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Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd’s Purs
WooJinChoi, SeongKeunKim, HeeKukPark, UyDongSohn, WonyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 4 33-39 (7 pages)
Shepherd’s purse, Capsella bursa-pastoris (L.) Medik., has been considered a health food for centuries in Asia and is known to contain the isothiocyanate compound sulforaphane. In this study, we evaluated the anti-inflammatory and antibacterial properties of a sulforaphane-containing solution (SCS) isolated from shepherd’s purse. SCS had significant anti-inflammatory activity indicated by the decreased levels of nitric oxide (NO), cytokines (interleukin 1β [IL-1β], IL-6, and IL-10), and... -
Activation of G Proteins by Aluminum Fluoride Enhances RANKL- Mediated Osteoclastogenesis
BoryungPark, Yu-MiYang, Byung-JaiChoi, MinSeukKim, DongMinShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 8 427-433 (7 pages)
form of oscillations, which plays essential roles by activating sequen-tially Ca2＋/calmodulin-dependent protein kinase, calcineurin and NFATc1, necessary in the osteoclast differentiation. However, it is not known whether Ca2＋ mobilization which is evoked in RANKL-in-dependent way induces to differentiate into osteoclasts. In present study, we investigated Ca2＋ mobilization induced by aluminum fluoride (AlF4−), a G-protein activator, with or without RANKL and the effects of AlF4−... -
Korean Red Ginseng Induced Cardioprotection against Myocardial Ischemia in Guinea Pig
KyuHeeLim, Chang-WonKang, Jin-YongChoi, Jong-HoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 5 283-289 (7 pages)
This study was designed to evaluate the protective effect of Korean red ginseng (KRG) against ischemia/reperfusion (I/R) injury in isolated guinea pig heart. KRG has been shown to possess various ginsenosides, which are the major components of Panax ginseng. These components are known naturally occurring compounds with beneficial effects and free radical scavenging activity. The heart was induced to ischemia for 60 min, followed by 120 min reperfusion. The hearts were randomly allocated into... -
Anti-Inflammatory and Anti-Superbacterial Activity of Polyphenols Isolated from Black Raspberry
SeongKeunKim, HyunaKim, SongAhKim, HeeKukPark, WonyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 11 73-79 (7 pages)
(LPS)- stimulated RAW 264.7 murine macrophages. However, root polyphenols showed stronger anti- inflammatory activity than fruit polyphenols. LPS-induced mRNA and protein expressions of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 levels were also decreased, confirming the anti- inflammatory activity. Root polyphenols showed lethal activity against methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Acinetobacter baumannii (CRAB), and Bacillus anthracis. In... -
Dipeptides Inhibit Melanin Synthesis in Mel-Ab Cells through Down-Regulation of Tyrosinase
Hyun-eLee, Eun-HyunKim, Hye-RyungChoi, UyDongSohn, Hye-YoungYun, KwangJinBaek, NyounSooKwon, Kyoung-ChanPark, Dong-SeokKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 9 287-291 (5 pages)
in a cell-free system. Both PS and VS down-regulated the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase. In a follow-up study also described here, the effects of these dipeptides on melanogenesis-related signal transduction were quantified. Specifically, PS and VS induced ERK phosphorylation, though they had no effect on phosphorylation of the cAMP response element binding protein (CREB). These data suggest that PS and VS inhibit melanogenesis through ERK... -
A Computational Model of the Temperature-dependent Changes in Firing Patterns in Aplysia Neurons
NamGyuHyun, Kwang-HoHyun, Kwang-BeomHyun, Jin-HeeHan, KyungminLee, Bong-KiunKaang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 8 371-382 (12 pages)
We performed experiments using Aplysia neurons to identify the mechanism underlying the changes in the firing patterns in response to temperature changes. When the temperature was gradually increased from 11oC to 31oC the firing patterns changed sequentially from the silent state to beating, doublets, beating-chaos, bursting-chaos, square-wave bursting, and bursting-oscillation patterns. When the temperature was decreased over the same temperature range, these sequential changes in the firing... -
Inhibitory Actions of HERG Currents by the Immunosuppressant Drug Cyclosporin A
SeungHoLee, SangJuneHahn, GyesikMin, JimokKim, Su-HyunJo, HanChoe, BokHeeChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.5 7 291-298 (8 pages)
a whole-cell, patch-clamp technique. CsA inhibited the HERG channel in a concentration-dependent manner, with an IC50 value and a Hill coefficient of 3.17ՌM and 0.89, respectively. Pretreatment with cypermethrine, a calcineurin inhibitor, had no effect on the CsA-induced inhibition of the HERG channel. The CsA-induced inhibition of HERG channels was voltage-dependent, with a steep increase over the voltage range of the channel opening. However, the inhibition exhibited voltage independence... -
P2X and P2Y Receptors Mediate Contraction Induced by Electrical Field Stimulation in Feline Esophageal Smooth Muscle
YoungRaeCho, HyeonSoonJang, WonKim, SunYoungPark, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 10 311-316 (6 pages)
It is well-known that electrical field stimulation (EFS)-induced contraction is mediated by a cholinergic mechanism and other neurotransmitters. NO, ATP, calcitonin gene-related peptide (CGRP), and substance P are released by EFS. To investigate the purinergic mechanism involved in the EFS-induced contraction, purinegic receptors antagonists were used. Suramine, a non-selective P2 receptor antagonist, reduced the contraction induced by EFS. NF023 (10−7∼10−4 M), a selective P2X... -
Acidic pH-activated Cl? Current and Intracellular Ca2＋ Response in Human Keratinocytes
SuJungPark, WonWooChoi, OhSangKwon, JinHoChung, HeeChulEun, YungEEarm, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 8 177-184 (8 pages)
on the surface of the skin. Herein, we investigated the effects of acidic pH on the membrane current and [Ca2＋]c of human primary keratinocytes from foreskins and human keratinocyte cell line (HaCaT). Acidic extracellular pH (pHe≤5.5) activated outwardly rectifying Cl− current (ICl,pH) with slow kinetics of voltage-dependent activation. ICl,pH was potently inhibited by an anion channel blocker 4,4`-diisothiocyanostilbene-2,2`-disulphonic acid (DIDS, 73.5% inhibition at 1ՌM). ICl,pH... -
Expression of Endothelin-1 and Its Receptors in Cisplatin-Induced Acute Renal Failure in Mice
SeokwooLee, DowhanAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 4 149-154 (6 pages)
was, therefore, undertaken to investigate changes in renal expression of ET-1 and its receptors in nephrotoxic ARF induced by cisplatin. Mice were intraperitoneally injected with 16 mg of cisplatin/kg at a single dose, and the expression of mRNA and protein was then quantified by real-time RT-PCR and Western blot, respectively. Immuno</SUB>histochemistry was conducted for localization. Three days after treatment, ET-1 transcript in cisplatin- treated mice was thirteen times higher than tha...
