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61.

p53 signaling is involved in leptin-induced growth of hepatic and breast cancer cells

MohanShrestha, Pil-HoonPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.5 6 487-498 (12 pages)

MohanShrestha, Pil-HoonPark 저
...
- 4,100원
In the present study, we examined if p53 signaling is implicated in leptin-induced growth of cancer cells. Herein, we demonstrated that leptin treatment significantly increased p53 protein expression in both hepatic (HepG2) and breast (MCF-7) cancer cells without significant effect on mRNA expression. Enhanced p53 expressionby leptin was mediated via modulation of ubiquitination, in particular ubiquitin specific protease 2 (USP2)-dependent manner. Furthermore, gene silencing of p53 by small...
62.

CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells

XuejiaoLiu, YulongChong, HuizeLiu, YanHan, MingshanNiu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.2 4 161-168 (8 pages)

XuejiaoLiu, YulongChong, HuizeLiu, YanHan, MingshanNiu 저
...
- 3,000원
renal cancer cells. We found that S109 inhibits the CRM1-mediated nuclear export of RanBP1 and reduces protein levels of CRM1. Furthermore, the inhibitory effect of S109 on CRM1 is reversible. Our data demonstrated that S109 significantly inhibits proliferation and colony formation of renal cancer cells. Cell cycle assay showed that S109 induced G1-phase arrest, followed by the reduction of Cyclin D1 and increased expression of p53 and p21. We also found that S109 induces nuclear accumulation of...
63.

Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells

Yun-HeeBae, JongHyoRyu, Hyun-JooPark, KwangRokKim, Hee-JunWee, Ok-HeeLee, Hye-OckJang, Moon-KyoungBae, Kyu-WonKim, Soo-KyungBae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 6 291-297 (7 pages)

Yun-HeeBae, JongHyoRyu, Hyun-JooPark, KwangRokKim, Hee-JunWee, Ok-HeeLee, Hye-OckJang, Moon-KyoungBae, Kyu-WonKim, Soo-KyungBae 저
...
- 3,000원
of breast cancer. Mutant p53 (R280K) is overexpressed in MDA-MB-231 triple-negative human breast cancer cells. The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis. We found that curcumin treatment resulted in an induction of apoptosis in MDA-MB-231 cells, together with downregulation of Notch1 and its downstream target, Hes1. This...
64.

Gecko Proteins Exert Anti-Tumor Effect against Cervical Cancer Cells Via PI3-Kinase/Akt Pathway

Ae-JinJeong, Chung-NamChung, Hye-JinKim, KilSooBae, SongChoi, WooJinJun, SangInShim, Tae-HongKang, Sun-HeeLeem, JinWoongChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 12 361-365 (5 pages)

Ae-JinJeong, Chung-NamChung, Hye-JinKim, KilSooBae, SongChoi, WooJinJun, SangInShim, Tae-HongKang, Sun-HeeLeem, JinWoongChung 저
...
- 1,500원
on cervical cancer cells, and its signaling mechanisms were assessed by viable cell counting, propidium iodide (PI) staining, and Western blot analysis. GP induced the cell death of HeLa cells in a dose-dependent manner while it did not affect the viability of normal cells. Western blot analysis showed that GP decreased the activation of Akt, and co-administration of GP and Akt inhibitors synergistically exerted anti-tumor activities on HeLa cells, suggesting the involvement of PI3-kinase/Akt...
65.

