Oxide Synthase and Subsequent Activation of Guanylate Cyclase

HyoungChulChoi, SangGonLee, JongHoKim, JooYoungKim, UyDongSohn, JeoungHeeHa, KwangYounLee, WonJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 7 343-351 (9 pages)

HyoungChulChoi, SangGonLee, JongHoKim, JooYoungKim, UyDongSohn, JeoungHeeHa, KwangYounLee, WonJoonKim 저
...
- 3,000원
This study was undertaken to investigate the mechanism of lipopolysaccharide (LPS) and nitric oxide (NO) as a regulator of vascular smooth muscle cell (VSMC) proliferation. VSMC was primarily cultured from rat aorta and confirmed by the immunocytochemistry with anti-smooth muscle myosin antibody. The number of viable VSMCs were counted, and lactate dehydrogenase (LDH) activity was measured to assess the degree of cell death. Concentrations of nitrite in the culture medium were measured as an...
604.

Effect of Propofol on Ion Channels in Acutely Dissociated Dorsal Raphe Neuron of Sprague-Dawley Rats

Bong-JaeLee, Moo-IlKwon, Min-ChulShin, Youn-JungKim, Chang-JuKim, SoonAeKim, Ee-HwaKim, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 10 189-197 (9 pages)

Bong-JaeLee, Moo-IlKwon, Min-ChulShin, Youn-JungKim, Chang-JuKim, SoonAeKim, Ee-HwaKim, Joo-HoChung 저
...
- 3,000원
To investigate propofol's effects on ionic currents induced by γ-aminobutyric acid (GABA) and glycine as well as on those produced by the nicotinic acetylcholine- and glutamate-responsive channels, rat dorsal raphe neurons were acutely dissociated and the nystatin-perforated patch-clamp technique under voltage- clamp conditions was used to observe their responses to the administration of propofol. Propofol evoked ion currents in a dose-dependent manner, and propofol (10⁣4 M) was used to...
605.

The Alteration of Ca2+-activated K+ Channels in Coronary Arterial Smooth Muscle Cells Isolated from Isoproterenol-induced Cardiac Hypertrophy in Rabbit

NariKim, JinHan, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 5 147-156 (10 pages)

NariKim, JinHan, EuiyongKim 저
...
- 3,000원
It has been proposed that Ca2⁢-activated K⁢ (KCa) channels play an essential role in vascular tone. The alterations of the properties of coronary KCa channels have not been studied as a possible mechanism for impaired coronary reserve in cardiac hypertrophy. The present studies were carried out to determine the properties of coronary KCa channels in normal and hypertrophied hearts. These channels were measured from rabbit coronary smooth muscle cells using a patch clamp technique....
606.

The Hyperthermic Effect of Nitric Oxide in Central Nervous System

Jae-KyungJung, UyDongSohn, Seok-YongLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 13 93-98 (6 pages)

Jae-KyungJung, UyDongSohn, Seok-YongLee 저
...
- 3,000원
4 nmol, i.c.v.) elicited marked febrile response, and this febrile response was completely blocked by indomethacin (a cyclooxygenase inhibitor). But, ODQ (selective guanylate cyclase inhibitor, 50μg, i.c.v.) did not inhibit fever induced by SNP. The cyclic GMP analogue dibutyryl-cGMP (100μg, i.c.v.) induced significant pyreses, which is blocked by indomethacin. NG-nitro-L-arginine methyl ester (L-NAME, non selective NOS inhibitor) inhibited fever induced by interleukin-1β (IL-1β, 10 ng,...
607.

Role of NF-κB Binding Sites in the Regulation of Inducible Nitric Oxide Synthase by Tyrosine Kinase

YoungSueRyu, JangHeeHong, JongHoLim, SoHyunBae, IhnSubAhn, JeongHoSeok, JaeHeunLee, GangMinHur 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 8 55-63 (9 pages)

YoungSueRyu, JangHeeHong, JongHoLim, SoHyunBae, IhnSubAhn, JeongHoSeok, JaeHeunLee, GangMinHur 저
...
- 3,000원
In macrophages, lipopolysaccharide (LPS) alone or in combination with interferon-γ (IFN-γ) has been shown to release a nitric oxide (NO) through the increase of the transcription of the inducible nitric oxide synthase (iNOS) gene. To investigate the exact intracellular signaling pathway of the regulation of iNOS gene transcription by LPS plus IFN-γ, the effects of protein tyrosine kinase (PTK) inhibitor and protein kinase C (PKC) inhibitors on NO production, iNOS mRNA expression, nuclear...
608.

Role of Angiotensin II and Nitric Oxide in the Rat Paraventricular Nucleus

Eun-KyoungYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 6 41-46 (6 pages)

Eun-KyoungYang 저
...
- 3,000원
To investigate the mutual relationship between angiotensin II (Ang II) and nitric oxide (NO) in paraventricular nucleus (PVN), Ang II receptor type Ia (AT1A), type Ib (AT1B), endothelial constitutive nitric oxide synthase (ecNOS), and neuronal constitutive nitric oxide synthase (ncNOS) mRNA levels of rat PVN were measured after unilateral carotid artery ligation. AT1A and AT1B mRNA levels were markedly elevated 6 hrs after unilateral carotid artery ligation. Losartan injection (10μg/0.3μl)...
609.

Altered Delayed Rectifier K+ Current of Rabbit Coronary Arterial Myocytes in Isoproterenol-Induced Hypertrophy

NariKim, JinHan, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 5 33-40 (8 pages)

NariKim, JinHan, EuiyongKim 저
...
- 3,000원
The aim of present study was to define the cellular mechanisms underlying changes in delayed rectifier K⁢ (KDR) channel function in isoproterenol-induced hypertrophy. It has been proposed that KDR channels play a role in regulation of vascular tone by limiting membrane depolarization in arterial smooth muscle cells. The alterations of the properties of coronary KDR channels have not been studied as a possible mechanism for impaired coronary reserve in cardiac hypertrophy. The present...
610.

Role of Gap Junctions in the Endothelium-Dependent Hyperpolarization of Vascular Smooth Muscle Cells

YoshimichiYamamoto, MeganF.Klemm, HikaruHashitani, RichardJ.Lang, TsuyoshiSoji, HikaruSuzuki 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 1 1-8 (8 pages)

YoshimichiYamamoto, MeganF.Klemm, HikaruHashitani, RichardJ.Lang, TsuyoshiSoji, HikaruSuzuki 저
...
- 3,000원
Hyperpolarization of arterial smooth muscle by acetylcholine is considered to be produced by the release of an unidentified chemical substance, an endothelium-derived hyperpolarizing factor (EDHF). Several chemicals have been proposed as the candidate for EDHF. However, none of them fulfil completely the nature and property of EDHF. Ultrastructural observation with electron microscope reveals that in some arteries, gap junctions are formed between endothelial and smooth muscle cells. In small...

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