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71.

Caffeine and 2-Aminoethoxydiphenyl Borate (2-APB) Have Different Ability to Inhibit Intracellular Calcium Mobilization in Pancreatic Acinar Cell

KyungJinChoi, KabSungKim, SeHoonKim, DongKwanKim, HyungSeoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.2 7 105-111 (7 pages)

KyungJinChoi, KabSungKim, SeHoonKim, DongKwanKim, HyungSeoPark 저
...
- 3,000원
Inositol 1,4,5-trisphosphate receptors (InsP3Rs) modulate Ca2＋ release from intracellular Ca2＋ store and are extensively expressed in the membrane of endoplasmic/sarcoplasmic reticulum and Golgi. Although caffeine and 2-aminoethoxydiphenyl borate (2-APB) have been widely used to block InsP3Rs, the use of these is limited due to their multiple actions. In the present study, we examined and compared the ability of caffeine and 2-APB as a blocker of Ca2＋ release from intracellular Ca2＋ stores...
72.

Are Spinal GABAergic Elements Related to the Manifestation of Neuropathic Pain in Rat?

JaeheeLee, SeungKeunBack, EunJeongLim, GyuChongCho, MyungAhKim, HeeJinKim, MinHeeLee, HeungSikNa 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.2 1 59-69 (11 pages)

JaeheeLee, SeungKeunBack, EunJeongLim, GyuChongCho, MyungAhKim, HeeJinKim, MinHeeLee, HeungSikNa 저
...
- 4,000원
Impairment in spinal inhibition caused by quantitative alteration of GABAergic elements following peripheral nerve injury has been postulated to mediate neuropathic pain. In the present study, we tested whether neuropathic pain could be induced or reversed by pharmacologically modulating spinal GABAergic activity, and whether quantitative alteration of spinal GABAergic elements after peripheral nerve injury was related to the impairment of GABAergic inhibition or neuropathic pain. To these aims,...
73.

R-type Calcium Channel Isoform in Rat Dorsal Root Ganglion Neurons

ZhiFang, JaeHongHwang, JoongSooKim, SungJunJung, SeogBaeOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.1 7 45-49 (5 pages)

ZhiFang, JaeHongHwang, JoongSooKim, SungJunJung, SeogBaeOh 저
...
- 1,500원
R-type Cav2.3 high voltage-activated Ca2+ channels in peripheral sensory neurons contribute to pain transmission. Recently we have demonstrated that, among the six Cav2.3 isoforms (Cav2.3a∼Cav2.3e), the Cav2.3e isoform is primarily expressed in trigeminal ganglion (TG) nociceptive neurons. In the present study, we further investigated expression patterns of Cav2.3 isoforms in the dorsal root ganglion (DRG) neurons. As in TG neurons, whole tissue RT-PCR analyses revealed the presence of two...
74.

Polyphenols of Rubus coreanum Inhibit Catecholamine Secretion from the Perfused Adrenal Medulla of SHRs

Byung-SikYu, Duck-MiNa, Mi-YoungKang, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 17 517-526 (10 pages)

Byung-SikYu, Duck-MiNa, Mi-YoungKang, Dong-YoonLim 저
...
- 3,000원
The present study was attempted to investigate whether polyphenolic compounds isolated from wine, which is brewed from Rubus coreanum Miquel (PCRC), may affect the release of catecholamines (CA) from the isolated perfused adrenal medulla of the spontaneously hypertensive rats (SHRs), and to establish its mechanism of action. PCRC (20∼180Ռg/ml) perfused into an adrenal vein for 90 min relatively dose-dependently inhibited the CA secretory responses to ACh (5.32 mM), high K＋ (56 mM), DMPP...
75.

Provinol Inhibits Catecholamine Secretion from the Rat Adrenal Medulla

Jung-HeeLee, Yu-SeungSeo, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 14 229-239 (11 pages)

Jung-HeeLee, Yu-SeungSeo, Dong-YoonLim 저
...
- 4,000원
The aim of the present study was to examine the effect of provinol, which is a mixture of polyphenolic compounds from red wine, on the secretion of catecholamines (CA) from isolated perfused rat adrenal medulla, and to elucidate its mechanism of action. Provinol (0.3∼3Ռg/ml) perfused into an adrenal vein for 90 min dose- and time-dependently inhibited the CA secretory responses evoked by ACh (5.32 mM), high K＋ (a direct membrane-depolarizer, 56 mM), DMPP (a selective neuronal nicotinic...
76.

Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum

SeungHyunJeun, HyeongSeokCho, KiJungKim, QingZhongLi, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 11 209-214 (6 pages)

SeungHyunJeun, HyeongSeokCho, KiJungKim, QingZhongLi, Ki-WugSung 저
...
- 3,000원
The striatum receives glutamatergic afferents from the cortex and thalamus, and these synaptic transmissions are mediated byՁ-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and N-methyl- D-aspartate (NMDA) receptors. The purpose of this study was to characterize glutamate receptors by analyzing NMDA/AMPA ratio and rectification of AMPA and NMDA excitatory postsynaptic currents (EPSCs) using a whole-cell voltage-clamp method in the dorsal striatum. Receptor antagonists were used to...
77.

Maternal Social Separation of Adolescent Rats Induces Hyperactivity and Anxiolytic Behavior

HyongRyolKwak, JaeWonLee, Kwang-JunKwon, ChangDonKang, IlYoungCheong, WanjooChun, Sung-SooKim, HeeJaeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.2 2 79-84 (6 pages)

HyongRyolKwak, JaeWonLee, Kwang-JunKwon, ChangDonKang, IlYoungCheong, WanjooChun, Sung-SooKim, HeeJaeLee 저
...
- 3,000원
Exposure to early stressful adverse life events such as maternal and social separation plays an essential role in the development of the nervous system. Adolescent Sprague-Dawley rats that were separated on postnatal day 14 from their dam and litters (maternal social separation, MSS) showed hyperactivity and anxiolytic behavior in the open field test, elevated plus-maze test, and forced-swim test. Biologically, the number of astrocytes was significantly increased in the prefrontal cortex of MSS...
78.

Forskolin Enhances Synaptic Transmission in Rat Dorsal Striatum through NMDA Receptors and PKA in Different Phases

HyeongSeokCho, HyunHoLee, SeJoonChoi, KiJungKim, SeungHyunJeun, Qing-ZhongLi, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.6 2 293-298 (6 pages)

HyeongSeokCho, HyunHoLee, SeJoonChoi, KiJungKim, SeungHyunJeun, Qing-ZhongLi, Ki-WugSung 저
...
- 3,000원
The effect of forskolin on corticostriatal synaptic transmission was examined by recording excitatory postsynaptic currents (EPSCs) in rat brain slices using the whole-cell voltage-clamp technique. Forskolin produced a dose-dependent increase of corticostriatal EPSCs (1, 3, 10, and 30ՌM) immediately after its treatment, and the increase at 10 and 30ՌM was maintained even after its washout. When the brain slices were pre-treated with <FONT SIZE=2>(DL)-2-amino-5-phosphonovaleric...
79.

Effects of Somatostatin on the Responses of Rostrally Projecting Spinal Dorsal Horn Neurons to Noxious Stimuli in Cats

SungJunJung, Su-HyunJo, SanghyuckLee, EunhuiOh, Min-SeokKim, WooDongNam, SeogBaeOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.5 6 253-258 (6 pages)

SungJunJung, Su-HyunJo, SanghyuckLee, EunhuiOh, Min-SeokKim, WooDongNam, SeogBaeOh 저
...
- 3,000원
Somatostatin (SOM) is a widely distributed peptide in the central nervous system and exerts a variety of hormonal and neural actions. Although SOM is assumed to play an important role in spinal nociceptive processing, its exact function remains unclear. In fact, earlier pharmacological studies have provided results that support either a facilitatory or inhibitory role for SOM in nociception. In the current study, the effects of SOM were investigated using anesthetized cats. Specifically, the...
80.

Single-Channel Recording of TASK-3-like K+ Channel and Up- Regulation of TASK-3 mRNA Expression after Spinal Cord Injury in Rat Dorsal Root Ganglion Neurons

InseokJang, Jun-HoLa, Gyu-TaeKim, Jeong-SoonLee, Eun-JinKim, Eun-ShinLee, Su-JeongKim, Jeong-MinSeo, Sang-HoAhn, Jae-YongPark, Seong-GeunH 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.5 5 245-252 (8 pages)

InseokJang, Jun-HoLa, Gyu-TaeKim, Jeong-SoonLee, Eun-JinKim, Eun-ShinLee, Su-JeongKim, Jeong-MinSeo, Sang-HoAhn, Jae-YongPark, Seong-GeunH 저
...
- 3,000원
Single-channel recordings of TASK-1 and TASK-3, members of two-pore domain K+ channel family, have not yet been reported in dorsal root ganglion (DRG) neurons, even though their mRNA and activity in whole-cell currents have been detected in these neurons. Here, we report single-channel kinetics of the TASK-3-like K+ channel in DRG neurons and up-regulation of TASK-3 mRNA expression in tissues isolated from animals with spinal cord injury (SCI). In DRG neurons, the single-channel conductance of...

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