Effect of 5-FU and MTX on the Expression of Drug-resistance Related Cancer Stem Cell Markers in Non-small Cell Lung Cancer Cells

HeeYi, Hee-JungCho, Soo-MinCho, KyulJo, Jin-APark, Soo-HanLee, Byung-JoonChang, Jin-SukKim, Ho-ChulShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.1 2 11-16 (6 pages)

HeeYi, Hee-JungCho, Soo-MinCho, KyulJo, Jin-APark, Soo-HanLee, Byung-JoonChang, Jin-SukKim, Ho-ChulShin 저
...
- 3,000원
the drug resistance-related cancer stem cell markers, ABCG2, IL-6R, and CD133 in non-small cell lung cancer (NSCLC) cell lines. A549, H460, and H23 NSCLC cell lines were treated with the anticancer drugs 5-fluorouracil (5-FU; 25 Ռg/ml) and methotrexate (MTX; 50 Ռg/ml), and the expression of putative CSC markers was analyzed by fluorescent activated cell sorter (FACS) and the gene expression level of abcg2, il-6r and cd133 by reverse transcriptase- polymerase chain reaction (RT-PCR)....
66.

Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species

Kyung-ChanKim, ChuHeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 7 391-397 (7 pages)

Kyung-ChanKim, ChuHeeLee 저
...
- 3,000원
HCT116 colon cancer cells. Hydrogen peroxide was also found to decrease E2F4 protein level, indicating the involvement of reactive oxygen species (ROS) in curucmin-induced downregulation of E2F4 expression. Involvement of ROS in E2F4 downregulation in response to curcumin was confirmed by the result that pretreatment of cells with N-acetylcystein (NAC) before exposure of curcumin almost completely blocked the reduction of E2F4 expression at the protein as well as mRNA level. Anti-proliferative...
67.

Literature Review of Postoperative Delirium in Geriatric Patients After Elective Gastrointestinal Cancer Surgery

Park Da-In, Choi-Kwon Smi 한국기초간호학회 Journal of Korean Biological Nursing Science 10 Pages

한국기초간호학회 Journal of Korean Biological Nursing Science 2018, Volume 20, No 3 5 177-186 (10 pages)

Park Da-In, Choi-Kwon Smi 저
...
- 3,000원
older adults are receiving cancer surgeries especially for gastrointestinal cancers, which brings forth attention to age-related postoperative complication prevention. Postoperative delirium (POD) is a common complication that rises after surgical procedures involving general anesthesia, largely in the elderly population. Due to its sudden onset and fluctuating symptoms, POD often goes underdiagnosed and undertreated even though it may lead to various adverse outcomes. POD in GI cancer surgical...
68.

Knowledge, Attitudes, and Practices in Oral Health among Families with Preschool Children in an Urban Poor Community in Metro Manila

Maritess Oliveros-Villarico, DDM, Aurorita T. Roldan 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 19 Pages

환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2008, Vol.2 No.1 3 35-53 (19 pages)

Maritess Oliveros-Villarico, DDM, Aurorita T. Roldan 저
...
- 4,800원
The knowledge, attitudes and practices in oral health of families with preschool Filipino children of selected communities in urban Metro Manila were explored. One hundred thirty-two randomly selected children were examined and interviewed as well as their parents. Results were correlated with parents\' educational attainment. Results revealed that parents had adequate knowledge in oral health, had desirable attitudes but practices were not congruent with them. Moreover, the parents\'...
69.

Screening of Differential Promoter Hypermethylated Genes in Primary Oral Squamous Cell Carcinoma

Khor. Goot Heah, Froemming. Gabrielle Ruth Anisah, Zain. Rosnah Binti, Abraham. Mannil Thomas, Thong. Kwai Lin 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 5 Pages

아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.20 8957-8961 (5 pages)

Khor. Goot Heah, Froemming. Gabrielle Ruth Anisah, Zain. Rosnah Binti, Abraham. Mannil Thomas, Thong. Kwai Lin 저

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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70.

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Fan. Yi, Zheng. Lei, Mao. Ming-Hui, Huang. Ming-Wei, Liu. Shu-Ming, Zhang. Jie, Li. Sheng-Lin, Zheng. Lei, Zhang. Jian-Guo 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 5 Pages

아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.20 8887-8891 (5 pages)

Fan. Yi, Zheng. Lei, Mao. Ming-Hui, Huang. Ming-Wei, Liu. Shu-Ming, Zhang. Jie, Li. Sheng-Lin, Zheng. Lei, Zhang. Jian-Guo 저

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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